Ansimar

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Ansimar

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Method of action: Bronchodilator

Treatment option:

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Ansimar

Property Description
Active Ingredient Doxofylline
Form Tablet, Syrup, Injection
Pharmacological Class Methylxanthine Bronchodilator
General Purpose Relief of airway obstruction
Origin Synthetic

Ansimar is a prescribed medication whose sole active component is Doxofylline (INN), a synthetic drug classified as a bronchodilator belonging to the methylxanthine derivative class. This specialized compound is chemically distinct from older xanthines, featuring a unique molecular modification (C₁₁H₁₄N₄O₄) designed to improve its therapeutic profile. Doxofylline is assigned the Anatomical Therapeutic Chemical (ATC) code R03DA11, positioning it among systemic agents for chronic obstructive airway diseases.


Composition, Origin, and Available Forms

The composition of Ansimar is defined by its monocomponent nature, containing only Doxofylline, which is entirely synthetic in origin. The medication is commonly supplied in pharmaceutical forms suitable for different patient needs, including an oral tablet and a syrup, and occasionally an injectable solution intended for intravenous use. Doxofylline is utilized for its role in increasing lung function in patients with chronic respiratory conditions, which is the cornerstone of its clinical recognition.


General Therapeutic Purpose and Foundational Action

The central function of Ansimar is to promote easier respiration by addressing and resolving the constriction of air passages. Its foundational action is based on bronchodilation, the essential process of relaxing the smooth muscle tissue that lines the bronchi. This mechanism is intended to widen the airways. This therapeutic benefit is clinically recognized for alleviating symptomatic tightness and obstruction typically encountered in individuals with chronic respiratory issues.

What side effects are possible with Ansimar?

Possible Side Effects and Safety Information

The safety profile of Ansimar, whose active component is Doxofylline, is primarily defined by adverse reactions commonly associated with the methylxanthine class of medications. Officially documented side effects most frequently affect the central nervous system, cardiovascular system, and gastrointestinal tract, though specific frequencies for many individual events are often classified as 'Frequency not known' in regulatory documents.

Documented Adverse Reactions

The following effects are listed in regulatory prescribing information, grouped by the affected System-Organ Class (SOC):

System-Organ Class Examples of Documented Reactions
Gastrointestinal Disorders Nausea, vomiting, epigastric pain.
Nervous System Disorders Headache, irritability, insomnia, dizziness, tremor.
Cardiac Disorders Tachycardia (increased heart rate), extrasystole (irregular heartbeats), palpitations.

Serious adverse reactions, which are typically associated with potential intoxication or overdose, include severe arrhythmias and seizures.


Safety Constraints and Considerations

The medicine is officially contraindicated in individuals with certain pre-existing conditions, including acute myocardial infarction, hypotension, and in those who exhibit hypersensitivity to Ansimar’s components or other methylxanthines. It is also contraindicated for use in lactating women.

Caution is specifically advised for administration in the elderly and in patients with conditions that may affect drug clearance, such as hepatic disease, renal disease, and congestive heart failure. Official labeling also restricts the concurrent use of Ansimar, stating that it should not be administered together with other xanthine derivatives.

Overdose and Emergency Response

The regulatory documentation for Ansimar (Doxofylline) specifies that immediate medical attention must be sought at the first sign of a suspected overdosage. The officially documented clinical manifestations of an overdose primarily affect the central nervous system and the cardiovascular system, indicating the need for prompt action.

Documented Manifestations

Overdose may present with serious symptoms, including seizure and severe arrhythmias, which are specifically identified in prescribing information as potential signs of intoxication. Other documented effects can include tachycardia, extrasystole, nausea, vomiting, epigastric pain, headache, irritability, and insomnia. Metabolic changes such as metabolic acidosis and hypokalemia are also noted in the context of xanthine overdosage, alongside a potential for gastrointestinal bleeding.

Emergency Management

In the event of an overdose, the drug administration must be stopped immediately. Treatment is entirely symptomatic and supportive, as the official regulatory labeling explicitly states that no specific antidote is known for Doxofylline. Procedures may include gastric emptying measures such as gastric lavage or inducing emesis (if no seizures have occurred), followed by the administration of activated charcoal and a cathartic. If seizures occur, establishing and maintaining an adequate airway is a required action.

Population Risk

The risk of toxicity is heightened in patients with underlying conditions such as liver disease or congestive heart failure due to a documented prolongation of the drug’s plasma half-life.

Therapeutic Uses of Ansimar

What Ansimar Treats: Main Uses and Benefits

Ansimar (Doxofylline) may be part of symptomatic management for conditions involving chronic obstructive airway diseases. Doxofylline is relevant for managing conditions characterized by periods of heightened symptoms, such as Chronic Obstructive Pulmonary Disease (COPD) and bronchial asthma. It may be part of symptomatic management, commonly used across conditions presenting with episodic or fluctuating manifestations.


The medication is applied to manage pronounced manifestations in clinical settings, primarily addressing the distressing cluster of respiratory symptoms that include shortness of breath (dyspnea), wheezing, and the sensation of chest tightness. The medication is applied when symptoms create noticeable physiological strain and supportive relief is needed.

“The support provided may assist with easing symptoms that interfere with daily functioning.”

Indications: The therapeutic use of Ansimar is focused on conditions where chronic airflow limitation causes significant symptomatic discomfort, specifically bronchial asthma and various forms of COPD. As an adjuvant treatment, this systemic medication contributes to improved comfort during symptomatic periods, and is relevant for easing distress during difficult episodes.

Quick Fact: Relief for Breathlessness
This continuous support may assist with easing symptoms that interfere with daily functioning and contributes to improved day-to-day comfort during symptomatic periods.

Eligibility and Restrictions for Use

Official Eligibility and Contraindications

Regulatory authorities define strict population-based rules for the use of Ansimar (Doxofylline) to ensure appropriate clinical management. These rules establish absolute prohibitions and specific conditions under which the medicine must be used with caution.

Absolute Contraindications (Must Not Use)

Ansimar is contraindicated and must not be administered in patients with the following conditions or characteristics:

  • Hypersensitivity: Known allergy to Doxofylline or to any other methylxanthine derivatives.
  • Acute Cardiac Status: Recent acute myocardial infarction (heart attack).
  • Circulatory Status: Existing hypotension (low blood pressure).
  • Lactation: Women who are breastfeeding (nursing mothers).

Conditional Use and Restrictions

Use of Ansimar requires caution and close monitoring in specific populations due to the potential for altered drug clearance or increased risk:

  • Age: Use is not established or not recommended in children under 6 years of age. Elderly patients require caution and may require dose adjustment.
  • Organ Function: Patients with hepatic dysfunction (liver disease) or renal impairment (kidney disease).
  • Comorbidities: Individuals with heart disease (e.g., congestive heart failure, cardiac arrhythmias), hyperthyroidism, hypoxemia, convulsive disorders, or a history of peptic ulcer.
  • Pregnancy: The drug should only be given to pregnant women if clearly needed, as safe use in humans has not been formally established due to limited clinical experience.

What should I know about interactions with other medicines?

The official regulatory profile for Ansimar (Doxofylline) establishes restrictions based on altered drug exposure and the potential for synergistic effects.

Formal Prohibitions and Exposure Modifiers

Co-administration with other xanthine preparations (derivatives) is formally prohibited due to the risk of additive toxicity. The regulatory profile documents numerous substances that modify Doxofylline's plasma levels by altering its hepatic clearance. Drugs documented to reduce clearance and increase systemic exposure include antibiotics such as erythromycin, troleandomycin, lincomycin, and agents like cimetidine, allopurinol, and propranolol. The influenza vaccine is also noted to decrease clearance. Conversely, phenytoin and other anticonvulsants are documented to increase clearance, resulting in reduced systemic exposure.

Pharmacodynamic and Substance Interactions

A risk of toxic synergism is documented when Doxofylline is co-administered with ephedrine or other sympathomimetic drugs. Regulatory information identifies cigarette smoking as an external factor that increases drug clearance. Furthermore, it is officially recommended to limit the consumption of beverages and food containing caffeine.

Population-Specific Considerations

Official labeling indicates that clearance is considerably slower in specific patient populations, including the elderly and those with severe liver disease, congestive heart failure, or chronic obstructive pulmonary disease (COPD). This slower clearance reflects the risk of accumulation also seen with clearance-reducing drug interactions.

Mechanism of Action

The mechanism of Doxofylline is a targeted action focused on the cellular mechanics of the respiratory system, relying on two primary pharmacodynamic domains.

Modulation of Intracellular Second Messengers

This mechanism primarily involves altering the balance of cyclic Adenosine Monophosphate (cAMP) within the bronchial smooth muscle cells. The drug acts by inhibiting certain Phosphodiesterase (PDE) enzymes (e.g., PDE2A1) and engaging in a modulatory interaction with mathbfbetamathbf2 -Adrenoceptor signaling. This leads to a molecular cascade where elevated cAMP levels decrease available intracellular calcium ions ( Ca^2+). This reduction in Ca^2+ is the molecular step that causes the relaxation of the airway smooth muscle.

Selective Receptor Avoidance and Ancillary Effects

A distinguishing mechanistic feature is the drug's minimal affinity for the adenosine receptors ( A1 and A2A) at therapeutic concentrations. This selective avoidance constrains the drug's action to peripheral systems. Additionally, the mechanism includes an ancillary modulatory effect on airway inflammatory processes, supported by evidence of its influence on the release of certain pro-inflammatory mediators, which modulates the microenvironment of the air passages.

Dosage and Administration Information

Official Administration Guidelines

Ansimar (Doxofylline) is administered via two primary routes, which define its use in both routine management and acute care.


Property Administration Guidelines
Route of Administration Oral (tablet/syrup) is for maintenance treatment; Intravenous (IV) (injection) is reserved for the acute phase.
Dosing Schedule (Adults) Standard oral dose is 400 mg. The oral dose may be increased up to a maximum of 1200 mg daily. The IV acute dose is 200 mg.
Frequency Pattern Oral doses are typically administered two to three times daily. IV doses may be repeated at 12-hour intervals at the physician's discretion.
Age-Group Administration Rules Older Adults (Elderly): The oral dose is reduced to 200 mg two or three times daily. Pediatric (> 6 years): Dosage is weight-based at 6 mg/kg of body weight, administered twice daily.

Special Procedural Conditions

Administration conditions are specifically defined to ensure proper use, particularly for the intravenous route.

  • IV Technique: The intravenous injection is typically administered slowly over a period of 15 to 20 minutes.
  • Patient Position: The IV dose is given to the patient while they are in a supine position (lying on their back), and the ampoule contents are preferably diluted before injection.
  • Dose Adjustment: Dosage reduction may be necessary for patients with known hepatic or cardiac impairment, as clearance may be reduced.

Connection to the Overall Use Protocol

The administration protocol follows a precise, dual-route structure where the oral regimen supports long-term scheduled administration, while the IV regimen is reserved for intervention during acute symptomatic periods. The use protocol is further structured by dose adjustments for older adults and pediatric patients, ensuring administration adheres precisely to defined numerical limits and procedural requirements.

Recent Clinical Evidence

Research evidence / Overview of studies for Ansimar (Doxofylline)


Evidence for Use in Chronic Obstructive Pulmonary Disease (COPD)

Research examined Doxofylline in adult patients with Chronic Obstructive Pulmonary Disease (COPD), a condition marked by functional limitations. The evidence base primarily consists of Randomized Controlled Trials (RCTs) and quantitative summaries of those trials, known as meta-analyses. These studies were observed in patients with conditions presenting with cycles of stability and flare-ups.

The research examined several important outcomes related to physical discomfort and functional measures, including monitoring changes measured in lung function (such as FEV1) and tracking changes measured in exercise tolerance. Data show patterns related to lung function measurements that were different from measurements reported in the placebo groups. Comparative research examined outcomes related to older xanthine derivatives.


Evidence for Use in Bronchial Asthma

Research was studied for Doxofylline in bronchial asthma, which is one of the conditions characterized by fluctuating or episodic manifestations. The evidence includes both Randomized Controlled Trials and subsequent meta-analyses where the medication was observed in studies against both placebo and older xanthine drugs. Studies examined outcomes capturing phases of heightened symptom activity, such as the rate of asthma events, and outcomes describing episodic or acute changes regarding the reliance on rescue medication.

Data show patterns related to functional measures and the reported frequency of asthma events when compared to placebo. Some comparative trials observed patterns related to asthma event rates and functional outcomes that differed from patterns seen with older drugs like theophylline.


What Remains Uncertain About Ansimar's Evidence

Findings from the research contribute to the broader evidence landscape, but they also highlight areas where more scientific investigation is needed.

Comparative Evidence: Comparative evidence is lacking against many of the newer, guideline-recommended long-acting bronchodilators used globally for both COPD and asthma. The research examined outcomes related to older xanthine drugs or placebo.

Long-Term Impact: There is limited information for long-term outcomes concerning the maintenance of functional benefits or the drug's impact on the long-term course of chronic respiratory illness. Follow-up durations were limited in many primary studies.

Key Studies & References

  1. Assessing the long-term efficacy and safety of doxofylline in treating asthma (LESDA study)

Frequently Asked Questions (FAQ)

Common questions about Ansimar (FAQ)

Q: How quickly should I feel the effects of Ansimar after taking it?

A: Official information regarding the drug’s pharmacokinetics indicates that the active ingredient typically reaches its highest concentration in the bloodstream approximately one hour after you take an oral tablet. This time frame indicates when the concentration in the blood is highest, which typically correlates with the onset of effect.


Q: What's the difference between Ansimar and other bronchodilators?

