Arasid

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Arasid

Treatment option: Leukemia

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Arasid

Property Description
Active Ingredient Cytarabine (Ara-C)
Form Solution for Injection
Pharmacological Class Antineoplastic Agent / Antimetabolite
Origin Synthetic (Pyrimidine Nucleoside Analog)
Primary Route Parenteral (IV, SC, or Intrathecal)

Arasid: Classification and Identity as a Cancer Therapy

Arasid is a pharmaceutical preparation distinguished by its active component, Cytarabine (Cytosine arabinoside, or Ara-C), which classifies it as a potent antineoplastic agent. The drug is clinically recognized as a cytotoxic drug utilized in specialized cancer treatment. Its specialized nature means its administration is strictly reserved for the hospital setting under expert medical supervision.

Composition and Type: The Role of Cytarabine as a Nucleoside Analog

The unique effectiveness of Arasid stems from its entirely synthetic nature as a pyrimidine nucleoside analog, an engineered compound created to mimic and interfere with cellular building blocks. Cytarabine is chemically classified as a nucleoside antimetabolite, confirming its function as a disruptive agent in cellular metabolism. The medication is supplied as a sterile aqueous solution for injection, ensuring parenteral delivery—via intravenous, subcutaneous, or intrathecal routes—which is essential for achieving the therapeutic concentrations required for systemic action in blood cancers.

General Purpose: Interfering with Malignant Cell Growth

The general purpose of Arasid is to achieve a targeted cytotoxic effect by specifically disrupting the reproductive capabilities of rapidly dividing cells. The drug operates with a distinguishing S-phase specificity, meaning its primary action targets cells that are actively synthesizing DNA. By inhibiting the critical function of DNA polymerase, Cytarabine effectively halts the uncontrolled growth characteristic of malignant cells, providing a foundational therapeutic action for managing hematological malignancies.

Regulatory References

  1. National Cancer Institute (NCI)

What side effects are possible with Arasid?

Possible side effects and safety information

Arasid (Cytarabine) is a potent antineoplastic agent whose officially documented risk profile is dominated by bone marrow suppression (Myelosuppression). This is classified as a very common effect and results in a reduction of essential blood cells, leading to leukopenia, thrombocytopenia, and anemia. These effects are often associated with serious complications, including life-threatening infection (due to low white blood cells) and hemorrhage.

Regulatory Classification of Adverse Reactions

Adverse reactions are officially categorized by the system-organ class affected and by frequency, based on regulatory labeling:

  • Very Common (ge 1/10): Includes Myelosuppression, Sepsis, Stomatitis and oral ulceration, Hepatic function abnormal, Alopecia (hair loss), Rash, and Pyrexia (fever).
  • Common (ge 1/100 to < 1/10): Includes Anorexia, Diarrhea, and Thrombophlebitis.

Serious and Systemic Toxicity

Regulatory documents explicitly detail several serious adverse reactions. These include severe pulmonary toxicity, such as Acute Respiratory Distress Syndrome (ARDS) and pulmonary oedema, which are mainly documented following high-dose regimens. Severe neurological adverse reactions, ranging from cerebellar dysfunction to rare reports of paralysis, and serious gastrointestinal ulceration and bowel necrosis are also documented. Additionally, cases of cardiomyopathy have been reported, primarily associated with high-dose protocols.

Special Population and Administration Safety Notes

The safety profile includes specific notes for certain contexts. The risk of Central Nervous System (CNS) toxicity is heightened in patients with pre-existing hepatic or renal impairment. Furthermore, the maximum drop in blood cell counts (nadir) typically occurs between 15 and 24 days after a dose. Arasid is designated as Pregnancy Category D, indicating documented evidence of human fetal risk.

Overdose and Emergency Response

Overdosage with Arasid (Cytarabine) is associated with severe, dose-limiting toxicities as officially documented in regulatory labeling. The clinical manifestations of overdose primarily involve profound and often fatal bone marrow suppression, leading to life-threatening complications such as severe infection and hemorrhage.

Overexposure may also result in severe and potentially irreversible organ system toxicities. These include irreversible Central Nervous System (CNS) toxicity, severe Gastrointestinal (GI) toxicity (including ulceration and peritonitis), and severe pulmonary complications, notably Adult Respiratory Distress Syndrome (ARDS) and pulmonary edema. Regulatory guidance notes that patients with pre-existing hepatic or renal impairment may face a higher likelihood of CNS toxicity following high-dose exposure.

Critically, there is no specific antidote known to reverse the effects of Cytarabine overdosage. Due to the potential for severe and sometimes fatal outcomes, official documents mandate that management requires medical care in a hospital setting.

