Aurizon

Quick links to important sections

Aurizon

Treatment option:

Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Aurizon

Property Description
Active Ingredients Marbofloxacin, Clotrimazol, Dexamethasone
Form Otic Suspension (Ear Drops)
Pharmacological Class Triple-Combination Antibiotic, Antifungal, and Corticosteroid
Common Use Managing external ear issues in dogs
Origin Synthetic, Fixed-Dose Combination

What Type of Medicine is Aurizon?

Aurizon, manufactured by Vetoquinol, is defined as a specialized prescription-only veterinary medicine, formulated exclusively as an otic preparation for use in dogs. This classification establishes the product's dedicated application in animal care, distinguishing it from human pharmaceuticals or general over-the-counter pet ear cleaners. It is developed as a dedicated veterinary solution for the treatment of canine otitis externa, utilizing a targeted approach.


Composition and Pharmacological Class of Aurizon

Aurizon is a synthetic, fixed-dose combination product containing three active ingredients: the potent antibacterial agent Marbofloxacin, the antifungal agent Clotrimazol, and the anti-inflammatory corticosteroid Dexamethasone. This configuration places it within a comprehensive pharmacological class that acts against bacteria, fungi, and inflammation simultaneously. The product is supplied as a homogeneous, oily suspension, which is the specific dosage form engineered for effective topical administration and sustained contact within the complex structure of the dog's ear. The antibiotic component, Marbofloxacin, is utilized for its activity against gram-negative and gram-positive bacteria frequently isolated in these cases.


General Therapeutic Action and Benefit

This medication is designed to provide a comprehensive, triple-action therapeutic benefit by combining agents that target both microbial pathogens and the resulting inflammation. The Marbofloxacin and Clotrimazol components work together to control the bacterial and fungal populations, while the potent Dexamethasone component reduces the associated swelling and discomfort. The combination of these agents is intended for managing microbial and inflammatory components of certain ear conditions. This supports the product's design as an efficient way to reduce both the underlying cause and the associated symptoms in a single topical application.

What side effects are possible with Aurizon?

Possible Side Effects and Safety Information

The official safety profile for this otic suspension is structured around documented adverse reactions and specific regulatory constraints, emphasizing effects observed following topical application.

Frequency-Classified Adverse Reactions

The following potential effects are classified according to their documented frequency in clinical use, based on the Summary of Product Characteristics (SmPC):

Classification Adverse Reaction Domain
Rare Deafness (partial hearing loss), primarily observed in elderly dogs.
Very Rare Changes in biochemical parameters (e.g., elevated ALP, ALT); Skin thinning.
Undetermined Hypoadrenocorticism (adrenal suppression); Delayed healing; Localized skin reactions.

These effects are generally grouped by the System-Organ Classes (SOC) they affect, which include Ear and Labyrinth Disorders, Skin and Subcutaneous Tissue Disorders, and Metabolism and Nutrition Disorders.

Significant Safety Patterns and Restrictions

The most clinically significant safety concerns listed are the potential for deafness and hypoadrenocorticism.

Safety is also conditional on the patient's existing condition. The product is strictly contraindicated if a perforation of the tympanic membrane (eardrum) is known or suspected. It is also contraindicated in patients with a known hypersensitivity to any of its active components (Marbofloxacin, Clotrimazol, Dexamethasone), or to related substances like fluoroquinolones.

Furthermore, regulatory documentation notes that the effects associated with the corticosteroid component, such as skin thinning and adrenal suppression, are linked to prolonged and intensive use.

Overdose and Emergency Response

Documented Overdose Manifestations and Severity

The official documentation regarding overdose for Aurizon Otic Suspension describes the profile based on findings in the target species. Regulatory summaries document that administration at three times the recommended topical dosage resulted in specific systemic changes.

These observed manifestations include shifts in biochemical parameters, such as an increase in alkaline phosphatase and aminotransferase levels, and alterations to haematological parameters, including limited neutrophilia, eosinopenia, and lymphopenia.

Importantly, the regulatory classification states that these specific changes are not serious and are defined as reversible once the course of treatment is stopped. No specific antidote for the combination product is listed in the official prescribing information; treatment is symptomatic and supportive.


When to Seek Urgent Medical Help

Regulator-mandated guidance focuses on the risk of accidental exposure to humans. Immediate action is explicitly required if the medicine is accidentally swallowed.

