C-NIM

Nimesulide

Rheumatoid arthritis, osteoarthritis, arthritis of various etiologies, arthralgia, myalgia, postoperative and post-traumatic pain, bursitis, tendinitis, algodismenorrhea, toothache and headache.

Inside, 1 tablet (100 mg) 2 times a day. The tablets are taken with sufficient water, preferably before meals. In the presence of gastrointestinal diseases, it is advisable to take the drug at the end of a meal or after a meal. Children over 12 years of age are prescribed at the rate of a single dose of 1.5 mg / kg 2-3 times a day, the maximum daily dose of the drug is 5 mg/kg. Adolescents with a body weight of more than 40 kg — 100 mg no more than 2 times a day.

Hypersensitivity, erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), bleeding from the gastrointestinal tract, intracranial hemorrhages, "aspirin" asthma, liver failure, renal failure (creatinine Cl <30 ml / min), severe heart failure, pregnancy, breastfeeding, children under 12 years of age.

With caution — arterial hypertension, heart failure, type 2 diabetes mellitus.

C-NIM is used to treat acute pain, osteoarthritis (pain and swelling of joints due to degeneration) and pain during periods.

Clinically important interactions involving interference with drug metabolism have not been described with C-NIM.

Gel: No clinically significant interactions involving interference with drug metabolism have been reported with topical application of C-NIM.

The frequency is classified by category, depending on the occurrence of the case: very often (>10), often (<10 – <100), sometimes (<100 – <1000), rarely (<1000 – <10000), very rarely (<10000).

GASTROINTESTINAL TRACT: often-diarrhea, nausea, vomiting, sometimes-constipation, flatulence, gastritis, very rarely-abdominal pain, stomatitis, tarry stools, gastrointestinal bleeding, ulcers and / or perforation of the stomach or duodenum.

CNS: sometimes-dizziness, rarely-a feeling of fear, nervousness, nightmares, very rarely-headache, drowsiness, encephalopathy (Reye's syndrome).

Respiratory organs: sometimes — shortness of breath, very rarely-bronchial asthma, bronchospasm.

Cardiovascular system: sometimes-arterial hypertension, rarely-tachycardia, hemorrhages, "hot flashes".

Sense organs: rarely - blurred vision, very rarely-dizziness.

Skin and mucous membranes: sometimes-itching, rash, increased sweating, rarely-erythema, dermatitis, very rarely-urticaria, angioedema, facial puffiness, multiform exudative erythema, including Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

Liver and biliary system: often-an increase in "hepatic" transaminases, very rarely-hepatitis, lightning hepatitis, jaundice, cholestasis.

Kidneys and urinary system: sometimes-edema, rarely-dysuria, hematuria, urinary retention, hyperkalemia, very rarely-renal failure, oliguria, interstitial nephritis.

Organs of hematopoiesis: rarely-anemia, eosinophilia, very rarely — thrombocytopenia, pancytopenia, purpura.

Allergic reactions: rarely-hypersensitivity reactions, very rarely-anaphylactoid reactions.

General reactions: rarely-general weakness, very rarely-hypothermia.

In case of other, not mentioned above, side effects or deterioration of health, you should immediately consult your doctor.

Symptoms: apathy, drowsiness, nausea, vomiting. They are usually reversible in the provision of supportive care for patients. Gastrointestinal bleeding, arterial hypertension, acute renal failure, respiratory depression may occur.

Treatment: symptomatic treatment of the patient and supportive care is required. There is no specific antidote. If the overdose occurred within the last 4 hours, it is necessary to induce vomiting, provide activated charcoal (60-100 g per adult), osmotic laxatives. Forced diuresis and hemodialysis are ineffective due to the high binding of the drug to proteins.