Components:
Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 26.06.2023
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Top 20 medicines with the same components:
Beclomethasone is used for the control of bronchial asthma in persons requiring continuous treatment. Such patients may include those with frequent asthmatic episodes that require medications to dilate the airways in the lung or those with asthmatic episodes at night.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.Clotrimazole® Troches are indicated for the local treatment of oropharyngeal candidiasis. The diagnosis should be confirmed by a KOH smear and/or culture prior to treatment.
Clotrimazole® Troches are also indicated prophylactically to reduce the incidence of oropharyngeal candidiasis in patients immunocompromised by conditions that include chemotherapy, radiotherapy, or steroid therapy utilized in the treatment of leukemia, solid tumors, or renal transplantation. There are no data from adequate and well-controlled trials to establish the safety and efficacy of this product for prophylactic use in patients immunocompromised by etiologies other than those listed in the previous sentence.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.In cardiological practice: treatment and prevention of ventricular arrhythmias (extrasystoles, tachycardia, atrial flutter, atrial fibrillation), including in acute myocardial infarction, implantation of artificial pacemaker in the glycoside intoxication, narcosis.
Anaesthesia: terminal, infiltration, conduction, spinal (epidural) anesthesia in surgery, obstetrics and gynecology, urology, ophthalmology, dentistry, otolaryngology, blockade of peripheral nerves and ganglion.
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ofloxacin tablets and other antibacterial drugs, Ofloxacin tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Ofloxacin tablets are indicated for the treatment of adults with mild to moderate infections (unless otherwise indicated) caused by susceptible strains of the designated microorganisms in the infections listed below. Please see DOSAGE AND ADMINISTRATION for specific recommendations.
Acute Bacterial Exacerbations of Chronic Bronchitis (ABECB) due to Haemophilus influenzae or Streptococcus pneumoniae.
Because fluoroquinolones, including Ofloxacin, have been associated with serious adverse reactions, and for some patients ABECB is self-limiting, reserve Ofloxacin for treatment of ABECB in patients who have no alternative treatment options.
Community-Acquired Pneumonia due to Haemophilus influenzae or Streptococcus pneumoniae.
Uncomplicated Skin and Skin Structure Infections due to methicillin-susceptible Staphylococcus aureus, Streptococcus pyogenes, or Proteus mirabilis.
Acute, Uncomplicated Urethral and Cervical Gonorrhea due to Neisseria gonorrhoeae.
Nongonococcal Urethritis and Cervicitis due to Chlamydia trachomatis.
Mixed Infections of the Urethra and Cervix due to Chlamydia trachomatis and Neisseria gonorrhoeae.
Acute Pelvic Inflammatory Disease (including severe infection) due to Chlamydia trachomatis and/or Neisseria gonorrhoeae.
NOTE: If anaerobic microorganisms are suspected of contributing to the infection, appropriate therapy for anaerobic pathogens should be administered.
Uncomplicated Cystitis due to Citrobacter diversus, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, or Pseudomonas aeruginosa.
Because fluoroquinolones, including Ofloxacin, have been associated with serious adverse reactions, and for some patients uncomplicated cystitis is self-limiting, reserve Ofloxacin for treatment of uncomplicated cystitis in patients who have no alternative treatment options.
Complicated Urinary Tract Infections due to Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Citrobacter diversus,* or Pseudomonas aeruginosa.*
Prostatitis due to Escherichia coli.
* = Although treatment of infections due to this organism in this organ system demonstrated a clinically significant outcome, efficacy was studied in fewer than 10 patients.
Appropriate culture and susceptibility tests should be performed before treatment in order to isolate and identify organisms causing the infection and to determine their susceptibility to Ofloxacin, USP. Therapy with Ofloxacin, USP may be initiated before results of these tests are known; once results become available, appropriate therapy should be continued.
As with other drugs in this class, some strains of Pseudomonas aeruginosa may develop resistance fairly rapidly during treatment with Ofloxacin, USP. Culture and susceptibility testing performed periodically during therapy will provide information not only on the therapeutic effect of the antimicrobial agent but also on the possible emergence of bacterial resistance.
Beclomethasone is used to help control symptoms of asthma and improve breathing. It is used when a patient's asthma has not been controlled sufficiently on other asthma medicines, or when a patient's condition is so severe that more than one medicine is needed every day. beclomethasone will not relieve an asthma attack that has already started.
Beclomethasone belongs to the family of medicines known as corticosteroids or steroids (cortisone-like medicines). It works by preventing certain cells in the lungs and breathing passages from releasing substances that cause asthma symptoms.
beclomethasone is available only with your doctor's prescription.
Clotrimazole lozenges are dissolved slowly in the mouth to prevent and treat thrush. Thrush, also called candidiasis or white mouth, is a fungus infection of the mouth and throat. clotrimazole may also be used for other problems as determined by your doctor.
Clotrimazole is available only with your doctor's prescription.
Ofloxacin is used to treat certain bacterial infections in many different parts of the body. It may also be used for other problems as determined by your doctor. Ofloxacin may mask or delay the symptoms of syphilis. It is not effective against syphilis infections.
