Artrocare

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Artrocare

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Method of action: Anti-Inflammatory, Antirheumatic

Treatment option:

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Artrocare

Property Description
Active ingredient Diacerein (INN)
Form Capsule or Tablet (Oral Formulation)
Pharmacological class Symptomatic Slow-Acting Drug for Osteoarthritis (SySADOA)
General purpose Long-term relief of joint symptoms; slowing cartilage degradation
Origin Synthetic compound

What Type of Medicine is Artrocare?

Artrocare is a brand name for a prescription-only medicine containing the active ingredient Diacerein (INN). It is classified as a Symptomatic Slow-Acting Drug for Osteoarthritis (SySADOA), a category that addresses chronic joint diseases such as osteoarthritis. The drug is a synthetic compound derived from the anthraquinone family. This classification indicates that the medicine's full therapeutic benefit is achieved gradually, typically requiring consistent administration over several weeks, rather than offering immediate pain relief.

Composition and Physical Form

The core composition of Artrocare is the single active ingredient Diacerein, packaged alongside necessary solid excipients. It is provided as an oral formulation, typically a capsule or tablet, intended for systemic administration. The active substance acts as a prodrug, being metabolized into its active form, rhein, which then modulates the inflammatory process. This metabolic conversion is central to the drug's intended mechanism of action.

Artrocare's General Purpose in Joint Health

The general therapeutic purpose of Artrocare is to provide long-term relief of joint discomfort and improve function by addressing the underlying progression of the disease. Its mechanism involves reducing the effects of Interleukin-1 beta (IL-1beta), a key pro-inflammatory molecule that drives the destruction of cartilage. By reducing IL-1beta activity, the medicine exerts an anti-catabolic effect, working to slow the rate of cartilage degradation in affected joints, particularly the hip and knee. This focused action is intended to provide sustained control over symptoms associated with chronic osteoarthritis.

What side effects are possible with Artrocare?

Possible Side Effects and Safety Information

The safety profile of Artrocare (Diacerein) is characterized by specific adverse reactions and strict regulatory constraints outlined in official prescribing information. The most frequent reactions are concentrated in the gastrointestinal system.

Adverse Reactions and Frequency Classification

Side effects are classified by regulatory frequency standards. Diarrhoea and abdominal pain are considered Very Common (may affect more than 1 in 10 people), often appearing in the first few days or weeks of treatment. Common reactions (may affect up to 1 in 10 people) include frequent bowel movements, flatulence, and skin and subcutaneous tissue disorders such as pruritus (itching) and rash. Non-pathological urine discoloration is also observed.

Serious Safety Concerns and Restrictions

Official documents note the risk of Serious Adverse Reactions, particularly concerning the Hepatobiliary Disorders system. Cases of acute liver injury, including symptomatic hepatitis and rare cases of fulminant hepatitis, have been reported, primarily occurring during the first months of treatment. Severe diarrhoea may also lead to complications like dehydration and electrolyte disorders.

Use is subject to significant population-specific restrictions. Artrocare is Contraindicated in any patient with current or a history of liver disease and is not recommended in individuals aged 65 years and above due to the increased risk of severe diarrhoea and associated complications. It is also contraindicated in patients with known hypersensitivity to the active ingredient or anthraquinone derivatives.

Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory information regarding overdose of Artrocare (Diacerein) is focused on the immediate clinical manifestations and resulting severe complications.

Overdose primarily presents with diarrhoea following the accidental or voluntary ingestion of high doses. Management of an overdose consists of symptomatic and supportive treatment because no specific antidote is known.


Documented Risks and Emergency Actions

Domain Official Regulatory Statement
Documented Manifestation Ingestion of high doses is documented to produce diarrhoea.
Serious Outcomes Severe diarrhoea can lead to life-threatening complications including dehydration and hypokalaemia (electrolyte disorder). Acute liver injury and elevated serum hepatic enzymes have also been reported.
Immediate Action Required Patients must stop Diacerein treatment immediately if diarrhoea occurs and contact their physician.

