Bloodfull

Cyanocobalamin (Bloodfull) (commonly known as Vitamin B12) is the most chemically complex of all the vitamins. Cyanocobalamin (Bloodfull)'s structure is based on a corrin ring, which, although similar to the porphyrin ring found in heme, chlorophyll, and cytochrome, has two of the pyrrole rings directly bonded. The central metal ion is Co (cobalt). Cyanocobalamin (Bloodfull) cannot be made by plants or by animals, as the only type of organisms that have the enzymes required for the synthesis of Cyanocobalamin (Bloodfull) are bacteria and archaea. Higher plants do not concentrate Cyanocobalamin (Bloodfull) from the soil and so are a poor source of the substance as compared with animal tissues. Cyanocobalamin (Bloodfull) is naturally found in foods including meat (especially liver and shellfish), eggs, and milk products. [HMDB]

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid (Bloodfull) is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]

An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. [PubChem]

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem]

Cyanocobalamin (Bloodfull) Nasal Spray is indicated for the maintenance of normal hematologic status in pernicious anemia patients who are in remission following intramuscular vitamin B12 therapy and who have no nervous system involvement.

Cyanocobalamin (Bloodfull) Nasal Spray is also indicated as a supplement for other vitamin B12 deficiencies, including:

I. Dietary deficiency of vitamin B12 occurring in strict vegetarians (Isolated vitamin B12 deficiency is very rare).

II. Malabsorption of vitamin B12 resulting from structural or functional damage to the stomach, where intrinsic factor is secreted, or to the ileum, where intrinsic factor facilitates vitamin B12 absorption. These conditions include HIV infection, AIDS, Crohn's disease, tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than vitamin B12 deficiency.

III. Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, HIV infection, AIDS, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces vitamin B12 deficiency. Structural lesions leading to vitamin B12 deficiency include regional ileitis, ileal resections, malignancies, etc.

IV. Competition for vitamin B12 by intestinal parasites or bacteria. The fish tapeworm (Diphyllobothrium latum) absorbs huge quantities of vitamin B12 and infested patients often have associated gastric atrophy. The blind loop syndrome may produce deficiency of vitamin B12 or folate.

V. Inadequate utilization of vitamin B12. This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.

It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption, use of a gluten-free diet in non-tropical sprue, or administration of antibiotics in tropical sprue. Such measures remove the need for long-term administration of vitamin B12.

Requirements of vitamin B12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with intranasal or oral supplementation.

Cyanocobalamin (Bloodfull) Nasal Spray is not suitable for vitamin B12 absorption test (Schilling Test).

iron-deficiency anaemia

Folic acid (Bloodfull) is used in the treatment and prevention of the folate deficiency state. It does not correct folate deficiency due to dihydrofolate reductase inhibitors. Folic acid (Bloodfull) is also used in women of child-bearing potential and pregnant women to protect against neural tube defects in their offspring. It is also used for the treatment of folate-deficient megaloblastic anaemia, chronic haemolytic states such as thalassaemia major or sickle-cell anaemia.

To avoid and correct vitamin deficiency, which may

result from an imbalanced or special diet, impaired

absorption, anorexia, slimming, pathological intestinal

flora, debilitating disease or therapy with drugs acting

as vitamin antagonists.

Nicotinamide (Bloodfull) syrup meets the increased vitamin requirements

during periods of intensive growth, and as a dietary

supplement in premature and newborn infants.

Oral

Prophylaxis of Riboflavin (Bloodfull) deficiency

Adult: 1-2 mg daily.

Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.

Oral

Riboflavin (Bloodfull) deficiency

Adult: Up to 30 mg daily in divided doses.

Child: 3-10 mg daily.

Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.

Oral

Microcytic anaemia

Adult: Associated with splenomegaly and glutathione reductase deficiency: 10 mg daily for 10 days.

Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.

treatment of vitamin B deficiencies and prevention of it.

Cyanocobalamin (Bloodfull) nasal spray contains Cyanocobalamin (Bloodfull), a man-made form of vitamin B12. Vitamin B12 is important for growth, cell reproduction, blood formation, and protein and tissue synthesis.

Cyanocobalamin (Bloodfull) nasal spray is used to treat vitamin B12 deficiency in people with pernicious anemia and other conditions.

Cyanocobalamin (Bloodfull) nasal spray is usually given after treatment with an injection form of this medicine.

Cyanocobalamin (Bloodfull) may also be used for purposes not listed in this medication guide.

