Bleomicina APS

a. Squamous cell carcinoma affecting the mouth, nasopharynx and paranasal sinuses, larynx, oesophagus, external genitalia, cervix or skin. Well differentiated tumours usually respond better than anaplastic ones.

b. Hodgkin's disease and other malignant lymphomas, including mycosis fungoides.

c. Testicular teratoma

d. Malignant effusions of serous cavities.

e. Secondary indications in which Bleomicina APSmycin has been shown to be of some value (alone or in combination with other drugs) include metastatic malignant melanoma, carcinoma of the thyroid, lung and bladder.

Adults

Routes of administration

Bleomicina APSmycin is usually administered intramuscularly but may be given intravenously (bolus or drip), intra-arterially, intrapleurally or intraperitoneally as a solution in physiological saline.

Local injection directly into the tumour may occasionally be indicated.

Recommended dose and dosage schedules

Squamous cell carcinoma and testicular teratoma:

Used alone the normal dosage is 15 x 10³ IU (1 vial) three times a week or 30 x 10³ IU (2 vials) twice a week, either intramuscularly or intravenously. Treatment may continue on consecutive weeks, or more usually at intervals of 3-4 weeks, up to a lifetime cumulative dose of 360 x 10³ IU. Continuous intravenous infusion at a rate of 15 x 10³ IU (1 vial) per 24 hours for up to 10 days, or 30 x 10³ IU (2 vials) per 24 hours for up to 5 days may produce a therapeutic effect more rapidly. The development of stomatitis is the most useful guide to the determination of individual tolerance of maximum therapeutic response. The dose may need to be adjusted when Bleomicina APSmycin is used in combination chemotherapy. Use in elderly or children - see below.

Malignant lymphomas:

Used alone the recommended dosage regime is 15 x 10³ IU (1 vial) once or twice a week, intramuscularly, to a total dose of 225 x 10³ IU (15 vials). Lifetime cumulative dose should not exceed 360 x 10³ IU. Dosage should be reduced in the elderly. The dose may need to be adjusted when Bleomicina APSmycin is used in combination chemotherapy. Use in elderly or children - see below.

Malignant effusions:

After drainage of the affected serous cavity 60 x 10³ IU (4 vials) Bleomicina APSmycin dissolved in 100 ml physiological saline is introduced via the drainage needle or cannula. After instillation, the drainage needle or cannula may be withdrawn. Administration may be repeated if necessary subject to a lifetime cumulative dose of 360 x 10³ IU (about 24 vials). Use in the elderly or children - see below.

Combination therapy:

Bleomicina APSmycin is commonly used in conjunction with radiotherapy, particularly in treatment of cancer of the head and neck region. Such a combination may enhance mucosal reactions if full doses of both forms of treatment are used and Bleomicina APSmycin dosage may require reduction, e.g. to 5 x 10³ IU at the time of each radiotherapy fraction five days a week. Bleomicina APSmycin is frequently used as one of the drugs in multiple chemotherapy regimes (e.g. squamous cell carcinoma, testicular teratoma, lymphoma). The mucosal toxicity of Bleomicina APSmycin should be borne in mind in the selection and dosage of drugs with similar toxic potential used in such combinations.

Elderly Patients:

The total dose of Bleomicina APSmycin used in the treatment of squamous cell carcinoma, testicular teratoma or malignant effusions should be reduced as indicated below:

Paediatric population

Administration of Bleomicina APSmycin to paediatrics should take place only under exceptional circumstances and in special centres. The dosage should be based on that recommended for adults and adjusted to body surface area or body weight.

Reduced kidney function

With serum creatinine values of 2-4 mg/dL, it is recommended to half the above dosages. With serum creatinine above 4 mg/dL, a further reduction in dose is indicated.

Preparation of solution

For intramuscular injections the required dose is dissolved in up to 5 ml of suitable solvents such as physiological saline. If pain occurs at the site of injection a 1% solution of lignocaine may be used as a solvent.

For intravenous injections the dose required is dissolved in 5-200 ml of physiological saline and injected slowly or added to the reservoir of a running intravenous infusion. For intra-arterial administration a slow infusion in physiological saline is used. For intra-cavitary injection 60 x 10³ IU is dissolved in 100 ml of normal saline.

For local injections Bleomicina APSmycin is dissolved in physiological saline to make a 1-3 x 10³ IU/ml solution.

Bleomicina APSmycin is contra-indicated in patients with acute pulmonary infection or chest X-ray findings suggesting diffuse fibrotic changes or greatly reduced lung function.

