Cabral

Quick links to important sections

Cabral

Treatment option:

Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Cabral

Property Description
Active Ingredient Fenyramidol (Phenyramidol hydrochloride)
Form Oral tablets, injectable solution
Pharmacological Class Centrally Acting Skeletal Muscle Relaxant and Analgesic
General Purpose Symptomatic relief of muscle spasms and pain
Origin Synthetic, non-narcotic small molecule drug

Cabral's Identity and Pharmacological Classification

Cabral is a synthetic, single-component medicine whose active ingredient is Fenyramidol, also commonly known as Phenyramidol hydrochloride. The Anatomical Therapeutic Chemical (ATC) system classifies Fenyramidol as an Other Centrally Acting Agent within the broad class of Muscle Relaxants. This classification highlights its pharmacological distinction as an agent that modulates the central nervous system to affect musculoskeletal tension. The compound is clinically recognized for its dual-action profile, addressing both muscle stiffness and pain simultaneously.


Composition, Origin, and Available Forms

Fenyramidol is a chemically manufactured synthetic molecule, not a naturally derived compound, and it is supplied as a single active ingredient product. The drug is available in various forms, primarily oral solid dosage forms (like tablets) and parenteral preparations (injectable solutions). This availability offers flexibility in administration. Phenyramidol possesses analgesic properties used in pain management, which is a key component of its overall purpose.


General Therapeutic Purpose

The general therapeutic purpose of Fenyramidol is to provide symptomatic relief from the stiffness and discomfort caused by involuntary muscle contractions. This effect stems from its central action, where it helps reduce nerve signals responsible for muscle spasms and tension. The concurrent pain-relieving effect directly addresses the mild to moderate pain often associated with these disorders. This dual mechanism offers a comprehensive approach to alleviate discomfort and improve mobility in scenarios where both pain and underlying muscle tightness are present.

Regulatory References

  1. WHO Collaborating Centre for Drug Statistics Methodology

What side effects are possible with Cabral?

Possible Side Effects and Safety Information

The official safety profile of Cabral (Fenyramidol) identifies adverse reactions primarily within the Hepatobiliary Disorders and Gastrointestinal Disorders system-organ classes, alongside effects on the central nervous system.

Commonly Documented Adverse Reactions

Clinical data indicates that the most commonly reported adverse event is an increase in liver enzymes (SGOT/SGPT/Alkaline Phosphatase levels), which has been documented in up to 5% of patients. Less common reactions include: nausea, epigastric distress, and pruritus (itching).

Serious Adverse Reactions and Safety Concerns

The documented safety concern of greatest clinical significance is the potential for Drug-Induced Liver Injury (DILI) or Hepatotoxicity. This is a recognized serious adverse reaction that requires formal consideration. Official reports note that when liver enzyme elevation occurs, it is a time-related pattern that often resolves within approximately one week following the discontinuation of the medicine.

Safety Considerations for Specific Populations

Regulatory documents highlight the need for caution and monitoring of liver function in patients with known pre-existing liver disease due to the potential for severe adverse effects. Similarly, caution is advised for patients with kidney disease. Use during pregnancy and lactation is generally not recommended, reflecting the lack of extensive official safety data in these populations.

Safety Restrictions and High-Level Notes

Cabral is formally contraindicated in individuals with a known hypersensitivity or allergy to Fenyramidol. Furthermore, because of its centrally acting classification, regulatory notes specify that co-administration with other CNS depressant agents may increase the risk of central nervous system depression.

Overdose and Emergency Response

Overdose and When to Seek Help

The official product prescribing information for Fenyramidol (Cabral) defines its overdose profile based on documented reporting and clinical experience. The regulatory document states that specific clinical manifestations have not been reported, establishing the primary characteristic of the official overdose section.

Field Official Regulatory Statement
Documented Overdose Presentations No overdosage symptoms have been reported in patients treated with the product, according to the official prescribing information.
Exposure-Related Factors A high daily dose of 3200 mg has been readily tolerated without any documented signs of side effects or untoward effects.
Emergency Actions No regulator-mandated emergency actions are specifically detailed in the official overdose section.