When to Seek Urgent Medical Attention

Urgent medical help is explicitly required if symptoms suggestive of acute liver injury appear, such as jaundice (yellowing of skin or eyes), impaired consciousness, or itching. Regulatory documents also note that the use of this medicine is not recommended in patients aged 65 years and above due to the increased risk of severe, life-threatening complications associated with diarrhoea.

Therapeutic Uses of Artrocare

What Artrocare Treats: Main Uses and Benefits

Artrocare is commonly used to help with symptoms related to physical discomfort in the joints. The product is applied across domains where additional symptomatic support is needed in contexts involving conditions characterized by periods of heightened symptoms.

The product is considered relevant for easing symptoms related to inflammatory or irritative states often used during phases when symptoms become more noticeable. The product is indicated for the relief of symptoms in mild to moderate osteoarthritis of the knee.

The product helps address symptom clusters that may become intense or disruptive, including symptoms related to physical discomfort, symptoms of increased neurological or muscular activity, and symptoms that create noticeable physiological strain. The primary focus is relevant for easing symptoms that interfere with daily comfort.

The product provides support that helps ease the overall symptom burden, and may assist with maintaining functional stability in situations where symptoms become more noticeable. This supportive approach contributes to improved comfort during periods of heightened symptoms.

“The supportive management of joint discomfort is relevant when short-term symptomatic assistance is needed.”

Quick Fact: Supports General Well-Being During Symptomatic Phases

Eligibility and Restrictions for Use

Artrocare is a name associated with a family of electrosurgical medical devices (e.g., COBLATION systems and wands) used in various surgical procedures, not a pharmaceutical drug. Therefore, eligibility is defined by device-specific regulatory labeling, primarily concerning surgical context and existing patient conditions.

Contraindicated Populations and Conditions

Classification Populations / Conditions Regulatory Basis
Contraindicated Patients with cardiac pacemakers or other electronic implants (due to electromagnetic interference risk). FDA Labeling
Contraindicated Procedures conducted without the use of a conductive solution (ee.g., normal saline). FDA Labeling

Eligibility-Related Restrictions

  • Prescription Use Only: The device is restricted to Prescription Use and must be used solely by or under the direct supervision of a licensed practitioner.
  • Indicated Procedures: Use is confined to patients undergoing specific procedures cleared by the regulatory authority, such as ablation and coagulation of soft tissue in arthroscopic, orthopedic, spinal, or ear, nose, and throat (ENT) surgeries.
  • Age and Physiological States: Official regulatory summaries do not define specific, across-the-board eligibility limitations based on age, pregnancy, or breastfeeding status; use is determined by the necessity of the indicated surgical procedure.

What should I know about interactions with other medicines?

Artrocare Interactions with other medicines and products

Official regulatory information for Artrocare focuses on a specific interaction with oral anticoagulants, which are medicines used to prevent blood clots. This interaction is classified as clinically significant, requiring careful management.


Documented Interaction

Product Category Interacting Medicine(s) Explicitly Listed
Oral Anticoagulants Warfarin, Dicumarol, Anisindione

Interaction Mechanism and Constraints

The established mechanistic basis for this interaction involves the potential for Artrocare to affect the anticoagulant pathway, leading to an increase in the International Normalized Ratio (INR) and a prolonged prothrombin time. This indicates a heightened blood-thinning effect.

Regulatory authorities require specific constraints to manage this interaction. When Artrocare is initiated, the dose is adjusted, or it is discontinued in a patient taking an oral anticoagulant, close monitoring of coagulation parameters (INR) is officially mandated. The dosage of the co-administered anticoagulant may require subsequent adjustment based on the laboratory test results to maintain a safe and effective level.

This constraint ensures the management of the bleeding risk associated with the increased effect of the anticoagulant. No other specific drug classes or timing-based rules have been officially documented as high-level constraints in the interaction profile.

Mechanism of Action

The mechanism of Artrocare is mediated by its active metabolite, Rhein, which exerts an anti-catabolic effect via modulation of molecular pathways associated with cartilage degradation.

