Components:
Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 26.06.2023
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Bu Mai Xin
Glucosamine
The total for the two dosage forms
osteochondrosis.
Solution for intramuscular administration complete with solvent
primary and secondary osteoarthritis,
spondyloarthrosis.
Powder for preparation of oral solution
osteoarthritis of the peripheral joints, joints of the spine, osteochondrosis.
Osteoarthritis of the peripheral joints and joints of the spine.
Osteoarthritis of the peripheral joints and spine.
Osteoarthritis of the peripheral joints and spine.
Inside, 2 tablets 3 times a day. A stable therapeutic effect is achieved when taking the drug for at least 6 months.
Individual intolerance, severe renal impairment, pregnancy, lactation.
Disorders of the gastrointestinal tract (epigastric pain, flatulence, diarrhea, constipation), skin allergic reactions.
Treatment: gastric lavage, symptomatic therapy.
The drug stimulates the regeneration of cartilage tissue, has an anabolic, anti-catabolic, chondroprotective, anti-inflammatory, analgesic effect.
Glucosamine sulfate, the active component of the drug, is a salt of the natural aminomonosaccharide glucosamine that is found in the body. Glucosamine stimulates the synthesis of proteoglycans (glucosaminoglycans and hyaluronic acid) by chondrocytes in the synovial fluid, inhibits enzymes (including collagenase, phospholipase A2), which cause the destruction of cartilage tissue, prevents the formation of superoxide radicals, suppresses the activity of lysosomal enzymes, initiates the process of sulfur fixation in the synthesis of chondroitinseric acid and promotes the normal deposition of calcium in bone tissue, prevents the damaging effect of corticosteroids on chondrocytes and disruption of the synthesis of glucosaminoglycans induced by NSAIDs.
Sulfonate groups are also involved in the synthesis of glycosaminoglycans in the metabolism of cartilaginous tissue, and solitairy side chains composed of proteoglycans, contributing to water retention, preserving the ductility of the matrix of cartilage.
Glucosamine sulfate stops the destruction of cartilage and reduces the symptoms of osteoarthritis. A decrease in clinical symptoms usually occurs 2 weeks after the start of treatment, while maintaining clinical improvement for 8 weeks after discontinuation of the drug.
Symptoms® The maximum makes up for endogenous glucosamine deficiency, stimulates the synthesis of proteoglycans and hyaluronic acid. Restores the enzymatic processes in the cells of the synovial membrane and articular cartilage, promotes the restoration of the cartilaginous surfaces of the peripheral joints and joints of the spine.
It has chondroprotective and anti-inflammatory properties. Reduces pain and the need for NSAIDs, inhibits the formation of superoxide radicals and enzymes that damage cartilage (collagenases and phospholipases).
To improve the supply of glucosamine to the joint tissues, a transdermal glucosamine complex was used — a complex of glucosamine and natural triglycerides.
Solution for intramuscular administration complete with solvent
After intravenous administration of glucosamine, the sulfate quickly passes through biological barriers and penetrates into tissues, mainly articular cartilage. T1/2 - about 60 hours, mainly excreted by the kidneys.
Powder for preparation of oral solution
It is quickly and completely absorbed in the small intestine. Bioavailability Of 26%, T1/2 - 70 hours —
- Correctors of bone and cartilage metabolism
Increases the absorption of tetracyclines, reduces the effect of semi-synthetic penicillins, chloramphenicol.
Compatible with paracetamol, NSAIDs and corticosteroids. When used together with NSAIDs, it enhances the anti-inflammatory and analgesic effect of the latter.