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Folic acid (Bloodfull) (vitamin B 9) is necessary for strong blood.

Lack of Folic acid (Bloodfull) may lead to anemia (weak blood). Your health care professional may treat this by prescribing Folic acid (Bloodfull) for you.

Some conditions may increase your need for Folic acid (Bloodfull). These include:

• Alcoholism
• Anemia, hemolytic
• Diarrhea (continuing)
• Fever (prolonged)
• Hemodialysis
• Illness (prolonged)
• Intestinal diseases
• Liver disease
• Stress (continuing)
• Surgical removal of stomach

In addition, infants smaller than normal, breast-fed infants, or those receiving unfortified formulas (such as evaporated milk or goat's milk) may need additional Folic acid (Bloodfull).

Increased need for Folic acid (Bloodfull) should be determined by your health care professional.

Some studies have found that Folic acid (Bloodfull) taken by women before they become pregnant and during early pregnancy may reduce the chances of certain birth defects (neural tube defects).

Claims that Folic acid (Bloodfull) and other B vitamins are effective for preventing mental problems have not been proven. Many of these treatments involve large and expensive amounts of vitamins.

Injectable Folic acid (Bloodfull) is given by or under the direction of your health care professional. Another form of Folic acid (Bloodfull) is available without a prescription.

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Riboflavin (Bloodfull) (vitamin B 2) is needed to help break down carbohydrates, proteins, and fats. It also makes it possible for oxygen to be used by your body.

Lack of Riboflavin (Bloodfull) may lead to itching and burning eyes, sensitivity of eyes to light, sore tongue, itching and peeling skin on the nose and scrotum, and sores in the mouth. Your doctor may treat this condition by prescribing Riboflavin (Bloodfull) for you.

Some conditions may increase your need for Riboflavin (Bloodfull). These include:

• Alcoholism
• Burns
• Cancer
• Diarrhea (continuing)
• Fever (continuing)
• Illness (continuing)
• Infection
• Intestinal diseases
• Liver disease
• Overactive thyroid
• Serious injury
• Stress (continuing)
• Surgical removal of stomach

In addition, Riboflavin (Bloodfull) may be given to infants with high blood levels of bilirubin (hyperbilirubinemia).

Increased need for Riboflavin (Bloodfull) should be determined by your health care professional.

Claims that Riboflavin (Bloodfull) is effective for treatment of acne, some kinds of anemia (weak blood), migraine headaches, and muscle cramps have not been proven.

Oral forms of Riboflavin (Bloodfull) are available without a prescription.

The recommended initial dose of Cyanocobalamin (Bloodfull) (Cyanocobalamin (Bloodfull)) Nasal Spray is one spray (500 mcg) administered in ONE nostril once weekly. Cyanocobalamin (Bloodfull) (Cyanocobalamin (Bloodfull)) Nasal Spray should be administered at least one hour before or one hour after ingestion of hot foods or liquids. Periodic monitoring of serum B levels should be obtained to establish adequacy of therapy.

Priming (Activation) of Pump

Before the first dose and administration, the pump must be primed. Remove the clear plastic cover and the plastic safety clip from the pump. To prime the pump, place nozzle between the first and second finger with the thumb on the bottom of the bottle. Pump the unit firmly and quickly until the first appearance of spray. Then prime the pump an additional 2 times. Now the nasal spray is ready for use. The unit must be re-primed before each dose. Prime the pump once immediately before each administration of doses 2 through 8.

How supplied

Cyanocobalamin (Bloodfull) (Cyanocobalamin (Bloodfull)) Nasal Spray is available as a spray in 3 mL glass bottles containing 2.3 mL of solution. It is available in a dosage strength of 500 mcg per actuation (0.1 mL/actuation). A screw-on actuator is provided. This actuator, following priming, will deliver 0.1 mL of the spray. Cyanocobalamin (Bloodfull) (Cyanocobalamin (Bloodfull)) Nasal Spray is provided in a carton containing a nasal spray actuator with dust cover, a bottle of nasal spray solution, and a package insert. One bottle will deliver 8 doses (NDC 67871-773-35).

