Aspec-EC

ASPEK-EC

A prototype of an analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as a cyclooxygenase inhibitor, which leads to inhibition of prostaglandin biosynthesis. Aspec-EC also inhibits platelet aggregation and is used to prevent arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)

An indication is a term used to refer to a list of conditions, symptoms, or diseases for which a medication is prescribed or used by a patient. For example, acetaminophen or paracetamol is used by the patient for fever, or the doctor prescribes it for headaches or body aches. Now fever, headache and body pains are the indications of paracetamol. The patient should be aware of the indications of medications used for common conditions, because they can be taken without a prescription at the pharmacy.

For use in the temporary relief of various forms of pain, inflammation associated with various conditions (including rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, and ankylosing spondylitis), and is also used to reduce the risk of death and/or non-fatal myocardial infarction in patients with previous infarction or unstable angina. (Acute Coronary Syndrome, Arthritis, Colorectal cancer, Headache, Juvenile Idiopathic arthritis, Migraine, Pain, Pericarditis, Polycythemia, Rheumatoid arthritis, Stroke, Systemic Lupus erythematosus, Thromboembolism, Transient Ischemic Attacks, Cardiovascular Diseases, Cardiovascular Events, Colorectal adenomas, Kawasaki disease, Preeclampsia, spondyloarthropathies,)

Treatment of aches and pains associated with headaches, colds and sore throats, as well as to reduce the temperature. It can be used to reduce the risk of death and reduce the devastating effects of an acute heart attack. It is also used to reduce the risk of heart attacks and strokes in some men and women who have already had a heart attack or ischemic stroke. It can also be used for other conditions identified by your doctor.

ASPEK-EC It is a nonsteroidal anti-inflammatory drug (NSAID). It works by inhibiting several different chemical processes in the body that cause pain, inflammation, and fever. It also reduces the tendency for blood to clot.

Individual. When taken orally, the dosage of Aspec-EC International Trade Association of America depends on the indications for use. The usual adult dose when used as an antipyretic and analgesic is 500-1000 mg / day (up to 3 g) and is divided into 3 doses.

For myocardial infarction, as well as for secondary prevention in patients after a previous myocardial infarction-40-325 mg once a day (usually 160 mg). As an inhibitor of platelet aggregation - at a dose of 300-325 mg / day, for a long time. For dynamic circulatory disorders in men, cerebral thromboembolism, including for the prevention of relapse - 325 mg / day with a gradual increase to a maximum of 1 g / day. For the prevention of thrombosis or occlusion of the aortic shunt - 325 mg every 7 hours after intranasal administration of the gastric tube, and then-through the mouth 325 mg 3 times a day (usually in combination with dipyridamole, which is canceled after 1 week, continuing long-term treatment with Aspec-EC)

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What is the most important information I need to know about Aspec-EC?

This medicine is contraindicated in the following situations:

Due to the presence of lactose, the drug is contraindicated in congenital galactosemia, impaired glucose absorption and galactose or lactase deficiency.

The use of this drug is not recommended during lactation: If ingested in breast milk, this drug is not recommended for use during breastfeeding.

Concomitant use of Aspec-EC with anti-inflammatory doses (> 1 g per dose and / or ? 3 g per day), analgesics or antipyretics (> = 500 mg at a dose and / or <3 g per day), oral anticoagulants and one patient had no history of peptic ulcer disease,anti-inflammatory drugs, clopidogrel (outside the approved indications for this combination in acute coronary syndrome), low-molecular-weight heparins and related (therapeutic doses and / or the elderly), unfractionated heparin (therapeutic dose and / or elderly), ticlopidine.

Use "ASPEC" - EC as directed by your doctor. Check the label on the medicine for accurate dosage instructions.

