Ancool

Aluminium hydroxide (Ancool) is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.

Each tablet contains Magnesium hydroxide (Ancool) 200 mg and Magnesium hydroxide (Ancool) 200 mg or with dimethicone 25 mg (for Magnesium hydroxide (Ancool)).

Each 5 mL suspension contains Magnesium hydroxide (Ancool) (as Magnesium hydroxide (Ancool) paste) 200 mg and Magnesium hydroxide (Ancool) (as Magnesium hydroxide (Ancool) gel) 225 mg or with dimethicone 25 mg (for Magnesium hydroxide (Ancool)).

Maalox suspension also contains methylparahydroxybenzoate E218, propylparahydroxybenzoate E216, anhydrous citric acid, sodium saccharin, crystallizing liquid sorbitol E420, mannitol powder E421, hydrogen peroxide, peppermint oil, concentrated HCl and purified water as excipients.

A dopamine D2 antagonist that is used as an antiemetic.

Aluminium hydroxide (Ancool) is a vaccine which helps prevent hepatitis A and typhoid

fever. Hepatitis A is an infectious illness of the liver caused by a virus.

Typhoid fever is an infectious illness caused by a type of bacteria called

Salmonella typhi.

This vaccine should only be given to adults and teenagers aged 15

years and above.

Treating acid indigestion, heartburn, sour stomach, and constipation. It may also be used for other conditions as determined by your doctor.

Magnesium hydroxide (Ancool) is an antacid. It works by neutralizing the acid in the stomach and by stimulating the bowels to move.

Pain, hyperacidity symptoms (eg, heartburn), eructation, nausea, vomiting, gastric discomfort, unnecessary urge to defecate, associated w/ esophagitis, gastritis, gastroduodenal ulcer or irritable colon.

Peptic ulcer & gastric hyperacidity. Simeticone (Ancool) Gastric hypermotility, spastic & irritable colon, flatulent dyspepsia, gastritis, heartburn, duodenitis, esophagitis, hiatus hernia, post-op abdominal pains, colic in childn.

Aluminum is a naturally occurring mineral. Aluminium hydroxide (Ancool) is an antacid.

Aluminium hydroxide (Ancool) is used to treat symptoms of increased stomach acid, such as heartburn, upset stomach, sour stomach, or acid indigestion. Aluminium hydroxide (Ancool) is also used to reduce phosphate levels in people with certain kidney conditions.

Aluminium hydroxide (Ancool) may be used for other purposes not listed in this medication guide.

Magnesium is a naturally occurring mineral. Magnesium is important for many systems in the body especially the muscles and nerves. Magnesium hydroxide (Ancool) also reduces stomach acid, and increases water in the intestines which may induce defecation.

Magnesium hydroxide (Ancool) is used as a laxative to relieve occasional constipation (irregularity) and as an antacid to relieve indigestion, sour stomach, and heartburn.

Magnesium hydroxide (Ancool) may also be used for purposes not listed in this medication guide.

Relieving pressure, bloating, and gas in the digestive tract. It may also be used for other conditions as determined by your doctor.

Simeticone (Ancool) is an antiflatulent and adsorbent combination. It works by breaking up gas bubbles, which makes the gas easier to eliminate.

Usual Adult Dose for Dyspepsia

500 to 600 mg orally 4 to 6 times a day as needed, between meals and at bedtime.

Usual Adult Dose for Duodenal Ulcer

500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime.

Usual Adult Dose for Erosive Esophagitis

500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime.

Usual Adult Dose for Gastric Ulcer

500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime.

Usual Adult Dose for Gastroesophageal Reflux Disease

500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime.

Usual Adult Dose for Zollinger-Ellison Syndrome

500 to 3600 mg orally 4 to 6 times a day as needed, between meals and at bedtime.

Usual Adult Dose for Hyperphosphatemia

500 to 1000 mg orally 4 times a day, with meals and at bedtime. The dosage should be titrated to the serum phosphate level.

Usual Pediatric Dose for Gastrointestinal Hemorrhage

G.I. hemorrhage prophylaxis:

0 to 4 weeks: 1 mL/kg orally every 4 hours as needed.

4 weeks to 1 year: 2 to 5 mL/dose every 1 to 2 hours, titrate to gastric pH > 3.5.

