Aviflu

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Aviflu

Method of action: Antivirals For Systemic Use

Treatment option: Influenza

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Aviflu

What is Aviflu? (Oseltamivir Phosphate)

Property Description
Active ingredient Oseltamivir Phosphate
Form Capsule, powder for oral suspension
Pharmacological class Neuraminidase inhibitor
Common use Management and prophylaxis of influenza A and B
Origin Synthetic (prodrug)

What Type of Medicine is Aviflu? (Identity and Classification)

Aviflu is a synthetic antiviral medication whose active ingredient is Oseltamivir Phosphate. It belongs to the specific pharmacological class of neuraminidase inhibitors, a group clinically recognized for their targeted efficacy against influenza viruses. Oseltamivir is designated as a prescription-only drug in the United States, underscoring its therapeutic specificity.

The medication is unique in that it is administered as a prodrug; it is biologically inactive until the body’s metabolism converts it into its potent, active form, oseltamivir carboxylate. This mechanism ensures the correct substance is available to inhibit the virus at concentrations suitable for systemic distribution.

Composition and Available Forms

The core component of Aviflu is the single active substance, Oseltamivir Phosphate. It is prepared for oral administration and is supplied in two primary dosage form(s): a hard capsule and a powder for oral suspension (liquid form). This dual availability is a differentiating factor, as the liquid suspension is specifically designed to facilitate administration to pediatric patients and others requiring precise, weight-based liquid dosing. Both forms are engineered to deliver the same amount of the active component into the body.

General Purpose and Mechanism Principle

The general purpose of Aviflu is to help manage infection caused by the influenza virus (Type A and B). It achieves this by the active metabolite targeting the viral enzyme neuraminidase. By inhibiting this enzyme, the drug prevents new virus particles from being released from the already infected cells, thereby halting the initial spread of the infection. This action limits the overall viral proliferation, providing the general benefit of managing the acute stages of the viral attack.

Regulatory References

  1. NIH Drug Information Portal

What side effects are possible with Aviflu?

Aviflu: Possible Side Effects and Safety Information

The safety profile for Oseltamivir Phosphate, as documented in official regulatory labeling, defines adverse reactions primarily by frequency and the body system affected. These classifications are based on controlled clinical trial data and post-marketing surveillance reports.

Frequency-Classified Adverse Reactions

The most commonly reported adverse reactions are classified as Very Common or Common in adult and adolescent populations. Very Common reactions include headache and nausea. Common reactions often involve the gastrointestinal system, such as vomiting, diarrhea, and abdominal pain. Gastrointestinal effects are frequently noted to occur on a single occasion, generally during the first or second day of treatment, and often resolve spontaneously.

System-Organ Class Common Adverse Reactions
Gastrointestinal Disorders Nausea, Vomiting, Diarrhea, Abdominal pain
Nervous System Disorders Headache, Dizziness

Serious Adverse Reactions and Safety Constraints

Certain clinically significant reactions are highlighted in the safety documentation. These include rare but documented instances of Severe Skin and Hypersensitivity Reactions, such as Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and anaphylaxis. Additionally, Neuropsychiatric Events (e.g., confusion, abnormal behavior, hallucinations) have been reported, primarily in pediatric and adolescent patients, with events often occurring early during the course of the illness.

Population-specific safety statements include a restriction against use in individuals with severe renal impairment who are not receiving dialysis, due to the reduced clearance of the active metabolite. Hypersensitivity to the active substance or excipients is a formal contraindication.

Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory information describes overdose with Aviflu (Oseltamivir Phosphate) primarily through documented clinical manifestations and specific mandates for emergency response.

Overdose reports often present with symptoms that are consistent with known adverse effects, most commonly involving the gastrointestinal system, such as nausea and vomiting.

Immediate Emergency Actions

The most severe manifestations require immediate emergency medical attention. Regulators explicitly advise contacting emergency services (e.g., 911) if the affected individual experiences seizure, collapse, trouble breathing, or cannot be awakened. Contact with the poison control helpline is also a mandated action following a suspected overdose.

Feature Official Regulatory Statement
Antidote Status No specific antidote is known.
Management Approach Treatment requires symptomatic and supportive care.
Key Clearance Measure Hemodialysis has been demonstrated to remove the active metabolite, oseltamivir carboxylate.

Population-Specific Risk

Patients with impaired renal function are at a particular risk for increased exposure to the active metabolite, as its elimination is exclusively via the kidneys. Due to this factor, the regulatory profile highlights that exposure is inversely proportional to declining renal function, which is a critical consideration in overdose.

Therapeutic Uses of Aviflu

Treatment of Established Influenza Illness

This medication is commonly used to help manage acute, symptomatic illness caused by the Influenza A and B viruses. It is applied across domains where additional symptomatic support is needed, primarily addressing the characteristic cluster of symptoms, including fever, headache, severe body aches, and respiratory distress. The primary benefit is to provide support that helps ease the overall symptom burden and may assist in easing the impact of these symptoms on functional stability.

“The therapeutic benefit supports patients during difficult episodes by easing distress and helping to maintain a sense of stability when symptoms are more noticeable.”

Moderating the Severity of Symptom Burden

Aviflu is relevant in conditions characterized by periods of heightened symptoms, aiming to ease challenging manifestations. It contributes to improved day-to-day comfort during periods of acute illness by being relevant for easing the intensity of constitutional discomfort. This provides supportive relief that offers symptomatic relief that helps patients cope more steadily and assists with maintaining functional stability. The medication is commonly applied in clinical settings for the prevention (prophylaxis) of symptomatic influenza following known or suspected exposure, offering support that may assist with the risk of contracting the full viral illness.

Quick Fact: Relief for Flu Symptoms
Symptom Focus: Symptoms related to systemic imbalance (fever, body aches, fatigue) and irritative states (cough, sore throat).
Primary Benefit: Supports shortening the duration and may assist with moderating the intensity of the overall symptom load.

Regulatory References

  1. Oseltamivir: MedlinePlus Drug Information

Eligibility and Restrictions for Use

Eligibility for Aviflu (Oseltamivir Phosphate)

Official regulatory documents define the eligible patient population for Aviflu based on age, hypersensitivity status, and organ function.

Populations for Whom Use is Allowed

Category Treatment Eligibility Prophylaxis Eligibility
Adults and Adolescents 13 years of age and older 13 years of age and older
Pediatric Patients 2 weeks of age and older 1 year of age and older

Contraindications and Restrictions

Use of Aviflu is strictly contraindicated in patients with a known serious hypersensitivity (allergy) to Oseltamivir Phosphate or any component of the formulation.

Age-Related Use Not Established: The safety and efficacy for treatment have not been established in neonates less than two weeks of age, and use for prophylaxis is not established in infants under one year of age.

Condition-Specific Restrictions: Patients with severe renal impairment require conditional use and mandatory dosage adjustment. The medicine is not recommended for patients with End-Stage Renal Disease (ESRD) who are not undergoing dialysis, or for patients with severe hepatic impairment.

Pregnancy and Lactation: Use during pregnancy is only permitted if the potential benefit justifies the potential risk. Caution is advised when administering the medicine to a nursing woman.

What should I know about interactions with other medicines?

Aviflu (Fluconazole) can alter the effects of many other medicines, primarily due to its inhibition of certain liver enzymes, specifically Cytochrome P450 (CYP) 2C9, 2C19, and 3A4. This enzymatic inhibition can lead to significantly increased blood concentrations and enhanced effects of co-administered drugs.

Contraindicated Combinations

Co-administration with specific medicines is strictly prohibited due to the high risk of severe, life-threatening heart rhythm abnormalities (QT prolongation and Torsades de pointes). These include pimozide, cisapride, astemizole, quinidine, and erythromycin. Concomitant use with terfenadine is also contraindicated, particularly at Aviflu doses of 400 mg per day or higher.

Significant Interactions Requiring Monitoring or Dose Adjustment

Aviflu necessitates caution and potential dose adjustments when used with many other products, including blood thinners like warfarin (increased bleeding risk), immunosuppressants such as cyclosporine and tacrolimus (increased exposure), and certain statins (increased risk of muscle damage). The concentration of oral antidiabetic agents (e.g., glipizide) can be elevated, which may lead to low blood sugar. Similarly, the effects of certain antiepileptic medicines (e.g., phenytoin, carbamazepine) and some antidepressants may be increased. Concomitant use with oral contraceptives may reduce their effectiveness, requiring the use of a reliable barrier method for at least one week after stopping Aviflu. The enzyme-inhibiting effect of Aviflu can persist for several days after treatment is discontinued.

Mechanism of Action

Aviflu, an azole compound, selectively accumulates within fungal cells. Its primary biological target is the fungal enzyme lanosterol 14-alpha-demethylase (Erg11p), a member of the cytochrome P450 family. The drug functions as a non-covalent inhibitor, binding to the heme iron of the active site of the target enzyme.

This molecular interaction blocks the ergosterol biosynthesis pathway by preventing the demethylation of lanosterol. The intracellular consequence is a cessation of ergosterol production, leading to the accumulation of toxic 14-alpha-methylated sterols within the fungal cell membrane. The presence of these abnormal sterols disrupts the close packing of membrane phospholipids, compromising the structural integrity, fluidity, and permeability of the cell membrane. This cascade results in a system-level physiological modulation of fungal organisms, disrupting essential cellular functions, arresting growth, and leading to cell lysis in certain conditions.

Dosage and Administration Information

Official Administration Guidelines

Aviflu (Oseltamivir Phosphate) is for oral administration only, available as capsules (30 mg, 45 mg, 75 mg) or as a powder for oral suspension (liquid form). The medicine may be taken with or without food, though administration with food is noted to potentially improve tolerability.

Standard Labeled Dosing Regimens

The standard adult dose is 75 mg, but the frequency and duration are determined by the intended use. Treatment must be initiated within 48 hours of influenza symptom onset, while prophylaxis should start within two days of exposure to an infected person.

Indication Adult Dose Frequency and Duration
Treatment 75 mg Twice daily (BID) for 5 days
Prophylaxis (Prevention) 75 mg Once daily (QD) for at least 10 days

Population-Specific Rules and Special Conditions

Pediatric dosing for children (1 year and older) is based on body weight. Infants aged two weeks to less than one year receive 3 mg/kg twice daily for 5 days.

Dose adjustment is required for adults with moderate-to-severe kidney impairment (creatinine clearance 10–30 mL/min). The treatment dose is reduced to 75 mg once daily for 5 days. For prophylaxis in this group, the dose is typically 75 mg every other day.

If a dose is missed, it should be taken as soon as it is remembered, unless the next dose is less than 2 hours away, in which case the missed dose must be skipped. Patients must not take two doses at once to compensate for a missed dose.

Recent Clinical Evidence

Aviflu, containing the active substance fluconazole, is an azole antifungal medication with an established history of use. Recent clinical studies and real-world evidence continue to support its efficacy and safety profile across various fungal infections. Fluconazole works by selectively inhibiting a key fungal enzyme, lanosterol 14-alpha-demethylase, which is essential for the production of ergosterol, a vital component of the fungal cell membrane. This disruption leads to increased cellular permeability and, ultimately, the death of the fungal cell.

Efficacy in Systemic and Mucosal Infections

Clinical trials have consistently demonstrated fluconazole's effectiveness in treating a range of conditions, including esophageal candidiasis in immunocompromised patients, where it has shown high rates of clinical and microbiological cure. Studies comparing fluconazole with newer antifungals for prophylaxis in high-risk groups, such as adults with acute lymphoblastic leukemia, have indicated comparable outcomes in preventing invasive fungal infections. In patients with deep-seated fungal infections, clinical cure or improvement rates often exceed 80%, with particular effectiveness noted against Candida species.

Safety and Tolerability

Fluconazole is generally well-tolerated. The most frequently reported adverse effects in clinical data include gastrointestinal issues, such as nausea, vomiting, abdominal pain, and diarrhea, as well as headache and skin rash. A rare but serious concern in clinical practice is the potential for hepatotoxicity (liver damage), which typically presents as elevated liver enzymes and may require immediate medical attention. High-dose, long-term use in pregnancy has been associated with an increased risk of certain birth defects, necessitating caution and alternative treatments when possible. Ongoing clinical surveillance reinforces the importance of monitoring patients for these adverse events, particularly those with pre-existing liver or heart conditions.

Frequently Asked Questions (FAQ)

Common questions about Aviflu (FAQ)


Q: Can Aviflu be used by people who are generally healthy?

Official regulatory documents indicate that the medicine is approved for the prevention or prophylaxis of influenza. This is typically used in individuals who have been exposed to an infected person. Prophylaxis is intended to reduce the risk of developing the illness.

Q: How long does it usually take for Aviflu to start working?

Studies show that the medicine's main effect is to reduce the overall duration of influenza symptoms. For patients who start treatment within 48 hours of symptom onset, this reduction has been noted to be up to 1.5 days. This observation is consistent with the drug's approved mechanism to limit the spread of the virus.

Q: Are there any specific foods or drinks that should be avoided when taking Aviflu?

Official administration guidelines state that the medicine can be taken with or without food, though taking it with food may help improve tolerability. No specific prohibitions regarding foods or non-alcoholic beverages are contained in the official regulatory documents.

Q: Does Aviflu affect birth control pills?

According to official product information, there is no clinically significant interaction expected between this medicine and hormonal birth control (oral contraceptives). This suggests a reduction in effectiveness is not anticipated by regulatory bodies.

Q: Is Aviflu known to cause changes in mood or sleep?

The official safety data notes that neuropsychiatric events have been reported, primarily in children and adolescents. These events have included abnormal behavior and delirium. While related to the central nervous system, sleep changes are not specifically listed as a common or defined adverse reaction.

Q: What makes Aviflu necessary for the condition it treats?

The medicine is approved for managing influenza because it is associated with specific clinical benefits. These include a decrease in the time it takes for symptoms to alleviate and a reduction in the incidence of complications related to the viral infection.

Q: Can people with heart conditions use Aviflu?

Pre-existing cardiac (heart) conditions are not listed as a formal contraindication in official documents. There are no specific warnings described in the official Oseltamivir labeling regarding rare, serious cardiac events related to its use.

Q: Are there any contraindications related to liver disease for Aviflu?

According to regulatory documents, the medicine is not recommended for patients who have severe hepatic impairment, which means severe liver disease. This lack of recommendation is based on the limited clinical data available for this specific patient group.

Q: What are the known potential benefits of Aviflu as stated by regulators?

Regulatory bodies state that the medicine is officially indicated for two purposes related to the influenza virus. These are the treatment of acute, uncomplicated illness caused by influenza A and B viruses, and the prevention of influenza, known as prophylaxis.

Q: Does Aviflu affect blood sugar levels?

Official documents do not describe a specific interaction between this medicine and medications used to control blood sugar levels (antidiabetic agents).

Q: Is the use of Aviflu restricted for people with certain mental health conditions?

Official drug labeling indicates that hypersensitivity (severe allergy) to the medicine's components is the only formal contraindication for its use. Pre-existing mental health conditions are not listed in the official documents as a formal restriction or contraindication for receiving the medicine.

Q: Are there studies comparing Aviflu across different patient populations?

Clinical data used for regulatory approval include studies examining the medicine in various patient populations. This includes different age groups, such as pediatric patients, as well as patients who may have other high-risk underlying health conditions.

Q: Is Aviflu approved for all stages of the condition it treats?

The indication for the medicine's use is limited by the timing of the infection. For the treatment of influenza, regulatory approval specifies that the medicine should be started when symptoms have been present for no more than 48 hours (two days).

Q: Does Aviflu contain any common allergens like gluten or lactose?

The capsule formulation of the medicine includes inactive ingredients, also known as excipients. Regulatory documents often list ingredients such as lactose and sodium benzoate as part of the formulation. This information is available in the official product labeling.

Q: What happens if I stop using Aviflu suddenly?

Official regulatory guidance emphasizes that completing the full recommended course is associated with the intended benefit. Discontinuing early may be associated with the re-emergence of symptoms or a reduced effect.

Q: Is it common to feel tired while taking Aviflu?

General tiredness or fatigue is not specifically categorized as a common side effect in the official regulatory documents. However, commonly reported adverse events include headache and dizziness, which may be reported alongside feelings of general unwellness.

Q: Are there any long-term research studies available for Aviflu?

The long history of the medicine means that regulatory documents confirm it has been subject to extensive post-marketing surveillance. This ongoing monitoring provides a large amount of long-term data on the drug's safety and usage patterns in the general population.

Q: Can Aviflu be used at the same time as cold and flu relief medicines?

Regulatory documents indicate that the medicine can be used concomitantly with common over-the-counter cold and flu relief medicines. Specifically, paracetamol (acetaminophen) and ibuprofen have been studied, and no clinically relevant drug interactions have been described.

Q: How is Aviflu different from a vaccine?

This medicine is an antiviral treatment that works by inhibiting the viral enzyme neuraminidase after the infection has started. A vaccine works differently; its purpose is to help the body build up an immune defense before exposure to a disease, offering protection against future infection.

Q: Does Aviflu have a risk of dependence or addiction?

Official regulatory documents and special warnings sections do not contain any documented reports or information suggesting a risk of physical dependence or addiction associated with the use of this medicine.

Q: Does Aviflu interact with common over-the-counter pain relievers?

Regulatory guidance states that the medicine can be co-administered with common over-the-counter (OTC) pain relievers. These include active ingredients such as acetaminophen and ibuprofen. No significant dose adjustments or interaction warnings are listed for these combinations in the official labeling.

Q: Is Aviflu commonly used in other countries?

The medicine is approved for use and distributed globally, with regulatory documents existing in many major countries and regions. These include approvals from international agencies such as the European Medicines Agency (EMA) and Health Canada.

Q: Are there any specific warnings for older adults using Aviflu?

Official documents state that no specific dose adjustment is typically required based on age alone for older adults. The safety and efficacy profiles observed in this group are generally described as similar to the general adult population.

Q: Are there any known interactions between Aviflu and herbal supplements?

Official regulatory documents focus on assessing and reporting interactions with co-administered prescription and over-the-counter medicines. Information regarding specific interactions with herbal supplements is typically not included in the official labeling.

Q: Is the ingredient in Aviflu considered a controlled substance?

The active ingredient in this medicine, Oseltamivir Phosphate, is subject to classification by national drug enforcement agencies. According to regulatory classifications in the U.S., the ingredient is not classified as a controlled substance.

Q: Does Aviflu cause weight changes?

Regulatory lists of both common and serious adverse effects, compiled from clinical trials and post-marketing data, do not include weight gain or weight loss as a documented reaction associated with the use of this medicine.

Q: How quickly does Aviflu clear from the body?

Pharmacokinetic studies describe how the medicine is processed by the body. The active form of the medicine typically has an elimination half-life of approximately 6 to 10 hours in most adult patients. The half-life refers to the time it takes for half of the drug to be eliminated from the body.

Q: Does Aviflu cause sensitivity to sunlight?

Photosensitivity, or an increased sensitivity to sunlight, is not listed among the reported adverse drug reactions in the official safety profile for the medicine.

Q: Are there any restrictions on driving while using Aviflu?

Official documents state that the medicine is not expected to affect a person's ability to drive or operate complex machinery. However, patients should observe for common reported side effects like dizziness, which could potentially affect concentration.

Q: What are the signs that Aviflu is having its intended effect?

The intended clinical effect of the medicine is primarily defined as a reduction in the overall duration and severity of the influenza symptoms a patient experiences. This is the main measurable benefit that is studied and reported in clinical trials.

Q: Is it true that Aviflu can interact with specific types of antibiotics?

Official drug interaction information notes that no clinically significant interactions are described between this medicine and the common classes of antibiotics. Interactions are assessed based on how one medicine affects the metabolism of the other.

Q: Does alcohol interact with Aviflu?

No specific interaction between this medicine and alcohol is described in official drug regulatory documents.

Q: Can Aviflu be crushed or split if needed?

The capsule formulation is generally administered by being swallowed whole. Official labeling provides instructions for pharmacists to prepare an oral suspension (liquid form) for patients who are unable to swallow the capsules.

Q: What does 'use conditions' mean in the context of Aviflu?

In regulatory terms, 'use conditions' refers to the specific parameters that define who can take the medicine and when. This includes the types of eligible patients (e.g., age, kidney function) and necessary timing parameters, such as the requirement to start treatment within 48 hours of symptom onset.

Q: Does Aviflu require special monitoring while being used?

For generally healthy patients, no routine laboratory monitoring is typically required during the course of the medicine. However, official documents specify that monitoring is necessary for patients with known or suspected kidney impairment.

How should Aviflu be stored and disposed of?

How to Store and Dispose of Oseltamivir Phosphate (Aviflu)

The storage requirements for oseltamivir phosphate differ by formulation and are defined by regulatory authorities.


Storage Requirements

Formulation Temperature Requirement Stability Constraint
Capsules Store at Controlled Room Temperature (20 C to 25 C). Keep in the original, tightly closed container and protect from moisture.
Prepared Suspension Must be refrigerated (2 C to 8 C) or stored at room temperature (up to 25 C). Must not be frozen. Stable for 17 days when refrigerated, or 10 days at room temperature.

Handling and Disposal

The medicine must be stored out of the sight and reach of children and pets. Unused or expired oseltamivir should be disposed of through a medicine take-back program or returned to a pharmacy. The product must not be disposed of via household wastewater.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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