• Take Aspek-EK orally with or without food. If an upset stomach occurs, take with food to reduce stomach irritation.
• Take Aspek-EK with a full glass of water (8 oz / 240 ml).
• Use Aspec-EC exactly as indicated on the package, unless your doctor has instructed you otherwise. If you are taking Aspec-EK without a prescription, follow all warnings and precautions listed on the label.
• If you are taking bisphosphonates (e.g., alendronate), cation exchange resins (e.g., sodium polystyrene), cephalosporins (e.g., cefpodoxime), imidazole antifungal drugs (e.g., ketoconazole), penicillamine, quinolone antibiotics (e.g., ciprofloxacin), or tetracycline antibiotics (e.g., doxycycline), do not take them simultaneously with Aspec-EC. Talk to your doctor about how you should take these other medications along with Aspec-EC.
• If you missed a dose of Aspec-EK and take it regularly, take it as soon as possible. If it's almost time for the next dose, skip the missed dose and return to your normal dosing schedule. Do not take 2 doses at once.

Ask your healthcare provider any questions you may have about how to use "ASPEC" - EC.

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Aspek-EK is used to reduce fever and relieve mild to moderate pain in conditions such as muscle aches, toothache, common colds, and headaches. It can also be used to reduce pain and swelling in conditions such as arthritis. Aspec-EC is known as salicylate and a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking a certain natural substance in your body to reduce pain and swelling. Consult your doctor before treating a child under 12 years of age.

Your doctor may advise you to take a low dose of Aspec-EK to prevent blood clots from forming. This effect reduces the risk of stroke and heart attack. If you have recently had surgery on clogged arteries (for example, bypass surgery, carotid endarterectomy, coronary stent), your doctor may advise you to use Aspec-EK in low doses as a "blood thinner"to prevent blood clots.

How to use Aspec-EC

If you are taking this medication for self-treatment, follow all instructions on the product packaging. If you are unsure of any information, contact your doctor or pharmacist. If your doctor has ordered you to take this medicine, take it exactly as prescribed.

Take this medicine by mouth. Drink a full glass of water with it (8 oz/240 milliliters), unless your doctor tells you otherwise. Do not lie down for at least 10 minutes after taking this medicine. If an upset stomach occurs while taking this medicine, you can take it with food or milk.

Swallow the intestinal-coated tablets whole. Do not crush or chew tablets covered with an intestinal-soluble coating. This can increase the upset stomach.

Do not crush or chew long-release tablets or capsules. This can release the entire drug at once, increasing the risk of side effects. Also, don't share extended-release pills unless they have a rating line and your doctor or pharmacist tells you to do so. Swallow the whole or divided tablet without crushing or chewing.

The dosage and duration of treatment depends on your state of health and response to treatment. Read the product label to find recommendations on how many pills you can take in 24 hours and how long you can self-medicate before you see your doctor. Do not take more medications or take them for longer than recommended, unless prescribed by your doctor. Use the lowest effective dose. Consult your doctor or pharmacist if you have any questions.

If you are taking this medicine to treat a headache on your own, contact your doctor immediately if you also have slurred speech, weakness on one side of your body, or sudden changes in vision. Before using this medicine, consult your doctor or pharmacist if you have headaches caused by head trauma, coughing, or flexion, or if you have a headache with persistent / severe vomiting, fever, and neck stiffness.

If you take this medicine as needed (rather than on a regular schedule), remember that pain medications work best if they are used when the first signs of pain appear. If you wait until the pain gets worse, the medication may not work. Aspec-EC with a special coating (intestinal-soluble coating) or slow release may take longer to stop the pain because it is absorbed more slowly. Ask your doctor or pharmacist to help you choose the best type of Aspec-EC for you.

You should not take this medication for self-treatment of pain for longer than 10 days. You should not use this medication for self-treatment of a fever that lasts more than 3 days. In these cases, see your doctor, because you may have a more serious condition. Tell your doctor immediately if you experience tinnitus or hearing problems.

If your condition persists or worsens (for example, new or unusual symptoms, redness/swelling of the painful area, pain/fever that does not go away or gets worse) or if you think you may have a serious medical problem, tell your doctor immediately.

