Bio-Lyte ORS

For systemic use of Ascorbic acid (Bio-Lyte ORS) Atlantic Laboratories: prevention and treatment of hypo- and avitaminosis of Ascorbic acid (Bio-Lyte ORS); providing increased need for Ascorbic acid (Bio-Lyte ORS) during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.

For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.

This medication is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. It may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).

Calcium plays a very important role in the body. It is necessary for normal functioning of nerves, cells, muscle, and bone. If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones. Having the right amount of calcium is important for building and keeping strong bones.

Oral

Hypoglycaemia

Adult: 10-20 g as single dose; may repeat in 10 min if needed.

Child: >2 yr: 10-20 g as single dose; may repeat in 10 min if needed.

Intravenous

Hypoglycaemia

Adult: 10-25 g (40-100 ml of 25% solution or 20-50 ml of 50% solution). Doses may be repeated in severe cases.

Child: ≤6 mth: 0.25-0.5 g/kg/dose; >6 mth: 0.5-1 g/kg/dose. Doses may be repeated in severe cases. Max: 25 g/dose.

Intravenous

Hyperkalaemia

Adult: 25-50 g combined with 10 units of regular insulin, administered over 30-60 minutes; may repeat if necessary. Alternatively, 25 g combined with 5-10 units of regular insulin infused over 5 minutes; may repeat if necessary.

Child: and infants: 0.5-1 g/kg (using 25% or 50% solution) combined with regular insulin (1 unit for every 4-5 g Dextrose (Bio-Lyte ORS) given); infuse over 2 hr, may repeat if necessary.

It is indicated for the treatment of infections caused by the following sensitive bacteria: Lower respiratory infection, urinary tract infection, septicoemia, skin soft tissue infection, bone and joint infection, and infection prevention in operations. Preoperative injection of a single dose of 1g cefonicid sodium can reduce incidence rate of postoperative infections due to contamination during operation or potential contamination. The use of this product in abdominal delivery (after shearing abdominal stalk) can reduce incidence rate of postoperative infections

Magnesium sulphate (Bio-Lyte ORS) Sulfate Injection, USP is suitable for replacement therapy in Magnesium sulphate (Bio-Lyte ORS) deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those observed in hypocalcemia. In such cases, the serum Magnesium sulphate (Bio-Lyte ORS) (Mg++) level is usually below the lower limit of normal (1.5 to 2.5 mEq/liter) and the serum calcium (Ca++) level is normal (4.3 to 5.3 mEq/liter) or elevated.

In total parenteral nutrition (TPN), Magnesium sulphate (Bio-Lyte ORS) Sulfate may be added to the nutrient admixture to correct or prevent hypomagnesemia which can arise during the course of therapy.

Magnesium sulphate (Bio-Lyte ORS) Sulfate Injection, USP is also indicated as a parenteral anticonvulsant for the prevention and control of seizures (convulsions) in severe toxemia of pregnancy. It effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

BECAUSE OF REPORTS OF INTESTINAL AND GASTRIC ULCERATION AND BLEEDING WITH CONTROLLED-RELEASE Potassium chloride (Bio-Lyte ORS) PREPARATIONS, THESE DRUGS SHOULD BE RESERVED FOR THOSE PATIENTS WHO CANNOT TOLERATE OR REFUSE TO TAKE LIQUID OR EFFERVESCENT POTASSIUM PREPARATIONS OR FOR PATIENTS IN WHOM THERE IS A PROBLEM OF COMPLIANCE WITH THESE PREPARATIONS.

1. For the treatment of patients with hypokalemia with or without metabolic alkalosis, in digitalis intoxications, and in patients with hypokalemic familial periodic paralysis. If hypokalemia is the result of diuretic therapy, consideration should be given to the use of a lower dose of diuretic, which may be sufficient without leading to hypokalemia.
2. For the prevention of hypokalemia in patients who would be at particular risk if hypokalemia were to develop e.g., digitalized patients or patients with significant cardiac arrhythmias, hepatic cirrhosis with ascites, states of aldosterone excess with normal renal function, potassium-losing nephropathy, and certain diarrheal states.

The use of potassium salts in patients receiving diuretics for uncomplicated essential hypertension is often unnecessary when such patients have a normal dietary pattern and when low doses of the diuretic are used. Serum potassium should be checked periodically, however, and if hypokalemia occurs, dietary supplementation with potassium-containing foods may be adequate to control milder cases. In more severe cases, and if dose adjustment of the diuretic is ineffective or unwarranted, supplementation with potassium salts may be indicated.

Sodium chloride (Bio-Lyte ORS) as isotonic solution: the dehydration of various origins. To maintain the volume of blood plasma during and after surgery. As a solvent for various drugs.

Hypertonic solution: violations of water-electrolyte metabolism: lack of sodium and chlorine ions; hypoosmotic dehydration of various origins (due to prolonged vomiting, diarrhea, burns with a gastric fistula, pulmonary hemorrhage, intestinal bleeding).

Eye drops and ointment: irritation of the cornea with inflammatory and allergic diseases (combined therapy).

Prophylaxis & treatment of cystine & uric acid renal calculi. Urinary alkalizer in gout therapy. Treatment of acidosis in renal tubular disorders; chronic metabolic acidosis resulting from chronic renal insufficiency or the syndrome of renal tubular acidosis especially when administration of K salts is contraindicated. Prophylactic agent for acid-aspiration pneumonitis. Used in pre-anaesth medication as a non-particulate acid-neutralizing buffer of gastric acid to lessen the danger from acid-aspiration pneumonitis.

Ascorbic acid (Bio-Lyte ORS) (Ascorbic acid (Bio-Lyte ORS)) occurs naturally in foods such as citrus fruit, tomatoes, potatoes, and leafy vegetables. Ascorbic acid (Bio-Lyte ORS) is important for bones and connective tissues, muscles, and blood vessels. Ascorbic acid (Bio-Lyte ORS) also helps the body absorb iron, which is needed for red blood cell production.

Ascorbic acid (Bio-Lyte ORS) is used to treat and prevent Ascorbic acid (Bio-Lyte ORS) deficiency.

Ascorbic acid (Bio-Lyte ORS) may also be used for purposes not listed in this medication guide.

Calcium is a mineral that is found naturally in foods. Calcium is necessary for many normal functions of your body, especially bone formation and maintenance. Calcium can also bind to other minerals (such as phosphate) and aid in their removal from the body.

Calcium lactate (Bio-Lyte ORS) is used to prevent and to treat calcium deficiencies.

Calcium lactate (Bio-Lyte ORS) may also be used for other purposes not listed in this medication guide.

Dextrose (Bio-Lyte ORS) (glucose) is a form of natural sugar that is normally produced by the liver. Glucose is a source of energy, and all the cells and organs in your body need glucose to function properly. Glucose as a medication is given either by mouth (orally) or by injection.

Dextrose (Bio-Lyte ORS) is used to treat very low blood sugar (hypoglycemia), most often in people with diabetes mellitus. Dextrose (Bio-Lyte ORS) is given by injection to treat insulin shock (low blood sugar caused by using insulin and then not eating a meal or eating enough food afterward). This medicine works by quickly increasing the amount of glucose in your blood.

Dextrose (Bio-Lyte ORS) is also used to provide carbohydrate calories to a person who cannot eat because of illness, trauma, or other medical condition. It is sometimes given to people who are sick from drinking too much alcohol.

