Aosept Plus

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Aosept Plus

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Aosept Plus

Property Description
Active Ingredient Hydrogen Peroxide (3%)
Form Aqueous Solution with Neutralizing Disc
Pharmacological Class Disinfecting Agent, Oxidizing Agent
General Use Cleaning and Disinfection of Contact Lenses
Origin Synthetic Chemical Compound

1. Classification and Fundamental Identity

Aosept Plus is fundamentally a peroxide-based lens care system formulated as an aqueous solution intended for the deep cleaning, protein removal, and disinfection of all types of soft and rigid gas permeable (RGP) contact lenses. Functionally, it is classified as a powerful Disinfecting Agent and Oxidizing Agent used exclusively for ex vivo lens hygiene. This classification highlights its reliance on the strong chemical properties of oxidation to achieve superior microbial efficacy, a property recognized for its robust germicidal action.

The system is a sophisticated, one-step solution developed from synthetic chemical compounds, distinguishing itself from standard multipurpose solutions by employing a mandatory chemical transformation process. Hydrogen peroxide systems generally offer high efficacy against various microbial pathogens, including the resilient Acanthamoeba species. The system’s design offers broad-spectrum protection against common contact lens-related infections.

2. Core Composition and Preservative-Free Formulation

The active ingredient in the Aosept Plus solution is Hydrogen Peroxide in a 3% concentration, stabilized with phosphonic acid. The system is a complex combination product that pairs this potent disinfectant with a unique lens case featuring a Platinum Neutralizing Catalyst—the AODISC. This component is the distinctive feature that transforms the product from a powerful disinfectant into a safe soaking solution.

The formulation is further characterized by the inclusion of non-active components like Poloxamer, a surfactant that assists in removing surface debris, and the HydraGlyde Moisture Matrix. Crucially, the solution is preservative-free. This formulation characteristic is significant for minimizing potential ocular irritation associated with common contact lens solution preservatives, providing a benefit for individuals with sensitive eyes.

3. General Purpose and Distinctive Benefit

The primary purpose of Aosept Plus is to deliver thorough lens hygiene, ensuring chemical disinfection is achieved while simultaneously preparing the lens for safe reinsertion. The system is designed so that the potent Hydrogen Peroxide is entirely converted into a gentle, sterile, saline-like solution through the required neutralization step. This mandatory process provides wearers with a cleaned and disinfected lens surface that is free of irritating chemical residues, which enhances wearing comfort and supports overall eye health, representing a key point of differentiation within the lens care market.

What side effects are possible with Aosept Plus?

Possible Side Effects and Safety Information

The safety profile of Aosept Plus, a 3% hydrogen peroxide-based lens care system, is defined primarily by the risk of acute, localized chemical injury if the mandatory neutralization process is not properly completed. Adverse events and safety characteristics are drawn from regulatory documents and post-market surveillance data, such as reports submitted to the U.S. Food and Drug Administration (FDA).

Officially Documented Adverse Reactions

The documented adverse reactions are confined exclusively to the Eye Disorders system-organ class. These reactions are typically of acute and immediate onset upon contact with the unneutralized solution.

Officially reported adverse reactions include ocular discomfort, eye pain, burning sensation, conjunctival erythema (redness), blurred vision, and foreign body sensation.

Serious Adverse Reactions documented in regulatory reporting systems, usually associated with accidental exposure to the unneutralized peroxide solution, include:

  • Corneal Ulcer
  • Corneal Erosion/Abrasion
  • Keratitis (including superficial punctate keratitis)

Safety Restrictions and Considerations

The fundamental safety constraint for this product is the mandatory requirement for complete chemical neutralization using the designated lens case and catalyst prior to lens insertion. The unneutralized 3% hydrogen peroxide is chemically potent and is explicitly restricted from being used as a rinsing agent for the eye or for lenses before immediate insertion.

No specific population-based safety constraints (e.g., related to renal or hepatic impairment) are explicitly defined in official safety summaries, as the risk is localized and exposure-dependent, not systemic.

