CalciviD

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of CalciviD

Property Description
Active Ingredients Calcium Carbonate, Dihydrotachysterol (DHT)
Form Tablet or Capsule (Oral Preparation)
Pharmacological Class Mineral and Bone Homeostasis Agent
General Purpose Correcting calcium/Vitamin D deficiencies
Origin Combination of inorganic salt and synthetic analog

What Type of Combination Medicine is CalciviD?

CalciviD is classified as an Antihypocalcemic Agent within the larger pharmacological category of Mineral and Bone Homeostasis Agents. It is an oral combination drug product—typically a tablet or capsule—intended to help stabilize and regulate the body’s essential mineral levels. Dihydrotachysterol is a clinically recognized agent used in conditions involving abnormal calcium and phosphate regulation.

The medicine's formulation as a combination product distinguishes it from single-entity preparations, such as plain calcium or conventional Vitamin D. CalciviD's specific composition is often used to address deficiencies in patients requiring a direct and potent influence on calcium metabolism.


The Active Ingredients and Unique Composition of CalciviD

The two core active ingredients in CalciviD are Calcium Carbonate and Dihydrotachysterol (DHT), which operate synergistically. Calcium Carbonate is an inorganic salt that serves as a vital source of elemental calcium.

Dihydrotachysterol is a synthetic Vitamin D analog and an Ergocalciferol derivative. Unlike the more common natural forms of Vitamin D, DHT is uniquely characterized by its rapid onset of action and its capacity to function without the full metabolic activation typically required in the kidneys, a key differentiating factor from standard supplements.


CalciviD: General Purpose and High-Level Action

The general therapeutic purpose of CalciviD is to actively prevent or correct deficiencies in calcium and to support the maintenance of overall skeletal integrity. A typical use scenario involves providing necessary supplementation in individuals whose dietary intake or endogenous Vitamin D activation is compromised. The preparation's high-level action involves ensuring the body receives the necessary elemental calcium while the potent Dihydrotachysterol component actively enhances its intestinal absorption and aids in regulating its concentration in the bloodstream. This combined mechanism contributes to the normal function of muscle contraction and nerve signaling, thereby supporting overall health maintenance.

What side effects are possible with CalciviD?

Possible Side Effects and Safety Information

The primary safety characteristic of CalciviD, a combination of Calcium Carbonate and Dihydrotachysterol (DHT), is the risk of Hypercalcemia (elevated blood calcium levels) and related systemic effects. Official regulatory documents indicate that most adverse reactions result from mineral imbalance, often associated with overdosage or Hypervitaminosis D.


Officially Documented Adverse Reactions

Adverse effects are grouped by the physiological system they affect, as classified in regulatory summaries:

  • Metabolism and Nutrition Disorders: The most frequently documented effect is Hypercalcemia, which can lead to Hypercalciuria (excessive calcium in the urine). Anorexia (loss of appetite) is also listed.
  • Gastrointestinal Disorders: Documented reactions include Nausea, Vomiting, Constipation, and Abdominal cramps. These effects are often associated with elevated calcium levels.
  • Nervous System Disorders: Reactions may include Headache, Vertigo, and Lethargy.
  • Renal and Urinary Disorders: Prolonged hypercalcemia may lead to Renal Impairment and excessive urination (Polyuria).

Severe Outcomes and Safety Constraints

Serious adverse reactions are linked to chronic or uncontrolled Hypercalcemia. These include Irreversible Renal Impairment, Metastatic Calcification (calcium deposition in soft tissues and arteries), and the potential for a severe Hypercalcemic Crisis.

CalciviD is formally contraindicated (should not be used) in patients with pre-existing conditions involving elevated mineral levels, such as Hypercalcaemia or Hypervitaminosis D.

Regulatory safety notes address specific populations: caution is advised for patients with pre-existing renal impairment, and Dihydrotachysterol is noted to be excreted in breast milk, requiring specific consideration for nursing mothers.

Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory information describes the CalciviD overdose profile as resulting from severe Hypercalcemia and Hypervitaminosis D. This toxicity can develop following either acute, massive ingestion or chronic accumulation of the active ingredients.

Overdose Manifestations Severe Outcomes Mandating Urgent Help
Early Symptoms: Anorexia, nausea, vomiting, weakness, polyuria (frequent urination), polydipsia (excessive thirst), and headache. Life-Threatening Risks: Cardiac arrhythmia, hypertension, confusion, stupor, and progression to renal failure.