In cases of human accidental ingestion, the official regulatory instructions state that a user must seek medical advice immediately and must present the package leaflet or container label to the treating physician. Similarly, if accidental contact with the medicine causes skin or eye symptoms that persist, urgent medical attention is required. This establishes the critical regulatory threshold for seeking professional help.

Therapeutic Uses of Aurizon

What Aurizon Treats: Main Uses and Benefits

This medication is applied across therapeutic domains involving certain distressing symptoms of otitis externa in dogs. It is commonly used for conditions characterized by periods of heightened symptoms that include mixed microbial infections. The formulation is intended to address the infectious components that contribute to the condition by targeting microbial populations of susceptible bacteria and pathogenic yeast.

The treatment supports the patient during difficult episodes by helping manage distressing manifestations related to significant symptoms of inflammation, such as swelling, redness, and debilitating pain or itching. It is relevant when supportive symptom management is appropriate for both acute episodes and recurrent, chronic symptom patterns of external ear inflammation. This provides support that helps ease the overall symptom burden, assisting with maintaining functional stability and supporting general well-being during symptomatic phases.

“The formulation is applied in addressing infectious components that contribute to the condition and helping manage distressing symptoms of inflammation.”

Quick Fact: Clinical Focus: Symptomatic Support The medication is commonly used when short-term symptomatic assistance is needed to assist with managing symptoms related to physical discomfort and inflammatory or irritative states.

Regulatory References

  1. UK Veterinary Medicines Directorate Summary of Product Characteristics

Eligibility and Restrictions for Use

Eligibility Profile: Who Can and Cannot Use Aurizon

Official regulatory documentation strictly defines the population for which Aurizon is eligible and the populations for whom it is prohibited or not recommended.

Allowed Population:

Classification Eligibility Status
Target Species Only for use in Dogs (canine species).
Physical Prerequisite Use is allowed only after the integrity of the tympanic membrane has been verified by a veterinary professional.

Populations For Whom Use Is Contraindicated:

The medicine must not be used in dogs under the following conditions:

  • Tympanic Membrane Perforation: Dogs confirmed to have a perforation of the eardrum are ineligible for treatment.
  • Known Hypersensitivity: Dogs with a known allergy to any of the active substances (Marbofloxacin, Clotrimazole, Dexamethasone) or other components of the formulation.
  • Reproductive Status: Pregnant, lactating, or breeding bitches are strictly ineligible.

Restricted or Advised Against:

Use is generally advised against for immature dogs due to the potential for arthropathies associated with the fluoroquinolone class of antibiotics. Caution may be advised for use in elderly dogs, a population where hearing loss has been observed in rare cases.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documentation for Aurizon (Marbofloxacin, Clotrimazol, Dexamethasone Otic Suspension) defines the interaction profile primarily around pharmacodynamic constraints and administration rules due to the topical route.

Documented Interaction Patterns

Property Classification
Medicinal Product Category Restriction Systemic Corticosteroids
Mechanistic Basis of Interaction Pharmacodynamic (Additive Glucocorticoid Effect)
Timing-based Administration Rule Must not be co-administered with other otic preparations

Official Interaction Statements and Cautions

1. Systemic Corticosteroid Co-Administration

Regulatory labels advise against using Aurizon in dogs that are already receiving systemic corticosteroid treatment for other conditions. This restriction is based on the potential for the Dexamethasone component to be systemically absorbed, resulting in an additive or cumulative glucocorticoid effect.

2. Population-Specific Interaction Caution

Caution is explicitly required when administering the product to dogs diagnosed with endocrine disorders, such as Cushing's syndrome or diabetes mellitus. The systemic effect of the absorbed glucocorticoid may exacerbate these pre-existing conditions.

3. Otic Co-administration Rule

The product label mandates a strict administration timing rule: Aurizon must not be co-administered with other otic preparations unless a veterinarian provides specific instruction to prevent localized interference.

Mechanism of Action

The product's function involves the coordinated action of three distinct pharmacological mechanisms that simultaneously target microbial agents and the resulting pro-inflammatory tissue response.

Dual-Pathway Interference with Pathogen Survival

The antibiotic Marbofloxacin acts as an inhibitor of bacterial enzymes DNA gyrase and Topoisomerase IV, thereby preventing DNA replication. Concurrently, the antifungal Clotrimazol blocks the synthesis of ergosterol by inhibiting Lanosterol 14-alpha demethylase, leading to disruption of the fungal cell membrane and subsequent cessation of biological activity.

