Anabel

Topical/Cutaneous

As antiseptic and disinfectant

Adult: As soln: Cleansing of skin, mucous membrane and wounds: 0.01-0.1%. Irrigation of deep wounds: 0.005%. Irrigation of bladder and urethra: 0.005-0.02%. Retention lavage of the bladder: 0.0025-0.005%. Disinfection and storage of surgical instruments: 0.13%; may be used w/ Na nitrite to avoid corrosion. As preservative: 0.01%-0.02% (ophth preparation); 0.002-0.2% (nasal and otic preparation). As shampoo: Seborrhoeic dermatitis: 0.2-0.5%. As cream: Napkin rash and other dermatoses: 0.13%. As vaginal douche: 0.02-0.05%. Refer to product information for specific directions for use.

Oral

Pain and fever

Adult: 435-870 mg every 4 hr when required.

Oral

Rheumatic disorders

Adult: 4.8-7.2 g daily in divided doses.

Buccal

Mouth lesions

Adult: Apply 8.7% gel on affected area.

How should I use Choline Salicylate (Anabel)?

Use Choline Salicylate (Anabel) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Choline Salicylate (Anabel) by mouth with or without food. If stomach upset occurs, take with food or a large glass of milk to reduce stomach irritation.
• Take Choline Salicylate (Anabel) with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Choline Salicylate (Anabel).
• If you miss a dose of Choline Salicylate (Anabel) and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Choline Salicylate (Anabel).

Uses of Choline Salicylate (Anabel) in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Choline Salicylate (Anabel) is used in combination with magnesium salicylate as part of anti-pain medication. It is used to relieve pain and discomfort in the mouth caused by ulcers, sores or dentures/ braces. It is also used for relief from pain, swelling and stiffness caused due to arthritis or shoulder problems.

Choline Salicylate (Anabel) description

A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. [PubChem]

Choline Salicylate (Anabel) dosage

Oral

Pain and fever

Adult: 435-870 mg every 4 hr when required.

Oral

Rheumatic disorders

Adult: 4.8-7.2 g daily in divided doses.

Buccal

Mouth lesions

Adult: Apply 8.7% gel on affected area.

Choline Salicylate (Anabel) interactions

See also:
What other drugs will affect Choline Salicylate (Anabel)?

Increased toxicity of warfarin. Antacids may reduce salicylate effects. Increased risk of GI bleeding when used with corticosteroids.

Choline Salicylate (Anabel) side effects

See also:
What are the possible side effects of Choline Salicylate (Anabel)?

No known side effects, Choline Salicylate (Anabel) is safe for pregnant women and children.

Choline Salicylate (Anabel) contraindications

See also:
What is the most important information I should know about Choline Salicylate (Anabel)?

Not to be used in

* Children and adolescents under 16 years of age.

* Allergy to salicylates, eg aspirin.

* Active peptic ulcer.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

What is Lidocaine (Anabel)?

Lidocaine (Anabel) topical jelly or ointment is used on different parts of the body to cause numbness or loss of feeling for patients having certain medical procedures. It is also used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, minor cuts, or scratches.

Lidocaine (Anabel) viscous topical solution is also used to treat sore mouth or throat and also reduce gagging during the taking of X-ray pictures and dental impressions.

Lidocaine (Anabel) skin patch is used to relieve pain caused by shingles (postherpetic neuralgia).

Lidocaine (Anabel) belongs to the family of medicines called local anesthetics. Lidocaine (Anabel) prevents pain by blocking the signals at the nerve endings in the skin. Lidocaine (Anabel) does not cause unconsciousness as general anesthetics do when used for surgery.

Lidocaine (Anabel) is available only with your doctor's prescription.