Ofloxacin belongs to the class of drugs known as fluoroquinolone antibiotics. It works by killing bacteria or preventing their growth. However, ofloxacin will not work for colds, flu, or other virus infections.
ofloxacin is available only with your doctor's prescription.
Usual Adult Dose for Allergic Rhinitis
Nasal metered aerosol (80 mcg): 2 nasal aerosol sprays in each nostril once a day (total dose 320 mcg per day)
Maximum dose: 4 nasal aerosol sprays per day
Nasal metered spray (42 mcg): 1 to 2 nasal inhalations (42 to 84 mcg) in each nostril twice a day (168 to 336 mcg/day)
Comments:
-Nasal metered spray: Symptomatic relief usually occurs within a few days after starting therapy; however, in some patients it may take as long as 2 weeks.
-Nasal metered spray should not be continued beyond 3 weeks in the absence of significant symptomatic improvement.
Uses:
-Treatment of the nasal symptoms associated with seasonal and perennial allergic rhinitis
-Relief of the symptoms of nonallergic (vasomotor) rhinitis
-Prevention of recurrence of nasal polyps following surgical removal
Usual Adult Dose for Prevention of Nasal Polyps
Nasal metered aerosol (80 mcg): 2 nasal aerosol sprays in each nostril once a day (total dose 320 mcg per day)
Maximum dose: 4 nasal aerosol sprays per day
Nasal metered spray (42 mcg): 1 to 2 nasal inhalations (42 to 84 mcg) in each nostril twice a day (168 to 336 mcg/day)
Comments:
-Nasal metered spray: Symptomatic relief usually occurs within a few days after starting therapy; however, in some patients it may take as long as 2 weeks.
-Nasal metered spray should not be continued beyond 3 weeks in the absence of significant symptomatic improvement.
Uses:
-Treatment of the nasal symptoms associated with seasonal and perennial allergic rhinitis
-Relief of the symptoms of nonallergic (vasomotor) rhinitis
-Prevention of recurrence of nasal polyps following surgical removal
Usual Pediatric Dose for Allergic Rhinitis
6 to 12 years of age:
Initial dose: Nasal metered spray (42 mcg): 1 to 2 nasal inhalations (42 to 84 mcg) in each nostril twice a day (168 to 336 mcg/day)
Maintenance dose: Nasal metered spray (42 mcg): 1 nasal inhalation (42 mcg) in each nostril twice a day (168 mcg/day)
Maximum dose: Nasal metered spray (42 mcg): 2 nasal inhalations (84 mcg) in each nostril twice a day (336 mcg/day)
12 years and older:
Nasal metered aerosol (80 mcg): 2 nasal aerosol sprays in each nostril once a day (total dose 320 mcg per day)
Maximum dose: 4 nasal aerosol sprays per day
Nasal metered spray (42 mcg): 1 to 2 nasal inhalations (42 to 84 mcg) in each nostril twice a day (168 to 336 mcg/day)
Comments:
-Nasal metered spray: Symptomatic relief usually occurs within a few days after starting therapy; however, in some patients it may take as long as 2 weeks.
-Nasal metered spray should not be continued beyond 3 weeks in the absence of significant symptomatic improvement.
Uses:
-Treatment of the nasal symptoms associated with seasonal and perennial allergic rhinitis
-Relief of the symptoms of nonallergic (vasomotor) rhinitis
-Prevention of recurrence of nasal polyps following surgical removal
Usual Pediatric Dose for Prevention of Nasal Polyps
6 to 12 years of age:
Initial dose: Nasal metered spray (42 mcg): 1 to 2 nasal inhalations (42 to 84 mcg) in each nostril twice a day (168 to 336 mcg/day)
Maintenance dose: Nasal metered spray (42 mcg): 1 nasal inhalation (42 mcg) in each nostril twice a day (168 mcg/day)
Maximum dose: Nasal metered spray (42 mcg): 2 nasal inhalations (84 mcg) in each nostril twice a day (336 mcg/day)
12 years and older:
Nasal metered aerosol (80 mcg): 2 nasal aerosol sprays in each nostril once a day (total dose 320 mcg per day)
Maximum dose: 4 nasal aerosol sprays per day
Nasal metered spray (42 mcg): 1 to 2 nasal inhalations (42 to 84 mcg) in each nostril twice a day (168 to 336 mcg/day)
Comments:
-Nasal metered spray: Symptomatic relief usually occurs within a few days after starting therapy; however, in some patients it may take as long as 2 weeks.
-Nasal metered spray should not be continued beyond 3 weeks in the absence of significant symptomatic improvement.
Uses:
-Treatment of the nasal symptoms associated with seasonal and perennial allergic rhinitis
-Relief of the symptoms of nonallergic (vasomotor) rhinitis
-Prevention of recurrence of nasal polyps following surgical removal
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
-The safety and efficacy of the nasal metered spray in patients younger than 6 years have not been established.
-The safety and efficacy of the nasal metered aerosol in patients younger than 12 years have not been established.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
-This drug should be administered by intranasal route only.
-Metered aerosol should be primed prior to initial use by actuating four times. If aerosol is not used for 7 consecutive days it should be primed by spraying 2 times.
-The manufacturer product information should be consulted for proper use.
Storage requirements:
-Consult the manufacturer product information.