Pharmacist Assembly Instructions For Cyanocobalamin (Bloodfull) (Cyanocobalamin (Bloodfull)) Nasal Spray

The pharmacist should assemble the Cyanocobalamin (Bloodfull) (Cyanocobalamin (Bloodfull)) Nasal Spray unit prior to dispensing to the patient, according to the following instructions:

1. Open the carton and remove the spray actuator and spray solution bottle.
2. Assemble Cyanocobalamin (Bloodfull) (Cyanocobalamin (Bloodfull)) Nasal Spray by first unscrewing the white cap from the spray solution bottle and screwing the actuator unit tightly onto the bottle. Make sure the clear dust cover is on the pump unit.
3. Return the Cyanocobalamin (Bloodfull) (Cyanocobalamin (Bloodfull)) Nasal Spray bottle to the carton for dispensing to the patient.

Mfd. for QOL Medical, LLC

Kirland, WA 98033, USA

1.866.469.3773

www.Cyanocobalamin (Bloodfull) (Cyanocobalamin (Bloodfull)).com

3078 Rev. 02/06

FDA rev date: 9/15/2006

1 cap daily.

Usual Adult Dose for Megaloblastic Anemia

1 mg orally, intramuscularly, subcutaneously or IV once a day. May continue until clinical symptoms of folate deficiency and the hematological profile have normalized.

Usual Adult Dose for Folic acid (Bloodfull) Deficiency

400 to 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Women of childbearing age, pregnant, and lactating women: 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Folic acid (Bloodfull) Deficiency

Infant:

0.1 mg orally, intramuscularly, subcutaneously or IV once a day.

Child:

Less than 4 years: up to 0.3 mg orally, intramuscularly, subcutaneously or IV once a day.

4 years or older: 0.4 mg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Vitamin/Mineral Supplementation

Recommended daily allowance (RDA):

Premature neonates: 50 mcg/day (15 mcg/kg/day).

Full-term neonates and infants 1 to 6 months: 25 to 35 mcg/day.

Children:

1 to 3 years: 150 mcg/day.

4 to 8 years: 200 mcg/day.

9 to 13 years: 300 mcg/day.

14 years and older: 400 mcg/day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Rarely, a dosage of 2 mg/day may be required, particularly in patients with malabsorption, alcoholism, chronic hemolysis, chronic exfoliative skin disease or who are on concomitant anticonvulsant therapy.

Dialysis

Folic acid (Bloodfull) is removed by both hemodialysis and peritoneal dialysis. The amount removed varies with type equipment used.

Because folate may accumulate in patients with end-stage renal disease, side effects may be more likely in this patient who is undergoing dialysis. Once this patient's body stores of folate are replete, three times a week dosing may be just as beneficial as once daily dosing but should portend a lower risk of side effects.

Other Comments

The recommended daily allowance of Folic acid (Bloodfull) for adult males and females ranges from 150 to 200 and 150 to 180 mcg/day, respectively.

There is a potential danger in administering Folic acid (Bloodfull) to patients with undiagnosed anemia, since Folic acid (Bloodfull) may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress.

Severe megaloblastic anemia may require therapy for 4 to 5 weeks. Once stabilized, if dietary intake is inadequate, maintenance therapy can be started.

Oral

Treatment and prophylaxis of nicotinic acid deficiency

Adult: Up to 500 mg daily in divided doses. May also be given via IM or by slow IV inj.

Topical/Cutaneous

Mild to moderate inflammatory acne

Adult: As a 4% gel: Apply bid, reduce to once daily or on alternate days if irritation occurs.

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule,

Oral:

B-2-400: 400 mg

Generic: 50 mg

Tablet,

Oral:

Generic: 25 mg, 50 mg, 100 mg

Dosing: Adult

Dietary supplement:

Oral: 100 mg once or twice daily

Prevention of migraine headache (off-label use):

Oral: 400 mg once daily (Rahimdel 2015; Schoenen 1998)

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Dietary supplement: Infants, Children, and Adolescents: A multivitamin preparation is most commonly used for the provision of Riboflavin (Bloodfull) supplementation in pediatric patients; the use of a single-ingredient Riboflavin (Bloodfull) product as a daily supplement for the prevention of deficiency in pediatric patients is very rare. If single-ingredient Riboflavin (Bloodfull) supplement is necessary, consult product labeling for appropriateness of product in infants and young children in particular.