Overdose and Emergency Response

The official overdose profile for this hydrogen peroxide solution is strictly defined by two primary exposures: acute ocular tissue injury and systemic risk from accidental ingestion. Regulatory documentation mandates that immediate action is required in all instances of overexposure.

Un-neutralized solution contact with the eye is officially documented to cause intense pain, stinging, burning, and visible signs of corneal injury and eye redness. Severe, unmanaged ocular exposure may potentially result in permanent visual impairment.

Accidental ingestion is associated with clinical manifestations of gastrointestinal irritation, including abdominal pain, nausea, and vomiting. A key physiological finding is gastric distention, resulting from the rapid release of oxygen gas. Regulatory sources indicate the systemic risk of air embolization is a severe potential complication of ingestion.

Immediate medical help must be sought for any known or suspected overexposure by calling a Poison Center/doctor and emergency services. Since no specific antidote is known, treatment is limited to supportive and symptomatic measures. For ocular exposure, this procedure includes copious irrigation with water or saline. Hospital observation is recommended for 24 to 48 hours following significant overexposure to monitor for delayed complications.

Therapeutic Uses of Aosept Plus

What Aosept Plus Treats: Main Uses and Benefits

This product category is used for the cleaning and disinfection of contact lenses. Aosept Plus is considered relevant across three primary therapeutic domains, including providing thorough cleaning and disinfection, addressing preservative intolerance, and assisting with the removal of protein and lipid deposits.

The system is applied in contexts where additional symptomatic assistance is needed. It is commonly used to help manage symptoms related to inflammatory or irritative states such as redness and dryness, often triggered by chemical sensitivities. It also helps address symptoms that interfere with daily functioning by ensuring lens clarity and comfort.

This formulation is commonly used to help with preventive ophthalmic hygiene and supports patients during episodes of heightened discomfort linked to contamination.

Quick Fact: Relief for Preservative-Induced Eye Irritation

Eligibility and Restrictions for Use

Who Can and Cannot Use Aosept Plus?

The population eligibility for Aosept Plus, a preservative-free lens care solution, is strictly defined by regulatory documents based on the intended use and chemical safety profile.


Eligibility Scope

Classification Eligible Population/Rule
Allowed Users All individuals who wear soft or rigid gas permeable (RGP) contact lenses.
Absolute Contraindication Patients with a known allergy or hypersensitivity to any of the solution's ingredients, including Hydrogen Peroxide or the Platinum Neutralizing Disc.
Age-Related Rules No mandatory minimum age restrictions or geriatric restrictions are documented in the regulatory label.
Systemic Conditions Use is not restricted by conditions such as hepatic (liver) or renal (kidney) impairment due to the product's ex vivo (outside the body) use.

Eligibility-Related Restrictions

All contact lens wearers are restricted by the critical safety requirement that the lens must not be inserted into the eye prior to the full completion of the mandatory minimum 6-hour neutralization soak within the dedicated lens case. Direct contact with the un-neutralized solution is prohibited for any individual. Official labeling does not contain specific eligibility status regarding pregnancy or lactation.

What should I know about interactions with other medicines?

Interaction Map: Interactions with other medicines and products — official regulatory information for Aosept Plus

Interaction scope

Medicinal product categories with documented interactions: Other contact lens solutions, saline solutions, and water (due to contraindicated chemical co-administration).

Specific interacting medicines (if explicitly listed): None listed (restrictions apply to substance categories, not specific systemic medicines).

Mechanistic basis of interactions (only if stated in label): Oxidizing chemistry requiring mandated chemical neutralization.

Timing-based interaction rules (if applicable): Mandatory separation time of a minimum of six (6) continuous hours between solution use and lens insertion.

Population-specific interaction notes (if applicable): None documented.

Interaction-related restrictions: Use of generic, non-contact lens grade hydrogen peroxide is prohibited. Re-use of the solution is prohibited. Use of any non-specialized lens case is prohibited.

