Artricom

Quick links to important sections

Artricom

Selected form

Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Artricom

Quick Facts

Property Description
Active ingredient Tenoxicam (INN)
Form Tablets, Lyophilized powder for injection
Pharmacological class Nonsteroidal Anti-inflammatory Drug (NSAID)
Common use Symptomatic relief of pain and inflammation
Origin Synthetic

What Type of Medicine is Artricom?

Artricom is the registered trade name for a medication containing the active ingredient Tenoxicam, a synthetic small molecule belonging to the oxicam subclass of Nonsteroidal Anti-inflammatory Drugs (NSAIDs). Tenoxicam is chemically a thienothiazine-derived monocarboxylic acid amide, and its anti-inflammatory properties are clinically recognized for managing musculoskeletal discomfort. This positions Artricom as a specialized agent typically requiring prescription-only status, differentiating it from many over-the-counter NSAIDs.

What is Artricom’s Main Active Ingredient and Forms?

The composition of Artricom is founded on Tenoxicam as a single active ingredient, avoiding the complexity of combined formulations. The medicine is produced in two principal dosage forms: readily available oral tablets and a sterile lyophilized powder designed for reconstitution into an injectable solution. This dual-form availability permits use via oral, intramuscular (IM), or intravenous (IV) routes. Tenoxicam is utilized in reducing inflammation associated with musculoskeletal conditions and has an established role in therapeutic management. This indicates the medicine is useful for addressing swelling and joint discomfort.

What is the General Purpose of Artricom?

The core purpose of Artricom is to provide symptomatic relief by effectively mitigating the symptoms of pain and inflammation. Its mechanism involves acting as a non-selective inhibitor of cyclooxygenase (COX) enzymes, which are responsible for the biosynthesis of prostaglandins—the body's chemical messengers that mediate swelling, fever, and localized pain. The drug is frequently used in scenarios involving acute flare-ups of chronic conditions like osteoarthritis, where reducing inflammation is critical. Tenoxicam is further used to treat painful, inflammatory, and degenerative disorders. This indicates the medicine helps to reduce the discomfort and stiffness commonly associated with conditions affecting the joints and muscles.

What side effects are possible with Artricom?

Possible Side Effects and Safety Information

Artricom (Tenoxicam) is officially associated with adverse reactions classified across several system-organ classes, consistent with its profile as a Nonsteroidal Anti-inflammatory Drug (NSAID). Safety information is structured by frequency and physiological system, as documented in regulatory prescribing information.

Adverse reactions are classified by frequency, with gastrointestinal effects such as dyspepsia, nausea, vomiting, and abdominal discomfort listed as Very Common. Other effects, including headache, dizziness, diarrhoea, and documented risks of gastrointestinal haemorrhage and peptic ulcer, are classified as Common.

Documented Serious Adverse Reactions

Regulatory labeling highlights the risk of serious, potentially fatal events. These include serious Gastrointestinal bleeding, ulceration, and perforation. The medicine is also associated with an increased risk of serious Cardiovascular Thrombotic Events, such as Myocardial Infarction (MI) and Stroke. Furthermore, severe, life-threatening cutaneous reactions like Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) have been documented as Very Rare.

Safety Constraints and Special Population Notes

The risk of serious cardiovascular events is noted to increase with the duration of use. Safety constraints formally contraindicate the use of Artricom in patients with pre-existing conditions such as severe heart failure, kidney failure, or severe liver failure. Specific safety considerations apply to the elderly population, who have a documented increased susceptibility to serious gastrointestinal and renal adverse events. The medicine is contraindicated during the third trimester of pregnancy.

Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory information addresses the manifestations and required immediate actions in the event of an overdose with Artricom (Tenoxicam).

Documented Overdose Manifestations

Symptoms and clinical signs listed in official product labeling range from common to severe and may include effects on the central nervous system and gastrointestinal tract.