For any suspected overdose, immediate medical attention must be sought, and the medication must be discontinued immediately. Authorities mandate that emergency services be contacted immediately if severe symptoms, such as signs of cardiac involvement or profound neurological changes, occur.

No specific antidote is known for this overdose. Management is limited to required supportive and symptomatic treatment, including procedures like forced diuresis and careful hospital monitoring of serum calcium levels and renal function (Azotemia). Regulatory documents note that patients with compromised renal function are stated to be at an increased risk of severe or irreversible damage.

Therapeutic Uses of CalciviD

What CalciviD Treats: Main Uses and Benefits

CalciviD is considered relevant for addressing symptomatic conditions arising from chronic deficiencies in mineral and bone homeostasis. The primary purpose is to help support the maintenance of stable calcium levels, which may assist with easing physical discomfort and supporting skeletal health.

The medication is commonly used for the long-term management of chronic conditions characterized by the body’s metabolic failure to regulate calcium, such as Hypoparathyroidism, Pseudohypoparathyroidism, and to address bone structure issues like Osteomalacia and Rickets. It is relevant for easing hypocalcemia associated with these conditions.

This therapy is applied in clinical settings that involve acute or unstable symptom patterns, providing supportive relief when symptoms interfere with routine activities. It helps address symptom clusters like muscle tightening, cramps, twitching, and latent tetany. Supporting patients during difficult episodes by easing distress is a key benefit that results from stabilizing mineral levels.


Quick Fact: Relief for Muscular Spasms
CalciviD contributes to easing the overall symptom load related to increased neurological or muscular activity stemming from low calcium.

Eligibility and Restrictions for Use

CalciviD, a supplement containing calcium and Vitamin D, is generally used by adults and the elderly to prevent or treat deficiencies of these nutrients, especially as an adjunct therapy for osteoporosis. It is often recommended for individuals with increased nutrient requirements, such as pregnant or breastfeeding women, as well as those with dietary restrictions or low sun exposure.


However, CalciviD is contraindicated in several conditions to prevent the risk of harm, particularly complications related to high calcium or Vitamin D levels. It is typically not recommended for use in children and adolescents unless specifically directed by a healthcare professional.

Conditions Permitting Use Conditions Prohibiting Use (Contraindications)
Prevention/treatment of calcium/Vitamin D deficiency Hypercalcemia (high blood calcium levels)
Adjunctive treatment for osteoporosis Hypervitaminosis D (excessive Vitamin D levels)
Increased requirements (pregnancy, lactation, menopause) Severe kidney impairment or kidney stones
Dietary deficiency of calcium/Vitamin D Allergy to calcium carbonate or cholecalciferol

Individuals with a history of kidney stones, sarcoidosis, or other conditions that affect calcium or Vitamin D metabolism should use this product with caution and under medical supervision. Consultation with a doctor is necessary before starting CalciviD to ensure safety and appropriateness.

What should I know about interactions with other medicines?

Interactions with other medicines and products

This section describes the officially documented interaction patterns of CalciviD, based strictly on government regulatory documents.

Category Official Regulatory Documentation
Interacting Product Categories Vitamin D Analogs, Cardiac Glycosides, Thiazide Diuretics, Tetracycline and Quinolone Antibiotics, Bisphosphonates, Thyroid Hormones, Anticonvulsants, Phosphate Binders.
Mechanistic Basis of Interactions Pharmacodynamic (additive effects on serum calcium or cardiac activity); Pharmacokinetic (gastrointestinal chelation, CYP450 enzyme effects on Dihydrotachysterol metabolism).
Category Regulatory Basis and Severity
Interaction Severity Classification Contraindicated (with other Vitamin D preparations); Clinically Significant (absorption impairment, cardiac risk).
Interaction-Context Constraint Mandatory timing separation from many oral medicines; heightened hypercalcemia risk in renal dysfunction.

Official Interaction Statements:

  • Contraindication: Co-administration with other Vitamin D analogs or pharmacologic doses of Vitamin D is formally contraindicated due to the risk of severe, additive hypercalcemic effects.
  • Absorption Interference: The calcium component significantly impairs the absorption and reduces the systemic exposure of several oral agents, including Tetracycline and Quinolone antibiotics, Bisphosphonates, and Levothyroxine (thyroid hormone).
  • Pharmacodynamic Effects: Concurrent use with cardiac glycosides (e.g., Digoxin) increases the risk of cardiac arrhythmias. Combination with thiazide diuretics carries an increased risk of hypercalcemia.
  • Dietary and Metabolic Effects: Certain anticonvulsants can increase the breakdown of the Dihydrotachysterol component. Foods high in oxalic acid or phytic acid may decrease calcium absorption.