Interaction classifications (high-level)

Interaction severity classification (as defined in official documents): Contraindicated Combinations and Mandatory Administration Conditions.

Regulatory basis (EMA / FDA / etc.): FDA Guidance, Health Canada Monograph.

Interaction-context constraints (as defined in official documents): Interaction constraints are procedural and chemical, governing the ex vivo use of the product to ensure neutralization of the active ingredient before ocular contact.

Resulting interaction structure

Official interaction statements:

  • Co-administration with any other contact lens solution, saline solution, or water is strictly prohibited to maintain the chemical balance required for disinfection and neutralization.
  • Lenses must be soaked for a minimum of six continuous hours in the specialized lens case before they can be safely inserted into the eye.
  • The solution is required to be used only with the specialized lens case containing the Platinum Neutralizing Catalyst to ensure proper chemical decomposition.
  • The use of generic or non-contact lens grade hydrogen peroxide is restricted due to the potential for damage to the lens and untested purity for ocular use.

Connection to the overall interaction profile: Regulatory documents define the product's interaction structure primarily through two domains: contraindicated chemical co-administration and mandatory administration timing separation. These restrictions are based on the need to manage the oxidizing properties of the 3% Hydrogen Peroxide solution, ensuring its complete chemical conversion to sterile saline prior to contact with the ocular surface, as detailed in official government monographs and guidance.

Mechanism of Action

Oxidative Disinfection and Debris Removal

The system's initial mechanism is the oxidative destruction of microbial structures. The Hydrogen Peroxide ( H2 O2) component generates highly reactive hydroxyl-free radicals ( HOcdot), which initiate a rapid, non-selective chemical attack. These radicals cause irreversible denaturation of microbial proteins and essential lipid peroxidation within cellular membranes, leading to the breakdown of the microbial cellular integrity pathway and achieving microbial sterilization. Simultaneously, a surfactant (Poloxamer) lowers the surface tension to physically lift protein and lipid deposits, assisting the oxidation by increasing microbial target exposure and promoting the suspension of debris.

️ Platinum-Catalyzed Neutralization

Once the disinfection and debris removal phases are complete, the Platinum Catalyst (AODISC) initiates a highly specific catalytic conversion pathway. This process accelerates the decomposition of residual H2 O2 into inert water ( H2 O) and oxygen ( O2) gas. This mandatory decomposition mechanism converts the solution from a chemically active disinfectant into a chemically inert, saline-like medium. This change in chemical state results in the final output of an inert, conditioned lens surface.

Adsorptive Surface Hydrophilicity

A complementary mechanism is the adsorptive surface modulation provided by the HydraGlyde Moisture Matrix copolymer. Its mechanistic role is to alter the lens surface energy pathway by enhancing water retention and stability at the lens-tear film interface. This resulting physiological effect contributes to the final hydrophilicity and wetting capacity of the lens surface.

Dosage and Administration Information

How to Use Aosept Plus: Administration Guidelines

The usage instructions for the Aosept Plus system are defined by a mandatory chemical process—the neutralization of the 3% hydrogen peroxide solution—which must be followed for the disinfection of contact lenses. The administration is a fixed chemical process that is independent of the user’s clinical status, as it applies to the device (the contact lens) and not a pharmacological dose for a patient.


Administration Scope

The route of use is ex vivo topical application to the contact lens; the solution itself is explicitly not for direct insertion into the eye or for use as a final pre-insertion rinsing agent. The system is intended for daily use for cleaning, disinfection, and storage of soft and rigid gas permeable (RGP) lenses. The required volume of solution is determined by filling the specialized lens case precisely to the indicator line for each cycle.


Key Procedural Requirements

Preparation requirements: The solution must be used exclusively with the proprietary lens case containing the AODISC (platinum neutralizer) to complete the required chemical transformation. The solution must never be diluted or mixed with other contact lens solutions.

Minimum Soak Time: Lenses must soak for a minimum of 6 hours or overnight to ensure the complete neutralization of the hydrogen peroxide into a safe, saline-like solution.

Solution Integrity: The volume of solution used for one cycle must never be reused; a fresh, measured volume is required for each daily disinfection cycle. There are no specified age-group administration rules.


Connection to the Overall Use Protocol

The use protocol is structured around this required, time-dependent chemical reaction. Adherence to the fixed volume, the use of the proprietary case, and the minimum 6-hour soaking time is necessary to ensure the contact lenses are thoroughly disinfected in a standardized manner.

Recent Clinical Evidence

Aosept Plus: Recent Clinical Evidence

The evidence base for Aosept Plus stems primarily from laboratory studies designed to meet regulatory standards and short-term clinical trials that examine patient experience. This overview summarizes the types of studies conducted and the patterns the research reports, without offering advice or interpretation.


Evidence Supporting the Disinfection of Contact Lenses

Research explored the parameters of the solution studied for disinfection using standardized laboratory measurement testing (bench studies). These studies monitored microbial load reduction against common pathogens and resilient protozoa like Acanthamoeba in controlled environments. Findings describe patterns observed in relation to established regulatory criteria. However, uncertainty remains as this evidence is highly reliant on in vitro data, which do not fully establish how real-world variables, like patient compliance, might influence the overall disinfection process.


Evidence Regarding Ocular Comfort and Preservative-Free Systems

Studies monitored patient-reported outcomes describing perceived discomfort in habitual contact lens wearers. These were often short-term comparative clinical trials that evaluated the solution against preserved multipurpose solutions (MPS). Findings describe patterns where patients reported subjective patient preference for, and self-assessed comfort with, the preservative-free system. The evidence includes subjective patient reports, and follow-up durations were limited (e.g., typically 90 days or less). Long-term effects and the durability of these comfort patterns are not fully established.


Studies on Lens Cleaning and Deposit Removal

The measurements of cleaning performance were evaluated in laboratory bench studies and clinical equivalence trials. Research examined the removal of naturally occurring tear film components, such as protein and lipid deposits. Clinical trials were conducted to confirm the system's substantial equivalence in overall cleaning performance to other market-established solutions. Comparative evidence to evaluate superiority remains limited, and variability across studies exists in deposit removal when testing different contact lens materials.

Frequently Asked Questions (FAQ)

Common questions about Aosept Plus (FAQ)


Q: What happens if I use Aosept Plus for less than the recommended time?

Official guidelines state that the contact lenses require a mandatory minimum soak time of 6 hours for the full neutralization of the solution. Inserting lenses before this period increases the likelihood of ocular discomfort, burning, or stinging sensations due to contact with unneutralized solution, as described in safety warnings.

Q: Can Aosept Plus cause blurry vision the day after use?

Blurred vision is listed as a reported adverse reaction in regulatory safety summaries, typically occurring alongside other symptoms like irritation or pain. These reported effects are often associated with accidental exposure or failure to complete the full neutralization cycle, according to regulatory summaries.

Q: How quickly does the neutralization process complete with Aosept Plus?

The official product instructions state that the neutralization process requires a minimum of 6 hours, or an overnight soak, to fully convert the disinfecting solution. This minimum period allows the platinum catalyst to complete the chemical conversion, changing the solution into a sterile, saline-like medium.

Q: Why does Aosept Plus sometimes sting or burn after application?

Stinging, burning, and pain are officially reported sensations that occur if the contact lens is inserted into the eye before the mandatory neutralization process has been fully completed. This sensation is attributed to the lens being inserted before the mandatory neutralization process is complete, meaning the potent hydrogen peroxide solution has not been fully converted.

Q: How does the peroxide component in Aosept Plus compare to standard hydrogen peroxide?

The product is formulated with a specific 3% concentration of contact lens grade hydrogen peroxide. Official warnings prohibit the use of generic, non-contact lens grade hydrogen peroxide. This grade is required as the purity and formulation of the contact lens product must meet specific regulatory standards for use in lens care.

Q: Why do some users report a bubbling sensation with Aosept Plus?

The bubbling sensation is a description of the normal and expected chemical pathway that occurs when the platinum catalyst (AODISC) is in use. This process converts the hydrogen peroxide into inert water and oxygen gas (O₂), and the release of this gas creates the visible bubbling or fizzing.

Q: What happens if a small amount of unneutralized Aosept Plus touches the eye?

Direct contact with the unneutralized solution is a chemical exposure that may cause acute reactions, such as severe eye pain, burning, and redness. Regulatory reports document serious outcomes associated with accidental exposure, such as corneal ulcer and keratitis, emphasizing the importance of complete neutralization.

Q: How do official sources describe the feeling of the solution on the eye if used improperly?

Official documents define the consequences of improper use as an acute chemical exposure, potentially resulting in severe eye pain, burning, conjunctival redness, and a sensation of a foreign body in the eye. Severe outcomes documented in regulatory reports include corneal erosion.

Q: Is the slight foaming or fizzing during neutralization normal?

Yes, the visible foaming or fizzing is the expected physical manifestation of the chemical reaction that occurs inside the lens case. This is a sign that the platinum catalyst is working correctly to convert the hydrogen peroxide into water and oxygen gas.

Q: Is Aosept Plus the same as other peroxide-based cleaning systems?

Aosept Plus is classified as a peroxide-based lens care system containing 3% hydrogen peroxide. While its core disinfecting mechanism is similar to other peroxide systems, its unique formulation includes components like the HydraGlyde Moisture Matrix, which differentiates its complete composition and surface interaction.

Q: Are there any materials that Aosept Plus should not be used with?

Official regulatory indications state that the system is approved for all soft and rigid gas permeable (RGP) contact lenses. Compatibility testing is part of the regulatory approval process to ensure safe use with these specific lens materials.

Q: Can I store my lenses in Aosept Plus for longer than the recommended time?

After the mandatory 6-hour disinfection and neutralization, official instructions state that lenses may be stored in the unopened case with the neutralized solution for up to 14 days. If the lenses are stored longer than this period, repeating the cleaning and disinfection cycle with a fresh solution is required by official guidance before the lenses are worn.

Q: Is there a maximum number of times I can reuse the Aosept Plus case?

Official storage and disposal instructions specify that the lens case, which contains the neutralizing disc, must be discarded and replaced. This replacement is required upon opening a fresh bottle of solution to ensure optimal function.

Q: Does Aosept Plus work differently on rigid gas permeable lenses versus soft lenses?

The system is officially indicated for use with both soft and rigid gas permeable (RGP) lenses. The oxidative chemical action, which is the core disinfecting mechanism, is standardized. Regulatory efficacy testing is conducted to ensure the system meets requirements for both lens categories.

Q: What kind of studies have been conducted on Aosept Plus's efficacy?

Evidence is drawn from both laboratory (bench) testing and short-term clinical trials. Studies examine the solution’s efficacy by measuring microbial load reduction against pathogens like bacteria and yeast, and by evaluating cleaning performance against natural tear film deposits.

Q: Is Aosept Plus sold in different concentrations globally?

Official regulatory documents define the active ingredient in the Aosept Plus solution consistently across jurisdictions as 3% Hydrogen Peroxide.

Q: What are the most common reported side effects mentioned in official documents?

The most frequently reported adverse reactions listed in safety summaries include localized ocular discomfort, pain, burning, and conjunctival redness. These events are typically associated with accidental contact or incomplete neutralization, as indicated in regulatory safety summaries.

Q: Are there any specific patient populations (e.g., children, elderly) where Aosept Plus use is described differently?

Official labeling does not contain mandatory minimum age restrictions, geriatric restrictions, or special administration rules based on systemic health conditions. The primary safety constraint applies to the ex vivo process of neutralization for all users.