System Documented Manifestations
Central Nervous System Headache, Drowsiness, Ringing in the ears (Tinnitus), Loss of consciousness
Gastrointestinal Nausea, Vomiting, Bleeding in the stomach

Required Emergency Actions

The immediate and definitive action mandated by regulatory authorities is to seek urgent medical assistance.

  • Urgent Medical Contact: If more Artricom is taken than should be, you must contact your doctor or a hospital accident and emergency department immediately.

Management and Antidote Status

Artricom overdose is managed primarily through supportive measures.

  • Treatment Strategy: Management of a suspected drug overdose is focused on providing supportive and symptomatic therapy to address clinical manifestations.
  • Antidote: Official labeling states that no specific antidote for Tenoxicam overdose is available.

Therapeutic Uses of Artricom

What Artricom Treats: Main Uses and Benefits

Artricom (Tenoxicam) is generally used for symptomatic relief, which contributes to easing the overall symptom load across various musculoskeletal and inflammatory conditions. The use of Artricom is considered relevant for managing symptoms related to inflammatory or irritative states.

The medicine is relevant in contexts where short-term symptomatic assistance is needed, and may assist with maintaining functional stability when symptoms interfere with routine activities. It is commonly used for conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute conditions like gouty arthritis, soft tissue injuries including sprains and strains, and pain associated with primary dysmenorrhea. The primary focus is on managing symptoms related to pain, stiffness, and swelling that create noticeable physiological strain. This supportive relief is applied across domains where additional symptomatic support is needed, which may help maintain a sense of stability during challenging symptomatic phases.


Quick Fact: Symptom Management Focus
Primary Use Focus Symptomatic management of pain, swelling, and stiffness
Common Target Acute and chronic musculoskeletal inflammatory conditions
Patient Benefit Provides support that helps ease the overall symptom burden

Regulatory References

  1. New Zealand Medsafe product information

Eligibility and Restrictions for Use

Artricom (Tenoxicam) eligibility is strictly defined by regulatory guidelines to ensure appropriate use. The medicine is generally approved for adults and adolescents 16 years of age and over.


Absolute Contraindications (Must Not Use)

Artricom is strictly contraindicated and must not be used by individuals with certain high-risk medical conditions, as defined in official regulatory labeling. This includes patients with:

  • Severe heart, hepatic, or renal failure.
  • Active peptic ulceration or a history of recurrent gastrointestinal bleeding or perforation.
  • Known hypersensitivity to tenoxicam or other Nonsteroidal Anti-inflammatory Drugs (NSAIDs).
  • Haemorrhagic diathesis (bleeding disorders).
  • Women in the third trimester of pregnancy.

Restricted and Conditional Use

Use is not recommended for the pediatric population (under 16) due to insufficient established data. Furthermore, Artricom is not recommended for women who are breastfeeding or those in the first or second trimesters of pregnancy.

Special caution and monitoring are required for use in the elderly, patients with pre-existing cardiovascular risk factors (e.g., uncontrolled hypertension), and those with non-severe hepatic or renal impairment.

What should I know about interactions with other medicines?

Artricom Interactions with other medicines and products

The interaction profile of Artricom (Tenoxicam) is formally defined by national regulatory documents, focusing on pharmacodynamic and pharmacokinetic effects that necessitate specific co-administration restrictions.

Documented Pharmacodynamic and Exposure-Altering Interactions

Interacting Agents Officially Documented Interaction Basis
Other NSAIDs, Salicylates Avoided use due to an increased risk of gastrointestinal adverse events, including ulceration and bleeding.
Oral Anticoagulants, SSRIs, Oral Corticosteroids Heightened risk of bleeding and hemorrhage when combined, resulting from additive pharmacodynamic effects.
Diuretics, Antihypertensive Agents Tenoxicam may diminish the therapeutic effect of these medicines, potentially reducing their blood pressure-lowering or volume-regulating actions.
Salicylates (Exposure) Formally documented to decrease the plasma concentration and increase the clearance of Tenoxicam by displacing it from protein-binding sites.
Highly Protein-Bound Drugs Potential for Artricom to displace co-administered highly protein-bound agents (e.g., Phenytoin), which necessitates careful monitoring.

Timing and Population-Specific Constraints

  • Mifepristone: A time-separation rule requires that Artricom should not be used for 8–12 days after Mifepristone administration to avoid reducing its efficacy.
  • Hepatic Impairment: The official profile notes the need for careful monitoring of liver function in this population, as reduced clearance may exacerbate risks.

Mechanism of Action

Artricom functions as a dual inhibitor targeting two key components within cellular signaling cascades: Janus Kinase 1 (JAK1) and Janus Kinase 2 (JAK2).

Following its systemic distribution, the molecule binds reversibly to the ATP-binding site of these intracellular tyrosine kinases, thereby functioning as a competitive inhibitor. This molecular interaction prevents the ATP-dependent phosphorylation of JAK1 and JAK2.

Inhibition of JAK1 and JAK2 disrupts the subsequent activation and phosphorylation of Signal Transducer and Activator of Transcription (STAT) proteins, specifically STAT1, STAT3, and STAT5, which are downstream effectors of the JAK-STAT pathway. This reduction in STAT phosphorylation diminishes their dimerization and subsequent translocation to the cell nucleus. Consequently, the drug attenuates the transcription of target genes, including those encoding various pro-inflammatory cytokines and chemokines, thus modulating the cellular inflammatory response. System-level physiological consequences involve the reduction of multiple pro-inflammatory cell signaling mediators and the subsequent dampening of immune cell activation and proliferation.

Dosage and Administration Information

Artricom (Tenoxicam) is administered via the oral route using tablets, or by intramuscular (IM) or intravenous (IV) bolus injection for initial or acute treatment phases. The core administration pattern for the medicine is a once-daily schedule, with the standard daily dose set at 20 mg for chronic disorders. The overarching principle for its use is to employ the lowest effective dosage for the shortest duration necessary to control symptoms.

In specific acute scenarios, a higher dose is utilized. For instance, in acute gouty arthritis, the dose is initiated at 40 mg once daily for two days before reducing to 20 mg once daily for the remaining course. The use of the injectable form is typically limited to the first one or two days of therapy, after which oral administration is to be continued.

Instructions for administration require that oral tablets be swallowed whole with water, preferably with or immediately after food. For the injectable form, the lyophilized powder must be reconstituted with the designated solvent and used immediately. Special rules govern its use in specific patient populations; for example, the medicine is not recommended for the pediatric population due to insufficient data, and older adults must be monitored carefully while on the lowest effective dose.

Recent Clinical Evidence

Artricom: Recent Clinical Evidence


Evidence for Chronic Inflammatory Conditions

Artricom (Tenoxicam) was studied in research exploring how symptoms change over time for chronic conditions like rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. The evidence base appears to be mainly composed of short- and medium-term Randomized Controlled Trials (RCTs). Studies monitored outcomes related to physical discomfort (pain intensity, stiffness) and changes in daily functioning using standardized patient-reported scales. Findings describe patterns observed in these studies where pain and stiffness were tracked over defined time intervals. Research primarily remains focused on short-term symptom changes; long-term outcomes extending beyond one year remain limited in existing controlled trials.


Evidence for Acute Symptomatic Use

Research was studied for episodes where symptoms become more noticeable in acute symptomatic patterns, including primary dysmenorrhea and acute musculoskeletal injuries (sprains and strains). Researchers conducted short-term RCTs, primarily examining outcomes describing episodic or acute changes in pain intensity over short intervals (hours post-dose) and the need for additional relief medication. While this research contributes to the broader evidence landscape of anti-inflammatory agents, follow-up durations were limited, focusing on immediate symptomatic patterns rather than long-term recovery rates.