General:
Metered aerosol:
-Do not puncture; do not use or store near heat or open flame.
-Do not throw canister into fire or incinerator.
Patient advice:
-Do not exceed the labeled dose amount.
-Avoid spraying into the eyes or mouth.
-Consult your patient leaflet for information regarding how to properly use and store this drug.
-If you have an applicator, check your patient leaflet for proper cleaning of your device.
Usual Adult Dose for Tinea Corporis
Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 weeks, depending on the nature and severity of the infection.
Usual Adult Dose for Tinea Cruris
Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 weeks, depending on the nature and severity of the infection.
Usual Adult Dose for Tinea Pedis
Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 to 8 weeks, depending on the nature and severity of the infection.
Usual Adult Dose for Cutaneous Candidiasis
Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.
Usual Adult Dose for Tinea Versicolor
Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.
Usual Adult Dose for Vaginal Candidiasis
Regimen 1: 100 mg (one 100 mg vaginal suppository) intravaginally once a day for 7 consecutive days alone or in combination with topical application of 1% Clotrimazole to affected area two times daily for 7 consecutive days.
Regimen 2: 200 mg (one 200 mg vaginal suppository) intravaginally once a day for 3 consecutive days alone or in combination with topical application of 1% Clotrimazole to affected area two times daily for 7 consecutive days.
Regimen 3: 500 mg (one 500 mg vaginal suppository) intravaginally once.
Regimen 4: One applicatorful of 1% clotrimazole vaginal cream intravaginally once daily (preferably at bedtime) for 7 consecutive days.
Regimen 5: One applicatorful of 2% clotrimazole vaginal cream intravaginally once daily (preferably at bedtime) for 3 consecutive days.
Studies have shown the three and seven day courses of clotrimazole to be equally effective. Patient compliance may be increased with a three day course. Patients who fail to achieve a cure with a single 500 mg dose should be treated with a 3 or 7 day course of clotrimazole.
Weekly or monthly clotrimazole vaginal suppositories appear to be effective topical regimens for chronic suppressive therapy in female patients with HIV.
Usual Pediatric Dose for Tinea Corporis
> 3 years: Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 weeks, depending on the nature and severity of the infection.
Usual Pediatric Dose for Tinea Cruris
> 3 years: Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 weeks, depending on the nature and severity of the infection.
Usual Pediatric Dose for Tinea Pedis
> 3 years: Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 to 8 weeks, depending on the nature and severity of the infection.
Usual Pediatric Dose for Cutaneous Candidiasis
> 3 years: Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.
Usual Pediatric Dose for Tinea Versicolor
> 3 years: Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.
Usual Pediatric Dose for Vaginal Candidiasis
> 12 years: Regimen 1: 100 mg (one 100 mg vaginal suppository) intravaginally once a day for 7 consecutive days alone or in combination with topical application of 1% Clotrimazole to affected area two times daily for 7 consecutive days.
Regimen 2: 200 mg (one 200 mg vaginal suppository) intravaginally once a day for 3 consecutive days alone or in combination with topical application of 1% Clotrimazole to affected area two times daily for 7 consecutive days.
Regimen 3: 500 mg (one 500 mg vaginal suppository) intravaginally once.
Regimen 4: One applicatorful of 1% clotrimazole vaginal cream intravaginally once daily (preferably at bedtime) for 7 consecutive days.
Studies have shown the three and seven day courses of clotrimazole to be equally effective. Patient compliance may be increased with a three day course. Patients who fail to achieve a cure with a single 500 mg dose should be treated with a 3 or 7 day course of clotrimazole.
Weekly or monthly clotrimazole vaginal suppositories appear to be effective topical regimens for chronic suppressive therapy in female patients with HIV.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Dialysis
Data not available
Adults and
Elderly:
The painful area should be covered with the plaster once daily for up to 12 hrs within a 24 hrs period. Only the number of plasters that are needed for an effective treatment should be used. When needed, the plasters may be cut into smaller sizes with scissors prior to removal of the release liner. In total, not >3 plasters should be used at the same time.The plaster must be applied to intact, dry, non-irritated skin (after healing of the shingles). Each plaster must be worn no longer than 12 hrs. The subsequent plaster-free interval must be at least 12 hrs. The plaster can be applied during the day or during the night.
The plaster must be applied to the skin immediately after removal from the sachet and following removal of the release liner from the gel surface. Hairs in the affected area must be cut off with a pair of scissors (not shaved).
Treatment outcome should be re-evaluated after 2-4 weeks. If there has been no response to Lignopad medicated plaster after this period or if any relieving effect can solely be related to the skin protective properties of the plaster, treatment must be discontinued as potential risks may outweigh benefits in this context. Long-term use of Lignopad medicated plaster in clinical studies showed that the number of plasters used decreased over time. Therefore, treatment should be reassessed at regular intervals to decide whether the amount of plasters needed to cover the painful area can be reduced, or if the plaster-free period can be extended.
Renal Impairment: In patients with mild or moderate renal impairment a dosage adjustment is not required. Lignopad medicated plaster should be used with caution in patients with severe renal impairment.
Hepatic impairment: In patients with mild or moderate hepatic impairment a dosage adjustment is not required. Lignopad medicated plaster should be used with caution in patients with severe hepatic impairment.
