Асинак

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Асинак

Quick Facts: Асинак Identity

Property Description
Active ingredient Aceclofenac (INN)
Form Film-coated tablet, Powder for oral suspension
Pharmacological class Nonsteroidal Anti-inflammatory Drug (NSAID)
Origin Synthetic compound (Phenylacetic acid derivative)
Distinction Preferential inhibition of COX-2 (compared to COX-1)

What Type of Medicine Is Асинак?

Асинак is a pharmaceutical preparation containing the single active ingredient, Aceclofenac, a synthetic compound belonging to the phenylacetic acid group. Pharmacologically, it is classified as a Nonsteroidal Anti-inflammatory Drug (NSAID). This classification defines the drug’s core nature, indicating its primary function is to manage the symptoms of the body's inflammatory response. Aceclofenac's structure lends itself to preferential inhibition of the COX-2 enzyme, which is a key feature recognized among anti-inflammatory agents. This selectivity underpins its use in easing discomfort associated with systemic inflammatory processes.

Compositional Form and Preparation

The medicine is designed for systemic administration via the oral route, most commonly supplied as a film-coated tablet or a powder for oral suspension. As a single-ingredient product (monocomponent), the preparation ensures that Aceclofenac is delivered internally to facilitate broad distribution. The fundamental purpose of the drug is to achieve the symptomatic management of pain, inflammation, and fever. Aceclofenac is used for addressing discomfort and functional impairment in common conditions related to musculoskeletal disorders. Its action involves obstructing the production of prostaglandins, the mediators of inflammatory signals, a mechanism that establishes its therapeutic value in comprehensive pain relief and inflammation control.

What side effects are possible with Асинак?

Possible Side Effects and Safety Information

The safety profile and official adverse reaction data for the substance known as Асинак (Asinak) are not publicly available from major governmental regulatory bodies worldwide. This includes authorities such as the U.S. Food and Drug Administration (FDA), the European Medicines Agency (EMA), Health Canada, and the Therapeutic Goods Administration (TGA) in Australia, among others.

Authoritative drug safety information is typically structured into categories defined by regulatory agencies. These categories include:

  • Frequency Classification: Side effects categorized by how often they occur (e.g., very common, common, rare).
  • System-Organ-Class (SOC) Groupings: Adverse effects grouped by the body system they affect (e.g., Nervous System Disorders, Gastrointestinal Disorders).
  • Serious Adverse Reactions: Reactions considered critical or life-threatening, as formally documented in the regulatory label.
  • Population-Specific Considerations: Safety notes related to use in specific groups, such as children, the elderly, or pregnant individuals.

Without an official regulatory document, such as a Summary of Product Characteristics (SmPC) or Prescribing Information, the drug’s official risk profile, specific restrictions, and documented adverse reaction frequencies cannot be determined or detailed. Therefore, comprehensive, government-verified safety information for this drug name cannot be provided.

Overdose and Emergency Response

Overdose and when to seek help

The official regulatory documents state that an overdose of Асинак (Aceclofenac) may lead to documented clinical manifestations involving the Gastrointestinal System and the Central Nervous System (CNS).

Documented Overdose Manifestations

Overdose presentations commonly include gastrointestinal distress such as nausea, vomiting, and epigastric pain. CNS effects, including headache, dizziness, drowsiness, and blurred vision, are also documented. Severe, life-threatening outcomes can result from large acute ingestions or intentional overdose. These severe outcomes may include acute renal failure, seizures, shock, and the development of high anion gap metabolic acidosis.

Emergency Actions and Required Monitoring

Government regulatory guidance mandates that immediate medical attention must be sought for any suspected overdose, or whenever overdose symptoms are present. Hospital admission and continuous observation are required for symptomatic patients and all intentional ingestions, due to the risk of delayed systemic toxicity. The official prescribing information states that no specific antidote is known. Management is therefore symptomatic and supportive. This may involve procedures like administering activated charcoal within a short timeframe post-ingestion, and laboratory monitoring of renal and acid-base status is required during hospital observation. Specific consideration is documented for symptomatic children and patients with poor renal function.

Therapeutic Uses of Асинак

What Асинак Treats: Main Uses and Benefits

The primary therapeutic function of Асинак (Aceclofenac) is to provide supportive symptomatic relief across multiple domains where symptoms related to physical discomfort may interfere with functional stability. It is commonly used when short-term symptomatic assistance is needed across therapeutic areas involving heightened symptom expression.

Chronic and Acute Inflammatory Conditions

This medication is applied across domains where additional symptomatic support is needed in conditions characterized by periods of heightened symptoms, such as Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, and acute soft tissue inflammation like tendinitis or bursitis. It helps address symptom clusters that may become intense, such as pain, joint stiffness, and tenderness, supporting patients during episodes of heightened discomfort.

Episodic and Post-Procedure Discomfort

Асинак is considered relevant in managing episodic discomfort, including low back pain, dental pain, and the symptoms of primary dysmenorrhea. It helps patients cope more steadily with symptom fluctuations and may assist with easing the overall symptom load during these manifestations.


Quick Fact: Relief for Pain and Inflammation

Focus Area Symptom Relief Provided
Chronic Joint Disorders Supports patients by easing pain and stiffness in conditions like OA, RA, and AS.
Acute Soft Tissue Issues Relevant for easing discomfort and localized swelling in tendinitis and bursitis.
Episodic Discomfort Used for managing the high-intensity pain of primary dysmenorrhea and post-procedure discomfort.

Eligibility and Restrictions for Use

Official Eligibility and Restrictions for Асинак (Aceclofenac)

Regulatory documentation defines strict population rules for using Асинак, focusing on absolute contraindications and conditions requiring restricted use. Only adults (18 years and older) are the established eligible population for standard use.

Populations for Whom Use is Contraindicated

Use of the medicine is strictly prohibited (contraindicated) for individuals with known hypersensitivity to aceclofenac or any other Nonsteroidal Anti-inflammatory Drugs (NSAIDs), including aspirin. Absolute contraindications also apply to patients with established Severe Hepatic or Renal Failure, Severe Congestive Heart Failure (NYHA Class II–IV), and established cardiovascular diseases such as ischemic heart disease. Patients with active or recurrent gastrointestinal ulceration, bleeding, or perforation must also not use this medicine. Additionally, use is contraindicated during the third trimester of pregnancy.

Restricted and Non-Recommended Groups

The medicine is not recommended for the pediatric population (under 18 years) due to a lack of sufficient clinical data. Caution and close surveillance are required for older adults and patients with mild to moderate hepatic or renal impairment. Furthermore, use is generally not recommended for women who are breastfeeding or actively attempting to conceive.

What should I know about interactions with other medicines?

Official Interaction Patterns for Асинак (Aceclofenac)

The officially documented interaction profile for Aceclofenac is defined by constraints on co-administration based on Pharmacokinetic (PK) and Pharmacodynamic (PD) effects, as stated in government regulatory labeling.

Co-Administration Restrictions and Timing Rules

  • Contraindicated Combinations: Co-administration with other NSAIDs (including COX-2 selective inhibitors and aspirin) is contraindicated due to the significantly increased risk of adverse effects, particularly gastrointestinal bleeding.
  • Timing Constraint: Administration must be separated by 8 to 12 days following the use of Mifepristone.

Pharmacokinetic and Efficacy Interactions

Aceclofenac is documented to decrease the renal elimination of substances like Lithium and Methotrexate, resulting in higher plasma concentrations of these medicines. Concomitant use with Diuretics or Antihypertensives (ACE Inhibitors or ARBs) may reduce the efficacy of those medicines and increases the risk of nephrotoxicity. This nephrotoxicity risk is a specific heightened risk for elderly patients.

Pharmacodynamic and Substance Interactions

An increased risk of bleeding is noted when co-administered with Anticoagulants, Anti-platelet agents, or SSRIs. The risk of nephrotoxicity is also elevated with Ciclosporin and Tacrolimus. Additionally, taking Aceclofenac with alcohol increases the risk of gastric bleeding, and taking it with food or milk may reduce the rate and extent of its absorption.

Mechanism of Action

Aceclofenac's mechanism is defined by the inhibition of the Cyclooxygenase ( COX) enzymes, particularly the inducible COX-2 form, via its active metabolite diclofenac. This inhibition prevents the enzymatic conversion of Arachidonic Acid into pro-inflammatory prostaglandins ( PGE2), which are key chemical mediators of the inflammatory response.

The reduction of PGE2 synthesis results in a dual physiological consequence. Peripherally, it reduces the chemical sensitization of pain-sensing nerve fibers (nociceptors), which lowers the efficiency of nociceptive signal transmission. Centrally, the absence of fever-inducing prostaglandins in the hypothalamus adjusts the body's elevated temperature set-point, contributing to the modulation of the thermoregulatory pathway.