1 to 12 years: 5 to 15 mL/dose orally every 1 to 2 hours, titrate to gastric pH > 3.5.

Usual Pediatric Dose for Hyperphosphatemia

1 to 12 years: use Al(OH)3 or aluminum carbonate gel product only: 50 to 150 mg/kg/day orally (as Aluminium hydroxide (Ancool) gel) administered in equally divided doses every 4 to 6 hours; titrate to normal serum phosphate level.

Usual Pediatric Dose for Peptic Ulcer

1 month to 1 year: 1 to 2 mL/kg/dose orally 1 to 3 hours after meals and at bedtime.

1 year to 12 years: 5 to 15 mL orally every 3 to 6 hours or 1 and 3 hours after meals and at bedtime.

Precautions

Patients with renal failure may accumulate aluminum with chronic use. Serum aluminum levels should be monitored or another antacid chosen.

Other Comments

Patients with Helicobacter pylori-associated ulcerative disease should be considered for anti-Helicobacter therapy (often bismuth salts, metronidazole and other antimicrobials).

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Suspension,

Oral:

Dulcolax Milk of Magnesia: 400 mg/5 mL (355 mL [DSC]) [sugar free]

Dulcolax Milk of Magnesia: 400 mg/5 mL (355 mL [DSC]) [sugar free; contains saccharin sodium]

Milk of Magnesia: 400 mg/5 mL (355 mL, 480 mL)

Milk of Magnesia: 400 mg/5 mL (30 mL) [contains methylparaben, propylene glycol, propylparaben]

Milk of Magnesia: 1200 mg/15 mL (355 mL [DSC])

Milk of Magnesia: 1200 mg/15 mL (355 mL [DSC]) [mint flavor]

Milk of Magnesia: 7.75% (360 mL, 480 mL)

Milk of Magnesia: 7.75% (355 mL [DSC], 473 mL) [mint flavor]

Milk of Magnesia: 7.75% (30 mL) [spearmint flavor]

Milk of Magnesia: 2400 mg/30 mL (30 mL) [alcohol free, dye free, sugar free]

Milk of Magnesia: 1200 mg/15 mL (355 mL) [cramp free, gluten free, stimulant free, sugar free; original flavor]

Milk of Magnesia: 1200 mg/15 mL (355 mL) [cramp free, gluten free, stimulant free, sugar free; contains saccharin sodium; mint flavor]

Milk of Magnesia: 1200 mg/15 mL (355 mL) [cramp free, stimulant free, sugar free; contains saccharin sodium]

Milk of Magnesia: 1200 mg/15 mL (355 mL) [gluten free, stimulant free, sugar free; unflavored flavor]

Milk of Magnesia: 1200 mg/15 mL (355 mL) [gluten free, stimulant free, sugar free; contains saccharin sodium]

Milk of Magnesia: 400 mg/5 mL (355 mL [DSC], 473 mL) [low sodium, sugar free]

Milk of Magnesia: 400 mg/5 mL (355 mL, 473 mL, 769 mL [DSC], 3780 mL) [stimulant free, sugar free]

Milk of Magnesia: 400 mg/5 mL (473 mL); 1200 mg/15 mL (355 mL [DSC]) [sugar free]

Milk of Magnesia Concentrate: 2400 mg/10 mL (100 mL, 400 mL) [lemon flavor]

Milk of Magnesia Concentrate: 2400 mg/10 mL (10 mL) [contains methylparaben, propylene glycol, propylparaben, saccharin sodium; lemon flavor]

Milk of Magnesia Concentrate: 2400 mg/10 mL (10 mL) [alcohol free, dye free, sugar free]

Phillips Milk of Magnesia: 400 mg/5 mL (355 mL) [cramp free, stimulant free, sugar free]

Tablet Chewable,

Oral:

Pedia-Lax: 400 mg [scored; stimulant free; contains fd&c red #40 aluminum lake; watermelon flavor]

Dosing: Adult

Antacid: OTC labeling:

Oral:

Liquid: Magnesium hydroxide (Ancool) 400 mg/5 mL: 5 to 15 mL as needed up to 4 times/day; do not exceed 60 mL in 24 hours