If an overdose is suspected, or if severe signs such as collapse, seizure, or trouble breathing are observed, individuals must seek immediate medical attention or call emergency services, as treatment is restricted to supportive and symptomatic measures.

Therapeutic Uses of Arasid

Quick Facts: Arasid Uses

  • Acute Myeloid Leukemia (AML): Used for induction of remission.
  • Acute Lymphocytic Leukemia (ALL): Utilized for remission induction.
  • Meningeal Leukemia: Administered to address and manage the presence of malignant cells in the central nervous system membranes.

Arasid is a prescription medication utilized in the therapeutic management of specific hematologic malignancies. The primary application of this drug is for the induction of remission in patients diagnosed with acute myeloid leukemia (AML), a form of cancer that affects the blood and bone marrow.

It is also employed to support treatment protocols for acute lymphocytic leukemia (ALL), often as part of a combination regimen with other therapeutic agents. Furthermore, Arasid is indicated for the management of meningeal leukemia, where it is used to address cancer cell proliferation within the protective membranes surrounding the spinal cord and brain.

This medication is a core component of several established chemotherapy protocols, reflecting its role in managing these serious conditions.

Eligibility and Restrictions for Use

Eligibility for Arasid (Cytarabine) According to Regulatory Labeling

Arasid (Cytarabine) is an antineoplastic agent whose use is strictly governed by governmental regulatory documents. Eligibility is defined by specific population groups, pre-existing conditions, and physiological states.

Absolute Contraindications (Must Not Use)

The medicine is formally contraindicated for use in patients with a known hypersensitivity to Cytarabine or any of its components. It is also contraindicated for patients with non-malignant blood disorders (e.g., severe bone marrow suppression, anaemia, leucopenia, or thrombocytopenia not caused by cancer), and in those with pre-existing degenerative or toxic encephalopathies.

Age and Condition Restrictions

Population Group Regulatory Status
Adults and Children Use is established for acute leukemia treatment.
Infants Safety and efficacy have not been established; use is not recommended.
Pregnancy Contraindicated / Use is not recommended due to the potential for fetal harm.
Breastfeeding Not recommended; women should refrain from breastfeeding during treatment.
Hepatic or Renal Impairment Requires caution; patients may have a higher risk of central nervous system toxicity.
Older Adults (> 60) High-dose therapy requires careful risk assessment due to the likelihood of age-related organ impairment.

Eligibility criteria require caution for those with pre-existing drug-induced bone marrow suppression, and patients of reproductive potential must use reliable contraception during and following treatment.

What should I know about interactions with other medicines?

Arasid Interactions with other medicines and products

This section outlines the officially documented interaction patterns for Arasid (Cytarabine) as stated in government regulatory prescribing information.


Documented Pharmacodynamic Interactions and Restrictions

Co-administration of live or live-attenuated vaccines is strictly contraindicated due to Arasid’s immunosuppressive effect, which carries a risk of serious or fatal infection. The antifungal efficacy of 5-Fluorocytosine (Flucytosine) is documented to be antagonized when combined with Arasid, potentially abolishing its therapeutic effect. The official label also notes that combining high-dose Arasid with other Central Nervous System (CNS) toxic treatments, such as radiation therapy, increases the risk of CNS toxicity.

Concurrent administration with a granulocyte-transfusion must be avoided due to the reported risk of severe respiratory insufficiency.


Pharmacokinetic and Population-Specific Interactions

Arasid, when used as part of combination chemotherapy, can substantially reduce the gastrointestinal absorption of oral Digoxin tablets, leading to lower plasma concentrations of the heart medication. Additionally, patients with pre-existing hepatic dysfunction or poor renal function have an officially noted increased likelihood of CNS toxicity following high-dose treatment, a caution tied to the drug’s clearance. No formal interactions with food, alcohol, or herbal products are documented in the regulatory prescribing information.


Physical Incompatibilities

Arasid solution is documented to be physically incompatible with several medicinal products, including Heparin, Insulin, and Fluorouracil, and should not be mixed with them.

Mechanism of Action

Targeted Cellular Interference and Enzyme Inhibition

Arasid (cytarabine) functions as an antimetabolite, requiring intracellular conversion to its active triphosphate form, cytarabine triphosphate (ara-CTP). This activation process dictates the drug's activity towards cellular replication. The central mechanistic domain involves competitive enzyme inhibition, where ara-CTP structurally mimics a natural deoxycytidine triphosphate nucleotide.


Modulating DNA Synthesis and Replication

During the synthesis phase (S-phase), the active ara-CTP molecule is incorporated into the growing DNA strand. This action leads to the targeted interference and inhibition of the DNA polymerase enzyme. The incorporation creates a structural defect that prevents the addition of subsequent natural nucleotides, thereby halting the necessary elongation and repair of the DNA molecule.


Resulting Cytotoxic Cascade

By corrupting the genetic replication pathway, Arasid initiates a predictable cytotoxic cascade. The blocked DNA synthesis and resulting irreparable DNA damage ultimately trigger programmed cell death (apoptosis) in rapidly dividing cells. The resulting apoptosis reduces the population of rapidly proliferating cells within targeted biological systems.

Dosage and Administration Information

Arasid (Cytarabine) administration is strictly governed by specialized protocols for antineoplastic agents, focusing on the procedural application of the drug. The medication is given via parenteral routes only, specifically through intravenous (IV) infusion or injection, subcutaneous (SC) injection for consolidation/maintenance, and intrathecal (IT) injection to treat meningeal disease.

Administration mandates constant supervision by physicians experienced in cytotoxic therapy and occurs primarily in a specialized hospital setting. Treatment follows precise, cyclic schedules, which define drug administration days and subsequent rest intervals. For adult remission induction, a common regimen involves daily doses of 100 mg/m^2 by continuous IV infusion for a set period, such as 5 to 10 consecutive days, before a necessary rest period begins. High-dose regimens (HiDAC) may involve up to 3 g/m^2 infused over 1 to 3 hours, administered every 12 hours for a limited number of doses per cycle.

Preparation is a required procedural step: the sterile solution must be diluted with approved fluids, such as Sodium Chloride 0.9%, prior to IV infusion. For the intrathecal route, a preservative-free preparation must be used. Dosage requires close management in specific populations; patients with compromised hepatic (liver) function may require careful dose reduction, as the liver is the main site of drug inactivation. While no mandatory dose reduction is stated for older adults, caution and meticulous dose management are emphasized.

Recent Clinical Evidence

The clinical research for Arasid (Cytarabine) is extensive and has been evaluated in established treatment protocols for specific blood cancers.

The primary evidence base for Acute Myeloid Leukemia (AML) comes from large Randomized Controlled Trials (RCTs) and meta-analyses. Researchers studied Arasid as the core drug within initial induction and subsequent consolidation protocols. Key outcomes measured include the achievement of Complete Remission (CR) and longer-term measures like Overall Survival (OS). Studies demonstrated that Arasid was utilized consistently in established treatment protocols. However, the evidence quality varies across studies regarding the optimal total dose for the consolidation phase, and data for frail older patients remain insufficient compared to fitter, younger adults.

For Acute Lymphocytic Leukemia (ALL), Arasid was evaluated in large-scale treatment protocol studies, primarily involving pediatric and adolescent populations. These studies monitored overall and relapse-free survival, observing that the integration of Arasid as part of the multi-drug regimen was associated with specific long-term survival rates. A limitation here is that Arasid is consistently used in combination with many other agents, making the contribution of the drug alone difficult to isolate.

Arasid was also studied for Meningeal Leukemia, where research focused on the specialized intrathecal route (direct injection into the spinal fluid). Studies monitored the clearance of leukemic cells from the Cerebrospinal Fluid (CSF). The evidence base for this specialized application is generally less extensive than the systemic research. Overall, research provides insight into short-term changes and overall patterns of use, but certainty remains low regarding the tailored optimal combination and dose intensity for specific subsets of patients.

Key Studies & References Cytarabine Injection For Intravenous, Intrathecal and Subcutaneous Use Only - FDA Labeling

Frequently Asked Questions (FAQ)

Common questions about Arasid (FAQ)

Q: Is Arasid considered a narcotic or controlled substance?

Arasid (Cytarabine) is officially classified as an antineoplastic agent, which means it is a type of chemotherapy drug. According to regulatory-based drug information, this medication is not designated as a narcotic or a controlled substance.

Q: Is it normal to feel tired when starting Arasid?

Studies and official product information indicate that feeling tired, experiencing weakness, and fatigue are common or very common documented side effects of Arasid (Cytarabine) treatment. The frequency of these effects means they are often reported by patients during their therapy.

Q: Is Arasid available as a generic version?

Yes, the active ingredient in Arasid is Cytarabine. Cytarabine is the generic name for the medicine and is available from various generic manufacturers as specified in regulatory product databases.

Q: What should I do if a side effect seems concerning?