Lidocaine (Anabel) indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Epidural

Epidural anaesthesia

Adult: 2-3 mL administered for each dermatome to be anaesthesised. Recommended doses are: Lumbar epidural 250-300 mg (as 1% soln) for analgesia and 225-300 mg (as 1.5% soln) or 200-300 mg (as 2% soln) for anaesth; for thoracic epidural: 200-300 mg (as 1% soln). For obstetric caudal analgesia, 200-300 mg (as 1% soln); for surgical caudal anaesth: 225-300 mg (as 1.5% soln). For continuous epidural or caudal anaesth, not to repeat max doses more frequently than 1.5 hrly.

Intramuscular

Emergency treatment of ventricular arrhythmias

Adult: 300 mg injected into the deltoid muscle, repeat after 60-90 min if necessary.

Intraspinal

Spinal anaesthesia

Adult: As hyperbaric soln of 1.5% or 5% Lidocaine (Anabel) in 7.5% glucose soln. Normal vaginal delivery: Up to 50 mg (as 5% soln) or 9-15 mg (as 1.5% soln). Caesarian operation: Up to 75 mg (as 5% soln). Other surgical procedures: 75-100 mg.

Intravenous

Pulseless ventricular fibrillation or ventricular tachycardia

Adult: 1-1.5 mg/kg repeated as necessary. Max: 3 mg/kg. For ventricular arrhythmias in more stable patients: Usual loading dose: 50-100 mg as an IV inj at 25-50 mg/min, may repeat once or twice up to a max of 200-300 mg in 1 hr, followed by 1-4 mg/min via continuous IV infusion. May need to reduce dose if the infusion is longer than 24 hr.

Intravenous

Intravenous regional anaesthesia

Adult: As 0.5% soln w/o epinephrine: 50-300 mg. Max: 4 mg/kg.

Mouth/Throat

Surface anaesthesia

Adult: As 2% soln: For pain: 300 mg rinsed and ejected for mouth and throat pain; or gargled and swallowed if necessary for pharyngeal pain. Not to be used more frequently than every 3 hr. Max (topical oral soln): 2.4 g/day. As 4% soln: Before bronchoscopy, bronchography, laryngoscopy, oesophagoscopy, endotracheal intubation, and biopsy in the mouth and throat: 40-200 mg. As 10% soln: For dentistry and otorhinolaryngology procedures: 10-50 mg sprayed to mucous membrane. As 4% soln: For laryngotracheal anaesth: 160 mg sprayed or instilled as a single dose into the lumen of the larynx and trachea.

Ophthalmic

Surface anaesthesia

Adult: Apply 2 drops to ocular area where procedure will take place; may reapply to maintain effect.

Parenteral

Percutaneous infiltration anaesthesia

Adult: As 0.5% or 1% soln: 5-300 mg.

Parenteral

Sympathetic nerve block

Adult: As 1% soln: 50 mg for cervical block or 50-100 mg for lumbar block.

Parenteral

Peripheral nerve block

Adult: As 1.5% soln: For brachial plexus block: 225-300 mg. As 2% soln: For dental nerve block: 20-100 mg. As 1% soln: For intercostal nerve block: 30 mg; for paracervical block: 100 mg on each side, repeated not more frequently than every 90 min; for paravertebral block: 30-50 mg; for pudendal block: 100 mg on each side. As 4% soln: For retrobulbar block: 120-200 mg.

Rectal

Haemorrhoids, Perianal pain and itching

Adult: Apply topically or using applicator insert rectally, up to 6 times daily.

Child: ≥12 yr Apply topically or using applicator insert rectally, up to 6 times daily.

Topical/Cutaneous

Surface anaesthesia

Adult: As 5% oint: Max: 20 g in 24 hr for skin and mucous membrane. As 2% gel: Approx 120-220 mg into urethra several min before examination. As 4% foam: Apply 3-4 times daily for pain relief. As soln: Apply 40-200 mg to affected area. As patch: Apply patch to painful area for up to 12 hr w/in a 24-hr period. Max: 1 patch/24 hr.