Tablet, chewable: Magnesium hydroxide (Ancool) 311 mg/tablet: 2 to 4 tablets every 4 hours up to 4 times/day; do not exceed 4 doses in 24 hours

Laxative (occasional constipation): OTC labeling:

Oral:

Liquid:

Magnesium hydroxide (Ancool) 400 mg/5 mL: 30 to 60 mL/day once daily at bedtime or in divided doses

Magnesium hydroxide (Ancool) 800 mg/5 mL: 15 to 30 mL/day once daily at bedtime or in divided doses

Magnesium hydroxide (Ancool) 1,200 mg/5 mL: 10 to 20 mL/day once daily at bedtime or in divided doses

Tablet, chewable: Magnesium hydroxide (Ancool) 311 mg/tablet: 8 tablets/day once daily at bedtime or in divided doses

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Note: Dose expressed as mg of Magnesium hydroxide (Ancool).

Antacid:

Oral: Children ≥12 years and Adolescents (Phillips 311 mg chewable tablet): 2 to 4 tablets every 4 hours up to 4 times per day. Do not exceed 4 doses in 24 hours.

Constipation, chronic:

Oral: Infants, Children, and Adolescents: Limited data available: 80 to 240 mg/kg/day divided once or twice daily (Wyllie 2011); usual adult dose is 2,400 to 4,800 mg/day

Constipation, occasional:

Oral:

Children 2 to <6 years: 400 to 1,200 mg/day in single or divided doses. Maximum daily dose: 1,200 mg/day

Children 6 to <12 years: 1,200 to 2,400 mg/day in single or divided doses. Maximum daily dose: 2,400 mg/day

Children ≥12 years and Adolescents: 2,400 to 4,800 mg/day in single or divided doses. Maximum daily dose: 4,800 mg/day

Fecal impaction, slow disimpaction: Limited data available:

Oral: Children and Adolescents: 160 mg/kg twice daily for 7 days (Pashankar 2005; Wyllie 2011)

Adult 3-8 tab daily in 3-4 divided doses. Max dose: 15 mg at 1 time & 45 mg/day.

Oral

Flatulence

Adult: 100-250 mg 3-4 times daily as required. May be given with an antacid.

Oral

Infant colic

Child: Infant: 20-40 mg to be given with feeds.

See also:
What is the most important information I should know about Aluminium hydroxide (Ancool)?

Aluminium hydroxide (Ancool) should not be given if:

• you are allergic (hypersensitive) to Aluminium hydroxide (Ancool) or any of the

ingredients (listed in Section 6)

• you are allergic (hypersensitive) to any other hepatitis A injection or

any other typhoid injection

• you are allergic to neomycin, an antibiotic used to treat skin infections

• you have a high temperature (fever).

Aluminium hydroxide (Ancool) should not be given if any of the above applies to you. If you

are not sure, talk to your doctor or pharmacist before having Aluminium hydroxide (Ancool).

See also:
What is the most important information I should know about Magnesium hydroxide (Ancool)?

Do NOT use Magnesium hydroxide (Ancool) if:

you are allergic to any ingredient in Magnesium hydroxide (Ancool)

Contact your doctor or health care provider right away if any of these apply to you.

Sensitivity to any of the ingredients; Impaired renal function.

See also:
What is the most important information I should know about Simeticone (Ancool)?

Simeticone (Ancool) should not be used whenever stimulation of gastrointestinal motility might be dangerous, e.g., in the presence of gastrointestinal hemorrhage, mechanical obstruction, or perforation.

Simeticone (Ancool) is contraindicated in patients with pheochro-mocytoma because the drug may cause a hypertensive crisis, probably due to release of catecholamines from the tumor. Such hypertensive crises may be controlled by phen-tolamine.

Simeticone (Ancool) is contraindicated in patients with known sensitivity or intolerance to the drug.

Simeticone (Ancool) should not be used in epileptics or patients receiving other drugs which are likely to cause extrapyramidal reactions, since the frequency and severity of seizures or extrapyramidal reactions may be increased.

Use Magnesium hydroxide (Ancool) chewable tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Magnesium hydroxide (Ancool) chewable tablets by mouth with or without food. Take Magnesium hydroxide (Ancool) chewable tablets with a full glass of water (8 oz/240 mL).
• Chew thoroughly before swallowing.
• If you miss a dose of Magnesium hydroxide (Ancool) chewable tablets, take it as soon as you remember. Continue to take it as directed by your doctor or on the package label.