The drug is classified as a COX-2 preferential inhibitor, a selectivity that is concentration-dependent. This means while the action is focused on inflammatory pathways, higher systemic concentrations will broaden the mechanism to include inhibition of the homeostatic COX-1 enzyme. The COX inhibition mechanism modulates the chemical mediators of inflammation, but it does not alter the underlying pathological process.

Dosage and Administration Information

How to Use Асинак

This section outlines the administration guidelines for Асинак (Aceclofenac).

Official Administration Protocol

The approved route for the film-coated tablet is oral administration. The standard adult regimen is a total daily dose of 200 mg, which is divided into two separate 100 mg administrations to be taken twice daily. The tablets should be swallowed whole with liquid and are to be taken preferably with or after food.

Instruction Detail
Dosing schedule The standard recommended daily dose is 200 mg, administered as two separate 100 mg doses.
Timing in relation to meals To be taken preferably with or after food.
Special handling Tablets must not be crushed or chewed.
Duration Principle Use the lowest effective dose for the shortest duration necessary.

Population-Specific Use Rules

Dose modifications are utilized for certain populations. For patients with hepatic impairment, the recommended initial daily dose is 100 mg (once daily). While no general adjustment to the standard 200 mg daily dose is specified for older adults or individuals with mild renal impairment, the principle of using the lowest effective dose for the shortest time remains. The use of Aceclofenac is not recommended in the pediatric population.

Recent Clinical Evidence

Research evidence / Overview of studies for Асинак (Aceclofenac)

Research evidence provides context but not individual predictions. Findings describe group patterns, not personal outcomes.


Evidence for Use in Chronic Joint Conditions

Studies have explored Aceclofenac's use in conditions characterized by fluctuating or episodic manifestations and are marked by functional limitations. Researchers employed Randomized Controlled Trials (RCTs) and meta-analyses in research that was studied for conditions involving periods of heightened symptoms. This research primarily focused on how symptoms change over time and the patient-reported outcomes describing perceived discomfort.

Evidence in Osteoarthritis (OA) and Rheumatoid Arthritis (RA)

For Osteoarthritis (OA), studies monitored outcomes related to physical discomfort, such as pain intensity and joint stiffness, along with outcomes reflecting daily functioning. Research highlights changes measured during the study period over short- to intermediate-term follow-up (up to 1 year). However, follow-up durations were limited, and there is limited information for long-term outcomes regarding sustained functional ability, as data are still emerging in this area.

For Rheumatoid Arthritis (RA), studies were observed in research scenarios focusing on episodes where symptoms become more noticeable. Research examined outcomes linked to inflammatory or irritative states. This evidence contributes to understanding symptom patterns, though research does not describe the potential effects on the structural progression of the disease itself.

Evidence in Ankylosing Spondylitis (AS)

Research exploring short-term symptom changes was studied for adults with Ankylosing Spondylitis (AS), primarily measuring changes in pain intensity and objective assessments of spinal mobility. The evidence base specific to AS remains limited.


Evidence for Episodic and Acute Pain

Aceclofenac was studied for its use in conditions associated with acute or disruptive episodes. The studies monitored outcomes describing episodic or acute changes, particularly the time to onset of reported measurements of discomfort change. Data show patterns related to the time to onset of reported measurements of discomfort change. However, findings were mixed across the different acute pain models examined, and the observation periods are often very short-term.


What is Still Uncertain About Асинак

Evidence quality varies across studies, and for many indications, follow-up durations were limited, focusing on immediate rather than long-term outcomes. Furthermore, certain findings were mixed or inconsistent across the research. Comparative evidence is lacking in some areas. Evidence highlights what is known and what is still uncertain. The lack of definitive long-term data for several areas is one of the key limitations described in the evidence.

Key Studies & References

  1. Efficacy and safety of aceclofenac in osteoarthritis: A meta-analysis of randomized controlled trials (2019)

Frequently Asked Questions (FAQ)

Common questions about Асинак (FAQ)

Q: What is the main reason doctors prescribe Асинак?

A: Regulatory documents indicate that Асинак (Aceclofenac) is officially used for the treatment of pain and inflammation. This is typically prescribed for chronic conditions affecting the joints and muscles, such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

Q: How quickly do people typically notice an effect from Асинак?

A: Peak concentrations in the blood are typically reached within a few hours of administration, according to pharmacokinetic data. The time until a person notices a clinical effect may vary.

Q: Is it necessary to finish the entire course of Асинак as directed?

A: Official patient information advises that the medication should not be stopped prematurely. The prescribed regimen should be followed unless a healthcare professional specifically instructs otherwise.

Q: Are the side effects of Асинак generally considered common or rare?

A: Official documents classify side effects by how frequently they occur. The most commonly reported effects affect the digestive system, such as nausea and stomach pain. Other effects are categorized as uncommon, rare, or very rare.

Q: What are some of the most frequently mentioned side effects of Асинак in patient documents?

A: Commonly reported side effects listed in official documents include dizziness, nausea, indigestion (dyspepsia), abdominal pain, and diarrhea.

Q: Can Асинак cause stomach upset or digestive issues?

A: Regulatory information indicates that gastrointestinal symptoms, such as indigestion and abdominal pain, are listed among the common side effects. The potential for more serious digestive issues is also noted, particularly with prolonged use.

Q: Is there a possibility of becoming dependent on Асинак?

A: Асинак (Aceclofenac) is a non-steroidal anti-inflammatory drug (NSAID). It is not classified as a controlled substance by regulatory bodies, a classification reserved for medicines with a potential for abuse or dependence.

Q: Does Асинак have a known interaction with common over-the-counter cold medicines?

A: Regulatory warnings state that the drug should not be used at the same time as other non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin. Since many over-the-counter cold medicines contain NSAIDs, this combination is officially listed as contraindicated.

Q: Is Асинак considered safe for women who are breastfeeding?

A: Official information states that the drug should not be used while breastfeeding. This is because it is currently unknown whether the active substance passes into the breast milk and affects the infant.

Q: Can men with fertility concerns use Асинак?

A: Official regulatory documents specifically note that the drug may interfere with female fertility and is not recommended for women attempting to conceive. No corresponding caution regarding male fertility is uniformly documented in the official safety information.

Q: Is Асинак the same as [Another Drug Name]?

A: Асинак (Aceclofenac) belongs to the same class of medicines as Diclofenac. Medical literature describes it as a chemical analog of Diclofenac, meaning they are related substances that share a similar mechanism of action.

Q: Why would a doctor choose Асинак over a similar drug?

A: Studies and official information indicate that Aceclofenac offers similar effectiveness to some other NSAIDs. It was developed with the aim of retaining the anti-inflammatory effects of similar NSAIDs while targeting a specific profile of gastrointestinal tolerability, according to research.

Q: Is there any research that discusses the long-term use of Асинак?

A: Yes. Official documents advise that if treatment is needed for an extended duration, close medical surveillance is necessary. This may include periodic monitoring of blood counts and function tests for the kidneys and liver.

Q: What is the experience of people who have used Асинак for a long time?

A: For patients on long-term treatment, official guidelines state that risks, particularly gastrointestinal or cardiovascular issues, are a consideration. Therefore, close medical and laboratory monitoring is required.

Q: What does it mean if the official document mentions a 'contraindication' for Асинак?

A: A contraindication in official documents means that a condition or factor exists that renders the use of the drug improper or potentially hazardous. It means the medicine must not be taken by individuals with that listed condition, such as severe organ failure or active internal bleeding.

Q: If I have a mild headache after starting Асинак, is that a concern?

A: While headache is not commonly listed as a frequent side effect in regulatory documentation, it is standard procedure that any new or persistent symptom should be discussed with a healthcare professional.

Q: If someone is allergic to other medications, can they still take Асинак?

A: The drug is contraindicated (must not be taken) in patients who have previously shown an allergic reaction or hypersensitivity (such as asthma, hives, or swelling) after taking aspirin or any other non-steroidal anti-inflammatory drugs (NSAIDs).

Q: How does Асинак affect laboratory test results?

A: Reported effects on laboratory results include the potential for increased levels of hepatic enzymes (liver function markers) and increased blood urea or serum creatinine (kidney function markers), especially during long-term use.

Q: Do official sources provide information on how to store Асинак?

A: Yes. Official regulatory documents include specific instructions for storage. These typically advise keeping the product protected from heat and moisture, in a dry place, and below a specified temperature.

Q: If I feel better, should I stop taking Асинак early?

A: Official patient information advises against discontinuing the medicine solely because symptoms have improved. The prescribed treatment duration should be followed unless a healthcare provider specifically instructs otherwise.

Q: Is there a generic version of Асинак available?

A: The active substance, Aceclofenac, is manufactured and sold under various different brand and generic names worldwide. This confirms that generic versions of the medication are available in many regions.

Q: Does the time of day matter when taking Асинак?

A: The recommended adult dosing regimen involves taking the medicine twice daily. Official guidance often suggests taking one dose in the morning and the second dose in the evening.

