Apohealth Sleep Assist

Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Apohealth Sleep Assist has also been administered in veterinary applications and was formerly used in parkinsonism. [PubChem]

Hypertension: this medicine is indicated for the treatment of hypertension.

Heart Failure:

this medicine is indicated for the treatment of chronic heart failure with reduction of systolic ventricular function, in combination with diuretics and when appropriate, digitalis and beta-blockers.

Myocardial Infarction:

-Short -term (4 weeks) treatment: this medicine is indicated in any clinically stable patients within the first 24 hours of an infarction.

-Long term prevention of symptomatic heart failure: this medicine is indicated in clinically stable patients with asymptomatic left ventricular dysfunction (ejection fraction <40%).

Type I Diabetic Nephropathy:

this medicine is indicated for the treatment of macroproteinuric diabetic nephropathy in patients with type I diabetes..

Apohealth Sleep Assist is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Antihistamines can cause drowsiness and are sometimes used a sleep aids.

Apohealth Sleep Assist is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms.

Apohealth Sleep Assist is also used as a short-term treatment for sleep problems (insomnia).

Apohealth Sleep Assist may also be used for purposes not listed in this medication guide.

Usual Adult Dose for Allergic Rhinitis

Apohealth Sleep Assist 5 mg oral tablet, chewable:

10 mg orally every 4 to 6 hours not to exceed 6 doses daily.

Usual Adult Dose for Allergic Conjunctivitis

Apohealth Sleep Assist 5 mg oral tablet, chewable:

10 mg orally every 4 to 6 hours not to exceed 6 doses daily.

Usual Adult Dose for Insomnia

12 years of age and older: 25 mg orally 30 minutes before bed

Maximum dose: Take once daily or as directed by physician

Comments: Do not use 25 mg Apohealth Sleep Assist in children under 12 years of age

Usual Pediatric Dose for Allergic Rhinitis

Apohealth Sleep Assist 5 mg oral tablet, chewable:

12 years or older: 10 mg orally every 4 to 6 hours not to exceed 6 doses daily

6 years to under 12 years: 5 mg orally every 4 to 6 hours not to exceed 6 doses daily

Usual Pediatric Dose for Allergic Conjunctivitis

Apohealth Sleep Assist 5 mg oral tablet, chewable:

12 years or older: 10 mg orally every 4 to 6 hours not to exceed 6 doses daily

6 years to under 12 years: 5 mg orally every 4 to 6 hours not to exceed 6 doses daily

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

See also:
What is the most important information I should know about Apohealth Sleep Assist?

OTC labeling: Do not use in children <12 years of age.

Canadian labeling: Additional contraindications (not in US labeling): Hypersensitivity to Apohealth Sleep Assist or any component of the formulation; narrow angle glaucoma; asthmatic attack; prostatic hypertrophy; stenosing peptic ulcer, pyloroduodenal obstruction; bladder-neck obstruction; concurrent use with monoamine oxidase-inhibitors.

Use Apohealth Sleep Assist chewable tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Apohealth Sleep Assist chewable tablets by mouth with or without food.
• Chew thoroughly before swallowing.
• Use Apohealth Sleep Assist chewable tablets exactly as directed on the package, unless instructed differently by your doctor. If you are taking Apohealth Sleep Assist chewable tablets without a prescription, follow any warnings and precautions on the label.
• If you miss a dose of Apohealth Sleep Assist chewable tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Apohealth Sleep Assist chewable tablets.

Use: Labeled Indications

Insomnia: Reduce difficulty falling asleep

Off Label Uses

Nausea and vomiting of pregnancy

Apohealth Sleep Assist is usually given in combination with pyridoxine for the treatment of nausea and vomiting of pregnancy. Data from a randomized placebo-controlled trial supports the use of Apohealth Sleep Assist and pyridoxine (Diclectin) in the treatment of nausea and vomiting of pregnancy.

See also:
What other drugs will affect Apohealth Sleep Assist?

The simultaneous use of Apohealth Sleep Assist with psychotropic, anticonvulsant medications and ethanol is observed enhancement inhibitory action alprazolam on the CNS.