Genomic Modulation of Inflammatory Gene Expression

The corticosteroid Dexamethasone modulates the local physiological response by acting as an agonist of the intracellular Glucocorticoid Receptor. This binding alters gene transcription, inhibiting the molecular pathways that synthesize pro-inflammatory mediators like prostaglandins and leukotrienes. This results in the inhibition of localized edema and the modulation of neural signaling associated with inflammatory pathways.

Mechanistic Synergy

The profile includes synergy: the anti-inflammatory mechanism diminishes localized edema, which results in enhanced local physical access for the anti-microbial components. This coordinated action enables the simultaneous cessation of microbial activity and the adjustment of the pro-inflammatory tissue response.

Dosage and Administration Information

The administration of Aurizon follows established procedural steps and a dosing schedule. The medicine is for auricular use, meaning it is applied topically by instilling the suspension directly into the external ear canal of dogs.


Administration Protocol and Duration

The regimen involves the application of ten drops per affected ear once daily. Before the initial administration, the external ear canal is cleaned and dried. Furthermore, the suspension is to be shaken well immediately prior to application.

Usage Parameter General Specification
Dose Amount Ten drops per affected ear
Dosing Frequency Once daily
Standard Duration 7 days initially
Extension Rule May be extended up to a maximum of 14 days following veterinary re-evaluation

Procedural Constraints

A precondition for administration is the verification of the tympanic membrane integrity by a veterinary professional. This procedural step is conducted before the treatment course begins. After the drops are administered, the base of the ear may be massaged briefly and gently to facilitate the distribution of the suspension. The fixed-dose components are delivered simultaneously via this standardized topical route, which defines the usage pattern. This framework structures the product's use within a time-bound course, subject to specific physical preconditions.

Recent Clinical Evidence

Research Evidence: Overview of Studies for Aurizon

Evidence for Use in Otitis Externa of Susceptible Bacterial and Fungal Origin

Aurizon was studied for conditions characterized by symptoms of external ear inflammation in dogs, a condition involving periods of heightened symptoms often linked to specific microbial populations. The primary evidence was evaluated in short-term, randomized controlled field trials (RCTs). These studies focused on client-owned dogs diagnosed with otitis externa where laboratory tests confirmed the presence of target bacteria sensitive to Marbofloxacin and target yeast (Malassezia pachydermatis) sensitive to Clotrimazol.

The research examined whether changes were measured in the outcomes related to physical discomfort, such as redness and swelling. The short-term field trials also monitored the microbial status of the ear canal. Research was observed in these settings to track how the target bacteria and yeast populations were affected in terms of reduction or clearance after the application of the medicine. These studies contribute to the broader evidence landscape by providing context on how the triple-combination formulation was evaluated in trials exploring the simultaneous infectious and inflammatory components of the condition.


Durability of Response and Longer-Term Follow-up Data

The primary evidence derived from short-term and intermediate follow-up studies is largely focused on short-to-intermediate-term responses. The follow-up durations were limited, with major assessments typically concluding around Day 14 or Day 21 after the start of treatment. This means that there is limited information for long-term outcomes beyond the initial treatment phase.

Consequently, the data for certain groups remain modest when considering the outcomes reflecting daily functioning or activity level over extended periods. Long-term outcomes are not fully established regarding the prevention of recurrence or the durability of the response in dogs with chronic, recurrent conditions characterized by fluctuating or episodic manifestations.

Key Studies & References Aurizon Summary of Product Characteristics (SPC) - UK Veterinary Medicines Directorate

Frequently Asked Questions (FAQ)

Common questions about Aurizon (FAQ)

Q: Is Aurizon the same type of medicine as [similar drug name]?

A: Aurizon is classified as a triple-combination veterinary otic suspension. Official documents define it by its specific composition, which includes the antibiotic Marbofloxacin, the antifungal Clotrimazole, and the corticosteroid Dexamethasone in one topical formulation. This combination and intended application are what determine its pharmacological classification.

Q: How quickly should I expect to see an effect from Aurizon?

A: Official studies used to evaluate this medicine often schedule the first formal re-evaluation of symptoms, such as physical discomfort and microbial status, as early as Day 3 or Day 7 of treatment. This suggests that initial changes and improvement may be tracked within the first week of application.

Q: Can Aurizon cause weight gain or loss?

A: Weight changes are not specifically listed as known side effects in the official product documentation. However, signs associated with systemic absorption of the corticosteroid component, such as increased thirst and increased urination, are described in relation to prolonged or intensive use.