Paediatric population: The safety and efficacy of Lignopad medicated plaster in children <18 years has not been established. No data are available.
Adults: Given orally in a usual daily dose of 300-600 mg of ofloxacin (3-6 tabs) divided into 2-3 doses. If used for leprosy, it is recommended to give a total of 400-600 of ofloxacin per day divided into 2-3 doses. In general, the dosage should be adjusted according to the causative organism and the severity of the symptoms. For leprosy, ofloxacin should as a rule be co-administered with other antileprosy drugs.
Urinary Tract Infections: 1 x 100 mg up to 2 x 100 mg (or 1 x 200 mg).
Kidney and Reproductive Organ Infections: 2 x 100 mg up to 2 x 200 mg.
Respiratory Tract and Ear, Nose and Throat: 2 x 200 mg.
Skin and Soft Tissue Infections: 2 x 200 mg.
Bones and Joint Infections: 2 x 200 mg.
Abdominal Infections: 2 x 200 mg.
Septicaemia: 2 x 200 mg.
It is important that the individual doses be given at approximately equal intervals.
Depending on the severity of the infection and on the presence of complicating factors or pathogens of moderate susceptibility, it may be necessary to increase the dose to up 2 x 400 mg daily.
Patients with Impaired Renal Function: The initial dose is the same as for patients with normal renal function, whereas the maintenance dose should be reduced as follows: Creatinine clearance: 50-20 mL/min: 100-200 mg every 24 hrs; <20 mL/min: 100 mg every 24 hrs; haemodialysis or
Peritoneal dialysis:
100 mg every 24 hrs. In individual instances, it may be necessary to increase the dosage.Patients with Impaired Liver Function: The excretion of ofloxacin may be reduced in patients with severe impairment of liver function (eg, cirrhosis with ascites). A maximum daily dose of 400 mg of ofloxacin should therefore not be exceeded.
Duration of Treatment: The duration of treatment depends on the response of the causative organism and on the clinical picture. In most cases of acute infection, a course of treatment lasting 7-10 days is sufficient. In salmonelloses, the duration of treatment is usually 7-8 days, in shigelloses 3-5 days and in intestinal infections caused by E. coli 3 days.
For uncomplicated infections of the lower urinary tract, 3-day treatment is usually sufficient.
In case of infections with β-haemolytic streptococci (eg, purulent tonsillitis or erysipelas), treatment must be continued for at least 10 days in order to prevent late complications eg, rheumatic fever or inflammation of the renal glomeruli (glomerulonephritis). However, since β-haemolytic streptococci are of varying susceptibility to ofloxacin, treatment of such infections requires individual proof of susceptibility.
Until further experience is available, the duration of treatment should not exceed 2 months.
See also:
What is the most important information I should know about Beclomethasone?
QVAR is contraindicated in the primary treatment of status asthmaticus or other acute episodes of asthma where intensive measures are required.
Hypersensitivity to any of the ingredients of this preparation contraindicates its use.
See also:
What is the most important information I should know about Clotrimazole?
Possible sensitivity to clotrimazole.
Rosacea, acne, perioral dermatitis, tuberculosis of the skin and varicose ulcers.
Clotrimazole is not indicated for ophthalmic use and should be used with caution around the eyes.
Teratogenicity: Corticosteroids have been shown to be teratogenic in animals following dermal application. As these agents are absorbed percutaneously, teratogenicity following topical application cannot be excluded.
Use in pregnancy: Clotrimazole should not be used during pregnancy.
Severe bleeding, shock, hypotension, infection of the proposed injection site, marked bradycardia, cardiogenic shock, severe forms of chronic heart failure, SSS in elderly patients, AV-block II and III degree (except in cases when the probe was introduced to stimulate the ventricles), severe liver function abnormalities.
For subarachnoid anesthesia - complete heart block, bleeding, hypotension, shock, infection of the venue lumbar puncture, septicemia.
Increased sensitivity to Lignocaine Haffkine Bio-Pharmaceutical Corporation and other amide type local anesthetics.
See also:
What is the most important information I should know about Ofloxacin?
Hypersensitivity to 4-quinolone antibacterials, ofloxacin or to any of the excipients of Ofloxacin.
Patients with past history of tendonitis and epilepsy or with a lowered seizure threshold; since animal experiments do not entirely exclude the risk of damage to the cartilage of joints in the growing subject.
Patients with latent or actual defects in glucose-6-phosphate dehydrogenase activity may be prone to haemolytic reactions when treated with quinolone antibacterial agents.
Use in pregnancy & lactation: The safety of Ofloxacin for use in human pregnancy has not been established. Reproduction studies performed in rats and rabbits did not reveal any evidence of teratogenicity, impairment of fertility or impairment of peri- and postnatal development. However, as with other quinolones, ofloxacin has been shown to cause arthropathy in immature animals and therefore, its use during pregnancy is not recommended. Studies in rats have indicated that ofloxacin is secreted in milk. It should therefore not be used during lactation.
Use in children: Ofloxacin is not indicated for use in children or growing adolescents.
Use Beclomethasone as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Beclomethasone comes with an additional patient leaflet, including detailed instructions for use of Beclomethasone. Talk to your pharmacist if you have questions about this information.