Dextrose (Bio-Lyte ORS) may also be used to treat hyperkalemia (high levels of potassium in your blood).

Lactobacillus Lactobacillus acidophilus (Bio-Lyte ORS) is a bacteria that exists naturally in the body, primarily in the intestines and the vagina. Lactobacillus Lactobacillus acidophilus (Bio-Lyte ORS) has been used as a probiotic, or "friendly bacteria."

Lactobacillus Lactobacillus acidophilus (Bio-Lyte ORS) has been used in alternative medicine as a likely effective aid in treating diarrhea in children with rotavirus.

Lactobacillus Lactobacillus acidophilus (Bio-Lyte ORS) has been used in alternative medicine as a possibly effective aid (in children or adults) in preventing diarrhea caused by antibiotics, travel, chemotherapy, or hospitalization. Lactobacillus Lactobacillus acidophilus (Bio-Lyte ORS) is also possibly effective in treating irritable bowel syndrome, bacterial vaginal infection, colic in babies, lung infections in children, skin problems in children who are allergic to milk, and other conditions.

Lactobacillus Lactobacillus acidophilus (Bio-Lyte ORS) has also been used to treat lactose intolerance, Crohn's disease, overgrowth of bacteria in the intestines, or vaginal yeast infections caused by antibiotics. However, research has shown that lactobacillus Lactobacillus acidophilus (Bio-Lyte ORS) may not be effective in treating these conditions.

Other uses not proven with research have included treating indigestion, urinary tract infections, intestinal problems in premature babies, high cholesterol, lyme disease, cold sores, acne, cancer, the common cold, and other conditions.

It is not certain whether lactobacillus Lactobacillus acidophilus (Bio-Lyte ORS) is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. Lactobacillus Lactobacillus acidophilus (Bio-Lyte ORS) should not be used in place of medication prescribed for you by your doctor.

Lactobacillus Lactobacillus acidophilus (Bio-Lyte ORS) is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Lactobacillus Lactobacillus acidophilus (Bio-Lyte ORS) may also be used for other purposes not listed in this product guide.

Magnesium sulphate (Bio-Lyte ORS) is used as a dietary supplement for individuals who are deficient in Magnesium sulphate (Bio-Lyte ORS). Although a balanced diet usually supplies all the Magnesium sulphate (Bio-Lyte ORS) a person needs, Magnesium sulphate (Bio-Lyte ORS) supplements may be needed by patients who have lost Magnesium sulphate (Bio-Lyte ORS) because of illness or treatment with certain medicines.

Lack of Magnesium sulphate (Bio-Lyte ORS) may lead to irritability, muscle weakness, and irregular heartbeat.

Injectable Magnesium sulphate (Bio-Lyte ORS) is given only by or under the supervision of a health care professional. Some oral Magnesium sulphate (Bio-Lyte ORS) preparations are available only with a prescription. Others are available without a prescription.

Potassium chloride (Bio-Lyte ORS) (Potassium chloride (Bio-Lyte ORS)) is used to prevent or to treat low blood levels of potassium (hypokalemia). Potassium levels can be low as a result of a disease or from taking certain medicines, or after a prolonged illness with diarrhea or vomiting.

Potassium chloride (Bio-Lyte ORS) contains Potassium chloride (Bio-Lyte ORS). Potassium is a mineral that is found in many foods and is needed for several functions of your body, especially the beating of your heart.

Potassium chloride (Bio-Lyte ORS) may also be used for other purposes not listed here.

Sodium chloride (Bio-Lyte ORS) is the chemical name for salt. Sodium chloride (Bio-Lyte ORS) can reduce some types of bacteria in certain body secretions, such as saliva.

Sodium chloride (Bio-Lyte ORS) inhalation is used to produce sputum (mucus, or phlegm) from the mouth to help improve lung function in people with cystic fibrosis, or to collect sputum for medical testing. This medication may also be used to dilute other medications inhaled through a nebulizer.

Sodium chloride (Bio-Lyte ORS) inhalation may also be used for other purposes not listed in this medication guide.

Citric acid and Sodium citrate (Bio-Lyte ORS) are both alkalinizing agents that make the urine less acidic.

The combination of citric acid and Sodium citrate (Bio-Lyte ORS) is used to prevent gout or kidney stones, or metabolic acidosis in people with kidney problems.

Citric acid and Sodium citrate (Bio-Lyte ORS) may also be used for other purposes not listed in this medication guide.

Important Preparation and Administration Instructions

• Ascorbic acid (Bio-Lyte ORS) vials contain 25, 000 mg of Ascorbic acid (Bio-Lyte ORS) and the largest recommended single dose is 200 mg. Do not give the entire contents of the vial to a single patient.
• Do not administer Ascorbic acid (Bio-Lyte ORS) as an undiluted intravenous sensitive.
• Minimize exposure to light because Ascorbic acid (Bio-Lyte ORS) is light sensitive.
• Ascorbic acid (Bio-Lyte ORS) is supplied as a Pharmacy Bulk Package (PBP) which is intended for dispensing of single doses to multiple patients in a pharmacy admixture program and is restricted to the preparation of admixtures for infusion:

a. Use only in a suitable ISO Class 5 work area such as a laminar flow hood (or an equivalent clean air compounding area)

b. Penetrate each PBP vial closure only one time with a suitable sterile transfer device or dispensing set that allows measured dispensing of the contents. Given that pressure may develop within the vial during storage, excercise caution when withdrawing contents from the vial.

c. Once the closure system has been penetrated, complete all dispensing from the PBP vial within 4 hours. Each dose must be used immediately. Discard unused portion.

d. Prior to administration, Ascorbic acid (Bio-Lyte ORS) must be diluted in a suitable infusion solution and the final solution for infusion must be isotonic (undiluted the osmolarity of Ascorbic acid (Bio-Lyte ORS) is approximately 5,900 mOsmol/L). Prior to preparing the admixture for infusion, calculate the osmolarity of the intended admixture for infusion. Add one daily dose of Ascorbic acid (Bio-Lyte ORS) directly to an appropriate volume of a suitable infusion solution (e.g., 5% Dextrose Injection, Sterile Water for Injection) and add appropriate solutes, as necessary, to make final solution isotonic. Sterile Water for Injection is highly hypotonic; adjust solute content, as necessary, to make thet final infusion solution isotonic prior to injection. Do not mix Ascorbic acid (Bio-Lyte ORS) with solutions containing elemental compounds that can be reduced (e.g., copper). The concentration of Ascorbic acid (Bio-Lyte ORS) in the final, admixture solution for infusion is to be the range of 1 to 25 mg of Ascorbic acid (Bio-Lyte ORS) per mL. For example, for the largest recommended dose:

Add 200 mg of Ascorbic acid (Bio-Lyte ORS) (equivalent to 0.4 mL of Ascorbic acid (Bio-Lyte ORS)) to 7.5 mL of Sterile Water for Injection to produce an infusion solution having an approximate osmolarity of 290 mOsmol/L. In this specific example, addition of solute is NOT necessary because the solution is isotonic.

e. Prepare the recommended dose based on the patient population [ see Dosage and Administration (2.2), (2.3)].

f. Visually inspect for particulate matter and discoloration prior to administration (the diluted Ascorbic acid (Bio-Lyte ORS) solution should appear colorless to pale yellow).

g. Immediately administer the admixture for infusion as a slow intravenous infusion [ see Recommended Dosage, (2.2)]

Recommended Dosage

Table 1 provides recommended doses of Ascorbic acid (Bio-Lyte ORS) based on patient population and infusion rates of diluted Ascorbic acid (Bio-Lyte ORS) solution.

