Artrocol

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Artrocol

Property Description
Active ingredient Ketoprofen
Form Multiple (Gel, Cream, Tablet, Injection, etc.)
Pharmacological class Nonsteroidal Anti-inflammatory Drug (NSAID)
Common general purpose Relieving pain and inflammation
Origin Synthetic (Propionic acid derivative)

Artrocol: What Type of Medicine Is It?

Artrocol is a medicinal preparation whose sole active substance is Ketoprofen, which is classified pharmacologically as a potent Nonsteroidal Anti-inflammatory Drug (NSAID). This high-level classification establishes the drug's fundamental role in managing the symptoms of pain and swelling. Chemically, Ketoprofen is identified as a Propionic acid derivative, a designation shared by substances of similar synthetic origin, and is clinically recognized for its robust action profile. Artrocol is designated as a single-ingredient product (monotherapy), relying exclusively on the established effects of Ketoprofen to achieve its therapeutic goals. The efficacy of this pharmacological class for reducing inflammation contributes to its use as a verified tool for symptomatic relief.

Artrocol’s Composition and Available Forms

The core constituent of Artrocol is the synthetic compound Ketoprofen, offered in a wide spectrum of dosage form(s) to address various patient needs. These include preparations for localized use such as Gel and Cream (for Topical application to the skin) and forms intended for systemic effect, such as Tablet, Suppository, and Solution for injection. This range of forms is a key feature, allowing selection of the optimal Route of administration based on whether the discomfort requires local relief or a comprehensive Systemic effect throughout the body.

General Purpose of Artrocol: Relieving Inflammation and Pain

The primary general purpose of Artrocol is to mitigate the key physical manifestations of discomfort, such as acute soreness or chronic stiffness. As an NSAID, the drug provides a valuable triple-action benefit: it acts as a strong Analgesic (pain reliever), a potent Anti-inflammatory agent, and an Antipyretic (fever reducer). This comprehensive symptomatic management defines its therapeutic role in addressing conditions where swelling and acute or chronic discomfort are present.

What side effects are possible with Artrocol?

Possible Side Effects and Safety Information

Artrocol, as an NSAID (Nonsteroidal Anti-inflammatory Drug), carries prominent regulatory warnings regarding serious adverse reactions that can occur without prior symptoms.

Serious Adverse Reactions (Boxed Warnings)

  • Cardiovascular Thrombotic Events: Use of this medicine is associated with an increased risk of serious, and potentially fatal, cardiovascular (CV) thrombotic events, including myocardial infarction (heart attack) and stroke. This risk may increase with higher doses and longer duration of use. The drug is contraindicated for the treatment of pain right before or after coronary artery bypass graft (CABG) surgery.
  • Gastrointestinal (GI) Events: The drug can cause serious, sometimes fatal, GI adverse effects, including bleeding, ulceration, and perforation of the stomach or intestines. This risk is greater in elderly patients and those with a prior history of peptic ulcer disease or GI bleeding.

Common Adverse Reactions

The most frequently reported adverse events primarily involve the gastrointestinal and nervous systems. These include:

System Organ Class Common Reactions (Frequency 1% to 10%)
Gastrointestinal Disorders Abdominal pain, indigestion (dyspepsia), nausea, diarrhea, constipation, flatulence.
Nervous System Disorders Headache, dizziness.
General Disorders Edema (fluid retention), and fatigue.

Safety Considerations

  • Pregnancy: The use of Artrocol is generally contraindicated late in pregnancy (from about 20 weeks gestation) due to the risk of fetal kidney problems and premature closure of a fetal heart duct.
  • Hypersensitivity: The drug is contraindicated in patients with a known history of asthma, hives, or other allergic-type reactions after taking aspirin or other NSAIDs.
  • Dose/Duration: To minimize potential risks, the lowest effective dose should be used for the shortest duration necessary.

Overdose and Emergency Response

Overdose and when to seek help

Official regulatory documents define the Artrocol (Ketoprofen) overdose profile by detailing documented manifestations and mandated emergency actions.

Documented Overdose Presentations

System Affected Regulatory-Listed Signs and Symptoms
Gastrointestinal Nausea, Vomiting, Epigastric pain, Abdominal pain
Central Nervous System Lethargy, Drowsiness, Headache, Dizziness, Convulsions

Severe Outcomes and Emergency Action

Overdose may lead to severe systemic complications. Regulatory sources document risks of gastrointestinal bleeding, acute renal failure, and CNS depression that can advance to respiratory depression and coma. Authorities explicitly mandate that individuals must seek immediate medical attention for suspected overdose.

Supportive Management and Antidote Status

There is no specific antidote known for Ketoprofen overdose. Therefore, management is required to be symptomatic and supportive. Procedures described in labeling may include measures such as gastric emptying or the administration of activated charcoal for recent, large ingestions. Hospital monitoring and observation for several hours are often required, particularly in cases involving the Elderly or those with underlying Renal or Hepatic impairment due to increased susceptibility to severity.

Therapeutic Uses of Artrocol

What Artrocol treats: main uses and benefits

Artrocol (Ketoprofen) is a non-steroidal anti-inflammatory drug (NSAID) used for the symptomatic management of discomfort and inflammatory processes. It is applied in clinical cases where additional relief is required to address physical strain and inflammation.

Ketoprofen is utilized to manage symptoms related to physical discomfort in conditions characterized by periods of heightened sensitivity. This includes the pain, tenderness, swelling, and stiffness associated with osteoarthritis and rheumatoid arthritis. It is also used to assist with the symptoms of menstrual pain.

Relief for Pain and Inflammation in Joints and Muscles

This medication is relevant for managing symptom clusters that interfere with daily comfort in musculoskeletal conditions. Artrocol is used when symptoms create noticeable physiological strain in chronic conditions like arthritis, providing support that helps ease the overall symptom burden during flare-ups.

Management of Acute Symptomatic Episodes

Artrocol is applied in settings involving acute or unstable symptom patterns, such as sudden episodes of discomfort from injuries like sprains, or for primary dysmenorrhea. It is used when symptoms intensify and relief is necessary to maintain functional stability, supporting patients during periods of heightened physical distress.


Quick Fact: Symptomatic Support for Musculoskeletal Discomfort

Artrocol is used for easing symptoms related to inflammatory or irritative states in joints and soft tissues, helping to manage symptom fluctuations.

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Artrocol, which contains the NSAID Ketoprofen, has specific eligibility rules and exclusions mandated by regulatory bodies like the FDA and EMA.

Official Contraindications

Use is absolutely prohibited for patients with a documented hypersensitivity to Ketoprofen, Aspirin, or any other NSAID, or a history of NSAID-induced asthma or severe allergic reactions. The medicine must not be used in cases of active gastrointestinal ulceration or bleeding, severe renal, hepatic, or heart failure, or conditions leading to hemorrhagic diathesis (bleeding tendency). It is also contraindicated for treating peri-operative pain during CABG surgery and during the third trimester of pregnancy.


Restricted and Conditional Use

Population Regulatory Status
Pediatric (Systemic) Safety and effectiveness not established.
Older Adults (Geriatric) Use requires close monitoring due to increased risk of GI and renal effects.
Pregnancy (1st/2nd Trimesters) Not recommended unless clearly necessary; use minimal dose and duration.
Lactating Women Not recommended; safety is not determined.
Impaired Organ Function Conditional use in non-severe cases; requires monitoring and dosage limits.
Attempting Conception Not recommended due to potential impairment of female fertility.

These official eligibility statements define that use is primarily established for non-restricted adults, while imposing formal exclusions and cautionary measures for other specific populations and clinical states.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documents define the interaction profile of Artrocol (Ketoprofen) based on pharmacokinetic and pharmacodynamic mechanisms. Co-administration is formally contraindicated with other Nonsteroidal Anti-inflammatory Drugs (NSAIDs), including high-dose salicylates and COX-2 selective inhibitors. Use is also contraindicated for the treatment of perioperative pain in the setting of Coronary Artery Bypass Graft (CABG) surgery.

The regulatory profile highlights a significant risk of pharmacodynamic intensification when combined with substances affecting hemostasis. This includes oral anticoagulants (e.g., Warfarin), antiplatelet agents, corticosteroids, and Selective Serotonin Reuptake Inhibitors (SSRIs), which together carry a synergistic risk of serious gastrointestinal bleeding. Additionally, the efficacy of Diuretics and ACE Inhibitors may be diminished, and the combination increases the risk of acute renal failure.

Regarding pharmacokinetic exposure, Ketoprofen may elevate the plasma concentration and increase the toxicity of drugs like Lithium and Methotrexate due to reduced clearance. For high-dose Methotrexate, the label specifies a mandatory separation, stating it must not be administered within 12 hours before or after Ketoprofen treatment. The use of alcohol is also documented as exacerbating the risk of gastrointestinal bleeding.