Migraine headache, prevention: Limited data available, efficacy results variable: Children ≥ 8 years and Adolescents:

Oral: 200 to 400 mg once daily; dosing based on a retrospective study of 41 patients (ages 8 to 18 years) who received 200 mg/day (n=21) or 400 mg/day (n=20) as prophylaxis for migraine and migraine-type headaches; results showed significant reduction in primary endpoint of frequency of headache attack; 68.4% of patients had a ≥50% decrease in headache frequency during treatment (Condò 2009). However, in a prospective, placebo-controlled study of 48 patients (ages 5 to 15 years), patients received 200 mg/day (n=27) or placebo (n=21) and in the treatment group (Riboflavin (Bloodfull)) no benefit compared to placebo for migraine frequency or intensity was observed; a high placebo responder rate was also reported (MacLennan 2008).

See also:
What is the most important information I should know about Cyanocobalamin (Bloodfull)?

You should not use this medication if you are allergic to cobalt, or if you have Leber's disease. Cyanocobalamin (Bloodfull) can lead to optic nerve damage (and possibly blindness) in people with Leber's disease.

To treat pernicious anemia, you will have to use this medication on a regular basis for the rest of your life. Not using the medication can lead to irreversible nerve damage in your spinal cord.

Pernicious anemia is also treated with folic acid to help maintain red blood cells. However, folic acid will not treat Vitamin B12 deficiency and will not prevent possible damage to the spinal cord. Use all of your medications as directed.

Avoid eating or drinking hot foods or liquids within 1 hour before or after using the nasal form of this medication.

Tell your doctor if you develop nasal congestion, a cold, or allergies. The nasal spray may not work as well if you are congested.

Your dose needs may change if you become pregnant, if you breast-feed, or if you eat a vegetarian diet. Tell your doctor about any changes in your diet or medical condition.

See also:
What is the most important information I should know about Folic acid (Bloodfull)?

Because it may mask the hematologic abnormalities while neurological damage progresses, Folic acid (Bloodfull) should not be used in the therapy of patients with vitamin B12 deficiency of any cause, unless there is associated folate deficiency. The Folic acid (Bloodfull) content of one tablet a day however, is unlikely to mask pernicious anemia should this condition be present. Also, pregnancy during pernicious anemia is very rare.

contraindicated in patients with hypersensitivity to any of its components.

See also:
What is the most important information I should know about Riboflavin (Bloodfull)?

None well documented.

do not use in the treatment of leber disease or tobaco intoxication.

Use Cyanocobalamin (Bloodfull) (b12) spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Cyanocobalamin (Bloodfull) (b12) spray. Talk to your pharmacist if you have questions about this information.
• Cyanocobalamin (Bloodfull) (b12) spray is used in the nose.
• Follow the directions provided by your doctor or other health care provider. If you are unsure how to use Cyanocobalamin (Bloodfull) (b12) spray, contact your doctor or other health care provider.
• Do not use Cyanocobalamin (Bloodfull) (b12) spray within 1 hour before or after eating or drinking hot foods or liquids.
• Prime the pump before the first use. Place the nozzle between the first and second finger with the thumb on the bottom. Point the nozzle away from yourself and others. Pump the unit firmly and quickly until the medicine sprays out, then spray two more times.
• Re-prime the pump before each dose. Point the nozzle away from yourself and others, then spray once.
• Use Cyanocobalamin (Bloodfull) (b12) spray in only 1 nostril each week.
• To use Cyanocobalamin (Bloodfull) (b12) spray, sit down and tilt your head back slightly. Place the tip of the spray container into the nose. Using a finger from your other hand, press against the opposite nostril to close it off. Breath gently through the open nostril and spray a dose of medicine from the container. After using the medicine, rinse the tip of the spray unit in hot water and dry with a clean tissue to prevent contamination.
• Cyanocobalamin (Bloodfull) (b12) spray is usually used 1 time per week. Do not use it more often than 1 time per week without checking with your doctor.
• This bottle contains 8 doses. Do not continue to use this bottle after 8 doses have been used. It may not give the correct amount of medicine.
• Continue to use Cyanocobalamin (Bloodfull) (b12) spray even if you feel well. Do not miss any doses.
• If you miss a dose of Cyanocobalamin (Bloodfull) (b12) spray, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Cyanocobalamin (Bloodfull) (b12) spray.

Use Folic acid (Bloodfull) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Folic acid (Bloodfull) may be administered as an injection by your health care professional.
• If you are using Folic acid (Bloodfull) at home, carefully follow the injection procedures taught to you by your health care provider. If the medicine contains particles, is discolored, or if the vial is cracked or damaged in any way, do not use it.
• Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
• If you miss a dose of Folic acid (Bloodfull), use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Folic acid (Bloodfull).

A surgeon or other healthcare provider will give you this medicine as part of your corneal collagen crosslinking procedure.