Q: Is it necessary to take Aurizon at the exact same time every day?

A: Regulatory guidance specifies that the medicine must be administered 'once daily'. While the documentation does not mandate a specific time of day, consistency in daily administration timing is often highlighted in the context of therapeutic schedules.

Q: Do I need to change my diet while using Aurizon?

A: Official product documentation, including the sections on dosage and administration, does not specify any required dietary changes or restrictions on food consumption in connection with the topical use of this medicine.

Q: What happens if I stop taking Aurizon suddenly?

A: The official regimen describes the use of the medicine for the full recommended duration of 7 to 14 days to manage the target pathogens effectively. Stopping earlier than the prescribed duration may be associated with treatment failure or recurrence. No specific rebound effects are noted upon sudden cessation.

Q: Is Aurizon safe to use if I have kidney problems?

A: The regulatory pharmacokinetic summary notes that the antibiotic component, Marbloxacin, is eliminated primarily through urine and feces. However, no specific caution or contraindication is listed in the official documents for the topical use of this product in animals with existing kidney conditions.

Q: Does Aurizon affect sleep or cause insomnia?

A: Sleep disturbances, such as insomnia, are not explicitly listed in the frequency-classified adverse reactions section of the official product information provided by regulatory agencies.

Q: Can Aurizon change my mood or cause irritability?

A: Changes in mood or irritability are not explicitly listed in the frequency-classified adverse reactions section of the official product documentation.

Q: How is Aurizon different from generic versions?

A: Aurizon is the brand name product. When generic versions are approved by regulatory agencies, they are required to contain the same active ingredients in the same strength and dosage form, and meet the same rigorous standards for quality, purity, and performance.

Q: Does Aurizon interact with common pain relievers like ibuprofen?

A: Official interaction warnings are focused on systemic corticosteroid co-administration and simultaneous use with other otic preparations. There is no specific official warning or caution in regulatory documents regarding non-steroidal anti-inflammatory drugs (NSAIDs) or common pain relievers for this topical formulation.

Q: Can I take vitamins or supplements while using Aurizon?

A: The regulatory interaction documentation does not include specific warnings or precautions regarding the co-administration of common vitamins or dietary supplements with this topical veterinary medicine.

Q: What should I do if I miss a dose of Aurizon?

A: Instructions for managing missed doses are typically determined by a veterinary professional based on the regulatory dosing guidance. The general principle for a 'once daily' schedule is to maintain the daily dosing routine.

Q: Can Aurizon make me feel dizzy or lightheaded?

A: Dizziness or lightheadedness are not explicitly listed in the frequency-classified adverse reactions section of the official product documentation.

Q: Are there any known interactions between Aurizon and caffeine?

A: The regulatory interaction documentation does not include specific warnings or precautions regarding the co-administration of caffeine with this topical veterinary medicine.

Q: Is there an official patient leaflet or guide for Aurizon?

A: Yes, official guidance documents like the Summary of Product Characteristics (SmPC) or the Veterinary Medicines Directorate (VMD) Product Information are produced by regulatory agencies and serve as the core authoritative source for the medicine’s detailed use and safety information.

Q: Can Aurizon interact with herbal remedies like St. John's Wort?

A: The regulatory interaction documentation does not include specific warnings or precautions regarding the co-administration of herbal remedies with this topical veterinary medicine.

Q: Is the side effect profile of Aurizon different for men and women?

A: Official adverse reaction data in regulatory documents and clinical trials do not differentiate the side effect profile based on the sex of the animal being treated.

Q: Can I take Aurizon if I have a history of heart issues?

A: Cardiac conditions or a history of heart issues are not listed in the official contraindications or precautions for the use of this topical medicine.

Q: Are there any food restrictions mentioned in the official documents for Aurizon?

A: Official product documentation does not mention any restrictions on food consumption or the need to administer the drops with food, given that the medicine is applied topically.

Q: How does the body eliminate Aurizon?

A: The regulatory summary indicates that the antibiotic component, Marbofloxacin, is primarily eliminated in the active form, with roughly two-thirds excreted in the urine and one-third in the feces. The other components are noted to be poorly absorbed into the body's system.

Q: Are there common reasons why a doctor might discontinue Aurizon?