Mechanism of Action

Enzyme-Targeted Pathway Modulation: The Eicosanoid Cascade

The core of Artrocol’s mechanism involves the non-selective inhibition of the enzymes Prostaglandin G/H synthase 1 (COX-1) and Prostaglandin G/H synthase 2 (COX-2). By binding to the active sites of these enzymes, the drug blocks the conversion of arachidonic acid into prostaglandins and other chemical mediators. This action halts the initial step in the Arachidonic Acid Cascade, which modulates the activity of mediators that are integrated into inflammatory and nociceptive signaling pathways.


Modulation of Nociception and Systemic Signaling

By suppressing prostaglandin synthesis, the drug modifies early molecular steps that normally sensitize peripheral nerve endings to stimuli. This modulation of the Nociceptive System results in a physiological effect characterized by reduced afferent signal transmission from peripheral nerve terminals. The mechanism influences hypothalamic thermoregulation by reducing PGE2 synthesis, engaging pathways that shift the set point for body temperature in response to elevated mediator activity.


Homeostatic Mechanisms and Pharmacological Constraints

The drug engages mechanisms that influence feedback regulation within pathways by acting on both COX forms. The inhibition of COX-1 affects systems where homeostatic mediators dominate, such as those that maintain the gastric mucosal barrier and regulate renal blood flow. This results in a modification of processes beyond inflammation, including a limitation on platelet aggregation due to reduced TXA2 production.

Dosage and Administration Information

How to Use Artrocol: Administration Guidelines

Artrocol, containing the active substance Ketoprofen, is administered according to guidelines that define its usage patterns, routes, and dosing schedules. These parameters govern how the medicine is prepared and taken.


Administration Routes and Forms

Ketoprofen is available for both systemic and localized use. The systemic route uses Oral forms, such as immediate-release (IR) capsules/tablets (e.g., 25 mg to 75 mg strengths) and extended-release (ER) capsules (e.g., 200 mg strength). For localized effect, the Topical/Cutaneous route is used via a gel or cream formulation.


Standard Dosing Regimens and Frequency

Usage Context Maximum Daily Dose Frequency Pattern
IR Oral (Chronic Use) 300 mg Typically three to four times daily (TID or QID)
ER Oral (Maintenance Use) 200 mg Once daily (QD)
Topical Gel 15 g (approx.) Two to four times daily

The immediate-release forms are often used on an as-needed basis for acute pain, with a standard single dose of 25 mg to 50 mg every 6 to 8 hours. The extended-release formulation is not recommended for acute pain and is restricted to the total daily limit of 200 mg.


Administration Requirements and Adjustments

Oral forms may be taken with food, milk, or an antacid to assist in intake. Topical gel must be applied with thorough, gentle massage and must not be used with occlusive dressings. Guidelines mandate reduced initial doses for older adults and specific maximum dose restrictions (e.g., le 150 mg/day) for patients with mild renal or hepatic impairment.

Recent Clinical Evidence

Research evidence / Overview of studies for Artrocol

Evidence for Use in Chronic Inflammatory Joint Conditions

Research was studied for its use in patients with conditions characterized by fluctuating or episodic manifestations, such as Osteoarthritis (OA) and Rheumatoid Arthritis (RA). These studies included adult patients and explored outcomes related to physical discomfort using standardized tools. Findings reported in these studies described patterns where measured changes in reported pain scale scores and indicators of joint stiffness were monitored across the observed populations. Evidence from meta-analyses indicates that the pharmacological class to which the drug belongs was observed in studies evaluating symptoms in these conditions. However, limited information for long-term outcomes is available, as follow-up durations were typically restricted to several weeks or a few months.


Evidence for Use in Acute and Localized Musculoskeletal Pain

Controlled trials was evaluated in adult patients experiencing acute, localized discomfort, such as that arising from sprains, strains, and low back pain. These studies explored outcomes linked to inflammatory or irritative states, alongside measurements of the time required to observe initial pain relief. Research indicates that trials described measurable patterns related to differences in pain intensity scores compared to inactive controls in the acute setting. Findings help contextualize how patients reported their experience of pain following administration, and research explored the onset of measured relief. The research exploring short-term symptom changes is limited in its insight into long-term progression, as follow-up durations were limited to the immediate post-injury phase.