Transdermal

Postherpetic neuralgia

Adult: As 5% patch: Apply to most painful area once daily for up to 12 hr w/in a 24-hr period. Max: Up to 3 patches in a single application.

Urethral

Surface anaesthesia

Adult: As 2% gel: Female: 60-100 mg inserted into the urethra several min before examination. Male: 100-200 mg before catheterisation and 600 mg before sounding or cystoscopy.

How should I use Lidocaine (Anabel)?

Use Lidocaine (Anabel) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Wash your hands well before and after using Lidocaine (Anabel).
• Shake well before each use.
• If you are using Lidocaine (Anabel) on your face, spray it into your hand. Gently apply. Do not spray Lidocaine (Anabel) directly onto your face.
• For other areas, hold the medicine 4 to 6 inches from the skin and spray onto the affected area. Allow the medicine to slowly dry.
• Do not use large amounts of Lidocaine (Anabel), especially over blistered or raw areas of your skin.
• Do not bandage or wrap the affected area, unless directed otherwise by your doctor.
• If you miss a dose of Lidocaine (Anabel), use it as soon as you remember. Continue to use it as directed by your doctor or on the package label.

Ask your health care provider any questions you may have about how to use Lidocaine (Anabel).

Uses of Lidocaine (Anabel) in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

How to use Lidocaine (Anabel) topical

Lidocaine (Anabel) description

Each gram contains Lidocaine (Anabel) 50 mg equivalent to Lidocaine (Anabel) 700 mg per 10 cm x 14 cm medicated plaster.

It also contains the following excipients: Self-Adhesive Layer: Glycerol, liquid sorbitol (crystallizing), carmellose sodium, propylene glycol (E1520), urea, heavy kaolin, tartaric acid, gelatin, polyvinyl alcohol, aluminum glycinate, disodium edetate, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), polyacrylic acid, sodium polyacrylate, purified water.

Backing Fabric and Release Liner: Polyethylene terephthalate (PET).

Lidocaine (Anabel) dosage

When Lidocaine (Anabel) USP, 5% is used concomitantly with other products containing Lidocaine (Anabel), the total dose contributed by all formulations must be kept in mind.

Adult

A single application should not exceed 5 g of Lidocaine (Anabel) USP, 5% containing 250 mg of Lidocaine (Anabel) base (equivalent chemically to approximately 300 mg of Lidocaine (Anabel) hydrochloride). This is roughly equivalent to squeezing a six (6) inch length of ointment from the tube. In a 70 kg adult this dose equals 3.6 mg/kg (1.6 mg/lb) Lidocaine (Anabel) base. No more than 17-20 g of ointment or 850-1000 mg Lidocaine (Anabel) base should be administered in any one day.

Although the incidence of adverse effects with Lidocaine (Anabel) USP, 5% is quite low, caution should be exercised, particularly when employing large amounts, since the incidence of adverse effects is directly proportional to the total dose of local anesthetic agent administered.

Dosage for children

It is difficult to recommend a maximum dose of any drug for children since this varies as a function of age and weight. For children less than ten years who have a normal lean body mass and a normal lean body development, the maximum dose may be determined by the application of one of the standard pediatric drug formulas (e.g., Clark's rule). For example, in a child of five years weighing 50 lbs., the dose of Lidocaine (Anabel) should not exceed 75-100 mg when calculated according to Clark's rule. In any case, the maximum amount of Lidocaine (Anabel) administered should not exceed 4.5 mg/kg (2.0 mg/lb) of body weight.

Administration

For medical use, apply topically for adequate control of symptoms. The use of a sterile gauze pad is suggested for application to broken skin tissue. Apply to the tube prior to intubation.

In dentistry, apply to previously dried oral mucosa. Subsequent removal of excess saliva with cotton rolls or saliva ejector minimizes dilution of the ointment, permits maximum penetration, and minimizes the possibility of swallowing the topical ointment.

For use in connection with the insertion of new dentures, apply to all denture surfaces contacting mucosa.

IMPORTANT: Patients should consult a dentist at intervals not exceeding 48 hours throughout the fitting period.

Lidocaine (Anabel) interactions

See also:
What other drugs will affect Lidocaine (Anabel)?

Beta-blockers increase the risk of bradycardia and hypotension. Norepinephrine and beta-blockers by reducing hepatic blood flow decrease (increased toxicity), isadrine and glucagon - increase the clearance of Lidocaine (Anabel). Cimetidine increases the plasma concentration of Lidocaine (Anabel) Haffkine Bio-Pharmaceutical Corporation (displaces from its association with proteins and slows inactivation in the liver). Barbiturates causing induction of microsomal enzymes stimulate the degradation of Lidocaine (Anabel) and reduce its activity. Anticonvulsants (hydantoin derivatives) accelerate the biotransformation in the liver (decreased concentration in the blood), for IV injections it may increases cardiodepressive action of Lidocaine (Anabel). Antiarrhythmics (amiodarone, verapamil, quinidine, aymalin) potentiate cardiac depression. Combination with novocainamide may cause CNS excitement and hallucinations. Lidocaine (Anabel) Haffkine Bio-Pharmaceutical Corporation strengthens the inhibitory effect of anesthesia (hexobarbital, thiopental sodium), hypnotics and sedatives on the respiratory center, weakens the cardiac effects of digitoxin, enhances muscle relaxation caused by drugs curare like (possible paralysis of respiratory muscles). MAO inhibitors prolong local anesthesia.

Lidocaine (Anabel) side effects

See also:
What are the possible side effects of Lidocaine (Anabel)?

Application Site Reactions

During or immediately after treatment with Lidocaine (Anabel) 5%, the skin at the site of application may develop blisters, bruising, burning sensation, depigmentation, dermatitis, discoloration, edema, erythema, exfoliation, irritation, papules, petechia, pruritus, vesicles, or may be the locus of abnormal sensation. These reactions are generally mild and transient, resolving spontaneously within a few minutes to hours.

Allergic Reactions

Allergic and anaphylactoid reactions associated with Lidocaine (Anabel), although rare, can occur. They are characterized by angioedema, bronchospasm, dermatitis, dyspnea, hypersensitivity, laryngospasm, pruritus, shock, and urticaria. If they occur, they should be managed by conventional means. The detection of sensitivity by skin testing is of doubtful value.

Other Adverse Events

Due to the nature and limitation of spontaneous reports in postmarketing surveillance, causality has not been established for additional reported adverse events including:

Asthenia, confusion, disorientation, dizziness, headache, hyperesthesia, hypoesthesia, lightheadedness, metallic taste, nausea, nervousness, pain exacerbated, paresthesia, somnolence, taste alteration, vomiting, visual disturbances such as blurred vision, flushing, tinnitus, and tremor.

Systemic (Dose-Related) Reactions

Systemic adverse reactions following appropriate use of Lidocaine (Anabel) 5% are unlikely, due to the small dose absorbed. Systemic adverse effects of Lidocaine (Anabel) are similar in nature to those observed with other amide local anesthetic agents, including CNS excitation and/or depression (light-headedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression and arrest). Excitatory CNS reactions may be brief or not occur at all, in which case the first manifestation may be drowsiness merging into unconsciousness. Cardiovascular manifestations may include bradycardia, hypotension and cardiovascular collapse leading to arrest.

To report SUSPECTED ADVERSE REACTIONS, contact Actavis at 1-800-272-5525 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch for voluntary reporting of adverse reactions.

Lidocaine (Anabel) contraindications

See also:
What is the most important information I should know about Lidocaine (Anabel)?

You should not receive this medication if you are allergic to Lidocaine (Anabel) or any other type of numbing medicine.

Before you receive Lidocaine (Anabel) injection, tell your doctor if you have liver or kidney disease, heart disease, coronary artery disease, circulation problems, or a history of malignant hyperthermia.

To treat irregular heart rhythms, your doctor may prescribe a LidoPen auto-injector. This is a prefilled automatic injection device to be used in an emergency. Keep the device with you at all times.

Your doctor will describe the signs and symptoms to watch for when deciding when it's time to use Lidocaine (Anabel) injection at home. Never use the LidoPen auto-injector without first calling your doctor.

With the LidoPen auto-injector you will also receive a CardioBeeper to transmit your heart rate and rhythm to your doctor over a telephone. Read all provided instructions and practice using the CardioBeeper.

Lidocaine (Anabel) can cause side effects that may impair your thinking or reactions. Unless absolutely necessary, do not drive after using this medication

Treating cold sores and fever blisters. It may also be used for other conditions as determined by your doctor.

Benzalkonium Chloride (Anabel) liquid is a topical antiseptic. It works by killing sensitive germs.

Choline Salicylate (Anabel) magnesium trisalicylate is a non-steroidal anti-inflammatory drug (NSAID) that contains a combination of Choline Salicylate (Anabel) and magnesium salicylate.

Choline Salicylate (Anabel) magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults.

Choline Salicylate (Anabel) magnesium trisalicylate may also be used for purposes not listed in this medication guide.

Topical/Cutaneous

As antiseptic and disinfectant

Adult: As soln: Cleansing of skin, mucous membrane and wounds: 0.01-0.1%. Irrigation of deep wounds: 0.005%. Irrigation of bladder and urethra: 0.005-0.02%. Retention lavage of the bladder: 0.0025-0.005%. Disinfection and storage of surgical instruments: 0.13%; may be used w/ Na nitrite to avoid corrosion. As preservative: 0.01%-0.02% (ophth preparation); 0.002-0.2% (nasal and otic preparation). As shampoo: Seborrhoeic dermatitis: 0.2-0.5%. As cream: Napkin rash and other dermatoses: 0.13%. As vaginal douche: 0.02-0.05%. Refer to product information for specific directions for use.

See also:
What is the most important information I should know about Benzalkonium Chloride (Anabel)?

Use in occlusive dressings, casts and anal or vaginal packs.

Use Benzalkonium Chloride (Anabel) liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Benzalkonium Chloride (Anabel) liquid is for external use only. Do not get it in your eyes or nose.
• Wash the affected area with warm water and a washcloth to remove any cosmetics (eg, lipstick), lotions, ointments, or other lip preparations.
• Prepare Benzalkonium Chloride (Anabel) liquid for use according to the directions on the label.
• Apply the medicine by rubbing the affected area firmly with the applicator tip. Be careful not to damage the skin. Throw the applicator away after use.
• Wash your hands immediately after using Benzalkonium Chloride (Anabel) liquid.
• Do not brush your teeth or drink soft drinks or fruit juices for at least 1 hour after you use Benzalkonium Chloride (Anabel) liquid.
• If your symptoms get better but return later, you may use another dose. Do not use more than 3 times per day.
• If you miss a dose of Benzalkonium Chloride (Anabel) liquid, use it as soon as you remember. Continue to use it as directed by your doctor or on the package label.

Ask your health care provider any questions you may have about how to use Benzalkonium Chloride (Anabel) liquid.

Bladder irrigation, ear, eye, nose and throat irrigation, gingivitis, perodontal diseases, preoperative disinfection of unbroken skin, stomatitis, thrush, tonsillitis, urethral irrigation.

See also:
What other drugs will affect Benzalkonium Chloride (Anabel)?

Increased risk of corneal toxicity when used as preservative in anaesthetic eye drops.

See also:
What are the possible side effects of Benzalkonium Chloride (Anabel)?

Paralysis of respiratory muscle, Allergic contact dermatitis, Apprehension, Collapse, Coma, Convulsion, Cyanosis (bluish discoloration of the skin), Death, Shortness of breath, Muscle weakness, Restlessness, Vomiting

A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.