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Бруфен СР

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Бруфен СР

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Бруфен СР

Property Description
Active ingredient Ibuprofen
Form Modified-release tablet (Sustained-release)
Pharmacological class Non-steroidal anti-inflammatory drug (NSAID)
Common use Pain, Inflammation, Fever (Antipyretic)
Origin Synthetic, Propionic acid derivative

What Type of Medicine is Бруфен СР?

Бруфен СР is a medicinal preparation whose active compound is Ibuprofen, officially classified as a Non-steroidal anti-inflammatory drug (NSAID). This product falls within the pharmacological class of Anti-inflammatory and Antirheumatic Products (Non-Steroids) and is utilized for its combined ability to reduce inflammation, alleviate pain (analgesic activity), and lower fever (antipyretic activity). Ibuprofen itself is a synthetic substance, specifically derived from propionic acid.

Composition and the Sustained-Release Tablet Form

The formulation of Бруфен СР contains Ibuprofen as its single active ingredient, which is administered as a racemic mixture of its R- and S-enantiomers. This medication is presented as a distinctive modified-release tablet, a specific sustained-release formulation designed for oral administration. The purpose of this unique pharmaceutical preparation is to control the rate at which the medication is released following administration, resulting in an extended absorption phase that maintains stable and prolonged plasma levels of the drug. This difference in drug release profile is intended to prolong the therapeutic effect over an extended period, which is particularly beneficial when consistent symptomatic relief is desired.

Regulatory References

  1. WHO Model Lists of Essential Medicines
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What side effects are possible with Бруфен СР?

The safety profile for this medicine, which contains the NSAID ibuprofen, is structured by government regulatory agencies based on System-Organ-Classes and frequency categories observed in clinical data.

Documented Adverse Reactions by Frequency

Adverse reactions are classified according to how often they appear in official documentation:

  • Common effects frequently involve the Gastrointestinal Disorders system, including dyspepsia, nausea, vomiting, abdominal pain, and flatulence. Other common reactions are headache, dizziness, fatigue, and rash.
  • Uncommon effects may include various forms of ulceration (gastric, duodenal), gastritis, anxiety, insomnia, visual impairment, and hypersensitivity reactions such as rhinitis.
  • Rare and Very Rare effects are documented across the Blood and Lymphatic System Disorders (e.g., thrombocytopenia), Hepatobiliary Disorders (e.g., hepatic failure), and the Nervous System (e.g., aseptic meningitis).

Serious Adverse Reactions and Safety Patterns

The use of NSAIDs is formally associated with an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which may be fatal. Likewise, there is an increased risk of serious gastrointestinal adverse events, such as bleeding, ulceration, and perforation of the stomach or intestines, which can occur without warning symptoms and may be fatal. The risk of cardiovascular events is noted to increase with the duration of use.

Population-Specific Considerations

Official labeling addresses specific populations: Older Adults (Elderly) have an increased frequency and higher risk of serious adverse reactions, particularly fatal gastrointestinal bleeding. Use is advised against at or after 20 weeks gestation due to the risk of fetal renal dysfunction.

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Overdose and Emergency Response

Overdose and When to Seek Help

Overdose with the active ingredient Ibuprofen (contained in Бруфен СР) requires immediate attention, as documented effects range from common to severe life-threatening outcomes.

Documented Manifestations and Severe Outcomes

Officially documented manifestations of an overdose typically begin with gastrointestinal symptoms, such as nausea, vomiting, abdominal pain, and mild central nervous system (CNS) effects, including lethargy, drowsiness, or headache.

Regulatory labels list severe outcomes associated with significant ingestion, including metabolic acidosis, which is a critical finding, and acute renal failure, hepatic damage, and major gastrointestinal bleeding. Severe CNS complications like seizures, loss of consciousness, or coma are documented risks. Pediatric patients and those with pre-existing hepatic or renal impairment are noted to have an increased risk of severe effects.

Emergency Actions Mandated by Regulators

It is officially required to seek immediate medical attention and contact emergency services for any suspected overdose. This action is mandated regardless of the severity of initial symptoms due to the potential for delayed toxicity, particularly with sustained-release formulations.