You will be given numbing eyedrops to prepare you for the procedure. You may also be given a sedative or anesthesia to help you relax. Although you will most likely be awake during the procedure, you should feel little or no discomfort. A special device will be placed around your eyelids to keep them open during the procedure.

Your eye surgeon will place Riboflavin (Bloodfull) ophthalmic drops into your eyes about every 2 minutes during the procedure.

After the procedure, the surgeon will place a contact lens on the treated eye to protect it for a short time.

Call your doctor right away if the contact lens falls out or feels like it is out of place inside your eye.

You may also need to use antibiotic or steroid eyedrops to prevent infection and reduce swelling after your procedure. Carefully follow all after-care instructions and do not miss any follow-up appointments.

How to use Cyanocobalamin (Bloodfull) nasal

Folic acid (Bloodfull) is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.

Folic acid (Bloodfull) supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of Folic acid (Bloodfull) either through their diet or supplements to prevent infant spinal cord birth defects.

How to use Folic acid (Bloodfull)

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition persists or worsens, or if you think you may have a serious medical problem, get medical help right away.

Nicotinamide (Bloodfull) is used to treat vitamin B3 deficiency and inflammatory skin diseases like acne and pellagra.

Riboflavin (Bloodfull) (Riboflavin (Bloodfull)) supplementation is used to prevent and treat Riboflavin (Bloodfull) deficiency. Riboflavin (Bloodfull) may prevent migraine headaches at high doses and be useful for prevention of eye conditions such as cataract, glaucoma and tired eyes (fatigue). Riboflavin (Bloodfull) is also used for boosting of immune system, and maintenance of healthy hair, skin, nails and mucous membranes.

See also:
What other drugs will affect Cyanocobalamin (Bloodfull)?

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Some products that may interact with this drug include: drugs that affect the bone marrow (such as chloramphenicol), vitamins/supplements that contain intrinsic factor.

Certain medications can decrease the absorption of vitamin B12, including: colchicine, metformin, extended-release potassium products, antibiotics (such as gentamicin, neomycin, tobramycin), anti-seizure medications (such as phenobarbital, phenytoin, primidone), medications to treat heartburn (such as H2 blockers including cimetidine/famotidine, proton pump inhibitors such as omeprazole/lansoprazole).

Vitamin B12 is an ingredient found in many combination vitamin and nutritional products. Tell your doctor or pharmacist if you are taking other products that contain Cyanocobalamin (Bloodfull), vitamin B12, or hydroxocobalamin.

Cyanocobalamin (Bloodfull) may interfere with certain laboratory tests (including intrinsic factor, blood tests for other types of anemia), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Certain drugs may interfere with laboratory tests for vitamin B12 levels, possibly causing false results. Tell laboratory personnel and all your doctors if you take any of the following: antibiotics (such as amoxicillin, erythromycin), methotrexate, pyrimethamine.

This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

See also:
What other drugs will affect Folic acid (Bloodfull)?

Medications that interfere with your bodys ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and Folic acid (Bloodfull). Folic acid (Bloodfull) supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, Folic acid (Bloodfull) will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental Folic acid (Bloodfull) should not exceed 1000 micrograms (g, sometimes mcg) per day to prevent Folic acid (Bloodfull) from masking symptoms of vitamin B12 deficiency. It is important for older adults to be aware of the relationship between Folic acid (Bloodfull) and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains Folic acid (Bloodfull).

Nicotinamide (Bloodfull): The clearance of primidone and carbamazepine may be reduced with the concomitant use of Nicotinamide (Bloodfull).

Zinc Oxide: The absorption of quinolones or tetracycline may be decreased with the concomitant use of zinc.

Cupric Oxide: Concomitant use of penicillamine and copper can cause decreased absorption of both substances.

See also:
What other drugs will affect Riboflavin (Bloodfull)?

Interactions for Riboflavin (Bloodfull) (Riboflavin (Bloodfull))

Alcohol - impairs the intestinal absorption of riboflavi

Antidepressants (tricyclics or phenothiazines) - requirements for Riboflavin (Bloodfull) may be increased in patients receiving these medications

Probenecid - concurrent use decreases gastrointestinal absorption of Riboflavin (Bloodfull); requirements for Riboflavin (Bloodfull) may be increased in patients receiving probenecid.

none known

See also:
What are the possible side effects of Cyanocobalamin (Bloodfull)?