Patients with a past history of hypersensitivity or idiosyncratic reaction to an analogue of Bleomicina APSmycin.

Pulmonary toxicity of Bleomicina APSmycin is both dose-related and age-related. It may also occur when lower doses are administered, especially in elderly patients, patients with reduced kidney function, pre-existing lung disease, previous or concurrent radiotherapy to the chest and in patients who need administration of oxygen. It is significantly enhanced by thoracic radiation and by hyperoxia used during surgical anaesthesia.

The earliest symptom associated with pulmonary toxicity of Bleomicina APSmycin is dyspnoea. Fine rales are the earliest sign. If pulmonary changes are noted, treatment should be discontinued until it can be determined if they are drug related. Patients should be treated with broad spectrum antibiotics and corticosteroids.

Patients undergoing treatment with Bleomicina APSmycin should have chest X-rays weekly. These should continue to be taken for up to 4 weeks after completion of the course and patients should be kept under clinical review for approximately 2 months. If breathlessness or lung infiltrates appear, not obviously attributable to tumour or to co-existent lung disease, administration of the drug must be stopped immediately and patients should be treated with a corticosteroid and a broad spectrum antibiotic. High oxygen concentrations should be used with caution in these cases.

Lung function tests which use 100% oxygen should not be used in patients who have been treated with Bleomicina APSmycin. Lung function tests using less than 21% oxygen are recommended as an alternative.

When Bleomicina APSmycin has been administered pre-operatively, reduced oxygen concentrations should be used during operation and post operatively.

Patients should be carefully monitored under the following conditions and Bleomicina APSmycin dosage should be reduced or prolong the dose interval based on clinical observation of the patient: These clinical conditions include the following:

- Patients treated previously or concurrently with radiation to the chest may develop more frequent or severe toxicity.

- Use with caution in patients with significant renal impairment as clearance may be reduced and toxicity increased.

- Use with caution in patients with severe heart disease or hepatic dysfunction as toxicity may be increased.

- Use with caution in patients with varicella as fatal systematic dysfunctions may occur.

Because Bleomicina APSmycin treatment may give rise to shock, if any abnormalities appear, withdraw Bleomicina APSmycin immediately, and take appropriate measures. (Because shock is likely to develop in patients with malignant lymphomas at the 1st - 2nd administration, you may start this drug treatment with lower dose and after establishing that no acute reactions to the drug occur, increase the dose to the usual level).

With long-term administration of Bleomicina APSmycin, peplomycin or other analogies of Bleomicina APSmycin, toxicity is thought to be additive, thus administration must be performed with care.

Attention should be paid to the appearance or exacerbation of infection and any bleeding tendency.

In adults or adolescents capable of reproduction, effects on the sexual glands should be considered.

Intravenous administration

Vascular pain may occur, therefore, it is important to pay due attention to concentration of the injection and administration rate. Give intravenously as slowly as possible.

Intramuscular administration

Avoid repeated injections at the same site and innervated sites, particularly if administering to paediatrics. If insertion of the injection needle evokes intense pain or if blood flows back into the syringe, withdraw the needle immediately and inject at a different site.

This depends on the patient's condition and should be considered in co-operation with the doctor.

The most frequently observed adverse reactions in 1613 patients receiving Bleomicina APSmycin were pulmonary manifestations such as interstitial pneumonia or pulmonary fibrosis (10.2%), sclerosis of skin, pigmentation (40.6%), fever and rigors (39.8%), alopecia (29.5%), anorexia and weight decrease (28.7%), general malaise (16.0%), nausea and vomiting (14.6%), stomatitis (13.3%) and nail changes (11.2%).

Tabulated Summary of Adverse Reactions with Bleomicina APSmycin:

The following adverse reactions have been reported with Bleomicina APSmycin during clinical studies and from post-marketing experience. They are listed below by system organ class and frequency (very common > 1/10; common > 1/100 to < 1/10; uncommon >1/1,000 to <1/100; not known (cannot be estimated from available data)).

* Following intravenous administration

Like most cytotoxic agents Bleomicina APSmycin can give rise to both immediate and to delayed toxic effects. The most immediate effect is fever on the day of injection. Fever may develop with a lag time of 4-5 hours or more after the administration of this drug. Because a dose- response relation exists between the fever and dose at a given time, if the fever is severe, appropriate measures should be taken such as administering a reduced dose at shorter intervals, or antihistaminic and antipyretic agents before and/or after administration of this drug.