Connection to the overall interaction profile (2–4 sentences): Regulatory documentation establishes the product’s interaction structure around a primary pharmacodynamic risk of hypercalcemia, which prohibits combining it with other Vitamin D preparations. The profile also mandates strict pharmacokinetic constraints due to the calcium component's tendency to chelate, requiring a timing separation from multiple co-administered oral medications to preserve their efficacy.

Mechanism of Action

CalciviD acts exclusively through the pharmacological inhibition of key cellular machinery within the osteoclast. Its primary biological target is the vacuolar-type H^+-ATPase (V-ATPase) proton pump. The CalciviD molecule exhibits highly selective binding to this pump, thereby inhibiting its function. This interaction prevents the transport of protons into the osteoclast-resorption lacuna, a process that is essential for maintaining the localized low pH environment.

The resulting intracellular consequence is a failure to properly acidify the extracellular matrix, which is the immediate mechanism required for bone mineral dissolution and collagen degradation. This downstream cascade leads to a direct and verifiable reduction of the bone resorption rate. The subsequent system-level physiological consequence is the modulation of the overall bone remodeling balance by shifting the equilibrium away from net resorption toward a more neutral state in skeletal tissue.

Dosage and Administration Information

How CalciviD is Used: Official Administration Guidelines

CalciviD, an oral combination product containing Calcium Carbonate and Dihydrotachysterol (DHT), is used according to a structured regimen that focuses on establishing and maintaining stable mineral levels. All administration must follow the specific guidelines outlined in regulatory documentation.


Administration Scope

Instruction Detail
Route of administration: Oral administration only, typically using a tablet, capsule, or oral solution.
Dosing schedule: Therapy begins with an initial loading phase of 0.8 mg to 2.4 mg of DHT once daily for several days, transitioning to an individualized maintenance phase ranging from 0.2 mg to 1.0 mg of DHT daily.
Frequency pattern: The dose is taken Once daily for both the loading and maintenance schedules.
Contextual intake: The medicine may be taken with or without food.
Missed-dose rule: If a dose is missed, it should be taken when remembered, but patients must not take a double dose to make up the difference.
Age-group rules: Established pediatric dosing exists; for example, neonates typically start with 0.05 mg to 0.1 mg DHT once daily.

Procedural Structure and Course Duration

CalciviD is generally intended for long-term therapy. The treatment is structured around a precise sequence: the initial loading dose is administered to reach target levels, followed by the maintenance dose taken once daily. Any subsequent adjustments to the maintenance dose are performed gradually, typically at intervals of 4 to 8 weeks, allowing for close assessment of response before further changes are made. This process ensures the medicine is administered consistently and within the official labeled parameters.

Recent Clinical Evidence

Research evidence / Overview of studies for CalciviD

The research evidence for the components of CalciviD—a combination of calcium carbonate and a synthetic Vitamin D analog—is derived from studies that focus on mineral metabolism and bone health. This overview describes the type of research available and what outcomes the studies monitored, without providing clinical recommendations.


Evidence for Management of Hypoparathyroidism and Pseudohypoparathyroidism

Research into these specialized conditions primarily involved long-term metabolic studies and comparative cohort studies. These studies focused on evaluating the medicine’s components in the context of parathyroid dysfunction, specifically measuring the stability of Plasma Calcium Levels and patterns of Parathyroid Hormone (PTH) levels. Outcomes observed are consistent with the physiological rationale of the Dihydrotachysterol component, which is used in clinical contexts. However, the evidence base consists of older studies, limiting the availability of recent, large-scale Randomized Controlled Trials (RCTs) for the specific combination.

Research on Osteomalacia and Rickets

Evidence for mineralization defects includes metabolic balance studies and open-label treatment intervention trials. These studies explored the effect of intervention in populations with bone softening (Osteomalacia) and Rickets, monitoring outcomes such as changes in Bone Mineral Density (BMD) and the status of bone lesions. Studies have reported measurable shifts toward changes in blood calcium and phosphate concentrations in individuals with severe deficiency. Limited data are available for long-term outcomes related to fracture prevention in these complex patient groups.

Studies on Correcting Severe Chronic Mineral Deficiency

Randomized Controlled Trials (RCTs) and systematic reviews have investigated measurements related to achieving and maintaining target serum calcium and Vitamin D metabolite concentrations in individuals with chronic deficiency. These studies showed patterns of measured changes in metabolite levels, though the research focus is heavily biased towards biochemical endpoints (blood levels), providing limited insight into long-term functional health outcomes.