The recommended maximum duration of daily treatment with Ascorbic acid (Bio-Lyte ORS) is seven days. If no improvement in scorbutic symptoms is observed after one week of treatment, retreat until resolution of scorbutic symptoms is observed.

Repeat dosing is not recommended in pediatric patients less than 11 years of age.

Dosage Reductions in Specific Populations

Women who are pregnant or lactating and patients with glucose-6-dehydrogenase deficiency should not exceed the U.S. Recommended Dietary Allowance (RDA) or daily Adequate Intake (AI) level for Ascorbic acid (Bio-Lyte ORS) for their age group and condition [ ​ see Warnings and Precautions (5.2) and Use in Specific Populations (8.1, 8.2)].

Usual Adult Dose for Hypocalcemia

325 to 650 mg orally 2 to 3 times a day before meals. Treatment may also consist of vitamin D orally.

Usual Adult Dose for Osteomalacia

325 to 650 mg orally 2 to 3 times a day before meals. Treatment may also consist of vitamin D orally.

Usual Adult Dose for Hypoparathyroidism

325 mg orally 3 times a day before meals. Treatment may also consist of vitamin D orally.

Usual Adult Dose for Pseudohypoparathyroidism

325 mg orally once a day before the breakfast meal. Treatment may also consist of vitamin D orally.

Usual Adult Dose for Osteoporosis

325 to 650 mg orally 3 times a day before meals. Osteoporosis can be affected by increased serum parathyroid hormone, excessive alcohol intake, tobacco use, certain drugs (corticosteroids, anticonvulsants, heparin, thyroid hormone), dietary vitamin D, and weight bearing exercise.

Usual Pediatric Dose for Hypocalcemia

Neonatal:

Oral

Hypocalcemia (dose depends on clinical condition and serum calcium level):

Dose expressed in mg of elemental calcium: 50 to 150 mg/kg/day in 4 to 6 divided doses; not to exceed 1 g/day

Dose expressed in mg of Calcium lactate (Bio-Lyte ORS): 400 to 500 mg/kg/day divided every 4 to 6 hours

Oral

Hypocalcemia (dose depends on clinical condition and serum calcium level):

Dose expressed in mg of elemental calcium:

Children: 45 to 65 mg/kg/day in 4 divided doses

Dose expressed in mg of Calcium lactate (Bio-Lyte ORS):

Infants: 400 to 500 mg/kg/day divided every 4 to 6 hours

Children: 500 mg/kg/day divided every 6 to 8 hours; maximum daily dose: 9 g

Renal Dose Adjustments

Patients with renal dysfunction have an increased risk of hypercalcemia. Periodically checking the serum calcium level, especially if signs or symptoms of hypercalcemia are detected, is recommended.

Liver Dose Adjustments

Data not available

Precautions

Calcium lactate (Bio-Lyte ORS) is contraindicated in patients with renal calculi, hypophosphatemia, or hypercalcemia.

Dialysis

Calcium is removed by hemodialysis. To ensure a positive net calcium flux into the patient during dialysis, a dialysate calcium concentration of 3.0 to 3.5 mEq/L is usually required. Mid-dialysis modest hypercalcemia is not uncommon when this concentration is used.

Calcium is removed by peritoneal dialysis. The standard peritoneal dialysate contains 3.5 mEq/L of calcium (in 1.5% dextrose) to maintain a positive calcium balance and to prevent calcium losses. When higher concentrations of dextrose are used, the net calcium balance may be negative because of a greater convective removal of calcium during ultrafiltration, which counterbalances the diffusion of calcium from the dialysate to the patient.

Other Comments

Recommended daily allowance (RDA): Dosage is in terms of elemental calcium:

1 to 6 months: 400 mg/day

6 to 12 months: 600 mg/day

1 to 10 years: 800 mg/day

11 to 24 years: 1200 mg/day

Adults greater than 24 years: 800 mg/day

Adequate intake (1997 National Academy of Science Recommendations): Dosage is in terms of elemental calcium:

1 to 6 months: 210 mg/day

7 to 12 months: 270 mg/day

1 to 3 years: 500 mg/day

4 to 8 years: 800 mg/day

9 to 18 years: 1300 mg/day

19 to 50 years: 1000 mg/day

Greater than 50 years: 1200 mg/day

Calcium lactate (Bio-Lyte ORS):

Elemental calcium: 130 mg/1 g (6.5 mEq calcium/gram)

Approximate equivalent dose: 700 mg of calcium salt

As directed by a physician. Dosage is dependent upon the age, weight and clinical condition of the patient as well as laboratory determinations.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.

All injections in VIAFLEX plastic containers are intended for intravenous administration using sterile equipment.

Additives may be incompatible. Complete information is not available.

Those additives known to be incompatible should not be used. Consult with pharmacist, if available. If, in the informed judgment of the physician, it is deemed advisable to introduce additives, use aseptic technique. Mix thoroughly when additives have been introduced. Do not store solutions containing additives.

How supplied

Dextrose (Bio-Lyte ORS) (hydrous Dextrose (Bio-Lyte ORS) (hydrous Dextrose (Bio-Lyte ORS)) ) Injection, USP in VIAFLEX plastic container is available as follows:

Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat. It is recommended the product be stored at room temperature (25deg;C/ 77deg;F); brief exposure up to 40deg;C/ 104deg;F does not adversely affect the product.

Directions For Use Of Viaflex Plastic Container

Warning: Do not use plastic containers in series connections. Such use could result in air embolism due to residual air being drawn from the primary container before administration of the fluid from the secondary container is completed.

To Open

Tear overwrap down side at slit and remove solution container. Some opacity of the plastic due to moisture absorption during the sterilization process may be observed. This is normal and does not affect the solution quality or safety. The opacity will diminish gradually. Check for minute leaks by squeezing inner bag firmly. If leaks are found, discard solution as sterility may be impaired. If supplemental medication is desired, follow “ To Add Medication” directions below.

Preparation for Administration

1. Suspend container from eyelet support.
2. Remove plastic protector from outlet port at bottom of container.
3. Attach administration set. Refer to complete directions accompanying set.

To Add Medication

Warning: Additives may be incompatible.

To add medication before solution administration

1. Prepare medication site.
2. Using syringe with 19 to 22 gauge needle, puncture resealable medication port and inject.
3. Mix solution and medication thoroughly. For high density medication such as potassium chloride, squeeze ports while ports are upright and mix thoroughly.

To add medication during solution administration

1. Close clamp on the set.
2. Prepare medication site.
3. Using syringe with 19 to 22 gauge needle, puncture resealable medication port and inject.
4. Remove container from IV pole and/or turn to an upright position.
5. Evacuate both ports by squeezing them while container is in the upright position.
6. Mix solution and medication thoroughly.
7. Return container to in-use position and continue administration.

Baxter Healthcare Corporation, Deerfield, IL 60015 USA. FDA revision date: n/a

Cap Adult Initially 4 cap. Subsequent dose: 2 cap. Childn Initially 2 cap. Subsequent dose: 2 cap. To be taken bd. Sachet Initial dose: Adult 2 sachet. Childn 1-2 sachet. Infant 1 sachet. Subsequent dose: 1 sachet. To be taken bd.