The incidence of adverse experiences described in the Table below are based on data from a short-term clinical trial in vitamin B12 deficient patients in hematologic remission receiving Cyanocobalamin (Bloodfull) (Cyanocobalamin (Bloodfull), USP) Gel for Intranasal Administration (N=24) and intramuscular vitamin B12 (N=25). In the pharmacokinetic study comparing Cyanocobalamin (Bloodfull) Nasal Spray and Cyanocobalamin (Bloodfull) Nasal Gel, the incidence of adverse events was similar.

The intensity of the reported adverse experiences following the administration of Cyanocobalamin (Bloodfull) (Cyanocobalamin (Bloodfull), USP) Gel for Intranasal Administration and intramuscular vitamin B12 were generally mild. One patient reported severe headache following intramuscular dosing. Similarly, a few adverse experiences of moderate intensity were reported following intramuscular dosing (two headaches and rhinitis; one dyspepsia, arthritis, and dizziness), and dosing with Cyanocobalamin (Bloodfull) (Cyanocobalamin (Bloodfull), USP) Gel for Intranasal Administration (one headache, infection, and paresthesia).

The majority of the reported adverse experiences following dosing with Cyanocobalamin (Bloodfull) (Cyanocobalamin (Bloodfull), USP) Gel for Intranasal Administration and intramuscular vitamin B12 were judged to be intercurrent events. For the other reported adverse experiences, the relationship to study drug was judged as "possible" or "remote". Of the adverse experiences judged to be of "possible" relationship to the study drug, anxiety, incoordination, and nervousness were reported following intramuscular vitamin B12 and headache, nausea, and rhinitis were reported following dosing with Cyanocobalamin (Bloodfull) (Cyanocobalamin (Bloodfull), USP) Gel for Intranasal Administration.

The following adverse reactions have been reported with parenteral vitamin B12:

Generalized: Anaphylactic shock and death.

Cardiovascular: Pulmonary edema and congestive heart failure early in treatment; peripheral vascular thrombosis.

Hematological: Polycythemia vera.

Gastrointestinal: Mild transient diarrhea.

Dermatological: Itching; transitory exanthema.

Miscellaneous: Feeling of swelling of the entire body.

See also:
What are the possible side effects of Folic acid (Bloodfull)?

Allergic sensitization has been reported following both oral and parenteral administration of Folic acid (Bloodfull).

Folic acid (Bloodfull) is relatively nontoxic in man. Rare instances of allergic responses to Folic acid (Bloodfull) preparations have been reported and have included erythema, skin rash, itching, general malaise, and respiratory difficulty due to bronchospasm. One patient experienced symptoms suggesting anaphylaxis following injection of the drug. Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg Folic acid (Bloodfull) daily for 1 month. Other side effects reported in patients receiving 15 mg daily include altered sleep patterns, difficulty in concentrating, irritability, overactivity, excitement, mental depression, confusion, and impaired judgment. Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folic acid (Bloodfull) therapy.

In an uncontrolled study, orally administered Folic acid (Bloodfull) was reported to increase the incidence of seizures in some epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin. Another investigator reported decreased diphenylhydantoin serum levels in folate-deficient patients receiving diphenylhydantoin who were treated with 5 mg or 15 mg of Folic acid (Bloodfull) daily.

CALL YOUR DOCTOR FOR MEDICAL ADVICE ABOUT SIDE EFFECTS. YOU MAY REPORT SIDE EFFECTS TO THE FDA AT 1-800-FDA-1088 OR LEADING PHARMA, LLC AT 844-740-7500.

Allergic sensitization has been reported rarely following oral and parenteral administration of Nicotinamide (Bloodfull).

At recommended doses, Nicotinamide (Bloodfull) is expected to be well tolerated. Gastrointestinal distress such as nausea or vomiting have been associated with the administration of Nicotinamide (Bloodfull) or zinc at doses greater than the recommended dose of Nicotinamide (Bloodfull)

Nicotinamide (Bloodfull): Dizziness, headache, hyperglycemia, nausea, vomiting, diarrhea, elevations in liver function tests, hepatotoxicity, blurred vision, flushing, rash.

See also:
What are the possible side effects of Riboflavin (Bloodfull)?

Adverse Reactions

Frequency not defined: Genitourinary: Urine discoloration (yellow-orange)

anaphylactic reactions rarely, severe cases can cause death, urine yellow colouration,peripheral neuropathy in case of prolonged useage, arrythmias,