The official regulatory guidance states that no specific antidote is known for Ibuprofen overdose. Management is symptomatic and supportive. Supportive procedures, such as administering activated charcoal or gastric lavage, are explicitly noted as options if performed within the first hour of ingestion. Hospital monitoring is required for observation of potential complications.

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Therapeutic Uses of Бруфен СР

What БруфЕН СР Treats: Main Uses and Benefits

The medication is commonly used to provide supportive symptomatic relief, particularly in situations involving symptoms related to inflammatory or irritative states and acute physical discomfort. Ibuprofen is applied in addressing pain, swelling, and fever across numerous presentations.

Therapeutic applications are considered relevant for easing symptoms related to chronic conditions like rheumatoid arthritis and osteoarthritis, symptomatic management of acute gout and primary dysmenorrhoea (menstrual pain), and assistance with pain from dental issues or soft-tissue injuries such as sprains.

The sustained-release nature is relevant in clinical settings that involve conditions involving episodic or fluctuating manifestations, contributing to easing the overall symptom load over an extended duration.

“The sustained-release nature is used to support long-term relief, assisting with the management of symptoms that interfere with daily functioning.”

This supportive approach is relevant when symptoms create noticeable functional strain. The medication plays a role in managing symptom clusters that may become intense or disruptive, contributing to improved comfort and supports general well-being during symptomatic phases.


Quick Fact: Relief for Pain, Inflammation, and Fever

This medication is generally used to help with three universal symptom domains: pain relief, inflammation (reduction of swelling and tenderness), and fever (fever reduction).

Regulatory References

  1. NIH MedlinePlus Drug Information
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Eligibility and Restrictions for Use

Who Can and Cannot Use Бруфен СР?

Eligibility for Бруфен СР, a sustained-release ibuprofen product, is strictly defined by official regulatory documentation and patient health status, focusing primarily on absolute contraindications and mandatory restrictions.

Official Regulatory Status

The medicine is generally indicated for use in adults and adolescents aged 12 years and over. Use is not recommended for children younger than 12, as the safety and efficacy of the sustained-release formulation are not established in this pediatric population.

Contraindicated Populations (Must Not Use) Use with Caution/Restriction (Conditional Use)
Patients with known hypersensitivity to Ibuprofen, Aspirin, or other NSAIDs. Elderly patients (due to increased risk of adverse events).
History of recurrent peptic ulceration or GI bleeding/perforation. Patients with mild-to-moderate renal or hepatic impairment.
Severe organ failure (NYHA Class IV heart failure, severe renal or hepatic failure). History of uncontrolled hypertension or inflammatory bowel disease.
During the third trimester of pregnancy (from 30 weeks gestation). Use should be avoided during a Varicella (chickenpox) infection.

Use is also absolutely prohibited for treating perioperative pain in the setting of coronary artery bypass graft (CABG) surgery. Use during the first and second trimesters of pregnancy requires careful consideration.

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What should I know about interactions with other medicines?

Interactions with other medicines and products

The regulatory interaction profile of Бруфен СР (Ibuprofen) is defined by pharmacokinetic and pharmacodynamic constraints documented in official labeling. Co-administration is contraindicated with other non-steroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors, and with Aspirin used at analgesic doses, due to an additive risk of adverse effects.

Pharmacokinetic and Exposure Constraints

Ibuprofen reduces the renal clearance of certain co-administered medicines, leading to increased plasma concentrations of substances like Lithium and Methotrexate, which may elevate the risk of toxicity. Conversely, co-administration with potent inhibitors of the CYP2C9 enzyme, such as Fluconazole, results in increased blood exposure of Ibuprofen itself.

Pharmacodynamic Risk and Timing

Pharmacodynamic interactions include a heightened risk of gastrointestinal bleeding when combined with anticoagulants, antiplatelet agents, SSRIs, or alcohol. A critical timing-based restriction applies to patients taking low-dose Aspirin for antiplatelet effect: regulatory information specifies that Ibuprofen must be administered at least 8 hours before or 30 minutes after taking immediate-release low-dose Aspirin to prevent interference with its therapeutic action.