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What other drugs will affect Aspec-EC?

When used simultaneously, antacids containing magnesium and / or aluminum hydroxide slow down and reduce the absorption of Aspec-EC.

With the simultaneous use of calcium channel blockers, agents that limit the intake of calcium or increase the excretion of calcium from the body, the risk of bleeding increases.

When used simultaneously with Aspec-EC, the effect of heparin and indirect anticoagulants, hypoglycemic agents, sulfonylureas, insulin, methotrexate, phenytoin, and valproic acid increases.

With the simultaneous use of Aspek-EK with SCS, the risk of developing an ulcerogenic effect and the occurrence of gastrointestinal bleeding increases.

With simultaneous use of decreasing the effectiveness of diuretics (spironolactone, furosemide).

When used concomitantly with other NSAIDs, the risk of side effects increases. Aspec-EC can reduce the plasma concentrations of indomethacin, piroxicam.

With the simultaneous use of gold preparations, Aspek-EK can induce liver damage.

With simultaneous use, the effectiveness of uricosuric drugs (including probenecid, sulfinpyrazone, benzbromarone) decreases.

With simultaneous application Aspects of EC and alendronate sodium may develop severe esophagitis.

With the simultaneous use of griseofulvin, the absorption of Aspec-EC may be impaired.

There is one known case of spontaneous hemorrhage in the iris when taking Ginkgo Biloba extract against the background of long-term use of Aspek-EK at a dose of 325 mg / day. It is believed that this may be due to an additive inhibitory effect on platelet aggregation.

With the simultaneous use of dipyridamole, it is possible to increase the C_max. salicylate in plasma and AUC.

When used concomitantly with Aspec-EC, the concentration of digoxin, barbiturates and lithium salts in the blood plasma increases.

With the simultaneous use of salicylates in high doses with carbonic anhydrase inhibitors, intoxication with salicylates is possible.

Aspec-EC at doses of less than 300 mg has little effect on the effectiveness of captopril and enalapril. When you receive ASPEK-EK in high doses may decrease the effectiveness of captopril and enalapril.

With simultaneous application of caffeine increases the rate of absorption, plasma concentrations and bioavailability Aspects of EC.

With the simultaneous use of Aspec-EC with metoprolol, it is possible to increase the C_max. salicylate in the blood plasma.

When using pentazocin against the background of long-term use of Aspec-EC in high doses, there is a risk of severe adverse reactions from the kidneys.

When used concomitantly, phenylbutazone reduces uricosuria caused by Aspec-EC.

With the simultaneous use of ethanol, it is possible to increase the effect of Aspek-EK on the gastrointestinal tract.

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What are the possible side effects of Aspec-EC?

The circulatory system: Hypotension, palpitations, tachycardia, and changes in electrocardiogram patterns may occur rarely.

Nervous System: If drowsiness, dizziness, sleep disorders, headache, tremor or infrequently anaphrodisia, agitation, hypomnesis,oculomotor crisis, paresthesia, dysarthria and ataxia occur, the dose of the drug should be reduced or discontinued.

Hypersensitivity: If a hypersensitivity symptom, such as a rash, appears, Aspec-EC should be discontinued.

Hematological effects: If hemopathy, such as leukopenia, occurs, Aspec-EC should be discontinued.

Hepatic effects: It is possible to increase the level of glutamine oxaloacetic transaminase, glutamine pyruvate transaminase, lactate dehydrogenase.

Gastrointestinal effects: Possible dipsia, constipation, anorexia, infrequently nausea, vomiting, diarrhea and abdominal pain.

The endocrine system: Inadequate antidiuretic hormone (SIADH) syndrome, such as hyponatremia, hypotonic symptom, isostenuria convulsions, and blurred consciousness, has been reported in patients treated with a similar compound (amitrypsin).

Other Adverse Reactions: It may be weariness, urinary retention and rinkles.