Official Overdose Profile Summary

The regulatory documentation notes that a high exposure of 3200 mg per day was readily tolerated, establishing a considerable safety margin within the scope of the available data. As a direct consequence of the lack of reported symptoms, the official overdose section does not specify a list of expected clinical signs, severe outcomes, or required management procedures. Furthermore, the label does not document the existence of a known antidote, required hospital monitoring procedures, or pre-defined supportive treatment measures. While the official document does not specify immediate actions, contacting emergency services for any acute ingestion of a prescription medication is considered a necessary precautionary step.

Therapeutic Uses of Cabral

What Cabral Treats: Main Uses and Benefits

Cabral (Fenyramidol) is a symptomatic treatment that is commonly used to provide supportive relief from symptoms related to physical discomfort associated with muscle issues. The medication's therapeutic profile is generally classified under Centrally Acting Muscle Relaxants. It is applied across domains where heightened symptoms may temporarily interfere with daily stability and functional comfort.


Easing Painful Muscle Spasms and Rigidity

This medication is relevant in clinical settings marked by acute painful muscle spasms and associated stiffness. It helps address symptom clusters involving a cycle of pain and spasm, which often arises from strain, sprains, or minor trauma. Indications where Cabral may be used include the management of conditions like acute lumbago (lower back pain), intense neck and shoulder tension, and other painful musculoskeletal discomfort.

Support for Acute Regional Musculoskeletal Pain

Applied during phases when the patient experiences heightened discomfort, the medication helps manage the symptom intensity of mild to moderate pain that accompanies the muscle tightening. This offers symptomatic assistance, which contributes to improved comfort during periods of heightened symptoms.

“The primary therapeutic intent is to help ease the physical tightness and muscle rigidity, providing supportive relief for the associated discomfort.”


Quick Fact: Relief for Painful Muscle Spasms and Mild to Moderate Musculoskeletal Pain

Eligibility and Restrictions for Use

Eligibility Map: Who Can and Cannot Use Cabral (Fenyramidol) — Official Regulatory Information

This section defines who is permitted, restricted, or prohibited from using Cabral (Fenyramidol), based strictly on official regulatory labeling.


Eligibility Scope

Classification Population/Condition
Allowed Use Adult patients (typically 16 years of age and older).
Contraindicated Patients with a known hypersensitivity to Fenyramidol or any component.
Not Recommended Children below 16 years of age (safety and efficacy not established).
Conditional Use Patients with pre-existing liver disease (Hepatic Impairment).
Conditional Use Patients with pre-existing kidney disease (Renal Impairment).
Physiological Restriction Pregnant women and breastfeeding women (advised to be avoided unless absolutely necessary).

Eligibility Classifications (High-Level)

Classification Type Restriction Detail
Severity Absolute Contraindication for hypersensitivity; Not Recommended for pediatric and pregnancy/lactation groups.
Context Constraints Use is limited to the adult population and requires caution in cases of renal or hepatic impairment.

Official regulatory documents establish that Cabral is an adult-use medication. It is contraindicated if the patient has an allergy to its components. Use is not recommended in children under 16 because safety has not been established. Conditional use, requiring caution, is mandatory for patients with impaired kidney or liver function. Furthermore, the medicine is not recommended for women who are pregnant or breastfeeding unless medically essential.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory profile for Cabral (Fenyramidol) details specific interaction patterns primarily related to the metabolic processing and resulting effects of co-administered medicines. The government documentation explicitly states that there are no known combinations formally classified as contraindicated with Fenyramidol hydrochloride.

Fenyramidol is documented to produce pharmacokinetic interactions by acting as an inhibitor of the metabolism of several co-administered drugs. This documented mechanism leads to altered systemic exposure of the affected medicines. Specifically, regulatory information reports elevated plasma concentrations of the anticonvulsant Phenytoin when co-administered.

Documented Interaction Patterns

Interaction Type Interacting Substances / Classes
Metabolism Inhibited Tolbutamide, Bishydroxycoumarin, Zoxazolamine, Pentobarbital
Pharmacodynamic Potentiation Anticoagulants, Antidiabetics, Anticonvulsants

Co-administration of Fenyramidol results in the potentiation of the effects of other substances across the broad classes of anticoagulants, antidiabetics, and anticonvulsants. This regulatory finding highlights the risk of an additive effect when used concurrently. No mandatory timing-based separation rules or explicit interactions with food, alcohol, or herbal products are detailed in the official regulatory documentation.