Co-administration with diuretics or certain antihypertensive agents (ACE inhibitors, ARBs) carries an increased risk of acute renal impairment, a caution often highlighted for elderly patients or those with existing volume depletion.

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Mechanism of Action

The Core Mechanism: Reversible Enzyme Inhibition

The fundamental action of Бруфен СР (Ibuprofen) is the reversible, non-selective inhibition of the Cyclooxygenase ( COX-1 and COX-2) enzymes. This molecular interaction interrupts the early steps of the Arachidonic Acid Cascade, specifically constraining the synthesis of prostanoids, primarily prostaglandins. This inhibition targets the molecular source of several physiological responses, resulting in modulation of the targeted physiological pathways.

Dual Modulation of Physiological Signaling

By constraining prostaglandin synthesis, the mechanism exerts effects in two distinct physiological areas. Peripherally, it reduces the creation of mediators that mediate the sensitization of peripheral nociceptors. Centrally, it limits PGE2 production in the hypothalamus, which is the mechanism by which the elevated thermoregulatory set-point is normalized. These dual mechanistic effects contribute to the compound's physiological profile.

Sustained Engagement of Target Enzymes

Since COX inhibition is reversible and concentration-dependent, the modified-release design of Бруфен СР extends the period during which the drug consistently engages the COX enzyme. This mechanical feature supports a prolonged modulation of the COX pathway kinetics within the body.

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Dosage and Administration Information

Administration and Dosing Principles

Бруфен СР is a modified-release tablet formulated for oral administration. To maintain the intended drug release profile, the tablet must be swallowed whole with plenty of fluid; it must not be chewed, crushed, broken, or sucked on.

The standard administration schedule utilizes a total daily dose of 1600 mg, typically achieved by taking two 800 mg tablets once daily. For severe or acute conditions, the total daily dosage may be temporarily increased up to a maximum of 2400 mg, which is administered in two divided doses. The single daily dose is preferably taken in the early evening to ensure the prolonged-release action provides symptomatic management overnight.


Context and Duration of Use

Administration must employ the lowest effective dose for the shortest necessary duration. While the dose may be taken on an empty stomach, patients with sensitive stomachs are directed to take the tablet with food or plenty of fluids.

The 800 mg modified-release tablet is not recommended for use in children under 12 years of age. Older adults and those with impaired kidney or liver function may require the lowest possible dose, and individual adjustments may be necessary to define the appropriate regimen.

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Recent Clinical Evidence

Evidence for use in Chronic Pain and Inflammation

Research examined the sustained-release formulation in adult patient groups dealing with chronic inflammatory conditions, such as Osteoarthritis and Rheumatoid Arthritis—conditions characterized by fluctuating or episodic manifestations. These studies included comparative randomized controlled trials and large observational settings exploring how symptoms change over time.

The outcomes monitored included measurements of outcomes related to physical discomfort, specifically symptom intensity or variability in pain scores during the day and night. Findings describe patterns observed in these outcomes related to functional limitations over the short-term observation period. However, follow-up durations were limited, typically only a few weeks in comparative trials. Consequently, there is limited information for long-term outcomes, meaning the durability of observed symptom changes over extended periods is uncertain.

Evidence for Acute and Cyclical Pain Management

The sustained-release formulation was studied for conditions associated with acute or disruptive episodes, such as post-operative pain and pain associated with Primary Dysmenorrhoea (menstrual pain). Studies explored time-related outcomes, such as outcomes describing the time to measured initial symptom change and the duration of the measured change in symptoms. Studies monitored the sustained-release format in trials exploring short-term changes in these pain outcomes.

For dysmenorrhoea, the primary evidence base often relates to the immediate-release form of the active ingredient. Comparative evidence specifically for the sustained-release formulation in this indication is limited.

Study Designs and Follow-up Duration

The sustained-release formulation was evaluated in trials that compared it against both inactive placebo tablets and the standard, immediate-release form of ibuprofen. Research observing responses over defined time intervals generally utilized short observation periods. For instance, studies exploring short-term symptom changes in acute pain typically monitored patients only for 6 to 24 hours post-dose. Similarly, the comparative trials for chronic conditions had follow-up durations that were limited to a few weeks, meaning they assessed only the short-term impact on symptom activity.

Evidence in Specific Patient Groups

Research has explored the use of this formulation primarily in general adult patient groups who meet the criteria for the studied conditions. The studies involved populations associated with conditions marked by functional limitations and those experiencing periods of heightened symptom activity.

Data show patterns related to adults aged 18 and older. However, data for certain groups remain insufficient regarding specific subgroups. For instance, data for children or for older adults with multiple complex health conditions (comorbidities) are generally limited in the sustained-release evidence landscape. The results apply only to the populations studied and research does not determine whether an individual outside of these studied groups will respond similarly.

Areas Where Research is Still Developing

The evidence highlights what is known—and what is still uncertain. A key limitation is the limited information for long-term outcomes regarding the use of the sustained-release formulation for chronic conditions. The research provides context but not individual predictions about long-term outcomes.

Although comparative studies with the immediate-release form were conducted to understand differences in drug release, comparative evidence with other long-acting pain relief medications is lacking for certain indications. Research is ongoing to provide insight into whether the observed patterns of symptom relief are observed when research examines patterns over many months or years. The current study results reflect the specific conditions under which they were conducted.

Key Studies & References

  1. Use of ibuprofen sustained release for treating osteoarthritic pain: a 4-week prospective multicenter open-label observational study
  2. Study Evaluating Ibuprofen 600 mg Extended Release (ER) For Dental Pain (NCT00913627)
  3. Data Sheet – Ibuprofen (relieve) (Medsafe Regulatory Document)
  4. World Health Organization Model List of Essential Medicines (21st List, 2019)
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Frequently Asked Questions (FAQ)

Common questions about Бруфен СР (FAQ)


Q: What is the difference between Бруфен СР and regular Бруфен?

The core difference is the way the medicine is released into the body. The 'СР' designation stands for sustained-release, meaning it is designed to work over a prolonged period.

This design supports a prolonged therapeutic effect, which is generally associated with needing fewer doses each day compared to regular (immediate-release) ibuprofen.


Q: What kind of pain is Бруфен СР typically used for?

According to official product information, the medicine is indicated for the relief of mild to moderate pain. This includes common issues like headache, dental pain, backache, rheumatic or muscular pain, and dysmenorrhoea (period pain).

It is also utilized for its ability to reduce fever.


Q: Is Бруфен СР used for migraines or just tension headaches?

The active ingredient, Ibuprofen, is listed in official documentation as being used for the relief of general headache pain and migraine pain.


Q: Can Бруфен СР cause drowsiness or affect alertness?

Regulatory data lists undesirable effects such as dizziness, headache, and somnolence (drowsiness). Official warnings state that if these effects occur, activities requiring mental alertness, such as driving or operating machinery, may be impaired.


Q: Is Бруфен СР described as safe for use during pregnancy?

Use of this medicine is strictly contraindicated (must not be used) during the third trimester of pregnancy, typically starting from 20 weeks onward, due to potential risks to the fetus. Use during the first and second trimesters requires careful consideration by a healthcare professional.


Q: Does regulatory information mention any known risks for the kidneys with long-term use?

Yes, official regulatory documents state that long-term use of NSAIDs like this one can be associated with renal (kidney) changes, such as renal papillary necrosis. For long-term users, regulatory information specifies that medical supervision and regular monitoring of renal function should occur.


Q: What kind of allergic reactions are listed in the safety data?

The documented range of allergic reactions spans from uncommon effects like rhinitis (runny nose) and hives (urticaria) to rare, severe reactions. These severe reactions include anaphylaxis and severe skin conditions like Stevens-Johnson Syndrome (SJS).


Q: How does the sustained release work differently from an immediate release tablet?

The sustained-release tablet is a modified formulation designed to control the rate at which the medicine is absorbed, allowing it to maintain therapeutic levels for a longer duration compared to immediate-release tablets.

This design supports a prolonged therapeutic effect, which is generally associated with needing fewer doses each day.


Q: Are there different strengths of Бруфен СР available?