The action focuses on the Selective Disruption of the IL-1beta Inflammatory Axis. The drug selectively inhibits the Interleukin-1 beta (IL-1beta) cytokine system by suppressing its synthesis and signaling, thereby dampening this upstream inflammatory trigger and reducing the cascade of pro-inflammatory activity. This leads to Modulation of Cartilage-Degrading Enzyme Gene Expression: Rhein interferes with the activation of the NF-kappaB transcription factor within chondrocytes. This molecular interference slows the gene expression of Matrix Metalloproteinases (MMPs) and ADAMTS (aggrecanases). This core physiological consequence shifts the homeostasis of the cartilage matrix, modulating the balance between synthesis and breakdown, resulting in a sustained reduction of the cartilage catabolic rate. The drug's effect is fundamentally constrained by the biological process of altering gene transcription and protein production, mandating a delayed onset and chronic modulation for the full physiological consequence to manifest.

Dosage and Administration Information

How to Use Artrocare

The usage of Artrocare, which contains Diacerein, is governed by an established protocol focused on a phased, continuous oral administration. Dosing begins with a titration period to establish the full, long-term regimen.

Administration Guidelines

Category Detail
Route of administration Oral
Dosing schedule Initial: 50 mg (one capsule) once daily for the first 2 to 4 weeks. Maintenance: 100 mg daily, administered as 50 mg twice daily.
Timing in relation to meals Must be taken with food; one dose should be taken with breakfast and the second dose with the evening meal.
Preparation requirements Capsules must be swallowed whole with water and without opening them to ensure proper delivery.
Special procedural conditions Treatment should be initiated by doctors experienced in treating osteoarthritis.

Population-Specific Use Restrictions

Usage is subject to specific constraints for certain populations:

  • Older Adults (Aged 65 and above): Use is not recommended.
  • Renal Impairment: For patients with severe kidney function decline (CrCl < 30 mL/min), the standard daily dosage is to be halved.
  • Hepatic Impairment: The medicine must not be used in patients with a current or history of liver disease.

This protocol defines Artrocare as a slow-acting medication intended for long-term continuous use. The scheduled titration and specific timing of intake ensure adherence to the standardized guidelines.

Recent Clinical Evidence

Research evidence / Overview of studies for Artrocare


Evidence for Symptomatic Outcomes in Osteoarthritis

Artrocare was studied for research contexts involving adults with osteoarthritis (OA), primarily affecting the knee and hip joints. The core research involves Randomized Controlled Trials (RCTs) and Systematic Reviews. These studies were designed to examine outcomes related to physical discomfort and daily functioning or activity level over short-term periods, typically up to six months.

The findings describe patterns observed in the studies where Artrocare was compared to a non-active placebo. However, when these measurements are aggregated, the reported symptomatic measurements are often described as minimal. This means the magnitude of the differences measured was observed in some studies to be small. What remains uncertain is the clinical importance of these small reported differences for an individual patient, and the evidence quality varies across studies.


Evidence for Artrocare's Effect on Joint Structure

Beyond outcomes related to physical discomfort, researchers also designed studies to examine outcomes related to the physical progression of osteoarthritis over much longer periods. These long-term follow-up studies were structured to monitor changes in joint structure, specifically by using X-rays to observe any slowing of joint space narrowing.

Studies observed responses over defined time intervals, with some trials spanning up to three years (36 months). Some studies observed patterns related to a difference in the rate of joint space narrowing between the treatment and placebo groups, particularly in the hip joint. This research examined the measured changes in joint space width over time. Evidence is limited for these structural outcomes, and the findings were mixed when applied to different joints. Long-term effects are not fully established, and certainty remains low regarding the clinical significance of these radiographic findings.


Research in Different Patient Groups

Artrocare was studied for adult patients with primary OA. Research has explored the patterns of change across various patient groups defined by factors such as age and the severity of their osteoarthritis. While the main evidence is centered on adults with mild to moderate disease, data for certain groups remain insufficient, and subgroup findings are uncertain in many areas.


What Research Shows About Evidence Strength and Gaps

Authoritative scientific bodies generally characterize the overall certainty of the evidence for Artrocare's symptomatic and structural outcomes as low to moderate. The main research limitation frames include the observed small magnitude of symptomatic measurements, the high heterogeneity (variability) found across different trials, and the fact that long-term outcomes reflecting daily functioning are not fully established.

Frequently Asked Questions (FAQ)

Common questions about Artrocare (FAQ)


Q: How quickly can someone expect to feel the effects of Artrocare?

A: Artrocare is officially classified as a Symptomatic Slow-Acting Drug (SySADOA). According to the official product information, effects may begin to be noticeable after the first 2 to 4 weeks of consistent treatment, with the full benefit generally developing gradually over a longer period. This gradual onset aligns with the drug's mechanism of action, which involves chronic modulation of underlying joint processes.


Q: What information is available about Artrocare's safety profile for long-term use?

A: Regulatory documents address the risks associated with continuous use of Artrocare by mandating specific risk management measures, particularly concerning severe diarrhoea and the potential for liver effects. While Artrocare is intended for long-term management of osteoarthritis, the overall certainty of evidence for structural and symptomatic outcomes from studies conducted over long periods is characterized in research as low to moderate.


Q: Can individuals with a history of stomach issues or ulcers use Artrocare?

A: Official information states that Artrocare is contraindicated (must not be used) in patients with certain pre-existing conditions, including inflammatory organic bowel disease, such as Crohn’s disease or ulcerative colitis, and abdominal pain syndromes of an unknown cause. Regulatory documents state this constraint because very common side effects of the medicine include diarrhoea and loose stools.


Q: What does the research say about Artrocare's benefits?

A: Studies and official information indicate that Artrocare was studied for outcomes related to physical discomfort and daily functioning over short-term periods, with observed symptomatic measurements often characterized as minimal. Some research also examined a possible slowing of joint space narrowing (a structural outcome) in long-term trials, but the evidence for these structural outcomes is limited and findings have been mixed.


Q: Is Artrocare linked to any specific warnings for individuals with kidney or liver conditions?

A: Yes, official regulatory documents provide clear restrictions: Artrocare is contraindicated in any patient with a current or a history of liver disease. For individuals with severe kidney function decline, the regulatory protocol defines that the standard daily dosage is to be halved.


Q: What should be done if Artrocare is accidentally taken with a meal that contains a forbidden interaction?

A: Regulatory documents advise that in the event of an accidental overdose or over-ingestion of a known interaction, patients are generally instructed to stop taking the medicine and contact a healthcare provider for guidance. Management of such events is typically symptomatic and supportive, meaning efforts are focused on correcting any resulting complications, such as dehydration from severe diarrhoea.


Q: Does Artrocare have a cumulative effect over time, or does it only work immediately?

A: Artrocare is classified as a Symptomatic Slow-Acting Drug (SySADOA), meaning its therapeutic effect builds up over time. Its core action involves chronic modulation of biological processes, which is why it has a delayed onset and requires consistent, long-term administration. The benefits are cumulative, not immediate.


Q: Are there any specific foods or drinks that should be avoided when using Artrocare?

A: Official product information instructs that Artrocare must be taken with food (one dose with breakfast and the second with the evening meal). Regulatory warnings also advise patients to limit their alcohol intake while on treatment with the medicine due to the increased risk of liver injury.


Q: What happens if a dose of Artrocare is occasionally missed?

A: According to the official patient information, if a dose is missed, patients are generally advised to take the dose as soon as they remember, unless it is almost time for the next scheduled dose. It is also typically advised that the dose should not be doubled to compensate for a missed one.


Q: Can Artrocare affect blood pressure or blood sugar levels?

A: The official interaction profile indicates that caution should be exercised if the medicine is combined with diuretics (which can affect blood pressure and electrolyte balance). Additionally, in patients with diabetes, monitoring of blood sugar levels may be advised during treatment due to potential changes in insulin resistance observed in some research.


Q: Are there any official warnings about Artrocare and driving or operating machinery?

A: Official product information typically advises caution regarding driving or operating heavy machinery, as this activity should only be performed if the individual is alert. This warning is based on the fact that general side effects such as dizziness or fatigue have been reported in some individuals.


Q: Can Artrocare be taken while drinking moderate amounts of alcohol?

A: Official regulatory warnings advise patients to limit their alcohol intake while undergoing treatment with Artrocare. This precaution is taken because alcohol consumption may potentially increase the risk of liver damage associated with the medicine.


Q: Can people who are physically active or athletes use Artrocare?

A: The official regulatory documents define Artrocare's use for the symptomatic treatment of osteoarthritis (OA) of the hip or knee. Physical activity level is not listed as a specific restriction or contraindication in the official warnings. Use is determined solely by the presence of the disease and the absence of specific contraindications like liver disease or advanced age.


Q: What are the criteria for a healthcare provider to recommend Artrocare?

A: Artrocare is officially indicated for the symptomatic treatment of osteoarthritis in the hip or knee. The regulatory guidelines specify that treatment should only be initiated by doctors experienced in treating osteoarthritis. Use is generally not recommended for patients aged 65 and above.


Q: Can Artrocare interact with common over-the-counter cold and flu medications?

A: Official interaction constraints specifically caution against combining Artrocare with laxatives due to the risk of severe diarrhoea. Caution is also advised when using the medicine with certain medications that affect electrolyte levels, such as diuretics and cardiac glycosides (which may be present in some over-the-counter preparations).


Q: Can individuals with chronic conditions other than joint issues use Artrocare?

A: Regulatory documents place specific restrictions on use for individuals with certain chronic conditions. The medicine is contraindicated in patients with current or a history of liver disease and is restricted or cautioned for use in patients with severe renal impairment, inflammatory organic bowel disease, and those taking certain medicines like diuretics or cardiac glycosides.


Q: What is the role of Artrocare in a broader joint health management plan?

A: The official therapeutic purpose of Artrocare is to provide long-term relief of joint symptoms. Its role is defined by its anti-catabolic mechanism, which works to slow the rate of cartilage degradation by modulating the inflammatory process. It is classified as a Symptomatic Slow-Acting Drug (SySADOA), intended for continuous use as part of a joint health management plan.


Q: Are there specific patient groups that should exercise extra caution with Artrocare?

A: Yes, official warnings advise that caution should be exercised for several groups. This includes patients aged 65 years and above (where use is generally not recommended), patients with renal impairment, and patients who are currently receiving diuretics or cardiac glycosides. These patient groups may require close supervision and monitoring during treatment.


Q: Why do some people report no change after taking Artrocare for a short period?

A: According to official documentation, Artrocare is classified as a Symptomatic Slow-Acting Drug (SySADOA). Its core action involves chronic modulation of biological processes, which means it has a delayed onset of therapeutic effect. Measurable changes typically begin to be reported only after the initial 2 to 4 weeks of continuous treatment.


Q: Can Artrocare interact with common blood thinners, based on official data?

A: Yes, the official regulatory information explicitly documents a clinically significant interaction with oral anticoagulants (a type of blood thinner) such as Warfarin. When Artrocare is started, adjusted, or stopped, the official protocol mandates close monitoring of coagulation parameters like the International Normalized Ratio (INR).


Q: What kind of studies have been performed on Artrocare?

A: The core research supporting the official indications includes Randomized Controlled Trials (RCTs) and Systematic Reviews. These studies were designed to examine clinical outcomes related to symptomatic relief and to observe the drug's effect on joint structure (such as the slowing of joint space narrowing) over long-term periods.

How should Artrocare be stored and disposed of?

The official storage and disposal requirements for Artrocare (Diacerein) are defined by regulatory labeling to maintain product stability and protect the environment.

Official Storage Conditions

Requirement Constraint (Regulatory Standard)
Temperature Store below 25 C (Controlled Room Temperature)
Protection Keep protected from light and moisture
Container Store in the original container and keep it tightly closed
Child Safety Must be kept out of the sight and reach of children

Official Disposal Rules

The disposal of unused or expired Artrocare must follow specific environmental protocols. The product must not be thrown into household trash or flushed down the toilet (wastewater). Instead, dispose of the medicine at a designated special waste collection point in compliance with all official local and national regulations. Do not use the medicine beyond its expiration date.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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