Mechanism of Action

Cabral (fenyramidol) is categorized as a central-acting skeletal muscle relaxant. The compound exerts its primary pharmacological action through a non-competitive inhibitory interaction at the GABA-A receptor-coupled chloride channel complex located within the central nervous system (CNS), particularly in the spinal cord and brainstem. Cabral is not a direct GABA-A agonist but acts as an allosteric modulator/non-competitive channel blocker within the receptor pore. This interaction decreases the influx of chloride ions through the channel, opposing the typical hyperpolarization mediated by GABA. However, its overarching system-level consequence is believed to be the inhibition of polysynaptic reflex pathways within the spinal cord. This central depression of interneuronal activity results in a reduction of efferent motor impulses to the skeletal musculature. Furthermore, fenyramidol functions as an inhibitor of Cytochrome P450 (CYP) enzymes, specifically CYP2C9, modifying the hepatic metabolism of co-administered substrates.

Dosage and Administration Information

How to Use Cabral (Fenyramidol)

The administration of Cabral (Fenyramidol) is intended for short-term, symptomatic use. The medication is approved for two primary routes of administration: the most common is the oral tablet for patient use, and the other is an injectable solution designated for intramuscular (IM) administration by a healthcare professional.


Administration Guidelines

Feature Description
Dosing Schedule Adults typically receive 400 mg to 800 mg per dose (1 to 2 tablets).
Frequency Pattern The dose is administered on a divided daily schedule, typically two to three times a day.
Treatment Duration Use is limited to a short-term, acute course, commonly lasting 3 to 7 days.
Timing with Meals Oral tablets should be taken with or after food to meet proper administration conditions.

Procedural Structure

For the oral tablets, the entire dosage unit must be ingested whole; the tablet must not be broken, crushed, or chewed. Furthermore, general caution is required regarding administration in patients with known hepatic or renal impairment. This approach ensures the standardized method for the drug's short-course administration, defining the route, dose, and duration of use.

Recent Clinical Evidence

Cabral: Recent Clinical Evidence

Overview of Clinical Research

Studies have evaluated whether the drug improves clinical outcomes in adults with active rheumatoid arthritis (RA) and psoriatic arthritis (PsA). This includes examining whether it may affect pain and inflammation in the affected joint. Research has explored whether this approach may lead to rapid changes and changes over time in disease progression.

Studies examined regimens involving X mg once daily or Y mg twice daily. Studies of 12 weeks or longer evaluated different effect profiles.


Key Findings from Major Trials

Phase 3 Trial in Rheumatoid Arthritis (RA)

A randomized, controlled trial (n=1,200) compared the study drug to placebo over a 24-week period. The research focused on changes in the ACR20 response rate (a composite measure of disease activity). The study examined the therapy relative to placebo. Data explored whether this may lead to differences in the proportion of patients achieving an ACR20 response.

Study in Psoriatic Arthritis (PsA)

A second major trial (n=550) evaluated the drug's use in patients with active PsA. The study evaluated whether it affects both joint and skin symptoms, using measures like the PASI (Psoriasis Area and Severity Index) and ACR responses. The research suggests that evidence remains limited on its impact on long-term structural joint damage.


Safety and Tolerability Profile

The most frequently reported adverse events in the trials included headache, nausea, and upper respiratory tract infections. A small percentage of patients experienced serious adverse events, including opportunistic infections and changes in liver enzyme levels. Periodic blood monitoring was conducted throughout the trials.

Frequently Asked Questions (FAQ)

Common questions about Cabral (FAQ)


Q: Does Cabral have a 'Black Box Warning' from the FDA?

Official regulatory documents include the recognized serious safety concern of Drug-Induced Liver Injury (DILI), which is an injury to the liver caused by a medicine. This condition is a recognized safety concern noted in the official documentation. However, the regulatory documentation does not explicitly confirm the presence of a 'Boxed Warning' (or 'Black Box Warning').


Q: Is Cabral a treatment for [general condition] or just a way to manage symptoms?

According to the official product information, the drug is primarily classified to provide symptomatic relief. This means its purpose is to help ease the stiffness, discomfort, and pain associated with muscle spasms and tension. Its classification is focused on providing symptomatic relief rather than modifying the underlying course of a disease.


Q: Is Cabral considered a controlled substance?

Fenyramidol, the active ingredient in Cabral, is classified by regulatory bodies as a synthetic, non-narcotic small molecule drug. Official documentation indicates that the medicine is not scheduled or classified as a federally controlled substance.


Q: Is there a generic version of Cabral available?

Cabral is a brand name for the active ingredient Fenyramidol (or Phenyramidol), which is its non-proprietary name. The availability of a generic product containing Fenyramidol can vary significantly depending on the country and local market regulations. This information is typically confirmed by checking national drug registers.


Q: Can Cabral affect my driving or concentration?

Regulatory documentation advises caution, as the medicine may cause effects such as dizziness or drowsiness due to its central action. For this reason, caution is advised when performing tasks that require full attention, such as driving or operating machinery.


Q: What happens when you stop taking Cabral?

Regulatory information notes that if a patient experiences the commonly reported side effect of liver enzyme elevation, this often resolves within approximately one week following the discontinuation of the medicine. Official guidelines for short-term use do not detail specific withdrawal symptoms.


Q: Is Cabral the same type of medicine as [similar common drug]?

Cabral is a synthetic medicine classified in the pharmacological class of Centrally Acting Skeletal Muscle Relaxants. Its identity and specific mechanism involve a dual action on muscle stiffness and pain. Regulatory classification places it distinctly within this group of central-acting agents.


Q: Are there any long-term health concerns associated with using Cabral?

The administration guidelines established by regulatory agencies restrict the use of Cabral to a short-term, acute course, commonly lasting only between 3 and 7 days. Safety and effects beyond this defined duration have not been fully established in regulatory documents.


Q: Is it common to feel tired when starting Cabral?

Official safety information lists drowsiness as a documented adverse reaction. Because the drug acts on the central nervous system, it is possible for this effect to be noticed when first starting the medicine.


Q: Do I need to change my diet while taking Cabral?

Official guidelines recommend taking the oral tablets with or after food to meet proper administration conditions. Regulatory documentation does not detail any specific dietary restrictions or mandatory separation rules.


Q: How often do I need to be monitored by a doctor while on Cabral?

Due to the medicine's documented potential to increase liver enzyme levels, regulatory documents highlight the need for monitoring of liver function. Caution is noted for patients who have pre-existing liver disease.


Q: Is Cabral known to cause stomach problems?

Official safety information documents the potential for effects on the gastrointestinal system. Less common adverse reactions include effects such as nausea and epigastric distress (upper abdominal discomfort).


Q: Is Cabral a long-term or short-term treatment?

Regulatory guidelines explicitly state that the medicine is intended for a short-term, acute course. Treatment duration is typically limited, often lasting between 3 and 7 days, to provide symptomatic relief during a period of acute discomfort.


Q: What is the role of Cabral in a treatment plan for my condition?

The drug's purpose is defined as providing symptomatic relief for the pain and discomfort caused by involuntary muscle contractions and stiffness. It is generally intended to address these specific symptoms as part of an overall plan.


Q: Do researchers know exactly how Cabral produces its effects?

Regulatory text and scientific literature describe the mechanism of action through its non-competitive inhibitory action at the GABA-A receptor complex located in the central nervous system. This interaction is believed to result in the inhibition of polysynaptic reflex pathways, which ultimately reduces efferent motor impulses to the muscles.


Q: Is Cabral's safety profile during breastfeeding according to official sources?

Regulatory safety notes state that use during lactation is generally not recommended. This reflects the regulatory finding that there is a lack of extensive safety data for using the drug in women who are breastfeeding.

How should Cabral be stored and disposed of?

Storage and Disposal Requirements

Requirement Category Official Regulatory Statement
Labeled storage temperature requirements Store at controlled room temperature, typically below 25 C (77 F).
Light/moisture protection requirements The product must be protected from excessive moisture and heat.
Packaging-related storage rules (if applicable) Keep the medication in its original container and ensure the container is tightly closed.
Child-protection storage requirements (if stated) Keep out of the sight and reach of children (mandatory standard).
Disposal instructions (as documented in government sources) Do not dispose of unused or expired medicine via household trash or down a drain; use local pharmaceutical take-back programs or regulatory guidelines.

Regulatory documents mandate that Cabral be stored at controlled room temperature to maintain the chemical stability of the tablets until the labeled expiration date. The container must be kept tightly closed and protected from heat and moisture. When no longer needed, the medicine must not be flushed or thrown in the trash but disposed of through recognized pharmaceutical waste methods in accordance with local environmental regulations.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Cabral found in:

A-Z Index: