АНГИОРУС

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АНГИОРУС

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Method of action: Angioprotective, Venotonic

Treatment option:

Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of АНГИОРУС

Quick Facts about АНГИОРУС

Property Description
Active ingredients Diosmin and Hesperidin
Form Film-coated tablet
Pharmacological class Phlebotonic / Venoactive drug
Common purpose Supporting vein wall integrity and tone
Origin Compounds derived from plant sources (bioflavonoids)

What Type of Medicine is АНГИОРУС? (Classification and Identity)

АНГИОРУС is a combination product classified as a phlebotonic or venoactive drug, a specialized type of medication formulated to protect and improve the function of the body's venous and capillary systems. This pharmacological class, which includes substances like Diosmin, is clinically recognized for its role in supporting vascular health within the WHO Anatomical Therapeutic Chemical (ATC) classification system. The medication is intended for oral administration and is typically presented as a film-coated tablet, establishing its identity as a specialized vascular protector.

The Active Composition: Diosmin and Hesperidin Bioflavonoids

The core of АНГИОРУС contains two primary active ingredients: the bioflavonoids Diosmin and Hesperidin, compounds that are naturally derived from plant sources, particularly citrus fruits. The formulation frequently utilizes a Micronized Purified Flavonoid Fraction (MPFF), a specialized process that reduces the particle size to enhance the bioavailability and absorption of the active substances when taken orally. The Diosmin/Hesperidin combination can inhibit inflammatory processes associated with microcirculatory damage. The properties of the active ingredients help mitigate the irritation and damage to small blood vessels.

General Purpose: Support for Vein Walls and Circulation

The general purpose of АНГИОРУС is to provide targeted support to the circulatory system by enhancing the functional properties of the venous network. The drug is intended to stabilize and strengthen the walls of small blood vessels, acting as a vascular protector to minimize fluid leakage. By enhancing venous tone and increasing capillary resistance, the medication helps to mitigate the consequences associated with impaired venous return, such as the discomforts experienced during prolonged standing. Phlebotonics are recognized for their role in improving venous tone and reducing capillary hyperpermeability.

What side effects are possible with АНГИОРУС?

Possible Side Effects and Safety Information

The safety profile for this medication, based on clinical data and post-marketing surveillance, details adverse reactions categorized by their frequency and the body system affected. Understanding these documented effects is essential for safe use.

Common Adverse Reactions

Adverse reactions that have been documented as Common (occurring in 1 to 10 out of 100 people) primarily involve the Gastrointestinal system. These effects are generally mild and may include:

  • Diarrhea
  • Dyspepsia (indigestion)
  • Nausea
  • Vomiting

Uncommon and Rare Effects

Uncommon or Rare adverse effects reported from clinical trials or spontaneous reports may affect the Nervous System or Skin and Subcutaneous Tissue.

  • Nervous System Disorders: Dizziness, headache.
  • Skin: Rash, pruritus (itching), urticaria (hives).

Safety Restrictions and Contraindications

This medication is contraindicated in individuals with a known hypersensitivity to the active substance(s) or any of the excipients listed in the formulation.

General Safety Precautions

Special caution is advised in cases where the treatment is taken with anticoagulant or antiplatelet medications due to a potential interaction that may affect blood clotting. Patients with significant hepatic or renal impairment should be closely monitored, as drug clearance may be altered. Furthermore, if diarrhea or other gastrointestinal discomfort persists, a review of treatment is typically warranted. The safety of use during pregnancy or breastfeeding is assessed on a benefit-risk basis, and professional medical advice must be sought before use in these populations.

Overdose and Emergency Response

Overdose and when to seek help

The information below summarizes the official descriptions of overdose and the emergency actions mandated by government regulatory documents for medicines containing Diosmin and Hesperidin.

Overdose Scope

Category Official Regulatory Statements
Documented Overdose Presentations Primarily involves exacerbation of gastrointestinal events (diarrhoea, nausea, abdominal pain) and skin events (pruritus, rash).
Physiological Systems Affected Gastrointestinal system and skin.
Dose-Related Factors The experience of overdose with the medicine is limited.
Emergency Response Statements Management of overdose should consist in treatment of clinical symptoms. No specific antidote is known.
When Immediate Medical Help is Required Consult the doctor or pharmacist immediately if more than the recommended dosage has been taken. Seek medical attention immediately.

Resulting Overdose Structure

Official Overdose Statements:

  • Overdose may present with gastrointestinal events including diarrhoea, nausea, and abdominal pain, along with skin events such as rash and pruritus.
  • It is mandatory to seek medical attention immediately upon suspected overdose.
  • Management of an overdose consists solely of symptomatic treatment, reflecting that no specific antidote is known for this scenario.

Connection to the Overall Overdose Profile:

The official regulatory profile for АНГИОРУС overdose defines the condition primarily by the occurrence of documented, non-severe manifestations in the gastrointestinal tract and skin. Due to the limited experience with overdose cases, regulators universally mandate that patients consult the doctor or pharmacist immediately or seek medical attention immediately when excessive consumption is suspected. Treatment is officially defined as supportive and symptomatic, reflecting the lack of a known specific antidote.

Therapeutic Uses of АНГИОРУС

What АНГИОРУС Treats: Main Uses and Benefits

АНГИОРУС (Angiorus), containing the active ingredients Diosmin and Hesperidin, is generally applied across domains where additional symptomatic support is needed for conditions involving episodic or fluctuating manifestations of venous disease. Its application is primarily in the therapeutic domain of supporting vascular and venous health, which supports general well-being during symptomatic phases.

The medication is commonly used to help manage symptoms associated with two main condition categories: venous circulation disorders and symptoms due to acute haemorrhoidal attack. In scenarios where symptoms become temporarily overwhelming, it offers symptomatic relief that helps patients cope more steadily with symptom fluctuations. It is particularly relevant for easing symptoms related to physical discomfort in the legs, such as swollen legs, pain, and early morning restless legs.

“The medicine assists with maintaining functional stability in conditions where symptoms may intensify temporarily.”

Quick Fact: Supports Comfort During Symptomatic Periods

Regulatory References

  1. Diosmin Hesperidin FDA Verification Portal

Eligibility and Restrictions for Use

Who Can and Cannot Use АНГИОРУС?

The population eligibility for this medicine is strictly defined by official regulatory labeling, classifying individuals based on absolute contraindications and the availability of clinical data.

Contraindications and Restrictions

Population Group Regulatory Status Status Detail
Hypersensitivity Contraindicated Must not be used by patients with a known allergy to Diosmin, Hesperidin, or any other component in the formulation.
Paediatric (Under 18) Not Recommended Safety and efficacy have not been established in children and adolescents, leading to a regulatory restriction in this age group.
Breastfeeding Women Not Recommended Use is inadvisable due to the absence of data regarding the excretion of the active ingredients into human milk.
Pregnancy Avoidance Preferred As a precautionary measure, use is generally preferable to avoid during pregnancy, in line with regulatory guidance.
Organ Impairment Use Not Established Safety and efficacy have not been established in patients with renal (kidney) or hepatic (liver) impairment.

The regulatory profile explicitly defines the adult population (18 years and older) as the group for whom the medicine's use is authorized. All other limitations—including the absolute ban for hypersensitivity and the 'not recommended' status for pediatric, pregnant, and lactating groups—are based on mandatory regulatory classifications concerning safety data or lack of established efficacy.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documentation for the active ingredients Diosmin and Hesperidin defines the interaction profile primarily through pharmacokinetic mechanisms, specifically the potential for altering the clearance of other co-administered medicinal products.

Pharmacokinetic Interaction Profile

The most commonly documented interaction risk relates to the potential for Diosmin to act as an inhibitor of certain metabolic pathways and transport systems. This includes the potential inhibition of specific cytochrome P450 ( CYP) enzymes, such as CYP3A4 and CYP2C9. Additionally, official data suggests the potential for inhibition of the drug efflux pump P-glycoprotein ( P-gp).

Interaction Type Official Regulatory Statement
Exposure Modification Co-administration may increase the systemic exposure (higher plasma concentration) of medicines that are sensitive substrates of CYP3A4, CYP2C9, or P-gp.
Contraindications No formal drug-drug contraindications based on interaction risk are explicitly documented in official regulatory labeling.
Timing/Separation No mandatory timing or dose separation requirements are specified in the official prescribing information.
Food/Substances No specific restrictions are officially documented for use with food, alcohol, or herbal products.

This interaction structure focuses on the potential for increased exposure of sensitive co-administered medicines that are cleared through these metabolic and transport pathways.

Mechanism of Action

Modulation of Venous Tone and Microcirculatory Integrity

The pharmacodynamic mechanism of АНГИОРУС is centered on dual action within the vascular system. The active metabolite, Diosmetin, functions as a modulator by enhancing the sensitivity of venous smooth muscle cells to the endogenous vasoconstrictor, norepinephrine (NE). This heightened sensitivity increases venous tone, a physiological adjustment that reduces the distensibility and capacity of the veins, thereby influencing blood flow dynamics.

Simultaneously, the bioflavonoids engage mechanisms for microvascular stabilization. This involves increasing the overall mechanical resistance of the capillary walls and decreasing capillary hyperpermeability. The compound also influences inflammatory pathways by suppressing the adhesion and migration of activated leukocytes to the capillary endothelium and inhibiting local pro-inflammatory mediators. This combined action structurally reinforces the vessel integrity, a physiological mechanism that modulates fluid dynamics in the interstitial space and reinforces capillary function.

Dosage and Administration Information

Administration Guidelines: How АНГИОРУС is Used

АНГИОРУС is administered via the oral route as a film-coated tablet, which is typically a Micronized Purified Flavonoid Fraction (MPFF) containing Diosmin and Hesperidin. The tablets are taken at mealtimes (midday and/or evening) as part of the administration routine.

Usage follows two distinct dosing patterns depending on the clinical context:

Dosing and Duration Regimens

Use Context Daily Dose Range Frequency and Duration
Chronic Use 1000 mg MPFF total dose. Typically two 500 mg tablets daily, taken in divided doses at mealtimes. This is part of a longer-term protocol, often exceeding several months.
Acute Use (Tapered) Starts at 3000 mg MPFF
ightarrow 2000 mg MPFF. 6 tablets of 500 mg daily for the first four days, reduced to 4 tablets of 500 mg daily for the next three days, establishing a fixed short-term, 7-day course.

No mandatory dose adjustment is specified for older adults or those with renal or hepatic impairment. However, the safety and efficacy have not been established for administration in children and adolescents under 18 years of age. For the acute regimen, guidelines suggest that if symptoms do not subside promptly after the short fixed course, treatment should be reviewed, as the administration of the product does not preclude other necessary clinical treatments.

Recent Clinical Evidence

Research Evidence / Overview of Studies

This overview describes the research studies that have been conducted on this drug, focusing on what was evaluated, rather than making claims about its effects.

Phase 1 and 2 Trials

Early phase studies focused on how the drug acts in the body. These initial trials primarily concentrated on understanding how the drug is processed, its absorption, and its initial safety profile.

Phase 2 trials further examined the drug's activity, reporting an observed change in symptom severity over a defined period in a subset of patients. These studies explored various dosing regimens to determine a range suitable for larger trials.

Some studies reported a statistically significant, dose-dependent decrease in pain scores. Findings from these early phases were used to design the subsequent larger-scale research.


Phase 3 Studies and Key Findings

Multiple Phase 3 studies have been conducted. These large-scale studies were typically designed to compare the intervention against a placebo or an existing treatment.

Efficacy and Symptom Reduction

One large-scale Randomized Controlled Trial (RCT) compared combination therapy to monotherapy and reported specific differences in outcomes. The study evaluated whether the combination was associated with changes in quality of life and the speed of reported symptom change.

A meta-analysis synthesizing data across pivotal Phase 3 trials examined the pooled data. This analysis focused on whether patients treated with the drug exhibited different rates of symptom recurrence compared to those receiving placebo.

Patient Subgroups

Research has explored whether outcomes differed across various patient subgroups:

  • Age: Studies examined whether the drug's activity varied in older adult populations compared to younger adult patients. The results of these studies varied.
  • Severity: Research explored whether the initial severity of the condition was associated with the magnitude of the observed outcome difference between treatment and control groups.

In summary, the available evidence is based on studies that examined the drug's activity and observed outcomes in this condition.

Key Studies & References

  1. Clinical and experimental studies on the anti-inflammatory and venotonic effects of diosmin and hesperidin

Frequently Asked Questions (FAQ)

Common questions about АНГИОРУС (FAQ)

Q: Is АНГИОРУС the same as other medicines for veins?

Regulatory documents classify АНГИОРУС as a phlebotonic, or venoactive drug, which is a specialized class of medicine intended to support the venous system. Products within this class share a common purpose, but they are not defined as identical. This medication is specifically composed of the bioflavonoids Diosmin and Hesperidin.

Q: Does АНГИОРУС interact with common pain relievers like ibuprofen?

Official documents do not specifically list named interactions with common pain relievers. However, the product's known pharmacokinetic profile indicates a potential to affect metabolic enzymes, like CYP3A4 and CYP2C9, and a drug transport pump (P-gp) in the body. These systems manage the clearance of many other medicines.

Q: What is the typical expectation for symptom improvement with АНГИОРУС?

The official administration guidance does not define a precise timeline for subjective symptom relief. However, for short-term use in acute conditions, the regulatory guidance stipulates that if symptoms do not subside promptly after the fixed course of treatment (e.g., 7 days), a review of the treatment is typically warranted.

Q: What is the difference between the 500mg and 1000mg versions of АНГИОРУС, if they exist?

The most commonly referenced dosage unit in official documents is the 500 mg film-coated tablet. When a 1000 mg dose is mentioned in chronic use guidelines, it is typically achieved by administering two 500 mg tablets daily.

Q: Why do some people experience allergic reactions to АНГИОРУС?

Official regulatory text identifies known hypersensitivity to the active ingredients (Diosmin and Hesperidin) or any other component in the formulation as a contraindication. Due to this, the medication is contraindicated (should not be used) in individuals with a known allergy to its components. The specific individual mechanism that causes the reaction is complex and is not detailed in the general regulatory product information.

Q: Are there any known severe allergic reaction signs associated with АНГИОРУС?

While known adverse effects include mild reactions such as rash or hives, official safety information advises monitoring for signs of a severe allergic reaction (hypersensitivity). These severe symptoms include swelling of the face, tongue, or throat, or difficulty breathing. If such symptoms are experienced, emergency medical help should be sought immediately.

Q: Can I take АНГИОРУС with my diabetes medication?

Official documents do not specifically mention interactions with diabetes medications. However, the known pharmacokinetic profile indicates the potential to inhibit certain metabolic enzymes and transport proteins. This potential interaction profile means that the exposure of other co-administered medicines could be affected.

Q: What happens if a person who cannot use АНГИОРУС takes it by mistake or takes more than prescribed?

The official documentation reports that specific severe adverse events have typically not been observed following the consumption of high doses. In such cases, specific management or intervention is generally not deemed necessary.

Q: Is АНГИОРУС available over the counter?

The distribution status of the medication is determined by the governing health authority in each country. The regulatory status, which dictates whether the medication requires a prescription or is available over-the-counter, is defined locally.

Q: What is the official chemical name of the active ingredient in АНГИОРУС?

The active ingredients are the bioflavonoids Diosmin and Hesperidin. These compounds have specific, defined chemical nomenclature (IUPAC names) that are detailed in the official regulatory documentation, alongside their common names.

Q: How does АНГИОРУС affect varicose veins according to regulatory documents?

Official regulatory documents describe the therapeutic use of the medication in relation to chronic venous insufficiency. This is the broad condition associated with symptoms like varicose veins, and the medication's use is indicated for the treatment of related signs and symptoms.

Q: Is it described in official sources that АНГИОРУС helps hemorrhoids?

Yes, the official therapeutic indications for this medication include the treatment of symptoms related to acute hemorrhoidal disease. This is a specific use context documented in regulatory labeling.

Q: How should I handle a missed dose of АНГИОРУС?

Regulatory patient information leaflets typically include standard guidance for managing a missed dose. This information is designed to help maintain the regular dosing schedule, without suggesting that a double dose should be taken to compensate for the missed one.

Q: Are there warnings about driving or operating machinery while taking АНГИОРУС?

Official regulatory documents, such as the Summary of Product Characteristics, generally state that there are no known effects on a person’s ability to drive or operate machinery.

How should АНГИОРУС be stored and disposed of?

How to Store and Dispose of Angiorus

Storage and disposal of Angiorus (Diosmin/Hesperidin) must comply strictly with official regulatory requirements to maintain product stability and protect the environment.

Official Storage Requirements

Condition Requirement
Temperature Store at a temperature not exceeding 30 C (86 F).
Packaging Keep the tablets in the original carton/box to ensure protection and integrity.
Safety The medicine must be kept out of the sight and reach of children.
Stability Do not use the product after the expiry date printed on the packaging.

Disposal Instructions

Unused or expired Angiorus tablets must not be thrown away with household trash or via wastewater. For safe disposal, patients should ask a pharmacist for the proper method, which helps to protect the environment.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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