Usual Adult Dose for Hypomagnesemia

500 to 1000 mg Magnesium sulphate (Bio-Lyte ORS) gluconate (27 to 54 mg elemental Magnesium sulphate (Bio-Lyte ORS)) orally 3 times a day.

Usual Adult Dose for Dietary Supplement

500 to 1000 mg Magnesium sulphate (Bio-Lyte ORS) gluconate (27 to 54 mg elemental Magnesium sulphate (Bio-Lyte ORS)) orally once a day.

Usual Pediatric Dose for Hypomagnesemia

10 to 20 mg/kg of elemental Magnesium sulphate (Bio-Lyte ORS) per dose orally 4 times a day. Use Magnesium sulphate (Bio-Lyte ORS) gluconate oral liquid preparations for more accurate measurement of dose.

Renal Dose Adjustments

Do not use without physician supervision in patients with renal impairment due to increased risk of hypermagnesemia. The use of Magnesium sulphate (Bio-Lyte ORS) salts are generally contraindicated in patients with severe renal dysfunction.

Liver Dose Adjustments

Data not available

Dose Adjustments

May increase by 500 to 1,000 mg/day (27 to 54 mg elemental Magnesium sulphate (Bio-Lyte ORS)) in order to achieve a normal serum Magnesium sulphate (Bio-Lyte ORS) level. Daily doses > 1,000 mg (54 mg elemental Magnesium sulphate (Bio-Lyte ORS)) should be given in 2 to 3 divided doses.

Precautions

Because Magnesium sulphate (Bio-Lyte ORS) is primarily eliminated by the kidney, there is significant risk of hypermagnesemia in patients with renal dysfunction.

Dialysis

Data not available; however, use of Magnesium sulphate (Bio-Lyte ORS) salts is generally contraindicated in renal failure.

Other Comments

Magnesium sulphate (Bio-Lyte ORS) supplements are often used with "low normal" serum Magnesium sulphate (Bio-Lyte ORS) levels in patients predisposed to hypomagnesemia (e.g., patients on diuretics).

The usual dietary intake of potassium by the average adult is 50 to 100 mEq per day. Potassium depletion sufficient to cause hypokalemia usually requires the loss of 200 or more mEq of potassium from the total body store.

Dosage must be adjusted to the individual needs of each patients. The dose for the prevention of hypokalemia is typically in the range of 20 mEq per day. Doses of 40 to 100 mEq per day or more are used for the treatment of potassium depletion. Dosage should be divided if more than 20 mEq per day is given such that no more than 20 mEq is given in a single dose. Because of the potential for gastric irritation, Potassium chloride (Bio-Lyte ORS) (Potassium chloride (Bio-Lyte ORS) extended-release) ® Extencaps® should be taken with meals and with a full glass of water or other liquid.

Patients who have difficulty swallowing capsules may sprinkle the contents of the capsule onto a spoonful of soft food. The soft food, such as applesauce or pudding, should be swallowed immediately without chewing and followed with a glass of cool water or juice to ensure complete swallowing of the microcapsules. The food used should not be hot and should be soft enough to be swallowed without chewing. Any microcapsule/food mixture should be used immediately and not stored for future use.

How supplied

Potassium chloride (Bio-Lyte ORS) (Potassium chloride (Bio-Lyte ORS) extended-release) ® Extencaps® are pale orange capsules monogrammed Potassium chloride (Bio-Lyte ORS) (Potassium chloride (Bio-Lyte ORS) extended-release) ® and "Ther-Rx"/ "010", each containing 600 mg microencapsulated Potassium chloride (Bio-Lyte ORS) (equivalent to 8 mEq K) in bottles of 100 (NDC 64011-010-04), 500 (NDC 64011-010-08) and Dis-Co® unit dose packs of 100 (NDC 64011-010-11).

Potassium chloride (Bio-Lyte ORS) (Potassium chloride (Bio-Lyte ORS) extended-release) ® 10 Extencaps® are pale orange and opaque white capsules monogrammed Potassium chloride (Bio-Lyte ORS) (Potassium chloride (Bio-Lyte ORS) extended-release) ® 10 and "Ther-Rx"/"009", each containing 750 mg microencapsulated Potassium chloride (Bio-Lyte ORS) (equivalent to 10 mEq K) in bottles of 100 (NDC 64011-009-04), 100 Unit-of-Use (NDC 64011-009-21), bottles of 500 (NDC 64011-009-08), and Dis-Co® unit dose packs of 100 (NDC 64011-009-11).

Store at controlled room temperature, between 20° C and 25° C (68° F and 77° F).

Dispense in tight container.

Manufactured by KV Pharmaceutical

for Ther-Rx Corporation., St. Louis, MO 63045

FDA rev date: 8/20/2003

All injections in VIAFLEX plastic containers are intended for intravenous administration using sterile and nonpyrogenic equipment.

As directed by a physician. Dosage, rate, and duration of administration are to be individualized and depend upon the indication for use, the patient’s age, weight, clinical condition, concomitant treatment, and on the patient’s clinical and laboratory response to treatment.

When other electrolytes or medicines are added to this solution, the dosage and the infusion rate will also be dictated by the dose regimen of the additions.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. Use of a final filter is recommended during administration of all parenteral solutions, where possible.

Do not administer unless the solution is clear and seal is intact.

Additives may be incompatible with Sodium chloride (Bio-Lyte ORS) Injection, USP. As with all parenteral solutions, compatibility of the additives with the solution must be assessed before addition. Before adding a substance or medication, verify that it is soluble and/or stable in water and that the pH range of Sodium chloride (Bio-Lyte ORS) Injection, USP is appropriate. After addition, check for unexpected color changes and/or the appearance of precipitates, insoluble complexes or crystals.

The instructions for use of the medication to be added and other relevant literature must be consulted. Additives known or determined to be incompatible must not be used. When introducing additives to Sodium chloride (Bio-Lyte ORS) Injection, USP, aseptic technique must be used. Mix the solution thoroughly when additives have been introduced. Do not store solutions containing additives.

After opening the container, the contents should be used immediately and should not be stored for a subsequent infusion. Do not reconnect any partially used containers. Discard any unused portion.

Adult: Add the contents of 1-2 sachets to a glass of cool water and mix. Sodium citrate (Bio-Lyte ORS) may be taken up to 4 times daily. Do not take for >5 days unless advised to do so by the physician.

See also:
What is the most important information I should know about Ascorbic acid (Bio-Lyte ORS)?

There are no contraindications to the administration of Ascorbic acid (Bio-Lyte ORS).

See also:
What is the most important information I should know about Calcium lactate (Bio-Lyte ORS)?

• Hypersensitivity to drug

• Ventricular fibrillation

• Hypercalcemia and hypophosphatemia

• Cancer

• Renal calculi

• Pregnancy or breastfeeding

Solutions containing Dextrose (Bio-Lyte ORS) may be contraindicated in patients with hypersensitivity to corn products.

Administration of solutions containing hypertonic Dextrose (Bio-Lyte ORS) is contraindicated in patients with intracranial or intraspinal hemorrhage, diabetic coma or delirium tremens, especially if such patients are already dehydrated.

See also:
What is the most important information I should know about Lactobacillus acidophilus (Bio-Lyte ORS)?