Research Limitations and Evidence Gaps

Research studies observed the effects of Artricom in groups such as older adults with osteoarthritis, but data for comorbidity-defined groups remain insufficient. The evidence base contains a smaller number of dedicated long-term studies, and long-term effects are not fully established beyond the scope of initial trial durations. The overall evidence quality varies across studies due to modest sample sizes and limited follow-up periods, and there is a lack of contemporary, large-scale comparative evidence against the full range of modern anti-inflammatory agents now available.

Key Studies & References

  1. Tenoxicam Devatis 20 mg powder and solvent for injection data sheet (Medsafe New Zealand)
  2. Committee for Medicinal Products for Human Use (CHMP) Assessment Report for Tilcotil (Tenoxicam) (European Medicines Agency)
  3. NICE Guideline: Osteoarthritis: care and management (Clinical Evidence Review of NSAIDs)

Frequently Asked Questions (FAQ)

Common questions about Artricom (FAQ)


Q: How is Artricom different from other common medications used for similar conditions?

Artricom's active ingredient, Tenoxicam, belongs to the oxicam subclass of NSAIDs. Official prescribing information often highlights its once-daily schedule, which is possible due to its long half-life. Furthermore, the medicine is available in both oral tablet and injectable forms, offering options for initial or acute treatment phases.


Q: Is Artricom the generic name or the brand name?

Artricom is the registered trade name given to the product. The single active ingredient in the medicine is called Tenoxicam, which is the generic name.


Q: What is the typical time frame for Artricom to start working?

Studies examining the use of Artricom for chronic disorders often show that the patient's therapeutic response increases over time. While the relief can be significant at the start of treatment, a universally standardized specific time frame (like a certain number of hours or days) for when the full effect is reached is not consistently detailed across all regulatory documents.


Q: What are the official considerations for taking Artricom during pregnancy?

Regulatory documents state that Artricom is restricted from use (contraindicated) during the third trimester of pregnancy. Its use is also not recommended during the first and second trimesters. This is due to the lack of established safety data and potential risks to the developing fetus.


Q: What does the official documentation say about Artricom and breastfeeding mothers?

Official information indicates that Artricom is not recommended for women who are breastfeeding. This recommendation is made because the safety of Artricom's use during lactation has not been fully established, and NSAIDs may potentially pass into breast milk.


Q: Is it necessary to have blood work done while using Artricom?

Official prescribing information notes the potential for effects on the liver and kidneys with NSAID use. Careful monitoring of these functions (which may involve blood tests) is often required, particularly for patients who are taking the medicine long-term, older adults, or individuals with pre-existing hepatic or renal issues.


Q: What types of dietary supplements are officially known to interact with Artricom?

Regulatory documents provide formal interaction warnings for specific drug classes, such as anticoagulants and salicylates. There is no categorical warning or listing for dietary supplements as a whole. However, any co-administered substance that affects hemostasis (how the blood clots) should be discussed with a healthcare provider.


Q: What is the guidance for patients taking Artricom who have an upcoming surgery?

Artricom is known to inhibit platelet aggregation, which is a process vital for normal blood clotting, or hemostasis. Caution and careful monitoring may be necessary for patients undergoing or planning any surgical procedures where normal clotting is critical.


Q: What does the drug classification of Artricom mean for a patient?

Artricom's classification as an NSAID (Nonsteroidal Anti-inflammatory Drug) defines its primary purpose: to provide symptomatic relief of pain, inflammation, and fever by reducing the creation of chemical messengers called prostaglandins. Because it belongs to this class, its use is officially associated with general NSAID risks, including potential gastrointestinal and cardiovascular events.


Q: According to regulatory data, what is the frequency of side effects like fatigue with Artricom?

While the regulatory safety tables detail the frequency of common effects like gastrointestinal discomfort and headache, official documents do not always assign a specific frequency classification (like 'Common' or 'Uncommon') for isolated symptoms such as fatigue. Fatigue may be noted as a potential symptom of other adverse effects.