The simultaneous use with blockers of histamine H2-receptor reduce the clearance of alprazolam and increase the inhibitory effect of alprazolam on the CNS; macrolide antibiotics reduce the clearance of alprazolam.

The simultaneous use with hormonal oral contraceptives increased T1/2 of alprazolam.

Simultaneous administration of Apohealth Sleep Assist with dextropropoxyphene observed a more pronounced CNS depression than in combination with other benzodiazepines, as may increase the concentration of alprazolam in blood plasma.

Simultaneous treatment with digoxin increases the risk of intoxication by cardiac glycosides.

Alprazolam increases the concentration of imipramine in plasma.

Simultaneous administration with itraconazole, ketoconazole increases the effects of alprazolam.

Simultaneous administration with paroxetine may increases the effects of alprazolam due to the inhibition of its metabolism.

Fluvoxamine increases the concentration of alprazolam in plasma and risk of its side effects.

Simultaneous administration of Apohealth Sleep Assist with fluoxetine may increase the concentration of alprazolam in plasma by decreasing its metabolism and clearance under the influence of fluoxetine which is accompanied by psychomotor disorders.

It can not be exclude the possibility of strengthening effect of alprazolam for simultaneous administration with erythromycin.

See also:
What are the possible side effects of Apohealth Sleep Assist?

Undesirable effects reported for captopril and/or ACE inhibitor include:

Blood and lymphatic disorders:

Very Rare: neutropenia/agranulocytosis, pancytopenia particularly in patients with renal dysfunction, anaemia (including aplastic and haemolytic), thrombocytopenia, lymphadenopathy, eosinophilia, auto-immune diseases and/or positive ANA-titres.

Metabolism and nutrition disorders:

Rare: Anorexia

Very Rare: Hyperkalaemia, hypoglycaemia

Psychiatric disorders:

Common: Sleep disorders.

Very Rare: Confusion, depression.

Nervous system disorders:

Common: Taste impairment, dizziness.

Rare: Drowsiness, headache and paraesthesia.

Very Rare: Cerebrovascular incidents, including stroke, and syncope.

Eye disorders:

Very Rare: Blurred vision.

Cardiac disorders:

Uncommon: Tachycardia or tachyarrhythmia, angina pectoris, palpitations.

Very Rare: Cardiac arrest, cardiogenic shock.

Vascular disorders

Uncommon: Hypotension, Raynaud syndrome, flush, pallor.

Respiratory, thoracic and mediastinal disorders:

Common: Dry, irritating (non productive) cough and dyspnoea.

Very Rare: Bronchospasm, rhinitis, allergic alveolitis / eosinophilic pneumonia.

Gastrointestinal disorders:

Common: Nausea, vomiting, gastric irritations, abdominal pain, diarrhoea, constipation, dry mouth.

Rare: Stomatitis/aphthous ulcerations.

Very Rare: Glossitis, peptic ulcer, pancreatitis.

Hepato-biliary disorders:

Very Rare: Impaired hepatic function and cholestasis. (including jaundice), hepatitis including necrosis, elevated liver enzymes and bilirubin.

Skin and subcutaneous tissue disorders:

Common: Pruritus with or without a rash, rash and alopecia.

Uncommon: Angioedema

Very Rare: Urticaria, Stevens Johnson syndrome, erythema multiforme, photosensitivity, erythroderma, pemphigoid reactions and exfoliative dermatitis.

Musculoskeletal, connective tissue and bone disorders:

Very rare: Myalgia, arthralgia.

Renal and urinary disorders:

Rare: Renal function disorders including renal failure, polyuria, oliguria, increased urine frequency.

Very Rare: Nephrotic syndrome.

Reproductive system and breast disorders:

Very Rare: Impotence, gynaecomastia.

General disorders:

Uncommon: Chest pain, fatigue, malaise.

Very Rare: Fever

Investigations:

Very Rare: Proteinuria, eosinophilia, increase of serum potassium, decrease of serum sodium, elevation of BUN, serum creatinine and serum bilirubin, decreases in haemoglobin, haematocrit, leucocytes, thrombocytes, positive ANAtitre, elevated ESR.

Intestinal angioedema has also been reported very rarely in patients with ACE inhibitors and should be included in the differential diagnosis of patients on ACE inhibitors presenting with abdominal pain.