Q: Are there warnings about using Aosept Plus while taking common over-the-counter medications?

The official interaction constraints defined in regulatory documents are procedural and chemical, governing the ex vivo use of the product. The labels list no specific systemic drug interactions, including with common over-the-counter medications.

Q: Can I use Aosept Plus solution if the neutralizing disc is missing or damaged?

Official instructions mandate that the solution must be used exclusively with the proprietary lens case containing the platinum neutralizer (AODISC). The disc is required to convert the potent hydrogen peroxide into a saline-like solution before the lenses can be inserted, as mandated by official instructions.

Q: Is Aosept Plus safe for people with known allergies to certain chemicals?

The system is officially contraindicated for any patient with a known allergy or hypersensitivity to any of the solution's specific ingredients. This includes the hydrogen peroxide, the Poloxamer surfactant, or the platinum neutralizing disc.

Q: Can Aosept Plus be used to clean specialty lenses, like Scleral lenses?

The product is officially indicated for use with soft and rigid gas permeable (RGP) contact lenses. Use with other specialty lenses, such as Scleral lenses, is outside of the product's defined regulatory scope.

Q: What is the shelf life of Aosept Plus once the bottle has been opened?

Official storage requirements specify a shelf life for the opened bottle, requiring that any unused solution remaining in the bottle must be discarded 3 months (90 days) after the bottle is first opened.

Q: What do official sources say about the risk of infection when using Aosept Plus correctly?

Official classification defines the system as a powerful Disinfecting Agent. Research reports on the system's germicidal action through oxidative destruction, which indicates the system is designed to meet microbial load reduction standards for contact lens care.

Q: Does Aosept Plus have different instructions for daily-wear versus extended-wear lenses?

The system's administration instructions are standardized, with the same procedural requirements for all indicated lens types. The solution is generally intended for the daily cleaning, disinfection, and storage of soft and RGP lenses.

Q: Do official documents mention any potential for Aosept Plus to damage lens coating?

Compatibility testing for the indicated lens types is a required part of the regulatory approval process. This testing ensures that the cleaning and disinfection system does not negatively affect the physical or optical integrity of the approved soft and RGP lenses.

Q: Is Aosept Plus described as being suitable for sensitive eyes?

The official formulation is preservative-free, a characteristic noted in regulatory documents as significant for minimizing potential ocular irritation. This formulation feature is noted for minimizing potential ocular irritation often associated with common contact lens solution preservatives.

Q: Are there any warnings about using Aosept Plus in certain climate conditions?

Official storage rules specify that the product must be stored at a temperature below 25 °C and protected from direct heat or sunlight. Instructions also note that the mandatory 6-hour neutralization may take longer in temperatures below 15 °C.

Q: Can Aosept Plus be used with lenses for astigmatism?

The solution is officially approved for all soft and rigid gas permeable (RGP) contact lenses. This general scope of indication includes lenses designed for astigmatism (toric lenses) that fall within the soft or RGP categories.

How should Aosept Plus be stored and disposed of?

Official Storage and Disposal Requirements

Official regulatory guidelines for Aosept Plus (hydrogen peroxide solution) define specific storage and handling constraints to maintain product efficacy and safety. The product must be stored at a temperature below 25°C and protected from direct sunlight.

Key Storage and Stability Rules

  • Temperature and Light: Store below 25°C, away from direct heat or light.
  • Container Integrity: Keep the bottle tightly closed and do not transfer the solution to other containers.
  • Shelf-Life: Discard any unused solution remaining in the bottle 3 months (90 days) after opening.
  • Child Safety: It is mandatory to keep the product out of the reach of children.

Disposal Instructions

The solution used for disinfection must be discarded after neutralization (typically after the mandatory 6-hour minimum soak). To maintain optimal function, the regulatory instructions specify that the AOCup lens case must also be discarded and replaced with a new one upon opening a fresh bottle of solution.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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