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Альбумин

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Альбумин

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Альбумин

Property Description
Active ingredient Human Albumin (Albumin Human)
Form Solution for Infusion
Pharmacological class Plasma Volume Expander
Common use Fluid balance and plasma volume maintenance
Origin Biological (Derived from human plasma)

What is Альбумин and its Biological Origin?

Альбумин is a widely recognized medicinal preparation whose sole active ingredient is the protein Human Albumin, which is identical to the most abundant protein naturally found in human blood plasma. The medication is classified as a Plasma Protein Fraction and has a biological origin, as it is manufactured from donated human blood plasma through a highly controlled purification process called fractionation. This process ensures the product is high-purity and ready for clinical use as a clear, sterile Solution for infusion. As a high-purity, single-protein product, Альбумин is typically distinguished from other, less specific plasma products by its focused role in fluid regulation.

Classification, Type, and Primary Function

The medication Альбумин is officially classified as a Plasma Volume Expander within the broader pharmacological group of Blood Substitutes. The clinical utility of this protein is based on its effectiveness in regulating colloid osmotic pressure. Its primary role involves regulating colloid osmotic pressure, as the preparation is used for restoring and maintaining plasma volume in patients with deficiencies. This classification shows that the medication's main general purpose is to support the circulatory system by effectively increasing the volume of circulating blood plasma.

Composition and Administration Type

Альбумин is a single-component product consisting only of the purified Human Albumin protein dissolved in a sterile aqueous solution that includes necessary electrolytes for stability. The only acceptable dosage form is an Intravenous solution, meaning it is administered solely through the Intravenous route directly into a vein. This method ensures that the protein is delivered immediately into the bloodstream, where it can begin its function of fluid regulation and its crucial transport function as a non-specific carrier for hormones and other vital circulating substances. This inherent transport function is a key feature that differentiates Human Albumin from purely synthetic volume expanders.

Regulatory References

  1. NIH MedlinePlus
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What side effects are possible with Альбумин?

Possible Side Effects and Safety Information

The safety profile for Human Albumin (Альбумин), as described in official regulatory documents, details potential adverse reactions primarily categorized by frequency and the body system affected. Most reactions are classified as uncommon or rare.


Adverse Reaction Classifications

Classification Symptoms (Representative of Class)
Uncommon Nausea, flushing (reddening of the skin), mild fever, and urticaria (hives).
Rare Primarily severe hypersensitivity reactions, including Anaphylactic Shock, which is officially documented as a Serious Adverse Reaction in regulatory labeling.

Adverse effects are often grouped into System-Organ-Classes (SOC) such as Immune System Disorders, Vascular Disorders, and Skin and Subcutaneous Tissue Disorders.


Administration and Volume Safety Constraints

Official labeling emphasizes specific safety constraints related to the volume-expanding function of the product. There is an explicit risk of circulatory overload and subsequent pulmonary oedema (fluid in the lungs) if the infusion rate is too fast or the dose is excessive. The medication must be used with particular caution in patients with pre-existing conditions susceptible to fluid volume increases, such as decompensated cardiac failure or severe hypertension.

Mild symptoms like flushing typically appear at the beginning of the infusion and are known to resolve rapidly when the administration rate is slowed or stopped. As Human Albumin is a plasma-derived product, a mandatory regulatory note is included regarding the theoretical risk of transmitting infectious agents; however, this risk is minimized by stringent manufacturing processes, including required virus inactivation and removal steps.

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Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory profile defines an overdose of Human Albumin as a state of cardiovascular overload or hypervolemia resulting from an excessive rate or volume of infusion. Because this medication is a plasma volume expander, an overdose is classified as a fluid-related event, not a direct toxicity.

Documented Overdose Manifestations

Official prescribing information documents specific clinical signs that indicate the onset of overload:

Sign of Overload Description
Cardiovascular effects Increased blood pressure, raised venous pressure, jugular venous distention.
Respiratory effects Dyspnea (shortness of breath), potential for pulmonary edema.
Systemic effects Headache, general signs of circulatory stress.

Emergency Actions and Urgent Care

Immediate medical attention is required upon the first appearance of any clinical signs of cardiovascular overload. The explicit, regulator-mandated action to mitigate the overload is to stop the infusion immediately or significantly slow the rate of administration.

  • Supportive Management: The management is procedural and supportive, focusing on resolving the volume excess. Patients experiencing overload require regular monitoring of vital signs, including arterial blood pressure, pulse rate, and central venous pressure.

  • Risk Populations: The official labels note that this manifestation of hypervolemia poses a special risk for patients with pre-existing conditions such as decompensated cardiac insufficiency or severe anemia, where the effects of overload may be particularly severe.

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Therapeutic Uses of Альбумин

What Альбумин Treats: Main Uses and Benefits

The primary therapeutic use of Альбумин is to address critical symptoms related to systemic imbalance by addressing symptoms related to severe protein deficiency and volume imbalance. This application is relevant in clinical contexts involving heightened systemic burden.

Supporting Circulation in Critical Volume Loss

The medication is commonly used to help manage acute, unstable symptom patterns, such as profound low blood pressure and the signs of shock resulting from trauma, surgery, or sepsis. This is relevant when supportive symptom management is appropriate, and is commonly used for managing symptoms that create noticeable physiological strain, especially where volume support is appropriate. The core benefit it provides is to help ease the overall symptom burden by supporting the patient's hemodynamics and supports general well-being during symptomatic phases related to poor organ perfusion.

Correcting Fluid Imbalance in Low Protein States

Альбумин is applied across domains where additional symptomatic support is needed to address critically low protein levels (hypoalbuminemia), which are symptoms linked to organ-specific functional stress, such as in severe liver cirrhosis or acute nephrosis. It is used to address symptoms that create noticeable physiological strain and may assist with maintaining functional stability. It can help address the symptom clusters that may become intense or disruptive, specifically by managing significant fluid accumulation like widespread edema (swelling) or ascites.


Quick Fact: Support for Systemic Symptoms Альбумин is commonly used to help manage symptoms stemming from critical circulatory volume loss and severe protein deficiency. This approach is relevant in contexts involving heightened systemic burden, such as trauma and severe liver disease complications.

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Eligibility and Restrictions for Use

Eligibility Profile: Albumin (Human)

This section outlines the official population eligibility and non-eligibility for Albumin (Human), based strictly on government regulatory documents (e.g., FDA, EMA).

Classification Status & Conditions
Contraindicated Use is forbidden in patients with known hypersensitivity to human albumin or its excipients. It is also contraindicated in patients with severe anemia or cardiac failure where intravascular volume is already normal or increased.
Restricted/Caution Use must be closely monitored and administered with caution in patients with pre-existing conditions that pose a risk of circulatory overload (hypervolemia) or severe hemodilution. These conditions include decompensated cardiac insufficiency, pulmonary edema, hypertension, and renal or post-renal anuria.
Age Group The medicine is established for use in adults and pediatric patients.
Pregnancy/Lactation Use is generally permitted only if clearly needed, as specific controlled studies on human reproduction and lactation are limited.

Regulatory documents establish that while the medicine is generally allowed for adults and children, it is absolutely prohibited for patients with hypersensitivity or volume-sensitive heart/blood conditions. All other uses are subject to formal restrictions to mitigate the potential for circulatory overload.

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What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory profile for Human Albumin is distinct because governmental prescribing information confirms a general absence of known specific drug–drug interactions. Authoritative sources, including major regulatory agencies, state that no specific interactions with other medicinal products have been formally documented. Therefore, the product label does not list any specific interacting medicines, substance categories, or require any specific timing separation rules for co-administered drugs.

The singular, mandatory restriction in the interaction profile is procedural and concerns the diluent substance. The solution must not be diluted with Sterile Water for Injection. This combination is formally classified as a Prohibited Combination in regulatory documents due to the serious risk of causing severe hemolysis (the rupture of red blood cells) in the recipient. The mandatory context constraint requires that if dilution is necessary, it must be performed using an appropriate isotonic solution, such as 0.9% sodium chloride or 5% glucose solution.

Official labeling contains no statements regarding interactions involving metabolic enzymes (CYP), drug transport systems, food, alcohol, herbal products, or supplements.

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Mechanism of Action

How Альбумин Works: Mechanisms of Action

Albumin, a large protein administered intravenously, acts primarily through three core physiochemical and biochemical mechanisms, which influences systemic physiochemical dynamics, distinct from receptor- or enzyme-driven drug actions.

Colloid Osmotic Pressure and Fluid Balance

Albumin is the main determinant of Colloid Osmotic Pressure (COP) in the plasma. By remaining confined to the bloodstream, it creates an osmotic gradient across the capillary walls. This action actively draws fluid from the interstitial space back into the circulation, a process that is key to retaining plasma volume and contributing to the dynamics of intravascular volume regulation.

Non-Specific Binding and Transport

Albumin functions as a versatile, high-capacity carrier molecule. It possesses multiple binding sites that non-specifically sequester various circulating substances, including insoluble bilirubin, free fatty acids, and some hormones and medications. This mechanism regulates the free concentration and distribution of these molecules, modulating the plasma concentration and distribution of these substances.

Endothelial Integrity and Oxidant Scavenging

Additionally, the protein exerts a stabilizing influence on the vascular endothelium, modulating the permeability and integrity of the blood vessel lining. Furthermore, Albumin acts as a significant non-enzymatic antioxidant, utilizing its cysteine residue (Cys-34) to neutralize damaging Reactive Oxygen Species (ROS), which results in the neutralization of circulating ROS load.

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Dosage and Administration Information

How to Use Human Albumin (Альбумин)

The guidelines for the use of Human Albumin, a plasma-derived volume expander, emphasize a highly controlled and individualized administration approach.


Administration and Dosing Principles

Usage Entity Administration Guidelines
Route of Administration Administered exclusively via Intravenous (IV) infusion.
Dosage Forms & Strengths Available as a Solution for Infusion in concentrations of 5% (50 g/L) and 25% (250 g/L).
Dosing Schedule Highly individualized; the dose and frequency are not fixed but are based on the patient’s measured circulating blood volume and clinical status, with administration being intermittent and as-needed.

Procedural and Concentration Rules

Administration is generally restricted to a monitored clinical setting. The maximum dose should not exceed 2 grams per kilogram (g/kg) of body weight per day.

For preparation, the 25% solution can be administered undiluted or mixed with isotonic solutions like 0.9% Sodium Chloride or 5% Dextrose in water. A critical procedural rule states that the solution must not be diluted with Sterile Water for Injection, nor mixed with protein hydrolysates or alcohol-containing solutions. The rate of infusion must be carefully controlled to prevent circulatory strain, with a slower rate often used for non-emergency volume expansion. For pediatric patients, the initial dose is calculated based on body weight, typically 0.5 to 1 g/kg.

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Recent Clinical Evidence

The research landscape for Human Albumin is based on multiple clinical evaluations, including high-quality randomized controlled trials (RCTs) and systematic reviews, primarily exploring its role in managing serious fluid and protein imbalances. The findings describe group patterns and reflect the specific conditions under which the studies were conducted. Research provides context but not individual predictions.


Evidence for Use in Acute Liver Disease Complications

Research has explored the use of Human Albumin in patients with liver cirrhosis. The studies monitored outcomes related to systemic or functional imbalance, such as the development of kidney dysfunction and changes in fluid distribution. This evidence is generally rated as High due to the consistency of study designs and synthesis across multiple RCTs.

Short-term RCTs monitored the development of a sharp decline in circulatory function (PICD) following large fluid removal. Research described observed patterns related to the incidence of PICD in the study groups. Human Albumin was also evaluated in trials as an adjunct to antibiotics for conditions like spontaneous bacterial peritonitis (SBP), monitoring survival and the incidence of acute kidney injury (AKI).


Evidence for Use in Critical Circulatory Volume Loss

Research has evaluated the product's function as a plasma volume expander for individuals experiencing acute volume deficits (hypovolemia) due to trauma, surgery, or shock. Multicenter RCTs monitored outcomes related to physiological strain, including overall survival (mortality) rates. Findings were mixed across different study populations regarding the ultimate impact on all-cause mortality, though research monitored patterns of circulating volume measurements in the study groups. Comparative evidence is lacking to definitively establish the role of this product over crystalloids across all critical care settings.


What Is Still Uncertain About Human Albumin Studies

Subgroup findings are uncertain, particularly for patients with co-existing conditions like traumatic brain injury (TBI), where some research data show patterns related to particular uncertainty. The evidence quality varies across studies, and long-term effects are not fully established, as many follow-up durations were limited to the acute phase of treatment.

Key Studies & References

  1. Albumin (human) | Protein Target - PubChem - NIH
  2. Physiology, Albumin - StatPearls - NCBI Bookshelf
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Frequently Asked Questions (FAQ)

Common questions about Альбумин (FAQ)


Q: Считается ли Альбумин безопасным препаратом?

As a medicinal product, Human Albumin has an established safety profile detailed in regulatory documents. These documents mandate specific precautions and contraindications for use. Furthermore, the manufacturing process includes required viral inactivation and removal steps to minimize the theoretical risk of transmitting infectious agents.


Q: Как долго Альбумин остается в организме?

Official pharmacological documents report that the half-life of Human Albumin in a healthy individual is approximately 15 to 19 days. It is distributed beyond the bloodstream into the entire extracellular space, although only about 10% typically leaves the intravascular compartment during the first two hours after the infusion.


Q: Есть ли риск аллергической реакции на Альбумин?

Yes, official safety information states that hypersensitivity or allergic reactions are possible with this product. If a patient experiences a suspected allergic reaction, which can range in severity, regulatory guidelines state that the infusion should be stopped immediately.


Q: Альбумин может влиять на артериальное давление?

Yes, because its primary function is to expand the circulating fluid volume, it is expected to influence blood pressure. Regulatory labels require that a patient's arterial blood pressure and pulse rate be monitored during administration. An increase in blood pressure may be a sign of circulatory overload, a condition that is typically addressed by the healthcare provider by adjusting or stopping the infusion rate.


Q: Альбумин может быть причиной повышения температуры?

Official safety data lists fever (pyrexia) as a possible, though uncommon, adverse reaction. Mild symptoms, including a mild fever, typically appear at the start of the infusion and are noted to resolve when the administration rate is slowed or discontinued.


Q: Как врачи определяют нужную дозировку Альбумина?

The dose is highly individualized for each patient and is not fixed. The required concentration and amount are determined by monitoring the patient's circulating blood volume and overall clinical status. Measures such Tike plasma oncotic pressure, which relates to the protein content in the blood, are used to guide the final dosage.


Q: Что чувствует пациент, когда получает Альбумин?

Most patients do not report significant effects, but official safety information notes that some may experience feelings of warmth (flushing), mild nausea, or fever, particularly at the beginning of the infusion.


Q: Сколько времени нужно ждать, чтобы увидеть эффект от Альбумина?

As a plasma volume expander, the effect on circulatory volume begins relatively quickly. Clinical studies note that the volume-expanding effect of concentrated solutions may be seen within approximately 20 minutes of administration.


Q: Есть ли у Альбумина неофициальные показания, о которых говорят в интернете?

Official regulatory documents define a precise set of therapeutic indications for the use of Human Albumin, focused on conditions like shock and hypovolemia. Regulatory constraints prohibit the discussion of any use outside of those officially approved, and the drug is only administered for the approved indications.


Q: Нужно ли менять образ жизни (диета, активность) во время лечения Альбумином?

Official regulatory labels contain no specific statements requiring changes to diet, activity, or overall lifestyle while a patient is receiving this treatment. The administration of Human Albumin typically occurs in a monitored clinical setting over a short period.


Q: Может ли Альбумин взаимодействовать с витаминами или БАДами?

Official drug labels contain no specific statements or warnings regarding an interaction between Human Albumin and vitamins, food, herbal products, or other supplements.


Q: Правда ли, что Альбумин могут использовать спортсмены?

The official uses for this product are solely therapeutic for specific medical conditions defined in regulatory documents. Its use outside of approved medical indications, such as in sports, is not addressed in regulatory drug labels.


Q: Альбумин делают из донорской крови?

Yes, Human Albumin is a biological product that is derived from donated human blood plasma. The source plasma is subject to mandatory donor screening and rigorous manufacturing processes, including virus inactivation steps, to ensure high standards of safety.


Q: Что делать, если при введении Альбумина стало плохо?

Official warnings state that if a patient experiences signs of cardiovascular overload (such as headache, difficulty breathing, or increased blood pressure) or an allergic reaction, official protocol requires the infusion to be slowed or stopped immediately by the healthcare team. Appropriate medical treatment is then implemented as needed.


Q: Есть ли данные о длительном использовании Альбумина?

Official documents and research summaries note that the long-term effects of this product are not fully established. Most clinical trials and evidence have focused on the acute phase of treatment for patients with severe conditions.


Q: Альбумин используют только в экстренных случаях?

While Human Albumin is indicated for acute and emergency conditions like shock or severe burns, regulatory indications also include chronic conditions. For example, it is used to help maintain circulating blood volume in certain patients with complications related to liver disease.


Q: Может ли Альбумин вызывать привыкание?

Official regulatory documents, including the full prescribing information, do not list any potential for abuse, dependence, or habit formation for Human Albumin.


Q: Что означает, если в анализах низкий уровень альбумина?

A low level of albumin in the blood, known as hypoalbuminemia, is a clinical marker often associated with certain underlying diseases. This condition can lead to an imbalance in fluid distribution and is one of the deficiencies for which Human Albumin is specifically indicated for therapeutic treatment.


Q: Есть ли альтернативы Альбумину, если он не подходит?

Yes, for the purpose of volume replacement, clinical guidelines supported by regulatory bodies often discuss the use of other solutions, such as crystalloids or synthetic colloids. The choice of fluid replacement is determined by the healthcare provider based on the patient's specific clinical requirements and condition.


Q: Может ли Альбумин вызвать головную боль?

Headache is listed in official safety information as a possible adverse reaction. Furthermore, headache is specifically mentioned as a potential early sign of circulatory overload, which is a condition that requires immediate attention and adjustment of the infusion rate.


Q: Можно ли принимать алкоголь во время лечения Альбумином?

Official labeling contains no specific statement or warning regarding an interaction between the product and alcohol.


Q: В чем разница между человеческим и животным альбумином?

The medicinal product Human Albumin is strictly a human-derived product from human blood plasma. The official regulatory profile for this medication does not contain any comparative information regarding non-human forms of albumin.


Q: Альбумин помогает восстановиться после операции?

Regulatory-supported professional guidelines generally advise against the routine use of Human Albumin solely for simple volume replacement or correction of low serum albumin levels during or after surgery, unless a specific deficiency is identified.


Q: Правда ли, что Альбумин иногда применяют для поддержания функции почек?

The product is used as part of established medical protocols for specific conditions associated with kidney dysfunction, such as Hepatorenal Syndrome and Spontaneous Bacterial Peritonitis (SBP). In these cases, it is used as an adjunct to other therapies in accordance with clinical guidelines.


Q: Описаны ли в официальных документах взаимодействия Альбумина с растительными сборами?

Official regulatory documents contain no statements regarding interactions involving food or herbal products/collecting materials (растительными сборами).

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How should Альбумин be stored and disposed of?

How to Store and Dispose of Human Albumin

Human Albumin solution must be stored and handled according to regulatory requirements to preserve its stability.

Storage and Handling

Condition Requirement
Temperature Store between +2 C and +25 C (36 F to 77 F). Do not freeze.
Protection Store the vial in its original carton to protect from light and keep it out of the sight and reach of children.
Inspection The solution must be clear; do not use if it is cloudy or contains deposits.
Shelf-Life After Opening The product contains no preservatives and must be used immediately after the container stopper is pierced, with administration completed within 4 hours.

Disposal Instructions

Any unused portion of the product remaining in an opened container must be discarded. Disposal of the unused medicinal product and any associated waste must be carried out in accordance with local pharmaceutical waste regulations.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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