A: Ansimar is classified as a methylxanthine derivative. Regulatory information notes that, unlike the older drug theophylline, Ansimar has a decreased affinity for certain cell receptors (A1 and A2A adenosine receptors). This unique molecular structure is thought to provide a more selective action compared to older xanthine drugs, with its primary function being to relax the smooth muscle tissue lining the bronchi.


Q: Does Ansimar cause drowsiness or fatigue?

A: The official product labeling lists several side effects related to the nervous system, including dizziness, irritability, insomnia, and tremor. General fatigue or drowsiness is not specifically listed in official labeling; however, other effects that may affect alertness, such as dizziness and tremor, are documented.


Q: Are there any common foods or drinks that interact with Ansimar?

A: The official recommendation is to limit the consumption of beverages and food containing caffeine while taking this medicine. Caffeine is documented in regulatory warnings due to the potential for interactions.


Q: How long does one dose of Ansimar usually last?

A: Studies on the elimination of the active ingredient show that it has a half-life of about 8–10 hours during long-term use. This measurement is a key factor in how clinicians determine the appropriate timing between doses.


Q: Can elderly patients safely use Ansimar?

A: For older adults, official guidance advises that administration requires caution. Because drug clearance may be slower in this population, regulatory documents recommend consulting a healthcare provider regarding appropriate dose adjustments.


Q: Are there generic versions of Ansimar available?

A: Ansimar is the brand name for the active compound Doxofylline. As Doxofylline is the internationally recognized name for the active ingredient, it is listed in global health indexes as a systemic agent, which is often available as a generic medicine.


Q: Can children take Ansimar, and if so, at what ages?

A: Official information states that the use of Ansimar is not established or recommended for children under 6 years of age. For children 6 years and older, the use is permitted, but the appropriate amount needed must be determined by a healthcare provider.


Q: Does Ansimar affect blood pressure or blood sugar levels?

A: Ansimar is contraindicated for use in patients with existing hypotension (low blood pressure), according to official labeling. Additionally, documented adverse reactions can include hyperglycemia (high blood sugar) in some individuals.


Q: Do studies support the long-term effectiveness of Ansimar for asthma?

A: The drug’s registration is based on evidence showing effectiveness over short- to medium-term use. However, the evidence base currently shows limited information regarding long-term outcomes concerning the maintenance of functional benefits, largely due to limited follow-up durations in many primary studies.


Q: Is it safe to use Ansimar if I have a heart condition?

A: The medicine is strictly contraindicated for individuals who have recently experienced an acute myocardial infarction (heart attack) or have hypotension (low blood pressure). Caution is also advised when administering the drug to patients with other heart issues, such as cardiac arrhythmias or congestive heart failure.


Q: Can pregnant or breastfeeding individuals use Ansimar?

A: Ansimar is formally contraindicated for use in women who are breastfeeding. For pregnant women, official guidance states that the drug should only be given if clearly needed, as safe use during human pregnancy has not been definitively established due to limited clinical experience.


Q: Can Ansimar interact with cold or allergy medicines?

A: Yes, regulatory documents specifically warn of a risk of toxic synergism (an intensified effect) when Ansimar is taken with sympathomimetic drugs, such as ephedrine. These types of decongestants are found in certain cold and allergy medicines, and the combination is documented to carry a risk.


Q: Does Ansimar help with coughing or only wheezing?

A: The medicine is primarily classified as a bronchodilator, and its core function is to relieve wheezing and shortness of breath by relaxing the airway muscles. Some research suggests that the active ingredient, Doxofylline, may also have an ancillary antitussive (cough-suppressing) effect.


Q: What is the active ingredient's half-life for Ansimar?

A: The half-life refers to the time it takes for the drug's concentration in the body to reduce by half. The elimination half-life for the active ingredient is typically about 8–10 hours for the oral formulation. The mean half-life after intravenous administration is much shorter, at approximately 65 minutes.


Q: Are there any warnings about driving or operating machinery while on Ansimar?

A: Official labeling lists adverse reactions affecting the nervous system, such as dizziness and tremor. Since these effects could potentially impair performance, caution regarding activities such as driving or operating machinery is often advised by healthcare professionals.

How should Ansimar be stored and disposed of?

How to Store and Dispose of Ansimar (Doxofylline)

Official labeling defines strict requirements for storing and handling Ansimar to ensure stability and safety.


Storage Requirements

Condition Requirement
Temperature Store at temperatures not exceeding 30°C.
Protection Must be protected from moisture and heat; keep the container tightly closed or in original packaging.
Child Safety Keep out of the reach and sight of children.

Disposal Instructions

Expired or unused Ansimar must be discarded properly in accordance with local pharmaceutical waste regulations. Regulatory guidance specifies that the medicine must not be flushed down a toilet or drain to prevent environmental contamination.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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