Ask your health care provider any questions you may have about how to use Magnesium hydroxide (Ancool) chewable tablets.

Use Simeticone (Ancool) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Simeticone (Ancool) as needed after meals and at bedtime, unless otherwise directed by your doctor.
• Simeticone (Ancool) may interfere with the absorption of many other medicines. Talk to your doctor about taking Simeticone (Ancool) 2 hours before or after taking any other medicine.
• If you miss a dose of Simeticone (Ancool) and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Simeticone (Ancool).

Aluminium hydroxide (Ancool) either alone or in combination with some other drugs is used to treat heartburn, upset or sour stomach, peptic ulcer and related pain, gastro esophageal reflux disease (GERD). It is also used in patients with kidney problems to reduce phosphate levels.

This medication is used to treat the symptoms of too much stomach acid such as stomach upset, heartburn, and acid indigestion. It is also used to relieve symptoms of extra gas such as belching, bloating, and feelings of pressure/discomfort in the stomach/gut. Simethicone helps break up gas bubbles in the gut. Aluminum and magnesium antacids work quickly to lower the acid in the stomach. Liquid antacids usually work faster/better than tablets or capsules.

This medication works only on existing acid in the stomach. It does not prevent acid production. It may be used alone or with other medications that lower acid production (e.g., H2 blockers such as cimetidine/ranitidine and proton pump inhibitors such as omeprazole).

If you are self-treating with this medication, carefully read the package instructions before you start using this product to be sure it is right for you. Some products have similar brand names but different active ingredients with different uses. Taking the wrong product could harm you. Ask your pharmacist if you have any questions about your product or its use.

How to use Magnesium hydroxide (Ancool)

Take this medication by mouth, usually after meals and at bedtime as needed. Follow all the directions on the product package or use as directed by your doctor. If you are uncertain about any of this information, consult your doctor or pharmacist.

If you are taking the chewable tablets, chew thoroughly before swallowing, then drink a full glass of water (8 ounces or 240 milliliters).

If you are using the liquid form of this medication, shake the bottle well before pouring each dose. Measure the dose out carefully using a medication spoon/cup. Do not use a household spoon because you may not get the right dose. Refrigerating the suspension may improve the flavor. Do not freeze. The liquid form works best if taken without other fluids. You can mix your dose with a little water if needed.

This product may react with other medications (including digoxin, iron, pazopanib, tetracycline antibiotics, quinolone antibiotics such as ciprofloxacin), preventing them from being fully absorbed by your body. Talk with your doctor or pharmacist about how to schedule your medications to prevent this problem.

If your acid problems persist or worsen after you have used this product for 1 week, or if you think you have a serious medical problem, seek immediate medical attention. If you are using this medication regularly on a daily basis for more than 2 weeks, you may have a medical problem that needs different treatment. Ask your doctor whether this is the right medication for you.

Oxetacaine (Ancool) is used to relieve pain associated with several conditions of digestive system like inflammation of the food pipe (esophagitis) or stomach (gastritis), hiatus hernia (protrusion of stomach into esophagus), heartburn of pregnancy, ulcers of the stomach and intestine (peptic ulcer), or long-term bowel disorders (irritable bowel syndrome).

This product is used to relieve symptoms of extra gas such as belching, bloating, and feelings of pressure/discomfort in the stomach/gut. Simethicone helps break up gas bubbles in the gut.

How to use Simeticone (Ancool)

Take this product by mouth, usually after meals and at bedtime or as directed by your doctor. Swallow the capsules whole. Do not crush or chew the capsules. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are self-treating with simethicone, the usual maximum amount for adults is 500 milligrams daily.

If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.

See also:
What other drugs will affect Aluminium hydroxide (Ancool)?

Using other medicines and vaccines

Please tell your doctor or pharmacist if you are taking or have recently

taken any other medicines including medicines obtained without

prescription. Aluminium hydroxide (Ancool) can be given at the same time as most other

routine vaccines. The doctor will ensure that the vaccines are injected

separately and into different parts of the body. Aluminium hydroxide (Ancool) must not be

mixed with other vaccines in the same syringe.

In particular talk to your doctor if:

• you are to be given ‘yellow fever vaccine

See also:
What other drugs will affect Magnesium hydroxide (Ancool)?

Some MEDICINES MAY INTERACT with Magnesium hydroxide (Ancool). Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Magnesium hydroxide (Ancool)

Azole antifungals (eg, ketoconazole), bisphosphonates (eg, alendronate), cation exchange resins (eg, sodium polystyrene sulfonate), cephalosporins (eg, cephalexin), mycophenolate, penicillamine, quinolone antibiotics (eg, ciprofloxacin), or tetracyclines (eg, doxycycline) because their effectiveness may be decreased by Magnesium hydroxide (Ancool)

This may not be a complete list of all interactions that may occur. Ask your health care provider if Magnesium hydroxide (Ancool) may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Oral tetracyclines, digoxin, oral iron preparations, anticholinergic drugs, barbiturates, quinines, quinidine, warfarin, vitamins, H2-receptor antagonists, oral isoniazid, Oxetacaine (Ancool), sodium fluoride, ketoconazole, phenytoin, phenothiazines and methenamine: Aluminium Mg may reduce the absorption of these agents.

See also:
What other drugs will affect Simeticone (Ancool)?

Before taking metoclopramide, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by metoclopramide.

Tell your doctor about all other medications you use, especially:

acetaminophen (Tylenol);

cyclosporine (Gengraf, Neoral, Sandimmune);

digoxin (digitalis, Lanoxin);

glycopyrrolate (Robinul);

levodopa (Larodopa, Atamet, Parcopa, Sinemet);

mepenzolate (Cantil);

tetracycline (Brodspec, Panmycin, Robitet, Sumycin, Tetracap, and others);

atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);

bladder or urinary medications such as darifenacin (Enablex), tolterodine (Detrol), or solifenacin (Vesicare);

bronchodilators such as ipratroprium (Atrovent) or tiotropium (Spiriva);

irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin), or propantheline (Pro-Banthine);

an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate); or

medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), haloperidol (Haldol), olanzapine (Zyprexa, Symbyax), prochlorperazine (Compazine), risperidone (Risperdal), thiothixene (Navane), and others.

See also:
What are the possible side effects of Aluminium hydroxide (Ancool)?

Applies to Aluminium hydroxide (Ancool): oral suspension

Get emergency medical help if you have any of these signs of an allergic reaction while taking Aluminium hydroxide (Ancool): hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using the medication and call your doctor at once if you have a serious side effect such as:

• severe stomach pain or constipation;

• bloody, black, or tarry stools;

• coughing up blood that looks like coffee grounds;

• pain when you urinate;

• extreme drowsiness; or

• tired feeling, loss of appetite, and muscle weakness.

Less serious side effects are more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

See also:
What are the possible side effects of Magnesium hydroxide (Ancool)?

Applies to Magnesium hydroxide (Ancool): chewable tablets, suspension, tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea.

Seek medical attention right away if any of these SEVERE side effects occur while taking Magnesium hydroxide (Ancool) (the active ingredient contained in Magnesium hydroxide (Ancool))

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); loss of appetite; muscle weakness; nausea; slow reflexes; vomiting.

Constipation, Diarrhoea, Dizziness, Weakness, Drowsiness, Dry mouth, Headache, Hypersensitivity reaction, Loss of appetite, Nausea

See also:
What are the possible side effects of Simeticone (Ancool)?

Get emergency medical help if you have any of these signs of an allergic reaction to metoclopramide: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using metoclopramide and call your doctor at once if you have any of these serious side effects:

tremors, or restless muscle movements in your eyes, tongue, jaw, or neck;

mask-like appearance of the face;

very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;

depressed mood, thoughts of suicide or hurting yourself;

hallucinations, anxiety, agitation, jittery feeling, trouble staying still;

swelling, fluid retention;

jaundice (yellowing of your skin or eyes); or

seizure (convulsions).

Less serious metoclopramide side effects may include:

feeling restless, drowsy, tired, or dizzy;

headache, sleep problems (insomnia);

nausea, vomiting, diarrhea;

breast tenderness or swelling;

changes in your menstrual periods; or

urinating more than usual.