Congenital galactosemia, glucose and lactose intolerance, lactase deficiency in patients with disabling. Hypersensitivity to this drug or one of its components Gynecological : Hypersensitivity. Estrogen-dependent tumors, endometriosis, vag hemorrhaging of unknown origin, females who are not yet sexually mature

See also:
What is the most important information I should know about Magnesium sulphate (Bio-Lyte ORS)?

Parenteral administration of the drug is contraindicated in patients with heart block or myocardial damage.

See also:
What is the most important information I should know about Potassium chloride (Bio-Lyte ORS)?

Potassium supplements are contraindicated in patients with hyperkalemia since a further increase in serum potassium concentration in such patients can produce cardiac arrest. Hyperkalemia may complicate any of the following conditions: chronic renal failure, systemic acidosis such as diabetic acidosis, acute dehydration, extensive tissue breakdown as in severe burns, adrenal insufficiency, or the administration of a potassium-sparing diuretic, e.g., spironolactone, triamterene, or amiloride.

Potassium chloride (Bio-Lyte ORS) (Potassium chloride (Bio-Lyte ORS) extended-release tablets) tablets are contraindicated in patients with known hypersensitivity to any ingredient in this product.

Controlled-release formulations of Potassium chloride (Bio-Lyte ORS) have produced esophageal ulceration in certain cardiac patients with esophageal compression due to an enlarged left atrium. Potassium supplementation, when indicated in such patients, should be given as a liquid preparation.

All solid oral dosage forms of Potassium chloride (Bio-Lyte ORS) are contraindicated in any patient in whom there is structural, pathological, e.g., diabetic gastroparesis, or pharmacologic (use of anticholinergic agents or other agents with anticholinergic properties at sufficient doses to exert anticholinergic effects) cause for arrest or delay in tablet passage through the gastrointestinal tract.

See also:
What is the most important information I should know about Sodium chloride (Bio-Lyte ORS)?

Due to potential toxicity of benzyl alcohol in newborns, Bacteriostatic Sodium chloride (Bio-Lyte ORS) Injection, USP, 0.9% containing benzyl alcohol must not be used in this patient population.

Bacteriostatic Sodium chloride (Bio-Lyte ORS) Injection, USP, 0.9% should not be used for fluid or Sodium chloride (Bio-Lyte ORS) replacement.

See also:
What is the most important information I should know about Sodium citrate (Bio-Lyte ORS)?

Renal failure or hypernatremia; in conjunction with hexamine mandelate or hexamine hippurate therapy because an acidic urine is needed.

Caution is advised in overt and occult cardiac failure. Concomitant use of urinary alkalinizers and quinolone antibiotics should be avoided. Crystalluria may be more likely to occur in alkaline urine.

Use Ascorbic acid (Bio-Lyte ORS) solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Ascorbic acid (Bio-Lyte ORS) solution may be taken with or without food.
• You may drop the dose of Ascorbic acid (Bio-Lyte ORS) solution directly into your mouth or mix it with cereal, milk, or water.
• Take Ascorbic acid (Bio-Lyte ORS) solution with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Ascorbic acid (Bio-Lyte ORS) solution.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Ascorbic acid (Bio-Lyte ORS) solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Ascorbic acid (Bio-Lyte ORS) solution.

Use Dextrose (Bio-Lyte ORS) exactly as directed on the label, or as prescribed by your doctor. Do not use this medicine in larger or smaller amounts or for longer than recommended.

The chewable tablet must be chewed before you swallow it.

If you take Dextrose (Bio-Lyte ORS) gel in a pre-measured tube, be sure to swallow the entire contents of the tube to get a full dose.

Your hypoglycemia symptoms should improve in about 10 minutes after taking oral Dextrose (Bio-Lyte ORS). If not, take another dose. Seek medical attention if you still have hypoglycemia symptoms after taking two doses.

Dextrose (Bio-Lyte ORS) injection is given through an IV into a vein. Do not inject this medicine into a muscle or under the skin. The injection should be given only as an intravenous (IV) injection and should be given slowly. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Dextrose (Bio-Lyte ORS) is injected.

You may be shown how to use an IV at home. Do not give yourself Dextrose (Bio-Lyte ORS) injection if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

Use a disposable needle, syringe, or prefilled syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

Call your doctor if your symptoms do not improve, or if they get worse.

Check the expiration date on your medicine label each time you use this medicine. If the medicine has been stored for a long time, the expiration date may have passed and the Dextrose (Bio-Lyte ORS) may not work as well.

Store at room temperature away from moisture and heat. Keep the medicine container tightly closed when not in use.

Use Magnesium sulphate (Bio-Lyte ORS) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Magnesium sulphate (Bio-Lyte ORS) by mouth with food.
• If you miss a dose of Magnesium sulphate (Bio-Lyte ORS) and are using it regularly, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Magnesium sulphate (Bio-Lyte ORS).

Use Potassium chloride (Bio-Lyte ORS) solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Potassium chloride (Bio-Lyte ORS) solution is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Potassium chloride (Bio-Lyte ORS) solution at home, a health care provider will teach you how to use it. Be sure you understand how to use Potassium chloride (Bio-Lyte ORS) solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
• Do not use Potassium chloride (Bio-Lyte ORS) solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
• Potassium chloride (Bio-Lyte ORS) solution MUST be diluted before use.
• It is very important to carefully check that the right amount of medicine is drawn into the syringe before injecting the medicine into its diluent solution.
• If this solution is given by way of a pumping device, be sure to stop the pumping action before the container runs dry or air embolism may occur.
• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
• If you miss a dose of Potassium chloride (Bio-Lyte ORS) solution, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Potassium chloride (Bio-Lyte ORS) solution.

Use Sodium chloride (Bio-Lyte ORS) nebulizer solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Sodium chloride (Bio-Lyte ORS) nebulizer solution is for inhalation in a nebulizer only. Do not take Sodium chloride (Bio-Lyte ORS) nebulizer solution by mouth or inject it.
• Sodium chloride (Bio-Lyte ORS) nebulizer solution is used to dilute other medicines. Follow the instructions provided by your doctor.
• Sodium chloride (Bio-Lyte ORS) nebulizer solution may come in a single-dose vial or in a container with multiple doses. Be sure to use the proper amount of Sodium chloride (Bio-Lyte ORS) nebulizer solution. If you are using Sodium chloride (Bio-Lyte ORS) nebulizer solution from a multiple-dose container, use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you are using a vial, use your dose immediately after opening the vial and throw away any unused medicine. Do not save the contents of an opened vial for later use.
• Do not use Sodium chloride (Bio-Lyte ORS) nebulizer solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
• This product is intended to dilute other medicines for use in a nebulizer. If you miss a dose of your medicine, follow the missed dose instructions for the medicine that you are mixing with this product.

Ask your health care provider any questions you may have about how to use Sodium chloride (Bio-Lyte ORS) nebulizer solution.

Use Sodium citrate (Bio-Lyte ORS) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Sodium citrate (Bio-Lyte ORS) after meals and at bedtime, unless directed otherwise by your health care provider.
• Shake well before using.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• Mix Sodium citrate (Bio-Lyte ORS) with water before swallowing. Follow with additional water, if desired.
• If you miss a dose of Sodium citrate (Bio-Lyte ORS), take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Sodium citrate (Bio-Lyte ORS).

Ascorbic acid (Bio-Lyte ORS) (Ascorbic acid (Bio-Lyte ORS)) is used to prevent or treat low levels of Ascorbic acid (Bio-Lyte ORS) in people who do not get enough of the vitamin from their diets. Most people who eat a normal diet do not need extra Ascorbic acid (Bio-Lyte ORS). Low levels of Ascorbic acid (Bio-Lyte ORS) can result in a condition called scurvy. Scurvy may cause symptoms such as rash, muscle weakness, joint pain, tiredness, or tooth loss.

Ascorbic acid (Bio-Lyte ORS) plays an important role in the body. It is needed to maintain the health of skin, cartilage, teeth, bone, and blood vessels. It is also used to protect your body's cells from damage. It is known as an antioxidant.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This vitamin may also be used with other vitamins for a certain eye condition (macular degeneration).

How to use Ascorbic acid (Bio-Lyte ORS)

Take this vitamin by mouth with or without food, usually 1 to 2 times daily. Follow all directions on the product package, or take as directed by your doctor.

If you are taking the extended-release capsules, swallow them whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Take this product with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise.

If you are taking the wafers or chewable tablets, chew them thoroughly and then swallow. If you are taking the lozenges, place the lozenge in your mouth and allow it to slowly dissolve.

If you are taking the powder, mix it thoroughly in the proper amount of liquid and stir well. Drink all of the liquid right away. Do not prepare a supply for future use. If you are using the liquid form of this vitamin, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

Dosage is based on your medical condition and response to treatment.

Use this vitamin regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

If you think you may have a serious medical problem, seek immediate medical attention.

This medication is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. It may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).

Calcium plays a very important role in the body. It is necessary for normal functioning of nerves, cells, muscle, and bone. If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones. Having the right amount of calcium is important for building and keeping strong bones.

How to use Calcium lactate (Bio-Lyte ORS)

Take this medication by mouth with food. If your product contains calcium citrate, then it may be taken with or without food. Follow all directions on the product package, or take as directed by your doctor. For best absorption, if your daily dose is more than 600 milligrams, then divide your dose and space it throughout the day. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are using the chewable product, chew it well before swallowing.

If you are using the effervescent tablet, allow the tablet to fully dissolve in a glass of water before drinking it. Do not chew or swallow the tablet whole.

If you are using the liquid product or powder, measure the medication with a dose-measuring spoon or device to make sure you get the correct dose. Do not use a household spoon. If the liquid product is a suspension, shake the bottle well before each dose.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

If your doctor has recommended that you follow a special diet, it is very important to follow the diet to get the most benefit from this medication and to prevent serious side effects. Do not take other supplements/vitamins unless ordered by your doctor.

If you think you may have a serious medical problem, seek immediate medical attention.

Carbohydrate depletion, dehydration, energy source, fluid depletion, hypoglycaemia, water replacement.

This product contains the bacteria Lactobacillus Lactobacillus acidophilus (Bio-Lyte ORS), which is naturally found in the stomach/intestines. Some conditions (such as antibiotic use) can cause problems with the normal balance of bacteria in the stomach/intestines, resulting in diarrhea. This product can help restore the normal balance of intestinal bacteria. This product has been used for diarrhea and other stomach/intestinal problems. It has also been used for vaginal and urinary tract infections.

Some diet supplement products have been found to contain possibly harmful impurities/additives. Check with your pharmacist for more details regarding the particular brand you use.

The FDA has not reviewed this product for safety or effectiveness. Consult your doctor or pharmacist for more details.

How to use Lactobacillus acidophilus (Bio-Lyte ORS)

Take this product by mouth. Refer to the label directions for your specific product to see if it should be taken with or without food or liquids (such as milk, fruit juice, or water). Refer to the label directions for your specific product to see if the dose should be swallowed whole, chewed, sprinkled onto food or mixed with liquid. If you have questions about any of the information, consult your doctor or pharmacist.

If you are using this product for diarrhea due to antibiotics, do not use for more than 2 days or if you have a high fever unless directed by your doctor.

Do not use in children younger than 3 years of age unless directed by your doctor.

If your condition persists or worsens or you think you may have a serious medical problem, seek immediate medical attention.

Magnesium sulphate (Bio-Lyte ORS) is used to treat constipation, Magnesium sulphate (Bio-Lyte ORS) deficiency, irregular heartbeat (Torsades de Pointes), high blood pressure during pregnancy, to reduce the risk of fits (pre-eclampsia), pain and swelling from sprains, bruises, or boils. It is also used to treat convulsions in children who have sudden and severe inflammation of the kidneys (acute nephritis).

This medication is a mineral supplement used to treat or prevent low amounts of potassium in the blood. A normal level of potassium in the blood is important. Potassium helps your cells, kidneys, heart, muscles, and nerves work properly. Most people get enough potassium by eating a well-balanced diet. Some conditions that can lower your body's potassium level include severe prolonged diarrhea and vomiting, hormone problems such as hyperaldosteronism, or treatment with "water pills"/diuretics.

How to use Potassium chloride (Bio-Lyte ORS)

Take this medication by mouth as directed by your doctor. To prevent stomach upset, take each dose with a meal and a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. Do not lie down for 10 minutes after taking this medication.

Do not crush, chew, or suck extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

Swallow the capsules whole. If you have trouble swallowing the capsules, tell your doctor or pharmacist. Some brands may be opened and the contents sprinkled onto a spoonful of cool, soft food such as applesauce or pudding. Immediately swallow the food/medication mixture without chewing. Do not prepare the mixture ahead of time. Drink a glass of cool water after each dose to make sure you swallow all the medication. Ask your pharmacist if you have questions about your brand.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. The dosage is based on your medical condition and response to treatment. Do not increase your dose or take it more often than prescribed. Do not take more than 20 milliequivalents per dose.

Tell your doctor if your condition does not improve or if you have symptoms of low potassium in the blood (such as irregular heartbeat, muscle weakness/cramps).

This product is used to treat dryness inside the nose (nasal passages). It helps add moisture inside the nose to dissolve and soften thick or crusty mucus. In babies and young children with stuffy noses who cannot blow their noses, using this product helps to make the mucus easier to remove with a nasal bulb syringe. This helps relieve stuffiness and makes breathing easier.

This product contains a purified gentle salt solution (also called saline or Sodium chloride (Bio-Lyte ORS) solution). It does not contain any medication.

How to use Sodium chloride (Bio-Lyte ORS) nasal

Spray this product into each nostril as needed or as directed by your doctor. This product may also be given into the nose as drops or a stream. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

Try not to touch the container tip to the inside of your nose. If this happens, rinse the tip with hot water and dry with a clean tissue before recapping the container.

If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.

Use: Labeled Indications

Anticoagulant:

Concentrate (triCitrasol): Anticoagulant used in granulocytapheresis procedures

Solution: Anticoagulant for use with cytapheresis device only

Off Label Uses

Regional anticoagulation for continuous renal replacement therapy circuit

Data from several small randomized, controlled trials support the use of regional Sodium citrate (Bio-Lyte ORS) to reduce the risk of clot formation in continuous renal replacement therapy (CRRT) circuits, thus prolonging circuit life and avoiding interruptions in therapy. It should be noted that patients with high bleeding risk, severe coagulopathy, metabolic abnormalities, or liver dysfunction were excluded from these trials.

See also:
What other drugs will affect Ascorbic acid (Bio-Lyte ORS)?

In an application with barbiturates, primidone increases the excretion of Ascorbic acid (Bio-Lyte ORS) in the urine.

With the simultaneous use of oral contraceptives reduces the concentration of Ascorbic acid (Bio-Lyte ORS) in blood plasma.

In an application of Rhea Ascorbic acid (Bio-Lyte ORS) with iron preparations Ascorbic acid (Bio-Lyte ORS), due to its regenerative properties, transforms ferric iron in the bivalent, which improves its absorption.

Ascorbic acid (Bio-Lyte ORS) in high doses can decrease urine pH that while the application reduces the tubular reabsorption of amphetamine and tricyclic antidepressants.

With the simultaneous use of aspirin reduces the absorption of Ascorbic acid (Bio-Lyte ORS) by about a third.

Rhea Ascorbic acid (Bio-Lyte ORS) in an application with warfarin may decrease effects of warfarin.

With the simultaneous application of Ascorbic acid (Bio-Lyte ORS) increases the excretion of iron in patients receiving deferoxamine. In the application of Ascorbic acid (Bio-Lyte ORS) at a dose of 500 mg / day possibly left ventricular dysfunction.

In an application with tetracycline is increased excretion of Ascorbic acid (Bio-Lyte ORS) in the urine.

There is a described case of reducing the concentration of fluphenazine in plasma in patients treated with Ascorbic acid (Bio-Lyte ORS) 500 mg 2 times / day.

May increase the concentration of ethinyl estradiol in the blood plasma in its simultaneous application in the oral contraceptives.

See also:
What other drugs will affect Calcium lactate (Bio-Lyte ORS)?

If you are taking this product under your doctor’s direction, your doctor or pharmacist may already be aware of possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Before using this product, tell your doctor or pharmacist if you use any of the following products: digoxin, cellulose sodium phosphate, certain phosphate binders (e.g., calcium acetate).

Calcium can decrease the absorption of other drugs such as bisphosphonates (e.g., alendronate), tetracycline antibiotics (e.g., doxycycline, minocycline), estramustine, levothyroxine, and quinolone antibiotics (e.g., ciprofloxacin, levofloxacin). Therefore, separate your doses of these medications as far as possible from your doses of calcium. Ask your doctor or pharmacist about how long you should wait between doses and for help finding a dosing schedule that will work with all your medications.

Check the labels on all your prescription and nonprescription/herbal products (e.g., antacids, vitamins) because they may contain calcium. Ask your pharmacist about using those products safely.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist

Additives may be incompatible. Consult with pharmacist, if available. When introducing additives, use aseptic technique, mixthoroughly and do not store.

Some opacity of the plastic due to moisture absorption during sterilization process may be observed. This is normal and does not affect the solution quality or safety. The opacity will diminish gradually.

See also:
What other drugs will affect Lactobacillus acidophilus (Bio-Lyte ORS)?

Lactobacillus Lactobacillus acidophilus (Bio-Lyte ORS) is sensitive to anti-infectives.

See also:
What other drugs will affect Magnesium sulphate (Bio-Lyte ORS)?

CNS Depressants— When barbiturates, narcotics or other hypnotics (or systemic anesthetics), or other CNS depressants are to be given in conjunction with Magnesium sulphate (Bio-Lyte ORS), their dosage should be adjusted with caution because of additive CNS depressant effects of Magnesium sulphate (Bio-Lyte ORS). CNS depression and peripheral transmission defects produced by Magnesium sulphate (Bio-Lyte ORS) may be antagonized by calcium.

Neuromuscular Blocking Agents— Excessive neuromuscular block has occurred in patients receiving parenteral Magnesium sulphate (Bio-Lyte ORS) sulfate and a neuromuscular blocking agent; these drugs should be administered concomitantly with caution.

Cardiac Glycosides— Magnesium sulphate (Bio-Lyte ORS) Sulfate should be administered with extreme caution in digitalized patients, because serious changes in cardiac conduction which can result in heart block may occur if administration of calcium is required to treat Magnesium sulphate (Bio-Lyte ORS) toxicity.

See also:
What other drugs will affect Potassium chloride (Bio-Lyte ORS)?

Aliskiren: Potassium Salts may enhance the hyperkalemic effect of Aliskiren. Monitor therapy

Angiotensin II Receptor Blockers: Potassium Salts may enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. Monitor therapy

Angiotensin-Converting Enzyme Inhibitors: Potassium Salts may enhance the hyperkalemic effect of Angiotensin-Converting Enzyme Inhibitors. Monitor therapy

Anticholinergic Agents: May enhance the ulcerogenic effect of Potassium chloride (Bio-Lyte ORS). Management: Patients on drugs with substantial anticholinergic effects should avoid using any solid oral dosage form of Potassium chloride (Bio-Lyte ORS). Avoid combination

Drospirenone: Potassium Salts may enhance the hyperkalemic effect of Drospirenone. Monitor therapy

Eplerenone: May enhance the hyperkalemic effect of Potassium Salts. Management: This combination is contraindicated in patients receiving eplerenone for treatment of hypertension. Consider therapy modification

Glycopyrrolate (Systemic): May enhance the adverse/toxic effect of Potassium chloride (Bio-Lyte ORS). This is specific to solid oral dosage forms of Potassium chloride (Bio-Lyte ORS). Avoid combination

Heparin: May enhance the hyperkalemic effect of Potassium Salts. Monitor therapy

Heparins (Low Molecular Weight): May enhance the hyperkalemic effect of Potassium Salts. Monitor therapy

Nicorandil: May enhance the hyperkalemic effect of Potassium Salts. Monitor therapy

Potassium-Sparing Diuretics: Potassium Salts may enhance the hyperkalemic effect of Potassium-Sparing Diuretics. Management: Avoid coadministration of a potassium-sparing diuretic and a potassium salt. This combination should only be used in cases of significant hypokalemia, and only if serum potassium can be closely monitored. Consider therapy modification

See also:
What other drugs will affect Sodium chloride (Bio-Lyte ORS)?

Caution must be exercised in the administration of Sodium chloride (Bio-Lyte ORS) Injection, USP to patients receiving corticosteroids or corticotropin.

Studies have not been conducted to evaluate additional drug/drug or drug/food interactions with Sodium chloride (Bio-Lyte ORS) (Sodium chloride (Bio-Lyte ORS) (Sodium chloride (Bio-Lyte ORS) injection) injection) Injection, USP.

See also:
What other drugs will affect Sodium citrate (Bio-Lyte ORS)?

General: Alkalinization of the urine due to the use of Sodium citrate (Bio-Lyte ORS), theoretically, may result in a decreased therapeutic effect of the following medications: Chlorpropamide, lithium, salicylates and tetracyclines. Alternatively, alkalinization of the urine due to the use of Sodium citrate (Bio-Lyte ORS), theoretically, may result in an increased therapeutic effect of the following medications: Amphetamines, ephedrine/pseudoephedrine.

Antacids: Concurrent use of antacids with citrates may result in systemic alkalosis. Concomitant administration of antacids with Sodium citrate (Bio-Lyte ORS) and sodium bicarbonate may promote the development of calcium stones in patients with uric acid stones and may also cause hypernatremia. Concurrent use of aluminum-containing antacids with citrate salts can increase aluminum absorption, possibly resulting in acute aluminum toxicity, especially in patients with renal insufficiency.

Quinolones: Citrates may reduce the solubility of ciprofloxacin, norfloxacin or ofloxacin in the urine. Patients should be observed for signs of crystalluria and nephrotoxicity.

Laxatives: Concurrent administration of citrates with laxatives may have an additive effect.

See also:
What are the possible side effects of Ascorbic acid (Bio-Lyte ORS)?

Applies to Ascorbic acid (Bio-Lyte ORS): oral capsule, oral capsule extended release, oral capsule liquid filled, oral granule, oral liquid, oral lozenge/troche, oral powder, oral powder for solution, oral powder for suspension, oral solution, oral syrup, oral tablet, oral tablet chewable, oral tablet extended release, oral wafer

In addition to its needed effects, some unwanted effects may be caused by Ascorbic acid (Bio-Lyte ORS) (the active ingredient contained in Ascorbic acid (Bio-Lyte ORS)). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking Ascorbic acid (Bio-Lyte ORS), check with your doctor or nurse as soon as possible:

Less common or rare: - with high doses

• Side or lower back pain

Minor Side Effects

Some of the side effects that can occur with Ascorbic acid (Bio-Lyte ORS) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common or rare: - with high doses

• Diarrhea
• dizziness or faintness (with the injection only)
• flushing or redness of skin
• headache
• increase in urination (mild)
• nausea or vomiting
• stomach cramps

See also:
What are the possible side effects of Calcium lactate (Bio-Lyte ORS)?

Applies to Calcium lactate (Bio-Lyte ORS): oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking Calcium lactate (Bio-Lyte ORS) (the active ingredient contained in Calcium lactate (Bio-Lyte ORS)) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects of Calcium lactate (Bio-Lyte ORS) may include:

• nausea or vomiting;

• decreased appetite;

• constipation;

• dry mouth or increased thirst; or

• increased urination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

See also:
What are the possible side effects of Dextrose (Bio-Lyte ORS)?

Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.

Too rapid infusion of hypertonic solutions may cause local pain and venous irritation. Rate of administration should be adjusted according to tolerance. Use of the largest peripheral vein and a small bore needle is recommended.

Dextrose (Bio-Lyte ORS) may be administered at a rate of 0.5 g/kg/hour without producing glycosuria. Hyperglycemia and glycosuria may be a function of rate of administration or metabolic insufficiency. Appropriate therapy may include slowing of the infusion rate and administration of insulin.

Too rapid administration of hypertonic Dextrose (Bio-Lyte ORS) solutions may result in hyperosmolar syndrome with signs of mental confusion and/or loss of consciousness. If undetected and untreated, this can lead to osmotic dehydration, hyperosmolar coma and death.

If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.

See also:
What are the possible side effects of Lactobacillus acidophilus (Bio-Lyte ORS)?

An increase in stomach gas may occur, but usually goes away with continued treatment. If this effect persists or worsens, notify your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: signs of infection (such as high fever, chills).

A very serious allergic reaction to this product is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

See also:
What are the possible side effects of Magnesium sulphate (Bio-Lyte ORS)?

The adverse effects of parenterally administered Magnesium sulphate (Bio-Lyte ORS) usually are the result of Magnesium sulphate (Bio-Lyte ORS) intoxication. These include flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and central nervous system depression proceeding to respiratory paralysis. Hypocalcemia with signs of tetany secondary to Magnesium sulphate (Bio-Lyte ORS) sulfate therapy for eclampsia has been reported.

See also:
What are the possible side effects of Potassium chloride (Bio-Lyte ORS)?

One of the most severe adverse effects is hyperkalemia. Gastrointestinal bleeding and ulceration have been reported in patients treated with Potassium chloride (Bio-Lyte ORS) (Potassium chloride (Bio-Lyte ORS) extended-release) ® Extencaps®. In addition to gastrointestinal bleeding and ulceration, perforation and obstruction have been reported in patients treated with other solid KCl dosage forms, and may occur with Potassium chloride (Bio-Lyte ORS) (Potassium chloride (Bio-Lyte ORS) extended-release) ® Extencaps®.

The most common adverse reactions to the oral potassium salts are nausea, vomiting, flatulence, abdominal discomfort, and diarrhea. These symptoms are due to irritation of the gastrointestinal tract and are best managed by taking the dose with meals, or reducing the amount taken at one time. Skin rash has been reported rarely with potassium preparations.

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What are the possible side effects of Sodium chloride (Bio-Lyte ORS)?

Post-Marketing Adverse Reactions

The following adverse reactions have been identified during postapproval use of Sodium chloride (Bio-Lyte ORS) Injection, USP. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

The following adverse reactions have been reported in the post-marketing experience during use of 0.9% Sodium chloride (Bio-Lyte ORS) Injection, USP and include the following:

hypersensitivity/infusion reactions, including hypotension, pyrexia, tremor, chills, urticaria, rash, and pruritus.

Also reported are infusion site reactions, such as infusion site erythema, injection site streaking, burning sensation, and infusion site urticaria.

The following adverse reactions have not been reported with 0.9% Sodium chloride (Bio-Lyte ORS) Injection, USP but may occur: hypernatremia, hyperchloremic metabolic acidosis, and hyponatremia, which may be symptomatic.

Hyponatremia has been reported for 0.45% Sodium chloride (Bio-Lyte ORS) Injection, USP.

The following adverse reactions have not been reported with 0.45% Sodium chloride (Bio-Lyte ORS) Injection, USP but may occur: hyperchloremic metabolic acidosis, hypersensitivity/infusion reactions (including hypotension, pyrexia, tremor, chills, urticaria, rash, and pruritus), and infusion site reactions (such as infusion site erythema, injection site streaking, burning sensation, infusion site urticaria).

If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.

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What are the possible side effects of Sodium citrate (Bio-Lyte ORS)?

The tartrate component of Sodium citrate (Bio-Lyte ORS) may be incompletely absorbed. Because of this Sodium citrate (Bio-Lyte ORS) may be exert a mild laxative effect. Prolonged and excessive use may cause a systemic alkolosis and / or hypernatremia.

Each tablet contains Ascorbic acid (Bio-Lyte ORS) 500 mg.

Ascorbic acid (Bio-Lyte ORS) (Ascorbic acid (Bio-Lyte ORS)) is a vitamin that is freely soluble in water. The superior formulation of Ascorbic acid (Bio-Lyte ORS) (Ascorbic acid (Bio-Lyte ORS)) assures substantial amounts per dose for prophylaxis and treatment of Ascorbic acid (Bio-Lyte ORS) deficiencies. This preparation has a very delectable grape (Ascorbic acid (Bio-Lyte ORS) Tablet) flavors.

The chemical compound calcium acetate is the calcium salt of acetic acid. An older name is acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form.

A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives.

Sodium chloride (Bio-Lyte ORS), also known as salt, common salt, table salt or halite, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions. Sodium chloride (Bio-Lyte ORS) is the salt most responsible for the salinity of seawater and of the extracellular fluid of many multicellular organisms. It is listed on the World Health Organization Model List of Essential Medicines.

Each 4 g of Sodium citrate (Bio-Lyte ORS) contains sodium bicarbonate 1760 mg, anhydrous Sodium citrate (Bio-Lyte ORS) 630 mg, anhydrous citric acid 720 mg and tartaric acid 890 mg.

It also contains the following excipients: Nature identical lemon flavor oil, terpeneless and sodium saccharin.

Sodium citrate (Bio-Lyte ORS) consists of formulation and pleasantly flavored granules. When added to water, Sodium citrate (Bio-Lyte ORS) effervesces and dissolves, forming a clear or orange-colored alkaline solution.