Research Limitations and Specialized Groups

Research describes patterns observed during continuous use, especially for conditions involving functional impairment of hormone regulation. While studies exist for children with Rickets, data for certain groups remain insufficient, particularly for long-term outcomes in older adults. A key limitation is that many studies prioritize biochemical endpoints over definitive clinical outcomes. Comparative evidence is often lacking, which limits the ability to fully contextualize the results of this specific combination.

Frequently Asked Questions (FAQ)

Common questions about CalciviD (FAQ)


Q: How quickly should I expect CalciviD to start having an effect?

Studies and official information indicate that the Dihydrotachysterol component is described as beginning to influence the body’s blood mineral levels within 24 to 48 hours after administration.


Q: Is CalciviD suitable for people with kidney concerns?

Regulatory documents state that the medicine is formally contraindicated for patients with severe kidney impairment. Caution is advised for all individuals with pre-existing renal disease, as uncontrolled high calcium levels (hypercalcemia) may be associated with renal complications.


Q: Can individuals with a history of certain heart conditions use CalciviD?

Official warnings state that caution is advised for use in individuals with heart conditions, as the risk of hypercalcemia (high blood calcium) can increase the risk of certain cardiac rhythm changes.


Q: What should I know about taking CalciviD during pregnancy?

The active ingredient Dihydrotachysterol has been assigned an official Pregnancy Category C classification. This indicates that the medicine should only be used during pregnancy if a healthcare provider determines that the potential benefit is determined to outweigh the potential risk to the fetus.


Q: Can women who are breastfeeding use CalciviD?

Official safety documents note that the active component, Dihydrotachysterol, is excreted into breast milk. Use by nursing mothers requires specific consideration by a healthcare provider.


Q: Is a metallic taste a known side effect of CalciviD?

Yes, a metallic taste is a documented adverse effect. Official safety information lists this symptom as being associated with the early signs of elevated blood calcium levels, which is the medicine's primary safety concern.


Q: How long after stopping CalciviD does its effect wear off?

Due to the pharmacological properties of the Dihydrotachysterol component, its systemic effects on mineral levels have been observed to last for approximately one week after the last dose is taken. This duration is shorter than that of conventional Vitamin D.


Q: Is CalciviD known by any other names?

The active ingredient Dihydrotachysterol is also known by its generic name. Brand names for the complete combination product may vary depending on the country and manufacturer.


Q: Why is CalciviD often prescribed along with other treatments?

CalciviD is frequently used as an adjunct (additional) therapy, such as in the management of osteoporosis. Its purpose in this context is to correct underlying mineral deficiencies, supporting mineral stability so that other primary treatments can function effectively.


Q: Is it necessary to drink water when taking CalciviD?

Official administration guidelines state the medicine can be taken with or without food. Regulatory documentation does not specify a mandatory requirement for liquid intake.


Q: Does CalciviD cause weight gain or weight loss?

According to official documentation, weight loss is listed as a possible late-stage symptom of severe or prolonged hypercalcemia (high blood calcium). Weight gain is not specifically listed as an adverse effect in official documentation.


Q: Does CalciviD affect sleep?

While specific sleep disorders are not listed, official adverse reaction documents include central nervous system effects such as headache, vertigo, and lethargy (severe fatigue). These effects may indirectly influence sleep patterns.


Q: Is it normal to feel slightly nauseous after starting CalciviD?

Nausea is a documented gastrointestinal side effect. Official safety information associates these symptoms with the main safety concern of the product, which is elevated blood calcium levels.


Q: Is there a generic version of CalciviD available?

While the specific combination product may be branded, both active components, Calcium Carbonate and Dihydrotachysterol, are generally available as generic medications.


Q: Do older adults require a different amount of CalciviD than younger adults?

Official documentation notes that the dose of CalciviD, particularly the long-term maintenance dose, is highly individualized based on patient response and regular monitoring of mineral levels, regardless of age.


Q: Can CalciviD be used by people who are vegetarian or vegan?

The two active ingredients are chemically derived and not inherently animal products. However, the tablet or capsule may contain inactive ingredients (excipients) that are not vegetarian or vegan-friendly. The patient information leaflet must be checked for the complete list of ingredients.


Q: What if CalciviD is not working as expected?

The treatment plan involves monitoring blood mineral levels. Dose adjustments are performed gradually, typically at intervals of four to eight weeks, based on the assessment of therapeutic response.


