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Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 26.06.2023
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Artroben (also known as Artroben Verde and branded in some countries as Difflam), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat.
Artroben Cream Forte is a topical anti-inflammatory and analgesic treatment for the relief of symptoms associated with painful musculo-skeletal conditions including:
Acute inflammatory disorders such as myalgia and bursitis. Traumatic conditions such as sprains, strains, contusions and the after effects of fractures.
When Artroben used externally it applied to affected skin 2-3 times / day in 2-4 weeks.
For local orally this medicine used 1-2 times / day, no more than 7 days.
Intravaginal - on 100-500 mg for 1-6 days.
Artroben oral rinse is not suitable for use in children under 12 years. The spray can be used in children at a dose of up to 1 puff per 4kg of body weight (under 6) or 4 puffs (6-12 years) every 1.5 - 3 hours.
Artroben is used in the treatment of pain and inflammation caused by sore throat, sore tongue and gums, mouth ulcers, discomfort and pain caused by dental surgeries, removal of tonsils (tonsillectomy) or the use of a naso-gastric tube, or oral ulceration due to radiation therapy.
Simultaneous administration of Artroben with amphotericin B, nystatin, natamycin activity of clotrimazole decreases.
Artroben Anti-Inflammatory Lozenges/Solution is generally well tolerated and adverse effects are minor.
Local Adverse Reactions: The most commonly reported reaction is oral numbness (2.6%). Occasional burning or stinging sensation may occur and has been reported in 1.4% of treated cases. Other local adverse effects were less common and included dryness or thirst (0.2%), tingling (0.2%), warm feeling in mouth and altered sense of taste (<0.1%).
Systemic Adverse Reactions: These were very uncommon and never of a serious nature. They consisted mainly of nausea, vomiting, retching, gastrointestinal disorders (0.4%), dizziness (0.1%), headache and drowsiness (<0.1%).