Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 2020-04-07
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Ameparomo is indicated for intestinal amebiasis - acute and chronic (NOTE - It is not effective in extraintestinal amebiasis); management of hepatic coma - as adjunctive therapy.
Adults and Pediatric Patients: Usual dose - 25 to 35 mg/kg body weight daily, administered in three doses with meals, for five to ten days.
Management of Hepatic Coma
Adults: Usual dose - 4 g daily in divided doses, given at regular intervals for five to six days.
Paromomycin sulfate is contraindicated in individuals with a history of previous hypersensitivity reactions to it. It is also contraindicated in intestinal obstruction.
Included as part of the PRECAUTIONS section.
The use of this antibiotic, as with other antibiotics, may result in an overgrowth of nonsusceptible organisms, including fungi. Constant observation of the patient is essential. If new infections caused by nonsusceptible organisms appear during therapy, appropriate measures should be taken.
The drug should be used with caution in individuals with ulcerative lesions of the bowel to avoid renal toxicity through inadvertent absorption.
See DOSAGE AND ADMINISTRATION section.
Nausea, abdominal cramps, and diarrhea have been reported in patients on doses over 3 g daily.
No information provided.