Evidence for Use in Primary Dysmenorrhea

Research for managing conditions associated with acute or disruptive episodes, specifically menstrual pain (Primary Dysmenorrhea), utilized Randomized Controlled Trials (RCTs) and Network Meta-Analyses (NMAs). These studies were conducted during periods of increased symptom activity and explored outcomes related to systemic or functional imbalance, such as pain severity. Studies reported patterns where differences were observed in reported pain severity scores when compared to placebo controls. Findings from NMAs were used to compare the drug’s position against other treatments in the same pharmacological class, with data showing monitored patterns related to its use for acute pain.


What is Still Uncertain About Artrocol Research

Follow-up durations were generally limited for assessing the long-term impact on chronic pain assessment. Comparative evidence is lacking to definitively compare this drug against every other treatment in its class for all indications. Furthermore, research provides context but not individual predictions, and data for pediatric populations are highly limited or generally unavailable. Generally, the results apply only to the populations studied and do not determine whether an individual will respond similarly.

Key Studies & References Ketoprofen: Drug Information - NIH MedlinePlus

Frequently Asked Questions (FAQ)

Common questions about Artrocol (FAQ)


Q: What is the main difference between Artrocol tablets and the Artrocol gel/solution?

Artrocol is available in forms for both systemic and localized use. The tablets are intended for systemic effects, meaning the active substance is absorbed and distributed throughout the body to manage widespread pain and inflammation. In contrast, the gel or solution formulations are for topical/localized use, intended to provide relief primarily at the area where they are applied on the skin.


Q: Is Artrocol considered a strong or weak pain reliever compared to common over-the-counter options?

Artrocol's active substance, Ketoprofen, is classified pharmacologically as a potent Nonsteroidal Anti-inflammatory Drug (NSAID). It is officially approved for the management of mild to moderate pain. Its classification confirms its role as an effective anti-inflammatory and analgesic agent.


Q: How quickly does Artrocol usually start working for chronic conditions like arthritis?

Studies on Artrocol's onset of action have generally focused on acute pain relief. In these acute studies, some patients reported feeling initial pain relief within 30 minutes to one hour after administration. Information regarding the time required to achieve maximum benefit for chronic conditions is limited, as clinical studies often focus on short-term outcomes.


Q: What is the half-life of Artrocol in the body?

The half-life refers to the time it takes for the drug's concentration in the blood plasma to reduce by half. According to official pharmacokinetic information, the average elimination half-life of Artrocol's active ingredient, Ketoprofen, is approximately two to four hours.


Q: What does it mean if Artrocol is described as a propionic acid derivative?

This description refers to the drug's chemical structure and its synthetic origin. A propionic acid derivative is a chemical classification shared by several drugs within the NSAID group, indicating a common chemical foundation for how these medications are synthesized and function.


Q: Are there different strengths or formulations of Artrocol available?

Yes, regulatory documents describe that Artrocol is supplied in multiple dosage forms, including tablets, capsules, and gels. These forms are available in various strengths, such as immediate-release oral capsules and extended-release forms, to suit different treatment needs.


Q: Can Artrocol cause increased sensitivity to sunlight (photosensitivity)?

Yes, official product information lists photosensitivity, or an increased sensitivity of the skin to sunlight, as a reported side effect. If this is a concern, patients typically discuss sun exposure precautions with a healthcare provider.


Q: Is it possible for Artrocol to cause ringing in the ears (tinnitus)?

Yes, ringing in the ears (tinnitus) has been reported as an adverse reaction associated with the use of Ketoprofen. If a patient experiences persistent tinnitus, they typically bring it to the attention of their healthcare provider.


Q: Can Artrocol cause problems with vision or blurred vision?

Official safety documents include reports of blurred vision and other visual disturbances among the listed side effects. Any changes in vision while taking this medication are generally reported to a healthcare provider.


Q: Is it normal to experience a change in urination while taking Artrocol?

Artrocol is associated with potential risks to kidney function. A noticeable change in the amount or frequency of urination could be a sign of a kidney-related issue. Such symptoms are typically considered signs that warrant a discussion with a healthcare provider.


Q: Does Artrocol interact with any common anti-diabetic medications?

Drug interaction studies indicate that NSAIDs like Artrocol can interact with certain anti-diabetic medications, such as Metformin. This combination may increase the risk of certain associated adverse conditions. The combination is usually reserved for cases where close clinical monitoring is appropriate.


Q: What should I do if I notice swelling in my ankles or feet while using Artrocol?