- Beclomethasone is only for the nose.
- Before using Beclomethasone for the first time, you must prime the device. Do not prime the device every day. To prime Beclomethasone, remove the protective dust cap from the device. Hold the device upright between your thumb and forefinger (the canister should be on top, pointing down). Spray 4 times into the air, away from your eyes and face. After the first priming, the dose counter should read 120.
- If Beclomethasone has not been used in more than 7 days, re-prime it by spraying 2 times.
- Clear your nose before using Beclomethasone by blowing it gently.
- To use Beclomethasone, remove the cap from the device.
- Tilt your head forward slightly. Carefully insert the tip of the spray container into one nostril, keeping the bottle upright. Point the tip slightly away from the nasal septum (wall between your nostrils). Using a finger from your other hand, press against the opposite nostril to close it off.
- Hold your breath and squeeze the spray container to release 1 spray. Continue to hold your breath for 5 seconds, then breathe out slowly through your mouth. Remove the device from your nostril.
- Repeat these steps in the same nostril or in your other nostril as directed by your health care provider.
- Do not spray Beclomethasone directly onto the nasal septum (the wall between your nostrils).
- Do not blow your nose for 15 minutes after using Beclomethasone.
- Wipe the nasal tip with a clean, dry tissue or cloth after use. Keep the device clean and dry at all times. Always replace the cap when finished.
- Throw the bottle away after 120 sprays (not counting the 4 sprays used to prime the device). Do not use Beclomethasone after the device reads 0. You may no longer receive the correct amount of medicine with each spray. Do not transfer any remaining medicine to another bottle.
- Do not use this device with a canister of medicine from any other inhaler. Do not use the canister with a device from any other inhaler. Do not remove the canister from the device.
- Use Beclomethasone on a regular schedule to get the most benefit from it. Using Beclomethasone at the same time each day will help you remember to use it.
- If you miss a dose of Beclomethasone, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Beclomethasone.
Use Clotrimazole as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Clotrimazole. Talk to your pharmacist if you have questions about this information.
- Clotrimazole is for vaginal use only. Do not use in the eyes or take by mouth.
- Some forms of this product come with 3 disposable applicators. If this product contains disposable applicators, throw away each applicator after use.
- Some forms of this product come with one applicator to be used for all 3 days of treatment. If this product contains only one applicator, do not throw it away after use. Separate the pieces of the applicator and wash with warm, soapy water immediately after use. Rinse thoroughly. Make sure the applicator is completely dry before the next use.
- If you are using this cream externally, squeeze a small amount onto your fingertip and gently apply to the irritated skin around the vagina.
- Wash your hands immediately after using Clotrimazole.
- To clear up your infection completely, use Clotrimazole for the full course of treatment. Keep using it even if you feel better in a few days.
- If you miss a dose of Clotrimazole, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Clotrimazole.
Use Ofloxacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Ofloxacin is only for the ear. Do not get it in your eyes, nose, or mouth.
- Before using, hold the ear drop container in your hand for 1 or 2 minutes to avoid dizziness that may result from putting cold drops into the ear. Lie down or tilt your head so that the affected ear faces up. For adults, gently pull the earlobe up and back to straighten the ear canal. For children, gently pull the earlobe down and back to straighten the ear canal. Drop the medicine into the ear canal. Keep the ear facing up for 5 minutes so the medicine can run to the bottom of the ear canal. A clean cotton plug may be gently inserted into the ear canal to prevent medicine from leaking out.
- To prevent germs from contaminating the medicine, do not touch the applicator to any surface, including the ear. Keep the container tightly closed.
- If you are using Ofloxacin for a middle ear infection, pump the flap over the ear 4 times after instilling the medicine in order to help it reach the middle ear.
- Ofloxacin works best if used at the same time each day.
- To clear up your infection completely, use Ofloxacin for the full course of treatment. Keep using it even if you feel better in a few days.
- If you miss a dose of Ofloxacin, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Ofloxacin.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.How to use Beclomethasone inhalation
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.This product is a combination of B vitamins used to treat or prevent vitamin deficiency due to poor diet, certain illnesses, alcoholism, or during pregnancy. Vitamins are important building blocks of the body and help keep you in good health. B vitamins include thiamine, riboflavin, niacin/niacinamide, vitamin B6, vitamin B12, folic acid, and pantothenic acid.
Some brands of B vitamins also contain ingredients such as vitamin C, vitamin E, biotin, or zinc. Consult your doctor or pharmacist if you have questions about the ingredients in your brand.
How to use Bco
Take this medication by mouth, usually once daily or as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.
If you are taking a brand that contains vitamin C, take this medication by mouth with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise.
If you are taking chewable tablets, chew the tablet thoroughly before swallowing.
If you are taking extended-release capsules, swallow them whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
If you are taking a liquid product, use a medication-measuring device to carefully measure the dose. Do not use a household spoon. Some liquid products need to be shaken before each dose. Some products that contain vitamin B12 need to be placed under the tongue and held there before swallowing. Follow label directions carefully to get the most benefit.
Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each day.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Pulseless ventricular fibrillation or ventricular tachycardia, epidural anaesthesia, spinal anaesthesia, surface anaesthesia, percutaneous infiltration anaesthesia, peripheral nerve block.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.Use: Labeled Indications
Treatment of acute exacerbations of chronic bronchitis, community-acquired pneumonia, skin and skin structure infections (uncomplicated), urethral and cervical gonorrhea (acute, uncomplicated), urethritis and cervicitis (nongonococcal) due to Chlamydia trachomatis infection, mixed infections of the urethra and cervix, pelvic inflammatory disease (acute), cystitis (uncomplicated), urinary tract infections (complicated), prostatitis
Note: As of April 2007, the CDC no longer recommends the use of fluoroquinolones for the treatment of gonococcal disease.
Off Label Uses
Epididymitis
Based on the Centers for Disease Control and Prevention (CDC) sexually transmitted diseases treatment guidelines and the Canadian Guidelines on Sexually Transmitted Infections, ofloxacin is an effective and recommended treatment option for acute epididymitis likely caused by enteric organisms (as monotherapy). The CDC guidelines also recommend ofloxacin in combination with ceftriaxone for acute epididymitis likely caused by sexually transmitted chlamydia and gonorrhea and enteric organisms in men who practice insertive anal sex.
Leprosy (multibacillary)
Data from a limited number of patients in an open-label, parallel assessment study suggest that ofloxacin, in combination with rifampin and minocycline (ROM), may be beneficial for the treatment of multibacillary leprosy. Additional trials may be necessary to further define the role of multiple and single dose ofloxacin regimens in paucibacillary leprosy. The World Health Organization Expert Committee on Leprosy and the National Hansen's Disease Program currently do not recommend ofloxacin for the treatment of paucibacillary leprosy.
Spontaneous bacterial peritonitis (treatment)
According to national and international guidelines regarding treatment of spontaneous bacterial peritonitis (SBP), ofloxacin may be considered as an alternative therapy to IV third-generation cephalosporins in patients with uncomplicated SBP who are not infected with a suspected quinolone-resistant organism. If fluoroquinolone-resistant, gram-negative bacteria are suspected as the causative organisms, when fluoroquinolones have been used for prophylaxis, or when patients are located in areas where incidence of quinolone-resistant bacterial infections are high, cefotaxime is the treatment of choice.
Traveler's diarrhea
Based on the Infectious Diseases Society of America Guidelines for the Practice of Travel Medicine and the American College of Gastroenterology (ACG) Guideline for the Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults, ofloxacin is an effective and recommended fluoroquinolone for antibiotic treatment of traveler's diarrhea.
No drug interactions have been described with inhaled beclomethasone.
See also:
What other drugs will affect Clotrimazole?
Clotrimazole should be used cautiously in patients with hyperthyroidism, hypertension and cardiac arrhythmias. All vasopressors should be used cautiously in patients taking monoamine oxidase (MAO) inhibitors.
Clotrimazole should not be administered concomitantly with other sympathomimetic drugs (such as isoproterenol) because of possible additive effects and increased toxicity.
Combined effects may induce serious cardiac arrhythmias. They may be administered alternately when the preceding effect of other such drug has subsided.
Administration of epinephrine to patients receiving cyclopropane or halogenated hydrocarbon general anesthetics such as halothane which sensitize the myocardium, may induce cardiac arrhythmia.. When encountered, such arrhythmias may respond to administration of a beta-adrenergic blocking drug. Clotrimazole also should be used cautiously with other drugs (e.g., digitalis, glycosides) that sensitize the myocardium to the actions of sympathomimetic drugs.
Diuretic agents may decrease vascular response to pressor drugs such as epinephrine.
Clotrimazole may antagonize the neuron blockade produced by guanethidine resulting in decreased antihypertensive effect and requiring increased dosage of the latter.
Beta-blockers increase the risk of bradycardia and hypotension. Norepinephrine and beta-blockers by reducing hepatic blood flow decrease (increased toxicity), isadrine and glucagon - increase the clearance of lidocaine. Cimetidine increases the plasma concentration of Lignocaine Haffkine Bio-Pharmaceutical Corporation (displaces from its association with proteins and slows inactivation in the liver). Barbiturates causing induction of microsomal enzymes stimulate the degradation of lidocaine and reduce its activity. Anticonvulsants (hydantoin derivatives) accelerate the biotransformation in the liver (decreased concentration in the blood), for IV injections it may increases cardiodepressive action of lidocaine. Antiarrhythmics (amiodarone, verapamil, quinidine, aymalin) potentiate cardiac depression. Combination with novocainamide may cause CNS excitement and hallucinations. Lignocaine Haffkine Bio-Pharmaceutical Corporation strengthens the inhibitory effect of anesthesia (hexobarbital, thiopental sodium), hypnotics and sedatives on the respiratory center, weakens the cardiac effects of digitoxin, enhances muscle relaxation caused by drugs curare like (possible paralysis of respiratory muscles). MAO inhibitors prolong local anesthesia.
See also:
What other drugs will affect Ofloxacin?
Drugs Known to Prolong QT Interval: Ofloxacin, like other fluoroquinolones, should be used with caution in patients receiving drugs known to prolong the QT interval (eg, class IA and III antiarrhythmics, tricyclic antidepressants, macrolides, antipsychotics).
Prolongation of bleeding time has been reported during concomitant administration of ofloxacin and anticoagulants.
There may be a further lowering of the cerebral seizure threshold when quinolones are given concurrently with other drugs which lower the seizure threshold eg, theophylline. However, ofloxacin is not thought to cause a pharmacokinetic interaction with theophylline, unlike some other fluoroquinolones.
Further lowering of the cerebral seizure threshold may also occur with certain nonsteroidal anti-inflammatory drugs.
In case of convulsive seizures, treatment with ofloxacin should be discontinued.
Ofloxacin may cause a slight increase in serum concentrations of glibenclamide administered concurrently; patients treated with this combination should be closely monitored.
Vitamin K Antagonists: Coagulation tests should be monitored in patients treated with vitamin K antagonists because of a possible increase in the effect of coumarin derivatives.
Cimetidine: Cimetidine has demonstrated interference with the elimination of some quinolones. This interference has resulted in significant increases in t½ and AUC of some quinolones. The potential for interaction between ofloxacin and cimetidine has not been reported.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): The concomitant administration of a NSAID with a quinolone, including ofloxacin, may increasethe risk of CNS stimulation and convulsive seizures.
Probenecid: The concomitant use of probenecid with certain other quinolones has been reported to affect renal tubular secretion. The effect of probenecid on the elimination of ofloxacin has not been reported.
Theophylline: Steady-state theophylline levels may increase when ofloxacin and theophylline are administered concurrently. As with other quinolones, concomitant administration of ofloxacin may prolong the t½ of theophylline, elevate serum theophylline levels and increase the risk of theophylline-related adverse reactions.
Theophylline levels should be closely monitored and theophylline dosage adjustments made, if appropriate, when ofloxacin is co-administered. Adverse reactions (including seizures) may occur with or without an elevation in the serum theophylline level.
Warfarin: Some quinolones have been reported to enhance the effects of the oral anticoagulant warfarin or its derivatives. Therefore, if a quinolone antimicrobial is administered concomitantly with warfarin or its derivatives, the prothrombin time or other suitable coagulation test should be closely monitored.
Antidiabetic Agents (eg, Insulin, Glyburide/Glibenclamide): Since disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concurrently with quinolones and an antidiabetic agent, careful monitoring of blood glucose is recommended when these agents are used concomitantly.
Cyclosporine: Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with some other quinolones. The potential for interaction between ofloxacin and cyclosporine has not been reported.
Drugs Metabolized by Cytochrome P450 (CYP450) Enzymes: Most quinolone antimicrobial drugs inhibit CYP450 enzyme activity. This may result in a prolonged t½ for some drugs that are also metabolized by this system (eg, cyclosporine, theophylline/methylxanthines, warfarin) when co-administered with quinolones. The extent of this inhibition varies among different quinolones.
Interactions with Laboratory Tests: Some quinolones, including ofloxacin, may produce false-positive urine screening results for opiates using commercially available immunoassay kits. Confirmation of positive opiate screens by more specific methods may be necessary.
See also:
What are the possible side effects of Beclomethasone?
The most commonly noted side effects associated with inhaled beclomethasone are mild cough or wheezing due to chemical irritation; these effects may be minimized by using an inhaled bronchodilator (e.g., albuterol or Ventolin) prior to the beclomethasone.
Oral candidiasis or thrush, a fungal infection of the mouth and throat, can occur in between 1 in 20 and 1 in 8 persons who use beclomethasone. The risk of thrush is greater with higher doses, but the risk in children is lower than in adults. Hoarseness may occur in as few as 1 in 20 or as many as 1 in 2 persons and is due to chemical irritation. A spacer device that can be attached to the inhaler and washing out the mouth with water following each use of beclomethasone reduces the amount of beclomethasone in the mouth and throat and reduces the risk of thrush and hoarseness.
Higher doses of inhaled beclomethasone (more than 1000 mcg/day) may result in more absorption into the body. This may decrease bone formation and increase bone breakdown (resorption), resulting in weak bones and a risk of fractures. Even higher doses (more than 1500 mcg/day in adults and 400 mcg/day in children) may suppress the adrenal glands and impair their ability to make natural glucocorticoid. People with such suppression (which can be identified by testing) need increased amounts of glucocorticoid orally or by the intravenous route during periods of high physical stress since higher amounts of glucocorticoids are needed by the body to fight physical stress. Patients receiving beclomethasone may develop easy bruising if enough beclomethasone is absorbed into the body from the lungs.
See also:
What are the possible side effects of Clotrimazole?
Applies to clotrimazole: lozenge/troche
In addition to its needed effects, some unwanted effects may be caused by clotrimazole (the active ingredient contained in Clotrimazole). In the event that any of these side effects do occur, they may require medical attention.
Minor Side Effects
Some of the side effects that can occur with clotrimazole may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
Note: Some of the side effects, such as abdominal or stomach cramping or pain or diarrhea, usually occur only when the medicine is swallowed
- Abdominal or stomach cramping or pain
- diarrhea
- itching
- nausea or vomiting
- unpleasant mouth sensations
Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Approximately 16% of patients can be expected to experience adverse reactions. These are localised reactions due to the nature of the medicinal product.
