Betamex LT

Relief of symptoms of atopic dermatitis, angioedema, urticaria, seasonal & perennial allergic rhinitis, food & drug allergic reaction, allergic contact dermatitis, severe seborrheic dermatitis, neurodermatitis, allergic asthma, ocular allergic manifestations (eg conjunctivitis, iridociclitis & allergic reactions to insect stings).

Adult & childn >12 yr 1 tab bid.

patients with systemic fungal infections in those with hypersensitivity to any component chemical structure or similar drugs, pregnancy and lactation.

Loratadine (Betamex LT): When administered concomitantly with alcohol, Loratadine (Betamex LT) has no potentiating effects as measured by psychomotor performance studies.

It has been reported an increase in plasma concentrations of Loratadine (Betamex LT) after administration of ketoconazole, erythromycin or cimetidine in controlled clinical studies, but there has been no clinically significant changes (including electrocardiographic). Caution should be exercised when co-administering other drugs that inhibit hepatic metabolism until they can make definitive interaction studies.

Betamethasone (Betamex LT): Concomitant use of phenobarbital, rifampin, phenytoin or ephedrine, may increase the metabolism of corticosteroids decreasing its therapeutic action.

Patients administered concomitantly with a corticosteroid and an estrogen can be observed by increasing the effects of corticosteroid.

Simultaneous administration of corticosteroids with diuretics that cause increased elimination of potassium, hypokalemia may increase the concomitant use of corticosteroids with cardiac glycosides may increase the chance of arrhythmias or digitalis toxicity associated with hypokalemia. Corticosteroids may increase potassium depletion caused by amphotericin B. In all these patients managed with either of these treatments combined, shall make determinations of serum electrolytes, particularly potassium levels should be monitored carefully.

Concomitant use of corticosteroids with anticoagulants of the coumarin type can increase or decrease the anticoagulant effect, possibly requiring dose adjustment.

The combined effects of nonsteroidal anti-inflammatory corticosteroid drugs or alcohol with corticosteroids may increase the incidence or increase the severity of gastrointestinal ulcers.

Corticosteroids may reduce concentrations of salicylate in blood. Aspirin should be used carefully in conjunction with corticosteroids in hypoprothrombinemia case.

When corticosteroids are administered to diabetics may require adjustment of antidiabetic drugs.

Concomitant use of corticosteroids with somatropin may inhibit the response to somatropin.

Adverse effects most frequently reported include fatigue, headache, drowsiness, dry mouth, gastrointestinal disturbances such as nausea and gastritis, and allergy symptoms such as rashes.

On rare occasions during the marketing of Loratadine (Betamex LT) have been reported cases of alopecia, anaphylaxis, hepatic failure.

fluid and electrolyte disorders: sodium retention, potassium loss, alkalosis hypocalcemic, fluid retention, congestive heart failure in susceptible patients, hypertension.

Musculoskeletal: Muscle weakness, corticosteroid myopathy, muscle wasting, worsening of myasthenic symptoms in myasthenia gravis, osteoporosis, spinal fractures, compression, aseptic necrosis of femoral and humeral heads, pathologic fracture of long bones, tendon rupture.

Gastrointestinal: peptic ulcer with possible subsequent perforation and hemorrhage, pancreatitis, abdominal distension, ulcerative esophagitis.

Dermatologic: Impairment of wound healing, skin atrophy, thin fragile skin, petechiae and ecchymoses, facial erythema, increased sweating, suppression of reactions such as allergic dermatitis, urticaria, angioedema.

Neurologic: convulsions, increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment, vertigo, headache.

Endocrine: Menstrual irregularities, development of cushingoid state, suppression of fetal intrauterine growth or childhood, lack of secondary response suprerrenal cortex or the pituitary, particularly in times of stress, such as trauma, surgery, or state disease, decreased carbohydrate tolerance, manifestations of latent diabetes mellitus, increased requirements for insulin or oral hypoglycemic agents in diabetic patients.

Ophthalmic: posterior subcapsular cataracts, increased intraocular pressure, glaucoma, exophthalmos.

Metabolic: negative nitrogen balance due to protein catabolism.

Psychiatric: Euphoria, violent changes of mood, from depression to frank psychotic manifestations, personality changes, excessive irritability, insomnia.

Other: anaphylactoid and hypersensitivity reactions and reactions or similar hypotensive shock