Cêgripe

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Cêgripe

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Cêgripe

What is Cêgripe? Identity and Composition

Property Description
Active Ingredients Paracetamol (Acetaminophen), Chlorphenamine (Chlorpheniramine)
Form Oral tablet
Pharmacological Class Analgesic, Antipyretic, H(1) Antihistamine combination
General Purpose Symptomatic relief of cold and flu-like conditions
Origin Synthetic compound

Cêgripe is defined as a synthetic, fixed-dose combination drug presented in an oral tablet form, primarily intended to manage the discomfort associated with the common cold and flu-like symptoms. Its identity rests on the integration of two distinct, chemically synthesized active components, making it a multi-component medication taken via the oral route. This specific formulation is classified as an agent that combines an analgesic and antipyretic with an H(1) antihistamine.

The drug’s core composition includes Paracetamol (Acetaminophen) and Chlorphenamine (Chlorpheniramine). The Paracetamol component is an established over-the-counter drug for temporary relief of minor aches and pains associated with the common cold. The inclusion of this component helps ease discomfort by mitigating the feeling of systemic illness.

The Dual-Action Formula and General Purpose

The Chlorphenamine component provides relief from allergic symptoms. Chlorphenamine is an agent for the symptomatic treatment of runny nose, sneezing, and ocular symptoms associated with upper respiratory tract infections. This dual formulation is clinically recognized for offering a streamlined approach to managing the most prevalent discomforts of a cold, such as fever, headache, and constant nasal discharge.

The singular general purpose of Cêgripe is to provide comprehensive symptomatic relief from these adverse effects. Its design makes it suitable for typical use scenarios involving generalized malaise. It is important to remember that Cêgripe is a palliative agent; its function is to alleviate symptomatic distress, not to eliminate the underlying viral or bacterial cause of the illness.

What side effects are possible with Cêgripe?

Possible Side Effects and Safety Information

Cêgripe is a combination medication containing Paracetamol (Acetaminophen) and Chlorphenamine (Chlorpheniramine), and its safety profile is defined by the officially documented adverse effects of these two components.

Adverse reactions are classified by frequency and System-Organ Class (SOC) in regulatory documents.


Key Adverse Reaction Categories

Classification Examples of Adverse Reactions (SOC)
Very Common Sedation, Somnolence (Nervous System)
Common Dizziness, Headache, Dry mouth, Fatigue, Blurred Vision (Nervous, Gastrointestinal)
Rare Blood disorders (Agranulocytosis, Thrombocytopenia), Serious allergic reactions (Immune System)

Serious Adverse Reactions and Safety Constraints

The primary serious concern associated with the Paracetamol component is the risk of Hepatic Injury, which includes liver failure and death, particularly when dosage limits are exceeded. Signs of liver damage can become apparent 12 to 48 hours following acute overdose. Official regulatory labeling also documents the risk of severe blood disorders and Serious Skin Reactions, such as exfoliative dermatitis.

A mandatory safety constraint is the prohibition of concurrent use with any other product containing Paracetamol to prevent unintentional overdose.

Population-Specific Safety Notes

The safety profile includes specific considerations for certain groups, as documented by regulatory bodies:

  • Older Adults and Children may be more susceptible to central nervous system effects, including paradoxical reactions like excitation or confusion.
  • Hepatic Impairment necessitates caution, and the use of the Paracetamol component is contraindicated in severe cases of liver disease.
  • The use of Chlorphenamine during the third trimester of pregnancy is noted in labeling due to the possibility of adverse reactions in the newborn.

Overdose and Emergency Response

Overdose and When to Seek Help

The regulatory profile for Cêgripe overdose centers on the dual risk posed by its active components, necessitating immediate and specialized medical intervention.

When Urgent Medical Help is Required

Immediate medical advice should be sought in the event of an overdose, even if you feel well. Prompt medical attention is critical for all individuals, including children, because the risk of severe, delayed organ damage may not be apparent in early symptoms. The official instruction is to contact a Poison Control Center or emergency medical services right away.

Documented Overdose Manifestations

Symptoms may be categorized into two groups. Initial signs of overdose from the Paracetamol component include pallor, nausea, vomiting, anorexia, and abdominal pain. However, severe liver damage may not manifest with clinical signs until 48 to 72 hours after ingestion. The Chlorphenamine component can acutely cause sedation, somnolence, dizziness, toxic psychosis, or anticholinergic effects.

Severe Outcomes and Specialized Care

Severe outcomes documented in regulatory labeling include potentially fatal hepatic failure, which may progress to encephalopathy or coma. Acute effects such as cardiac arrhythmias, cardiovascular collapse, seizures, and acute renal failure are also documented. N-acetylcysteine is the specific antidote required for the Paracetamol component. Management includes rapid administration of the antidote and symptomatic/supportive measures focused on cardiac, respiratory, renal, and hepatic functions. The overdose hazard is noted as greater in individuals with non-cirrhotic alcoholic liver disease or malnutrition.

Therapeutic Uses of Cêgripe

The primary role of Cêgripe is to provide supportive symptomatic relief for discomforts associated with conditions involving episodic or fluctuating manifestations, such as the common cold and flu-like syndromes. The combination is commonly used across domains where additional symptomatic support is needed.

Easing Systemic Symptoms, Pain, and Fever

Cêgripe is commonly used in situations involving symptoms related to systemic imbalance, such as headache, minor body aches, and general malaise that accompany acute infections. By helping to reduce fever and ease the associated physical discomfort, it provides support that may help ease the overall symptom burden during periods of heightened physiological strain.

Managing Nasal Discharge and Irritation

The medication is applied in addressing a cluster of symptoms, including persistent runny nose, repetitive sneezing, and watery eyes. This support contributes to improved day-to-day comfort and may assist with maintaining a sense of stability when symptoms interfere with routine activities.

Quick Fact: Used for managing Headache and Runny Nose (Concurrent Symptoms)

Regulatory References

  1. DailyMed overview from the National Library of Medicine

Eligibility and Restrictions for Use

Who Can and Cannot Use Cêgripe?

The eligibility for Cêgripe use is strictly defined by regulatory bodies based on age, concurrent medication, and pre-existing health conditions.


Absolute Contraindications (Must Not Use)

Cêgripe is officially prohibited for individuals with known hypersensitivity to its components, or for those who have taken a Monoamine Oxidase Inhibitor (MAOI) within the last 14 days. It is also contraindicated in patients with severe hypertension, severe coronary artery disease, narrow-angle glaucoma, urinary retention, or severe hepatic or renal impairment.


Age-Related Eligibility and Conditional Use

Use is not recommended for children under 6 years of age as eligibility is not established. Older adults (ge 65 years) must use with caution due to a higher susceptibility to neurological side effects, requiring consideration of a lower daily dose.

Conditional use and close medical consultation are mandated for patients with non-severe organ impairment, prostatic hypertrophy, asthma, or epilepsy. Furthermore, the medicine is not to be used during pregnancy or lactation unless explicitly deemed essential by a physician, as the safety profile for the combination product has not been established in these physiological states.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Contraindicated Combinations

The co-administration of Cêgripe is strictly contraindicated with certain substances based on official regulatory documentation. This includes Monoamine Oxidase Inhibitors (MAOIs) due to the risk of intensifying the anticholinergic effects of Chlorphenamine. A mandatory fourteen-day (14-day) separation period is required after the discontinuation of MAOI therapy. Additionally, co-administration with any other product containing Acetaminophen (Paracetamol) is prohibited to prevent exceeding the maximum daily dose and the resulting risk of severe hepatic damage.


Documented Interaction Patterns

Pharmacodynamic interactions may result in additive central nervous system (CNS) depression when Cêgripe is used with other CNS depressants, such as hypnotics or anxiolytics. Chronic alcohol consumption also contributes to additive CNS depression and increases the risk of severe liver damage associated with the Paracetamol component. Regarding pharmacokinetics, substances like Metoclopromide or Domperidone may increase the rate of Paracetamol absorption, while Colestyramine may reduce it, requiring a time separation of one to six hours to mitigate this effect. Furthermore, the Chlorphenamine component is documented to inhibit the metabolism of Phenytoin, potentially leading to toxicity, and enzyme-inducing drugs may increase the Paracetamol-related risk of hepatic damage.

Mechanism of Action

Central Regulation of Fever and Pain Signaling

This domain involves the active component initiating inhibition of prostaglandin synthesis within the Central Nervous System (CNS), specifically in the brain's hypothalamic center. This mechanism modulates chemical mediator concentration and contributes to the modulation of the body's core temperature set point and a resultant modulation of nociceptive signaling threshold.


Inverse Agonism on Histamine H1 Receptors

This action is centered on the antihistamine component acting as an inverse agonist at the Histamine H1 receptor, stabilizing it in an inactive state. This molecular event prevents histamine from binding and initiating its characteristic inflammatory cascade, which results in the limitation of vascular permeability and glandular secretion in the upper respiratory tract. The combination of these two distinct mechanisms facilitates coordinated modulation of both systemic temperature regulation and mucosal fluid dynamics.

Dosage and Administration Information

How to Use Cêgripe: Official Administration Guidelines

The correct use of Cêgripe (Paracetamol/Chlorphenamine Maleate) is based on established product labeling. This information outlines the approved route, standard dosing, timing, and conditions of intake.

Administration and Dosage Schedule

Field Official Instruction
Route of Administration Oral (Via oral)
Standard Dosing 1 to 2 tablets per dose for adults and children ge 12 years (or ge 30 kg).
Frequency and Timing Take doses every 6 or 8 hours. A minimum interval of 6 hours between doses is mandatory. One dose is recommended at bedtime (ao deitar).
Maximum Dose Do not exceed the maximum daily dose, which is often limited to the equivalent of 3000 mg of Paracetamol per 24 hours.

Special Conditions for Use

Condition Instruction
Tablet Intake Swallow the tablet(s) whole with water; do not chew (sem mastigar).
Meal Timing Administration is recommended preferably after meals (de preferência após as refeições).
Duration of Use Do not use for more than 5 consecutive days, unless instructed otherwise by a healthcare professional.
Pediatric Use Not recommended for children under 12 years of age or those with a body weight under 30 kg.
Elderly Use A dose reduction is recommended for the elderly population.

These instructions define the precise boundaries for the medicine's proper use, including the mandated minimum time between doses and the maximum duration of treatment.

Recent Clinical Evidence

Research evidence / Overview of studies for Cêgripe


Evidence for Multi-Symptom Relief in Cold and Flu Syndromes

The research evidence for medications like Cêgripe, which combine an analgesic (Paracetamol) and an antihistamine (Chlorphenamine), is primarily drawn from short-term Randomized Controlled Trials (RCTs) and Systematic Reviews. These studies were used in research exploring how symptoms change over time in adults dealing with the common cold or flu-like syndromes. Studies typically monitored individuals experiencing conditions involving periods of heightened symptoms to understand how the combination's use corresponded with symptom records.

Researchers in these trials focused on collecting patient-reported outcomes describing perceived discomfort. A primary measurement used in this research was the Total Symptom Score (TSS), a composite scale designed to monitor metrics in affected adults for common cold symptoms such as body aches, fever, headache, sneezing, and runny nose. The evidence contributes to the broader research landscape concerning short-term investigations for acute conditions.


Research on Specific Symptom Endpoints

Beyond the composite Total Symptom Score, research also examined outcomes related to physical discomfort and specific inflammatory or irritative states. Studies explored the monitored intensity of individual outcomes capturing phases of heightened symptom activity, such as persistent headache, fever, and nasal discharge. Research also examined the consumption of any additional rescue medication by participants during the trial, as this is an outcome reflecting daily functioning or activity level.


Key Research Gaps and Uncertainties

The follow-up durations were limited in most pivotal efficacy studies, typically lasting only a few days, aligning with the acute nature of the common cold. Due to this short-term focus, there is limited information for long-term outcomes related to Cêgripe. Furthermore, many robust trials examined formulations that contained a third active ingredient (a nasal decongestant) alongside Paracetamol and Chlorphenamine. This makes it challenging for research to definitively describe the precise pattern of observed symptom metrics for the specific dual-component product (Cêgripe). Limited data are also available from controlled, dedicated trials specifically evaluating this combination in younger children.

Key Studies & References Efficacy and Safety of a Fixed-Dose Combination of Paracetamol, Phenylephrine, and Chlorpheniramine Syrup in the Symptomatic Treatment of Common Cold in Children: A Post Marketing Surveillance Study in India

Frequently Asked Questions (FAQ)

Common questions about Cêgripe (FAQ)


Q: What is the main difference between Cêgripe and a regular pain reliever like paracetamol?

A: Cêgripe is described in official documents as a fixed-dose combination drug. It contains Paracetamol (Acetaminophen), which relieves pain and fever, and Chlorphenamine, which is an H1 antihistamine. This combination provides a dual approach to manage both pain/fever and allergic cold symptoms like a runny nose and sneezing.


Q: Does Cêgripe contain any ingredients that cause drowsiness?

A: Yes. Regulatory safety documents list sedation and somnolence (drowsiness) as Very Common adverse reactions. Official product information indicates that the antihistamine component, Chlorphenamine, is the part of the formula generally associated with this effect.