The official product information detailing the administration schedule refers to 800 mg tablets. The availability of any other specific sustained-release strengths for this product would be detailed in the official package information.


Q: Are changes in blood pressure or heart rhythm mentioned as potential side effects?

Hypertension (high blood pressure) is listed as a very rare potential undesirable effect in regulatory data. Furthermore, serious cardiovascular events associated with NSAID use may present with signs such as a fast or irregular heartbeat.


Q: How quickly does Бруфен СР usually start to work?

As a sustained-release formulation, the medicine is designed for a prolonged effect rather than a rapid peak in concentration. Official information indicates that the onset of action may be delayed if the tablet is taken shortly after eating a meal.


Q: How long are the effects of Бруфен СР expected to last?

The sustained-release design ensures the active ingredient is released over an extended period. This mechanism is intended to provide prolonged symptom management, which supports the product's typical dosing schedule of only once or twice a day.


Q: Is there a warning about driving or operating machinery while using Бруфен СР?

Yes, official product information contains warnings regarding caution. If side effects such as dizziness, headache, or drowsiness occur, activities requiring mental alertness, such as driving or operating machinery, may be impaired and should be avoided.


Q: Are there any specific foods to avoid when taking Бруфен СР?

Regulatory information does not list any specific foods that are prohibited while using this medicine. However, official guidance states that taking the tablet shortly after a meal may cause the onset of the medicine's action to be delayed.


Q: Is Бруфен СР suitable for people with asthma?

The medicine is considered inappropriate (contraindicated) for individuals who have previously had an allergic reaction, such as asthma or bronchospasm, after taking Aspirin or any other NSAID. Caution is specifically required for patients who have a known history of bronchial asthma.


Q: What does official guidance say about using Бруфен СР while breastfeeding?

Official guidance indicates that the active ingredient, Ibuprofen, is known to pass into breast milk in very small amounts. It is often cited as a preferred pain reliever for nursing mothers. Consultation with a healthcare professional is necessary prior to use.


Q: Is the effect of Бруфен СР reduced if taken with food?

Regulatory information notes that taking the medicine shortly after a meal may delay the initial onset of its action. However, official documents do not state that the overall therapeutic effect or the full benefit of the sustained release is reduced by consuming food.


Q: What should a patient do if they miss a scheduled time to take the medicine?

Official patient information states that a dose should not be doubled to compensate for a forgotten one. If a dose is missed, patients should revert to the normal schedule and take their next dose at the usual time.


Q: Are there any warnings about sun exposure while taking this drug?

Photosensitivity reactions (increased sensitivity to sunlight) are documented as an uncommon side effect in regulatory documents. Protective measures against sun exposure are generally advised.


Q: Is there information on how the drug is eliminated from the body?

Official pharmacological information states that the active ingredient is metabolized (broken down) primarily in the liver. The resulting metabolites are then mainly excreted from the body via the urine.


Q: What are the signs of taking too much Бруфен СР?

Regulatory documents list several symptoms associated with overdose, which can include dizziness, headache, vomiting, nausea, and abdominal pain. More serious signs may involve confusion, a decreased level of consciousness, and seizures. If overdose is suspected, immediate medical assistance is necessary.


Q: Does the regulatory body recommend any specific monitoring while on this medicine?

Yes, official documentation advises that patients receiving long-term treatment with this NSAID should undergo regular medical supervision. Monitoring specifically includes regular assessment of renal (kidney) function to check for adverse events.

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How should Бруфен СР be stored and disposed of?

How to Store and Dispose of Brufen SR

Official regulatory documentation outlines specific requirements for the storage and disposal of Brufen SR (Ibuprofen sustained-release tablets).

Required Storage Conditions

The product must be stored at a temperature not exceeding 25°C and should be maintained in its original package. This container rule helps protect the tablets from environmental factors such as moisture. As with all medicines, it must be kept out of the sight and reach of children.

Handling and Disposal

Handling instructions require the sustained-release tablets to be swallowed whole without being crushed or chewed. For disposal, any unused or expired medicine must be discarded in accordance with local regulations and should not be thrown into household waste or wastewater unless explicitly permitted by local authorities.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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