Official patient information leaflets consistently describe contacting your healthcare provider immediately if a fever, chills, any signs of infection, or severe and potentially life-threatening side effects are experienced. This regulatory information emphasizes when to seek urgent professional attention.

Q: Are there any mental side effects that have been noted with Arasid?

Official regulatory documents list several neurological and psychiatric adverse reactions. These documented effects may include confusion, agitation, personality changes, memory impairment, and problems with sleep (insomnia).

Q: Does Arasid impact blood sugar levels?

Regulatory adverse reactions lists include metabolic function changes. Specifically, official information indicates that Arasid (Cytarabine) treatment may potentially lead to hyperglycemia, which is the official term for increased blood sugar levels.

Q: Is Arasid known to cause dry mouth?

While dry mouth is not always explicitly listed as a standalone side effect, official adverse event data notes that very common effects such as mouth sores (stomatitis/mucositis), vomiting, and dehydration are documented. These documented issues may cause or be associated with the symptom of dry mouth.

Q: Can Arasid affect sleep patterns?

Yes, official adverse reactions data confirm that sleep problems, including insomnia (difficulty sleeping), have been noted as a very common adverse reaction associated with Arasid (Cytarabine) treatment.

Q: What are the restrictions regarding driving or operating machinery while on Arasid?

The official label notes that Arasid does not directly affect the ability to drive or use machinery. However, if treatment-related symptoms such as severe tiredness, dizziness, or neurological side effects occur, official guidance states that avoiding driving and operating machinery is recommended.

Q: How long has Arasid been approved for use by regulatory bodies?

Official drug databases indicate that the active ingredient in Arasid, Cytarabine, has a long history of regulatory acceptance. Initial approval by major bodies like the FDA dates back to before 1982.

Q: Can Arasid be taken by older adults?

Use of Arasid in older adults is established for the treatment of acute leukemia. Official guidance states that careful risk assessment is required, particularly with high-dose therapy, due to the recognized higher likelihood of toxicity in this population.

Q: Is Arasid safe to use long-term?

According to official regulatory protocols, Arasid is administered using 'cyclic schedules' that define specific days of treatment followed by necessary rest periods. Treatment frequency often continues until disease progression or unacceptable toxicity is observed, rather than as continuous long-term daily use.

Q: Are there any known severe allergic reactions associated with Arasid?

Yes, severe allergic reactions, including life-threatening reactions such as anaphylaxis, are listed in official documents as possible adverse events. Hypersensitivity to Cytarabine is an absolute contraindication, meaning the medicine must not be used.

Q: Can Arasid be used safely by people with heart problems?

Official safety protocols indicate that high-dose Arasid can cause severe cardiovascular toxicity, such as cardiomyopathy (heart muscle disease). Because of this, serious pre-existing heart conditions are noted risk factors that require careful risk assessment when considering treatment.

Q: Does using Arasid require a change in lifestyle or diet?

Official guidance implicitly mandates certain adjustments. Regulatory documents describe the need for prescribed steroid eye drops to minimize ocular toxicity and ensuring adequate antiemetic support. The guidance also includes minimizing infection risks due to the immunosuppression associated with the medicine.

Q: Why is Arasid sometimes used with another medicine?

Arasid is commonly used as a core drug within established multi-drug chemotherapy protocols, as indicated in official labeling. This use in combination is intended to target malignant cells through multiple different mechanisms to increase therapeutic effectiveness.

Q: What is the risk profile of Arasid compared to placebo in clinical trials?

Arasid’s documented risk profile is characterized by significant toxicities, including severe bone marrow suppression (myelosuppression) and other systemic issues. These risks are inherent consequences of its cytotoxic action.

Q: What specific safety issues is Arasid monitored for?

Official guidance on monitoring requires frequent blood tests to check for bone marrow suppression (myelosuppression). Additionally, regular checks are performed for signs of liver or kidney impairment, as issues with these organs can increase the risk of neurological toxicity.

How should Arasid be stored and disposed of?

Storage and Disposal of Arasid (Cytarabine)

Arasid (Cytarabine) is a cytotoxic drug, requiring strict adherence to official regulatory storage and disposal mandates.


Storage Conditions

The medicine must be stored at Controlled Room Temperature, between 20 C to 25 C (68 F to 77 F), with permitted excursions up to 30 C. It is mandatory to protect the vial from freezing and to store it in the original carton to maintain protection from light. The product must be kept out of the sight and reach of children.


Disposal Instructions

Disposal of any unused product or waste material must be done in accordance with local requirements for cytotoxic agents and pharmaceutical waste. Due to its hazardous classification, the drug should not be disposed of via household waste or wastewater.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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