Components:
Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 22.05.2022
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Production of local or regional anaesth by infiltration techniques; IV regional anaesth, by peripheral nerve block techniques eg intercostal blocks; major plexus blocks eg brachial plexus blocks & by epidural & subarachnoid blocks. As Spray: Surface anaesth: In dentistry Otorhinolaryngology for maxillary sinus Paracentesis During delivery Introduction of instruments & catheters into the resp & digestive tract Laryngeal & tracheal procedures As Gel: As a surface anaesth & lubricant for the male & female urethra during cystoscopy, catheterisation, exploration by sound & other endourethral procedures, nasal & pharyngeal cavities in endoscopic procedures eg gastroscopy & bronchoscopy, during proctoscopy & rectoscopy & tracheal intubation. Symptomatic treatment of pain in connection w/ cystitis & urethritis. As Rectal Cream or suppositories for hemorrhoids
Ophthalmic
Local anaesthesia
Adult: Use as a 0.4% solution in short ophthalmic procedures. Instil 1 drop into the conjunctival sac to allow tonometry after 60 sec; a further drop after a 90 sec interval produces sufficient anaesthesia for the fitting of contact lenses; 3 drops at 90 sec intervals produces sufficient anaesthesia after 5 min for a foreign body to be removed from the corneal epithelium or for incision of a meibomian cyst through the conjunctiva.
Known hypersensitivity to similar drugs (ester - type local anaesthetics), para-aminobenzoic acid or its derivatives or to any other ingredient in this preparation.
The metabolism of ester-type local anaesthetics may be inhibited by anticholinesterases, increasing the risk of systemic toxicity.
Ester derivatives such as tetracaine, benzocaine, or procaine that are hydrolysed to para-aminobenzoic acid may antagonise the activity of aminosalicylic acid or sulfonamides. Ester-type local anaesthetics such as procaine and cocaine that are hydrolysed by plasma cholinesterase may competitively enhance the neuromuscular blocking activity of suxamethonium; the amide local anaesthetic, lidocaine may have a similar effect.
There is an increased risk of myocardial depression when amide-type local anaesthetics such as bupivacaine, levobupivacaine, lidocaine, or ropivacaine are given with antiarrhythmics.
If local anaesthetics containing adrenaline are given for epidural or paracervical block during labour the use of an oxytocic drug post partum may lead to severe hypertension. Although there is no clinical evidence of dangerous interactions between adrenaline-containing local anaesthetics and MAOIs or tricyclic antidepressants, great care should nevertheless be taken to avoid inadvertent intravenous doses of the local anaesthetic preparation.
Ocular: Increased intraocular pressure, burning, photophobia, blurred vision, irritation, hyperemia, conjunctivitis, blepharoconjunctivitis, punctate keratitis, synechiae.
Systemic: Use of Cyclopentolate has been associated with psychotic reactions and behavioral disturbances, usually in pediatric patients, especially with a 2% concentration. These disturbances include ataxia, incoherent speech, restlessness, hallucinations, hyperactivity, seizures, disorientation as to time and place, and failure to recognize people. This drug produces reactions similar to those of other anticholinergic drugs, but the central nervous system manifestations as noted above are more common. Other toxic manifestations of anticholinergic drugs are skin rash, abdominal distention in infants, unusual drowsiness, tachycardia, hyperpyrexia, vasodilation, urinary retention, diminished gastrointestinal motility and decreased secretion in salivary and sweat glands, pharynx, bronchi and nasal passages. Severe manifestations of toxicity include coma, medullary paralysis and death.
Opulets Benox is the name of a local anesthetic, which is used especially in ophthalmology and otolaryngology. Opulets Benox binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.