The most commonly reported adverse reactions were administration site reactions (eg, burning, dermatitis, erythema, pruritus, rash, skin irritation and vesicles).
Adverse reactions that have been reported in studies of post-herpetic neuralgia patients receiving the plaster. They are listed by system organ class and frequency. Frequencies are defined as very common (≥1/10); common (≥1/100-<1/10); uncommon (≥1/1,000-<1/100); rare (≥1/10,000-<1/1000); very rare (<1/10,000); not known (cannot be estimated from the available data).
Skin and Subcutaneous Tissue Disorders: Uncommon: Skin lesion.
Injury, Poisoning and Procedural Complications: Uncommon: Skin injury.
General Disorders and Administration Site Conditions: Very common: Administration site reactions.
The following reactions have been observed in patients receiving the plaster under post-marketing conditions: Injury, Poisoning and Procedural Complications: Very rare: Open wound.
Immune System Disorders: Very rare: Anaphylactic reaction, hypersensitivity.
All adverse reactions were predominantly of mild and moderate intensity. Of those <5% lead to treatment discontinuation.
Systemic adverse reactions following the appropriate use of the plaster are unlikely since the systemic concentration of lignocaine is very low. Systemic adverse reactions to lignocaine are similar in nature to those observed with other amide local anaesthetic agents.
See also:
What are the possible side effects of Ofloxacin?
Subjects with Otitis Externa
In the phase III clinical trials performed in support of once-daily dosing, 799 subjects with otitis externa and intact tympanic membranes were treated with ofloxacin otic solution. The studies, which served as the basis for approval, were 020 (pediatric, adolescents and adults), 016 (adolescents and adults) and 017 (pediatric). The following treatment-related adverse events occurred in two or more of the subjects.
An unexpected increased incidence of application site reaction was seen in studies 016/017 and was similar for both ofloxacin and the active control drug (neomycin-polymyxin B sulfate-hydrocortisone). This finding is believed to be the result of specific questioning of the subjects regarding the incidence of application site reactions.
In once daily dosing studies, there were also single reports of nausea, seborrhea, transient loss of hearing, tinnitus, otitis externa, otitis media, tremor, hypertension and fungal infection.
In twice daily dosing studies, the following treatment-related adverse events were each reported in a single subject: dermatitis, eczema, erythematous rash, follicular rash, hypoaesthesia, tinnitus, dyspepsia, hot flushes, flushing and otorrhagia.
Subjects with Acute Otitis Media with Tympanostomy Tubes (AOM TT) and Subjects with Chronic Suppurative Otitis Media (CSOM) with Perforated Tympanic Membranes
In phase III clinical trials which formed the basis for approval, the following treatment-related adverse events occurred in 1% or more of the 656 subjects with non-intact tympanic membranes in AOM TT or CSOM treated twice-daily with ofloxacin otic solution:
Other treatment-related adverse reactions reported in subjects with non-intact tympanic membranes included: diarrhea (0.6%), nausea (0.3%), vomiting (0.3%), dry mouth (0.5%), headache (0.3%), vertigo (0.5%), otorrhagia (0.6%), tinnitus (0.3%), fever (0.3%). The following treatment-related adverse events were each reported in a single subject: application site reaction, otitis externa, urticaria, abdominal pain, dysaesthesia, hyperkinesia, halitosis, inflammation, pain, insomnia, coughing, pharyngitis, rhinitis, sinusitis, and tachycardia.
Post-marketing Adverse Events
Cases of uncommon transient neurospsychiatric disturbances have been included in spontaneous post-marketing reports. A causal relationship with ofloxacin otic solution 0.3% is unknown.
An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma.
Clotrimazole is used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet). Clotrimazole is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but also presumed to interfere with yeast membrane structure and function.
Each 10 cm x 14 cm plaster contains lignocaine 700 mg (5% w/w). Lignopad also contains the following excipients: Self-adhesive layer: Methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), propylene glycol (E1520), glycerol, crystallising liquid sorbitol, carmellose sodium, urea, heavy kaolin, tartaric acid, gelatin, polyvinyl alcohol, aluminum glycinate, disodium edetate, polyacrylic acid, sodium polyacrylate, purified water. Backing fabric and release liner: Polyethylene terephthalate (PET).
Ofloxacin Solution also contains benzalkonium chloride as inactive ingredient.
Ofloxacin is (±)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido [1,2,3,-de][1,4]benzoxazine-6-carboxylic acid.
Ofloxacin has a molecular formula of C18H20FN3O4, molecular weight of 361.37 and melting point of 260°-270°C (decomposition). Ofloxacin occurs as pale yellowish-white to light yellowish-white crystals or crystalline powder, is odorless and has a bitter taste. It is freely soluble in glacial acetic acid, sparingly soluble in chloroform, slightly soluble in water, methanol, ethanol and acetone and very slightly soluble in ethyl acetate. It is slowly colorized by light and has no specific rotation.
Partition Coefficient: Chloroform: 0.1 mol/L phosphate buffer (pH 7.4):4.95. N-Octanol: 0.1 mol/L phosphate buffer (pH 7):0.33.
pH: 6-7. Osmotic pressure ratio (to physiological saline) 1-1.2.