Q: How quickly is Cêgripe expected to start providing relief?

A: Studies and general information on the Paracetamol component indicate that relief of fever or pain is often reported to begin within an hour of taking the medicine. The time required for a noticeable effect may vary.


Q: If I miss a scheduled time to take Cêgripe, what should I do?

A: Official guidance for medicines containing Chlorphenamine suggests that if a dose is missed, it should be taken as soon as it is remembered, unless it is already almost time for the next scheduled dose. Regulatory guidance indicates that two doses should not be taken at the same time to compensate for a missed dose.


Q: Are there different versions or strengths of Cêgripe available, and how do they differ?

A: The specific formulation defined in official regulatory documents is the oral tablet containing the fixed doses of Paracetamol and Chlorphenamine. The official information is restricted to this described dual-component tablet.


Q: Why is Cêgripe sometimes discussed in relation to pain relief even though its main use is for colds?

A: Cêgripe contains Paracetamol (Acetaminophen), which is an established drug component included for the temporary relief of minor aches and pains and to reduce fever. Therefore, while its overall purpose is cold and flu relief, its composition includes a primary agent for pain management.


Q: Is it true that Cêgripe might be less effective if taken with food, according to some reports?

A: Official instructions state that administration is recommended preferably after meals. Regulatory documents also note that certain substances, such as Colestyramine, may reduce the rate of Paracetamol absorption and require separation to mitigate this effect. Official guidance indicates that administration is recommended preferably after meals.


Q: Is Cêgripe intended to treat all types of colds, or only specific symptoms?

A: Cêgripe is described as a palliative agent, meaning its function is solely for the symptomatic relief of discomfort associated with cold and flu-like conditions. It is described to help manage specific symptoms such as fever, headache, runny nose, and sneezing, but its function is not to eliminate the underlying viral or bacterial cause of the illness.


Q: Can Cêgripe be taken if I am already taking herbal supplements?

A: Official regulatory bodies advise that before taking any medication alongside a dietary supplement, including herbal products, it is important to discuss the potential for interactions. Official interaction warnings are primarily focused on interactions with other prescribed and over-the-counter drugs.


Q: What are the general rules for stopping Cêgripe if symptoms improve?

A: Cêgripe is approved for use for the symptomatic relief of acute conditions. Official instruction is not to use it for more than 5 consecutive days unless otherwise directed. This duration aligns with its use for temporary, acute symptoms.


Q: Does Cêgripe have a known risk of dependence or addiction?

A: The active ingredients in Cêgripe, Paracetamol and Chlorphenamine, are generally not classified as controlled drugs, which means they are not typically associated with a risk of dependence or addiction.


Q: Can Cêgripe cause light sensitivity or changes to vision?

A: Regulatory safety documents list blurred vision as a Common adverse reaction associated with Cêgripe. Light sensitivity (photophobia) is not among the common or severe adverse reactions explicitly listed in the standard safety classifications provided by official sources.


Q: Can Cêgripe cause changes in mood or sleep patterns?

A: Regulatory safety information documents that mental/mood changes (such as confusion) can occur. In some populations, such as children, the medicine may cause agitation and excitement instead of drowsiness. Sedation and somnolence are also listed as very common side effects that can affect sleep.


Q: What happens if Cêgripe is taken when a person doesn't actually have cold symptoms?

A: Cêgripe is intended solely for symptomatic relief of cold and flu-like conditions. Using it when no symptoms are present means the medicine’s components are being taken without the intended palliative purpose, potentially resulting in exposure to side effects such as the Very Common effect of sedation and somnolence.

How should Cêgripe be stored and disposed of?

How to Store and Dispose of Cêgripe

Official regulatory documents define specific conditions for storing and disposing of Cêgripe (Paracetamol + Chlorphenamine Maleate) tablets.


Storage Requirements

Cêgripe must be stored at room temperature, ensuring the temperature does not exceed 25 C. The medicine requires protection from environmental factors, specifically by storing it away from light and excessive moisture.

  • Child Safety: All product labeling mandates that Cêgripe must be kept out of the reach and sight of children.
  • Packaging Integrity: Do not use the medicine if the packaging or blister unit is opened or shows any signs of tampering.

Disposal Instructions

Unused or expired Cêgripe must be discarded following specific pharmaceutical waste procedures to protect the environment. Regulatory sources instruct that the medicine must not be disposed of via household waste or wastewater (e.g., flushing down the toilet or sink).

Patients must ask a pharmacist how to dispose of medicines no longer required to utilize official collection methods.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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