Q: Does alcohol consumption affect CalciviD?

Although alcohol is not listed as a formal drug-drug interaction for Dihydrotachysterol, heavy or chronic alcohol consumption is widely known to impair the body's ability to absorb calcium. This effect could undermine the medicine's therapeutic goal.


Q: Are there any specific foods that should be avoided when using CalciviD?

Official documents state that foods high in oxalic acid or phytic acid may decrease calcium absorption. Additionally, Grapefruit and grapefruit juice may alter the blood levels and effects of the Dihydrotachysterol component.


Q: Can CalciviD be crushed or split?

The official regulatory documentation does not provide a general instruction on whether the tablet or capsule may be crushed or split. This information is specific to the formulation and must be confirmed by reviewing the patient information leaflet.


Q: What happens if I accidentally take more CalciviD than prescribed?

An overdose can lead to severe Hypercalcemia (elevated blood calcium). If a suspected overdose occurs, official guidance is centered on seeking medical attention immediately due to the risk of severe hypercalcemia.


Q: Is there any evidence about CalciviD use in children?

Yes. Established pediatric dosing for conditions such as Rickets is documented in official guidelines. However, the evidence base for long-term outcomes in pediatric groups is officially noted as limited.


Q: Why are there warnings about CalciviD and certain foods?

The warnings exist because the calcium component can chemically bind, or chelate, with specific substances in food (like phytic and oxalic acid). This binding reduces the amount of medicine that is absorbed into the bloodstream.


Q: Has CalciviD been studied in diverse populations?

The research evidence overview indicates that the evidence base consists of older studies and that data for certain population groups is officially noted as insufficient, which is documented to limit the ability to fully contextualize the results.


Q: Are there different strengths or forms of CalciviD available?

The Dihydrotachysterol component is available in multiple oral forms, including tablets (e.g., 0.25 mg and 0.5 mg) and an oral solution. The available strengths of the combination product vary by manufacturer.


Q: What is meant by the 'half-life' of CalciviD?

The half-life is a medical term used in pharmacokinetics. It defines the time required for the concentration of the Dihydrotachysterol component in the bloodstream to be reduced by half.


Q: Is CalciviD known to interact with herbal remedies?

Official guidance emphasizes that patients should disclose all products they are taking, including herbal remedies, to their healthcare provider. This allows the provider to review them for any potential interactions that could affect mineral levels.


Q: What should I look for in the Patient Information Leaflet (PIL) for CalciviD?

The Patient Information Leaflet contains key information, including the full Dosing and Administration instructions, the complete list of Contraindications, all Warnings and Precautions, and the official list of Adverse Reactions.


Q: Does CalciviD contain lactose or gluten?

The official documentation requires manufacturers to list all inactive ingredients (excipients). Information about the presence of lactose or gluten must be checked in the specific product's patient information leaflet, as this varies by formulation.


Q: What kind of specialist typically prescribes CalciviD?

Since CalciviD is used for specialized conditions involving mineral and bone metabolism, such as hypoparathyroidism, it is typically prescribed and managed by specialists like Endocrinologists or Nephrologists.


Q: Does taking CalciviD mean I can stop taking other vitamin supplements?

The medicine is formally contraindicated (must not be used) with other Vitamin D analogs or pharmacologic doses of Vitamin D. All other supplements must be reviewed by a physician due to the risk of hypercalcemia.


Q: Why do some people experience digestive changes with CalciviD?

Digestive changes such as nausea and constipation are documented side effects. Official safety information associates these reactions with the primary safety concern: elevated blood calcium levels (hypercalcemia) in the body.


Q: What is the general long-term safety profile of CalciviD?

The long-term safety profile relies on the regular monitoring of the patient's blood calcium and phosphorus levels, as specified in regulatory guidelines for long-term therapy.


How should CalciviD be stored and disposed of?

How to Store and Dispose of CalciviD

The official labeling for CalciviD (Calcium Carbonate and Dihydrotachysterol) dictates specific storage conditions to maintain the product's stability.


Storage Requirements

The medicine must be stored at controlled room temperature, typically between 20 C to 25 C. It is mandatory to protect the product from moisture and light and to ensure the container remains tightly closed when not in use. The product must not be frozen and should be used only until the expiration date printed on the package.

Disposal and Child Safety

To prevent accidental ingestion, the medication must be kept out of the sight and reach of children at all times. Disposal of unused or expired CalciviD should be done through a recognized drug take-back program or by following specific local regulatory instructions for pharmaceutical waste, avoiding release to the environment.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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