The majority of patients who receive a full course of Bleomicina APSmycin develop lesions of the skin or oral mucosa. Induration, hyperkeratosis, reddening, tenderness and swelling of the tips of the fingers, ridging of the nails, bulla formation over pressure points such as elbows, loss of hair and stomatitis are rarely serious and usually disappear soon after completion of the course.

The most serious delayed effect is interstitial pneumonia, which may develop during, or occasionally after, a course of treatment. This condition may sometimes develop into fatal pulmonary fibrosis, although such an occurrence is rare at recommended doses. Previous or concurrent radiotherapy to the chest is an important factor in increasing the incidence and severity of lung toxicity.

A few cases of acute fulminant reactions with hyperpyrexia and cardiorespiratory collapse have been observed after intravenous injections of doses higher than those recommended. Hypotension, hyperpyrexia and drug-related deaths have been reported rarely following intra-cavitary instillation of Bleomicina APSmycin.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme

Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

The acute reaction to an overdosage of Bleomicina APSmycin would probably include hypotension, fever, rapid pulse and general symptoms of shock.

Treatment is purely symptomatic. In the event of respiratory complications the patient should be treated with a corticosteroid and a broad-spectrum antibiotic. There is no specific antidote to Bleomicina APSmycin.

ATC code: LO1D C01, other cytotoxic antibiotics

Bleomicina APSmycin is a basic, water-soluble glycopeptide with cytotoxic activity. The mechanism of action of Bleomicina APSmycin is believed to involve single-strand scission of DNA, leading to inhibition of cell division, of growth and of DNA synthesis in tumour cells.

Apart from its antibacterial and antitumour properties, Bleomicina APSmycin is relatively free from biological activity. When injected intravenously it may have a histamine-like effect on blood pressure and may cause a rise in body temperature.

Bleomicina APSmycin is administered parenterally. After intravenous (IV) administration of a bolus dose of 15 x 10³ IU/m² body surface, peak concentrations of 1 to 10 IU are achieved in plasma. Following the intramuscular (IM) injection of 15 x 10³ IU peak plasma concentrations of about 1 IU/ml have been reported. The peak plasma concentration is reached 30 minutes after an IM injection. Continuous infusion of Bleomicina APSmycin 30 x 10³ IU daily, for 4 to 5 days, resulted in an average steady state plasma concentration of 100-300 milli IU/ml. After IV injections of Bleomicina APSmycin in a dose of 15 x 10³ IU/m² body surface, the area under the serum concentration curve is, on average, 300 milli IU x min x ml^-1.

Bleomicina APSmycin is only bound to plasma proteins to a slight extent. Bleomicina APSmycin is rapidly distributed in body tissues, with the highest concentrations in skin, lungs, peritoneum and lymph. Low concentrations are seen in the bone marrow. Bleomicina APSmycin could not be detected in cerebrospinal fluid after intravenous injection. Bleomicina APSmycin appears to cross the placental barrier.

The mechanism for bio-transformation is not yet fully known. Inactivation takes place during enzymatic breakdown by Bleomicina APSmycin hydrolase, primarily in plasma, liver and other organs and, to a much lesser degree, in skin and lungs. When Bleomicina APSmycin was administered as an IV bolus injection in a dose of 15 x 10³ IU/m² body surface, initial and terminal half-lives were 0.5 and 4 hours respectively. Given as a continuous intravenous infusion in a dose of 30 x 10³ IU daily for 4 to 5 days Bleomicina APSmycin disappears from plasma with initial and terminal half-lives of about 1.3 hours and 9 hours, respectively. About two thirds of the administered drug is excreted unchanged in the urine, probably by glomerular filtration. Approximately 50% is recovered in the urine in the 24 hours following an IV or IM injection. The rate of excretion, therefore, is highly influenced by renal function; concentrations in plasma are greatly elevated if usual doses are given to patients with renal impairment with only up to 20% excreted in 24 hours. Observations indicate that it is difficult to eliminate Bleomicina APSmycin from the body by dialysis.

Animal experiences have revealed that Bleomicina APSmycin, like most cytotoxics, may have teratogenic and carcinogenic potential.

Bleomicina APSmycin has been reported to cause fibrosarcoma and renal carcinoma in a laboratory animal (rat) administered subcutaneously.

Bleomicina APSmycin has been reported to cause foetal malformation in laboratory animals (mice and rats).

Bleomicina APSmycin solution should not be mixed with solutions of essential amino acids, riboflavine, ascorbic acid, dexamethasone, aminophylline or frusemide.

Bleomicina APSmycin should be handled with care. Precautions should be taken to avoid Bleomicina APSmycin coming into contact with skin, mucous membranes or eyes, but in the event of contamination the affected part should be washed with water.