Q: Can Artricom cause changes in mood or sleep patterns?

Official documentation does not typically list major mood changes among its adverse reactions. However, general central nervous system effects such as headache and dizziness are reported. Some research studies looking into sleep disturbance in patients using Artricom have indicated no significant changes in sleep.


Q: What are the official warnings about Artricom and grapefruit juice?

Official Artricom regulatory documents do not list grapefruit juice as a formally documented food interaction or restriction that requires dose alteration. As with any medication, patients should review the official package insert for any food or drug warnings and consult with a healthcare provider about any concerns.


Q: Is it okay to drink alcohol while taking Artricom?

Regulatory-aligned advice suggests that Artricom does not have a direct interaction with alcohol. However, official regulatory advice suggests that alcohol use may intensify certain side effects like dizziness or stomach discomfort.


Q: Does Artricom interact with birth control pills?

The official drug interaction lists for Artricom do not typically include oral contraceptives as an agent that requires restriction or dose alteration due to a documented interaction.


Q: Are there any genetic factors that influence how Artricom works?

Yes, official annotation notes that Artricom's active ingredient is processed by the body through certain enzymes. Variations in the CYP2C9 gene are noted as a factor that can influence drug processing, potentially leading to increased drug exposure in individuals with certain genetic profiles.


Q: Where can I reliably find the official package insert for Artricom?

Official prescribing information, such as the Summary of Product Characteristics (SmPC) or the FDA Label/DailyMed, can be reliably found on the websites of national health regulatory agencies (e.g., EMA, FDA, MHRA). These resources contain the full, authorized safety and efficacy data.


Q: Has there been any research on Artricom's effect on quality of life?

Yes, research studies have been conducted to examine Artricom's effect on patient quality of life. These studies use standardized measurement tools, such as the Medical Outcomes Study Short-Form 36 assessment questionnaire, to track changes in a patient's overall well-being during treatment.


Q: What regulatory body in the US or Europe was the first to approve Artricom for its current use?

The active ingredient Tenoxicam was historically approved and marketed in several countries, including the United Kingdom and other jurisdictions. While the drug is globally regulated, the single first-approving regulatory body is not consistently named in a single regulatory document.


Q: What does the term 'mechanism of action' mean for Artricom in plain language?

The 'mechanism of action' describes how the medicine works inside the body. For Artricom, it works by blocking certain enzymes (known as cyclooxygenase, or COX) that are responsible for the creation of chemical signals that cause pain, swelling, and fever. By blocking these enzymes, the medicine helps to reduce inflammation and discomfort.


Q: Is Artricom ever prescribed for children or adolescents?

Official prescribing information states that Artricom is not recommended for use in patients under 16 years of age. This restriction is in place because the appropriate dosage and safety for use have not been officially established in the pediatric population.


Q: Can people with pre-existing heart conditions use Artricom?

Artricom is restricted from use (contraindicated) by patients with severe heart failure. However, for patients with a history of hypertension or mild to moderate congestive heart failure, official documents emphasize the need for appropriate monitoring and caution due to the risk of fluid retention and edema associated with NSAIDs.

How should Artricom be stored and disposed of?

Artricom (Tenoxicam) must be stored and disposed of according to the medicine's official regulatory labeling.

Storage Conditions

The tablets and lyophilized powder must be stored at room temperature, generally between 15 C and 30 C. The medication requires protection from both light and excessive heat, meaning it should not be stored in humid areas like a bathroom or left on window sills. The injectable powder form must also be protected from freezing before reconstitution.

Stability and Handling

Once the lyophilized powder is prepared (reconstituted), the solution is intended to be used immediately to ensure stability. All forms of Artricom must be kept out of the sight and reach of children.

Disposal Instructions

Unused or expired Artricom must be disposed of in accordance with local regulations for medicinal products, often requiring return to a pharmacy or approved collection point. The product should not be discarded into wastewater or sewers.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Artricom found in:

A-Z Index: