Altermon

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Altermon

Quick Facts

Property Description
Active ingredient Urofollitropin (FSH)
Form Lyophilized powder for solution for injection
Pharmacological class Gonadotropin
Common use Facilitating ovarian stimulation and spermatogenesis
Origin Urinary source (purified from human urine)

What Type of Medicine is Altermon (Urofollitropin)?

Altermon is a highly purified prescription-only medicine whose active component, Urofollitropin, places it in the gonadotropin pharmacological class, belonging to the group of Pituitary and hypothalamic hormones and analogues. It is clinically recognized as a vital agent in managing fertility issues, specifically for patients requiring targeted hormonal support to stimulate reproductive function. As a complex biological product, its action is based on supplementing a natural glycoprotein hormone, a mechanism well-supported by pharmacological studies.

Composition, Origin, and Form of Altermon

The core component of this single-active ingredient product is Urofollitropin (FSH). Altermon is distinctive due to the origin/type of its active substance, as it is a highly purified form extracted from a urinary source—specifically, from the urine of postmenopausal women. This purification process is designed to yield FSH with minimal traces of Luteinizing Hormone (LH). Altermon is supplied as a lyophilized powder for solution for injection, which requires reconstitution with an aqueous solvent prior to administration via subcutaneous injection or intramuscular injection.

General Purpose and Mechanism of Action

The general purpose of Altermon is to facilitate essential biological processes of reproduction where hormonal signalling is inadequate, a principle clinically used in Assisted Reproductive Technologies (ART). The mechanism principle involves supplying exogenous FSH, which directly binds to specific receptors on target cells in the ovaries and testes. This targeted cellular activation is known to successfully promote follicular development in women and support spermatogenesis induction in men, centering the drug's utility on enhancing the core hormonal requirements for achieving fertility.

What side effects are possible with Altermon?

Possible Side Effects and Safety Information

The safety profile for Altermon (Urofollitropin) is defined by data collected in clinical studies and documented in official government regulatory labels.

Frequency-Classified Adverse Reactions

Adverse reactions are classified by frequency based on regulatory standards:

Classification Common Reactions (Examples)
Very Common (ge 1/10) Ovarian Hyperstimulation Syndrome (OHSS), Headache, Abdominal Cramps, Injection Site Reactions
Common (ge 1/100 to < 1/10) Nausea, Vomiting, Abdominal Pain, Pelvic Pain, Hot Flashes, Fatigue

These effects are typically associated with the Reproductive System and Gastrointestinal Disorders System-Organ Classes (SOCs).

Serious Adverse Reactions

The regulatory profile documents rare but serious risks, including:

  • Severe Ovarian Hyperstimulation Syndrome (OHSS): A serious complication requiring immediate medical evaluation.
  • Pulmonary and Vascular Complications: Reports include thromboembolic events such as blood clots (e.g., pulmonary embolism, stroke, or arterial occlusion).
  • Ovarian Torsion: Twisting of the ovary, which can compromise blood supply.
  • Hypersensitivity Reactions: Documented instances of severe allergic reactions, including anaphylaxis.

Regulatory Safety Restrictions and Populations

Official labeling defines specific restrictions and populations where safety data are limited:

  • Contraindications: The medicine is explicitly contraindicated (must not be used) in individuals with certain conditions, including primary gonadal failure (high baseline FSH levels), sex hormone-dependent tumors, uncontrolled endocrine disorders, and abnormal uterine bleeding of undetermined cause.
  • Pregnancy: The medicine is contraindicated in women who are already pregnant.
  • Unstudied Populations: Safety and efficacy in the pediatric and geriatric populations, as well as in patients with significant renal or hepatic impairment, have not been established or studied.

These statements ensure the safe use of the product by establishing the mandatory boundaries and known risks as defined by regulatory bodies (FDA, EMA, etc.).

Overdose and Emergency Response

The official regulatory profile for Altermon (Urofollitropin) documents the risk of overstimulation, with the only established overdose manifestation being the development of Ovarian Hyperstimulation Syndrome (OHSS). This condition is consistently classified by regulators into mild, moderate, and severe forms. Documented signs that may indicate overstimulation include severe abdominal pain, significant abdominal bloating, rapid weight gain (exceeding established thresholds), persistent nausea and vomiting, and decreased urine output.

When Immediate Medical Help is Required

The official labeling mandates that patients seek immediate medical attention for symptoms consistent with severe OHSS or signs of serious complications. Severe OHSS is officially documented as a life-threatening condition due to the associated risks of thromboembolism (blood clots) and pulmonary complications.

In the event of suspected overstimulation, Human Chorionic Gonadotropin (hCG) must be withheld as it can worsen the syndrome's progression. Management of the condition is strictly symptomatic and supportive, reflecting the official regulatory statement that no specific antidote is known for Urofollitropin overdosage. Hospital monitoring is required for severe cases to manage potential vascular changes and fluid accumulation.

Therapeutic Uses of Altermon

What Altermon Treats: Main Uses and Benefits

Altermon is a targeted hormonal therapy used in the specialized field of reproductive medicine and is applied in addressing specific reproductive challenges. It generally may be part of symptomatic management within both assisted and unassisted fertility efforts. The medication is applied across critical areas of reproductive function.


The primary therapeutic applications include addressing female infertility due to ovulatory dysfunction (oligo-anovulation), providing controlled ovarian stimulation for Assisted Reproductive Technology (ART) procedures like IVF, and supporting male factor infertility stemming from specific hormonal deficiencies (hypogonadotropic hypogonadism).

Therapeutic Focus and Benefit

This medication addresses conditions involving symptoms related to systemic imbalance, specifically where functional egg release is absent or irregular in women, or where sperm production is impaired in men due to inadequate hormonal stimulation. Altermon plays a role in managing symptoms that create noticeable physiological strain by supporting the required reproductive processes. This generally contributes to improved day-to-day comfort during symptomatic periods by contributing to the necessary physiological support required in these clinical phases.

“The treatment provides essential support that may assist with maintaining the functional stability required in challenging clinical phases of infertility.”

Quick Fact: Primary Use: Reproductive Functional Support
Primary Use Domain Used in situations involving symptoms related to systemic imbalance.
Symptom Category Systemic imbalance affecting ovulation and spermatogenesis.
Therapeutic Benefit Contributes to easing the overall burden of reproductive dysfunction.

Eligibility and Restrictions for Use

Eligibility Map: Who Can and Cannot Use Altermon — Official Regulatory Information

Altermon (Urofollitropin) is strictly reserved for use in adults of reproductive age and is subject to multiple contraindications outlined in official governmental prescribing information.

Classification Official Regulatory Status
Populations for whom use is allowed Adult women requiring ovulation induction or controlled ovarian stimulation; adult men with specific hypogonadotropic hypogonadism.
Populations for whom use is contraindicated Patients with high endogenous Follicle-Stimulating Hormone (FSH), indicating primary gonadal failure. Patients with hypersensitivity to urofollitropin or excipients. Patients with sex hormone-dependent tumours (e.g., ovarian, breast, uterine) or tumours of the pituitary/hypothalamus.
Age-related eligibility rules Use is limited to adults. Pediatric and geriatric populations are not established or not indicated for use.
Condition-specific eligibility rules Contraindicated in cases of uncontrolled non-gonadal endocrinopathies (e.g., thyroid/adrenal dysfunction) and abnormal uterine bleeding or ovarian cysts/enlargement of undetermined origin.
Pregnancy and lactation status Pregnancy is contraindicated. Use during lactation/breastfeeding is not recommended or contraindicated by regional authorities.

Connection to the overall eligibility profile: Official regulatory documents define eligibility by establishing absolute contraindications that exclude populations where the treatment is ineffective (primary gonadal failure) or carries specific risks (hormone-dependent tumours). Eligibility is confirmed only for the adult reproductive-age population experiencing specific functional deficiencies.

What should I know about interactions with other medicines?

Interaction Map: Interactions with other medicines and products — official regulatory information for Altermon

The official regulatory profile for Altermon (Urofollitropin) confirms that no known significant drug-drug interactions are documented, nor are complex metabolic interactions involving CYP enzymes or drug transporters reported. The interaction structure is defined by the necessary procedural and dose-limiting restrictions required when combining Altermon with other hormonal agents to manage the cumulative pharmacodynamic outcome.

Interaction scope
Medicinal product categories with documented interactions: Other hormonal therapies used in assisted reproductive technology (ART), specifically gonadotropins and GnRH antagonists.
Specific interacting medicines (if explicitly listed): Menotropins and GnRH Antagonists.
Mechanistic basis of interactions (only if stated in label): Pharmacodynamic additive effect (for gonadotropins); procedural constraint on co-administration (for GnRH antagonists).
Timing-based interaction rules (if applicable): When co-administered with Menotropins, the total initial combined daily dose must adhere to specified regulatory limits. When co-administered with GnRH Antagonists, the products must not be mixed and require the use of different injection sites.
Interaction-related restrictions: Restriction on the total combined dose when co-administered with another gonadotropin product.
Interaction classifications (high-level)
Interaction severity classification (as defined in official documents): Clinically significant interaction (due to mandatory dosing restriction); procedural restriction.
Regulatory basis: U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) public information.

Official interaction statements:

  • No known significant interactions are generally documented with other drugs or with food, alcohol, or herbal products.
  • Co-administration with Menotropins results in a pharmacodynamic additive effect that requires a mandatory restriction on the total combined dose.
  • Urofollitropin must not be physically mixed with a GnRH antagonist and requires administration at separate injection sites.

Mechanism of Action

Altermon functions as a dual ATP-competitive inhibitor of the catalytic domains of both the mechanistic Target of Rapamycin (mTOR) kinase and Class I Phosphatidylinositol 3-Kinase (PI3K). The compound exhibits non-selective interaction across the four primary PI3K isoforms (p110alpha, beta, gamma, and delta). By directly binding to the ATP-binding pocket of these enzymes, Altermon sterically prevents the phosphorylation of their respective substrates. In the PI3K/AKT/mTOR signaling cascade, this simultaneous inhibition blocks the generation of Phosphatidylinositol (3,4,5)-trisphosphate (PIP3) by PI3K and directly suppresses the kinase activity of mTOR, thereby disrupting the regulatory functions of both mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2).

Intracellularly, the suppression of mTORC1 activity reduces the phosphorylation of downstream effectors, specifically ribosomal protein S6 Kinase 1 (S6K1) and Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1). This cascade ultimately modulates mRNA translation and ribosomal biogenesis. Inhibition of mTORC2 disrupts the phosphorylation and subsequent activation of AKT, while the upstream PI3K inhibition reduces the essential signaling input that promotes cell survival. The resulting system-level consequence is a net reduction in cellular proliferation and a shift toward G0/G1 cell cycle arrest.

Dosage and Administration Information

How to Use Altermon

Altermon (Urofollitropin) is administered according to a strict, monitored protocol. This section describes the high-level, procedural patterns of its use, focusing on administration routes, dose ranges, and treatment schedules established for the medication.


Administration and Preparation

Altermon is supplied as a lyophilized powder for solution for injection and is approved for administration via subcutaneous injection (SC) or intramuscular injection (IM). The powder requires reconstitution with the provided sterile solvent immediately before use. The resulting solution must be visually inspected to ensure it is clear and colorless; any unused reconstituted portion must be discarded. The injection site should be alternated daily for proper procedural administration.

Official Dosing and Cycle Structure

The dosage regimen is specifically tailored to the patient’s condition and response, operating within strict parameters. Administration is typically once daily within a treatment cycle, with dose adjustments permitted no more frequently than once every two days.

Indication Typical Starting Dose Range Maximum Daily Dose Frequency Pattern
Induction of Ovulation 75 IU to 150 IU daily 450 IU Once daily
ART Procedures 225 IU daily 450 IU Once daily
Spermatogenesis Induction 450 IU weekly (e.g., 150 IU x 3) N/A Two to three times weekly

For female indications, the administration course is generally short-term and should not exceed 12 days in a single cycle. The treatment phase is completed by the administration of Human Chorionic Gonadotropin (hCG), given 24 to 48 hours after the final Altermon dose.


Population-Specific Use

Dosing protocols do not include specific recommendations for pediatric or geriatric patients, nor are there formal adjustments provided for those with renal or hepatic impairment.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Altermon


Evidence for Controlled Ovarian Stimulation (COS) in ART

Altermon, whose active component is urofollitropin, was evaluated in research exploring its role in women undergoing Assisted Reproductive Technology (ART) procedures, such as In Vitro Fertilization (IVF). The research mainly took the form of Randomized Controlled Trials (RCTs) and systematic reviews.

The studies research examined how treatment affected outcomes related to reproductive function. Researchers monitored outcomes such as the number of eggs (oocytes) retrieved and rates of clinical pregnancy. These trials often included adult women whose ovarian response was characterized in research as falling within the expected range under stimulation protocols. Findings describe patterns observed in the studies, with some trials reporting measured outcomes that relate to other preparations studied in the same research setting.

Evidence for Ovulation Induction (OI)

Altermon was evaluated in research exploring its ability to cause the release of an egg (ovulation) in women who rarely or never ovulate on their own (oligo-anovulation). This evidence was observed in research contexts and primarily comes from Randomized Controlled Trials (RCTs). The research examined outcomes related to systemic or functional imbalance by monitoring the ovulation rate and subsequent clinical pregnancy and live birth rates.

Evidence for Spermatogenesis Induction in Men

Altermon was studied for its role in men who have specific hormonal deficiencies known as hypogonadotropic hypogonadism. Due to the rarity of this specific condition, the evidence landscape relies more on smaller, focused clinical studies and cohort studies. Researchers monitored how sperm production (spermatogenesis) was affected over defined time intervals. The outcomes research described included changes in sperm concentration and testicular size, with monitoring often continuing for longer than two years.

What Is Still Uncertain About Altermon Research

The evidence base is substantial in the area of ART, but still contains specific research limitation frames. For instance, long-term effects are not fully established, particularly concerning outcomes that extend many years beyond the treatment period in women. The research provides context but not individual predictions, as studies report how symptoms evolved in the observed populations under controlled conditions, and individual patient responses may vary.

Frequently Asked Questions (FAQ)

Common questions about Altermon (FAQ)

Q: Is Altermon the same type of medicine as [Similar Medicine Name]?

According to official product information, Altermon’s active ingredient, Urofollitropin, belongs to the pharmacological class of gonadotropins. This means it is a hormone that stimulates the reproductive organs. Its action is based on supplementing Follicle-Stimulating Hormone (FSH), and it is a highly purified product.

Q: What are the main differences between Altermon and other drugs for the same condition?

Official regulatory descriptions state that Altermon is a highly purified form of Urofollitropin, which is primarily FSH. A key feature of its composition is that it contains only minimal or trace amounts of Luteinizing Hormone (LH) activity. This specific profile is one factor that distinguishes it from other combination gonadotropin medicines used for reproductive treatment.

Q: Is Altermon considered safe for long-term use?

Studies indicate that treatment with Altermon is typically short-term, with administration generally not exceeding 12 days in a single treatment cycle. Research has also noted that long-term effects extending many years beyond the treatment period are not fully established in the evidence base.

Q: Do I need to get blood tests done while I am taking Altermon?

The official prescribing protocol includes requirements for close medical monitoring during treatment. This monitoring typically involves a combination of laboratory tests, such as checking serum estradiol levels, and physical examinations using tools like vaginal ultrasounds. These procedures are utilized to assess the body’s response and to help manage the potential risk of complications like Ovarian Hyperstimulation Syndrome (OHSS).

Q: Are there any side effects of Altermon that mainly affect women or men differently?

The safety profile lists adverse reactions observed across all indications. However, many of the most serious and common effects, such as Ovarian Hyperstimulation Syndrome (OHSS) or pelvic pain, are directly related to its intended use in women for ovarian stimulation.

Q: Why do doctors prescribe Altermon instead of non-drug treatments?

The general purpose of Altermon is to provide specific hormonal support (FSH) to help trigger essential biological reproductive processes. It is used in situations where the body’s natural hormonal signaling is inadequate to support processes like follicular development or sperm production. Its targeted mechanism of action addresses a hormonal deficiency that non-drug treatments cannot correct.

Q: How should I expect to feel in the first week of starting Altermon?

Official safety information notes that certain common adverse reactions may occur during the treatment cycle. These can include headache, abdominal pain, nausea, or localized reactions where the medicine is injected. Any new or persistent symptoms are statements intended for discussion with a healthcare provider.

Q: Does Altermon cause weight gain or weight loss?

General weight gain or loss is not consistently noted as a common side effect in the official adverse reaction profile. However, rapid weight gain is specifically listed in the warnings as a key sign of the serious medical condition known as Ovarian Hyperstimulation Syndrome (OHSS). Rapid increases in weight are regulatory warning signs that should be addressed by a healthcare provider.

Q: What happens if I miss a dose of Altermon? (General question, not asking for instructions)

Regulatory instructions for patients explicitly state that if a dose is missed, a person should not attempt to compensate by taking a double dose. Official guidance directs individuals to contact the prescribing healthcare provider immediately for specific instructions on how to proceed.

Q: Does Altermon affect sleep patterns, like causing insomnia or making me drowsy?

Insomnia (difficulty sleeping) and drowsiness are not listed among the very common side effects in the official safety profile. However, other common adverse reactions, such as headache or depression, are known to be reported and may potentially impact a person's sleep patterns.

Q: Is Altermon a controlled substance?

Altermon is classified as a highly purified biological product and requires a valid prescription for use. Regulatory authorities do not classify Altermon (Urofollitropin) as a controlled substance due to a lack of recognized potential for abuse.

Q: Can Altermon cause dizziness or lightheadedness when standing up?

The official adverse reaction list includes dizziness as a common side effect reported during clinical trials. Although not explicitly listed as lightheadedness upon standing, dizziness is a reported effect described in official product information.

Q: How quickly does Altermon leave the body after I stop using it?

Regulatory information provides the drug’s half-life in the Pharmacokinetics section, which describes how quickly the active substance is eliminated from the body. This information serves as the scientific basis for determining how long the medicine remains active after the final administration.

Q: Can Altermon affect my ability to drive or operate machinery?

Official safety information generally indicates that this medicine does not typically impair the ability to drive or use complex machinery. However, a note of caution is given in regulatory documents because certain side effects, like headache or dizziness, are commonly reported and could potentially affect concentration or motor skills.

Q: Is Altermon available as a generic version, or is it only branded right now?

Altermon's active component is Urofollitropin. Its current status as a branded product or a biosimilar (a type of generic for biologics) is officially tracked by government bodies, such as the FDA Purple Book. It is available under various trade names that contain the Urofollitropin active ingredient.

How should Altermon be stored and disposed of?

The unreconstituted Altermon powder must be stored in the original container to ensure protection from light. Storage temperature is specified to be between 2 C and 25 C, and the product must not be frozen. To prevent accidental ingestion, the medicine must be kept secured and out of the sight and reach of children.

Once the solution is prepared, it is for immediate, single use. Any remaining portion of the mixed solution must be discarded without delay. Disposal of expired or unused medicine must comply with local regulatory requirements. All used injection materials, including needles and syringes, must be placed into a designated, puncture-resistant sharps disposal container and handled according to community or state laws.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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