Fluid retention, or edema, particularly noted as swelling in the ankles or feet, is listed as a common side effect. If swelling occurs, it is generally recommended that the patient discuss this side effect with their healthcare provider.


Q: What happens if I forget to take a dose of Artrocol?

Official instructions usually advise that if a dose is missed, a patient may take it as soon as they remember, unless it is nearly time for the next scheduled dose. Official instructions typically advise patients who miss a dose to skip it if it is nearly time for the next dose, and to not take a double dose.


Q: Is Artrocol addictive or habit-forming?

Artrocol's active substance, Ketoprofen, is a non-opioid pain reliever classified within the Nonsteroidal Anti-inflammatory Drug (NSAID) class. It is not classified as a controlled substance and is therefore not considered to be addictive or habit-forming.


Q: Does Artrocol interact with specific types of antidepressants (SSRIs)?

Yes, regulatory documents highlight a significant interaction risk with Selective Serotonin Reuptake Inhibitors (SSRIs), which are a common class of antidepressants. Taking Artrocol concurrently with SSRIs is documented to increase the synergistic risk of serious gastrointestinal bleeding.


Q: Is Artrocol used to treat gout or other inflammatory joint conditions?

Artrocol is indicated for a range of inflammatory and pain conditions. Regulatory documents confirm its use for the symptomatic treatment of acute flare-ups of gout in some formulations, in addition to its established use for osteoarthritis and rheumatoid arthritis.


Q: Can Artrocol be used in children or teenagers?

For systemic use (oral capsules/tablets), official regulatory information states that the safety and effectiveness of Artrocol have not been established in the pediatric population (children and teenagers). Specific age restrictions may apply depending on the product formulation and local regulations.


Q: Does taking Artrocol affect my ability to drive or operate machinery?

Official labels advise that because Artrocol may cause side effects like dizziness, drowsiness, or blurred vision, patients should observe how they react to the medication before performing tasks like driving or operating machinery.


Q: Is Artrocol safe to use if I am also taking medication for high blood pressure?

Artrocol can potentially reduce the effectiveness of certain high blood pressure medications, such as ACE Inhibitors and Diuretics. The use of this combination has been associated with an increased risk of acute kidney injury. Regulatory documents indicate that patients taking this combination typically require close clinical monitoring by a healthcare professional.


Q: Is Artrocol a prescription-only medication?

In most major jurisdictions, the systemic forms of Artrocol's active ingredient are generally restricted to prescription-only status. However, certain lower-dose or topical formulations may be available over-the-counter in some regions, depending on local pharmaceutical regulations.


Q: Is it normal to feel a bit dizzy or drowsy when first starting Artrocol?

Official safety information lists dizziness and drowsiness among the common side effects reported by patients (occurring in 1% to 10% of users). For any patient experiencing these effects, caution is generally advised, particularly when beginning treatment.


Q: How long can a person safely take Artrocol for chronic pain management?

To minimize the risk of serious side effects, regulatory warnings advise using the lowest effective dose for the shortest duration necessary. A patient's treatment duration is typically continually reassessed by a healthcare provider to confirm ongoing need.


Q: Does Artrocol interact with common drugs for acid reflux or heartburn?

While oral Artrocol may be taken with simple antacids to help reduce stomach irritation, the official label does not specifically detail interactions with stronger, prescription acid-suppressing drugs. However, given the known gastrointestinal risks of the drug class, any concerns regarding co-administration should be discussed with a healthcare professional.


Q: Can Artrocol be taken on an empty stomach, or should it always be taken with food?

Official administration instructions state that oral forms may be taken with food, milk, or an antacid to assist in swallowing and minimize potential stomach irritation. Taking it with food may slow the rate at which the drug is absorbed.


How should Artrocol be stored and disposed of?

Official Storage and Disposal Instructions

This section outlines the requirements for storing and disposing of Artrocol, based on regulatory labeling.

Storage Requirement Official Classification
Temperature Store at room temperature (e.g., typically not above 25 C or 30 C). Do not freeze or refrigerate (unless specifically instructed).
Protection Keep Artrocol in the original container/outer carton to protect from light and moisture.
Child Safety Keep this medicine out of the sight and reach of children.
Stability Do not use the product after the expiration date printed on the packaging.
Disposal Do not dispose of Artrocol in household trash or wastewater (e.g., flushing down the toilet). Dispose of unused or expired medicine through an approved drug take-back program or pharmacy collection point, following local regulations.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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