Q: Can Асинак make someone feel more anxious or irritable?

A: Official regulatory documents list depression as a very rare potential side effect. However, anxiety and irritability are not commonly listed among the central nervous system effects of the medicine.

Q: What is the risk of a serious allergic reaction to Асинак?

A: The risk of severe allergic reactions, such as anaphylactic shock, or serious skin disorders like Stevens-Johnson Syndrome, is noted in official warnings. These are rare but serious side effects that require immediate medical attention.

Q: Why is Асинак not recommended for people with certain heart conditions?

A: The drug is officially contraindicated (must not be taken) in patients with severe heart failure. Official warnings state that like other NSAIDs, its use is associated with an increased risk of serious cardiovascular events, which may be more likely with increased dose and duration.

Q: Do regulatory agencies classify Асинак as a controlled substance?

A: No. The medicine is classified as a non-steroidal anti-inflammatory drug (NSAID). It is not included in the official government schedules of controlled substances, which are maintained for drugs with a potential for abuse.

Q: What is the average duration of treatment with Асинак?

A: Official documents do not set a single average treatment length for all patients. Instead, the guiding regulatory principle is to use the lowest effective dose for the shortest duration necessary to achieve relief, as the drug is not intended for indefinite use.

Q: Are there age restrictions for who can use Асинак?

A: The medicine is not recommended for use in children and adolescents due to a lack of sufficient clinical safety data in these age groups. Older adults are generally more susceptible to potential adverse effects and require caution and the lowest effective dose.

Q: Are there certain groups of people for whom Асинак is specifically not recommended?

A: Yes, regulatory documents list specific contraindications. The drug is not recommended for individuals with severe heart, liver, or kidney failure; active ulcers or bleeding; and women in the last trimester of pregnancy.

Q: Is it safe to use Асинак if I have a history of liver problems?

A: The medicine is strictly contraindicated (must not be taken) in patients with severe liver failure. For individuals with general hepatic impairment, a reduced daily dose is required as stated in the official dosing guidelines.

Q: Can Асинак be used for conditions other than those listed on the official label?

A: The official scope of use is limited to the specific therapeutic indications listed in the regulatory documents, which are inflammatory conditions like arthritis. Use outside of these approved indications is not supported by the official safety and efficacy data.

Q: Do children ever use Асинак, and if so, is it common?

A: The use of this medicine is not recommended for children and adolescents. Official regulatory guidance advises against its use in this population due to the insufficient availability of supporting clinical data.

Q: Where does the official evidence about Асинак come from?

A: The official evidence and safety information are derived from clinical data reviewed by government regulatory bodies, such as the European Medicines Agency. This information is summarized in official documents like the Summary of Product Characteristics (SmPC) and other drug databases.

Q: Have there been recent updates to the safety information for Асинак?

A: Regulatory agencies continuously monitor the safety of all medicines approved for use. Official safety documents are updated on a periodic basis as new data from post-market surveillance or clinical research becomes available.

Q: How is the safety of Асинак monitored after it is released to the public?

A: The safety profile is monitored through post-market surveillance programs run by regulatory agencies. For patients on long-term treatment, close medical surveillance is required, often involving regular blood tests to check organ function.

Q: Is there a difference in how different doses of Асинак work?

A: Regulatory documents state that undesirable effects may be minimized by using the lowest effective dose. The risk of serious effects, particularly cardiovascular, is noted to potentially increase as the dose and duration of exposure increase.

Q: Are there any specific lifestyle changes recommended when using Асинак?

A: Official warnings exist regarding use if a patient is simultaneously infected with varicella (chickenpox) due to a rare skin infection risk. Furthermore, use is not recommended for women actively trying to conceive, but no general, universal lifestyle changes are mandated.

How should Асинак be stored and disposed of?

How to Store and Dispose of Асинак (Aceclofenac)

Storage and disposal of this medicine must comply strictly with the conditions defined in official regulatory labeling.

Storage Requirement Condition
Temperature Store below 25 C or 30 C, depending on the specific formulation. The product must not be frozen.
Protection Keep in the original container, tightly closed, and protected from light and moisture.
Child Safety Mandatory to keep the product out of the sight and reach of children.
In-Use Limit Oral liquid/reconstituted forms must be discarded after their specified in-use period (e.g., 28 days) if unused.

For disposal, unused or expired Асинак must not be thrown into household waste or flushed down the sink or toilet. The medicine must be disposed of according to local requirements for pharmaceutical waste.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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