A: Regulatory guidance requires re-evaluation by the veterinarian after the initial 7 days of treatment to determine if continuation is necessary. Reasons for discontinuation described in guidance often include lack of clinical improvement after re-evaluation at Day 7, or the occurrence of an adverse reaction.

Q: Is it true that Aurizon must be taken with food?

A: This medicine is an otic suspension (ear drops) applied topically to the ear canal, and therefore, it is not taken with food.

Q: Are there any known effects of Aurizon on blood pressure?

A: Effects on blood pressure are not explicitly listed in the frequency-classified adverse reactions section of the official product documentation.

Q: Are there common long-term side effects associated with Aurizon?

A: Official documentation links effects such as thinning of the skin and suppression of adrenal function (Hypoadrenocorticism) to the prolonged and intensive use of the topical corticosteroid component.

Q: Can older adults safely use Aurizon?

A: Use is advised against in immature animals. Caution is advised for elderly animals, as rare cases of deafness or partial hearing loss, which may be transient, have been reported in this population.

Q: Why is Aurizon sometimes prescribed instead of other treatments?

A: The medicine is designed to provide a comprehensive, triple-action therapeutic benefit. It combines an antibiotic, an antifungal, and an anti-inflammatory agent in a single formulation for the concurrent management of microbial and inflammatory issues.

Q: Does Aurizon require any special monitoring or blood tests?

A: Mandatory monitoring includes veterinary verification of the eardrum integrity before initial use. While changes in certain biochemical parameters (like ALP, ALT) are known corticosteroid effects, regulatory documents do not mandate routine follow-up blood tests.

Q: What is the risk of developing a serious side effect from Aurizon?

A: Serious side effects, such as deafness or changes in certain biochemical parameters, are officially classified as Rare (1 to 10 animals per 10,000 treated) or Very Rare (less than 1 animal per 10,000 treated).

Q: Are the effects of Aurizon temporary or permanent?

A: The intended therapeutic effect is temporary, lasting for the course of treatment. The rare adverse effect of deafness has been reported to be mostly of a transient nature, although regulatory documents do not rule out the possibility of permanent cases.

Q: Why do some people say Aurizon did not work for them?

A: The medicine is only indicated for conditions caused by bacteria and fungi that are sensitive to its active ingredients. Lack of efficacy can be associated with the presence of resistant pathogens or a failure to complete the full, recommended treatment duration.

Q: Do I need a special prescription or monitoring to get Aurizon?

A: Aurizon is officially classified as a veterinary medicine subject to prescription. Mandatory monitoring required by the label includes veterinary verification of the eardrum integrity before the start of use.

Q: What is the difference between an allergy and a common side effect of Aurizon?

A: Official documentation notes that known hypersensitivity (allergy) to the ingredients is a strict contraindication (the medicine must not be used). A side effect is a potential, expected adverse reaction that is classified by frequency and is monitored during correct use.

Q: Is Aurizon associated with any skin reactions or rashes?

A: The official safety profile lists localized skin reactions, such as transient redness and inflammation at the application site, as a rarely reported side effect.

Q: Can Aurizon affect the results of common lab tests?

A: Yes, regulatory documents note that changes in biochemical and hematological parameters are usual adverse reactions associated with corticosteroids, including an increase in certain enzymes like alkaline phosphatase (ALP) and aminotransferase (ALT).

Q: Is Aurizon a controlled substance?

A: Aurizon is officially classified as a veterinary medicinal product subject to veterinary prescription. It is not classified as a controlled substance in its regulatory documents.

Q: What is the estimated 'half-life' of Aurizon in the body?

A: Due to the topical administration and very low systemic absorption of the ingredients, a precise, numerical systemic half-life is not consistently provided in primary regulatory labels. The antibiotic component is described as being eliminated slowly.

How should Aurizon be stored and disposed of?

Storage and Disposal Requirements for Aurizon

Aurizon ear drops must be stored according to specific conditions mandated by regulatory labeling to ensure product stability.


Storage and Stability

The product must not be stored above 30 C. Official requirements specify that the product must be kept out of the sight and reach of children and is designated for animal treatment only. A crucial stability rule is that the shelf life after the immediate packaging is first opened is 2 months; any remaining product must be discarded after this period. The unopened product has a shelf life of 2 years.

Disposal Instructions

Unused or expired Aurizon must not be disposed of via wastewater or household waste. Disposal must utilize national collection systems or take-back schemes for veterinary medicinal products, following local legal and regulatory requirements for pharmaceutical waste.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Aurizon found in:

A-Z Index: