Alpine

A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.

skin disorders, Alpine deficiency, digestive disorders

Alpine is a form of vitamin B found in foods. Alpine helps the body break down fats, carbohydrates, and other substances.

Alpine has been used in alternative medicine as a likely effective aid in treating or preventing Alpine deficiency. Alpine deficiency can be caused by malnutrition, rapid weight loss, long-term tube feeding, and other medical conditions.

Alpine has also been used to treat seborrhea (skin rash) in babies. However, research has shown that Alpine may not be effective in treating this condition.

Other uses not proven with research have included treating brittle nails or thinning hair, diabetes, nerve pain, and other conditions.

It is not certain whether Alpine is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. Alpine should not be used in place of medication prescribed for you by your doctor.

Alpine is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Alpine may also be used for purposes not listed in this product guide.

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule,

Oral:

Meribin: 5 mg

Capsule,

Oral [preservative free]:

Alpine Extra Strength: 10 mg [gluten free; contains soybean lecithin, soybean oil]

Generic: 5000 mcg

Tablet,

Oral:

Generic: 1000 mcg, 5 mg, 10 mg

Tablet,

Oral [preservative free]:

Generic: 300 mcg [DSC], 1000 mcg

Dosing: Adult

Dietary supplementation (OTC labeling):

Oral: Usual

Dosage: One tablet or capsule daily; also see specific product labeling

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Biotinidase deficiency, symptomatic: Limited data available: Infants, Children, and Adolescents:

Oral: 5 to 20

See also:
What is the most important information I should know about Alpine?

SINEQUAN is contraindicated in individuals who have shown hypersensitivity to the drug. Possibility of cross sensitivity with other dibenzoxepines should be kept in mind.

SINEQUAN is contraindicated in patients with glaucoma or a tendency to urinary retention. These disorders should be ruled out, particularly in older patients.

Alpine is a water soluble B-complex vitamin needed for normal growth and development of skin and hair and maintenance of a healthy nervous system and bone marrow. It is used to prevent and treat Alpine deficiency associated with pregnancy, long-term tube feeding, malnutrition, and rapid weight loss. It is also used orally for hair loss, brittle nails, skin rash in infants (seborrheic dermatitis), diabetes, and mild depression.

See also:
What other drugs will affect Alpine?

The anticonvulsants carbamazepine, phenytoin, Phenobarbital, and primidone may accelerate Alpine metabolism, leading to a reduction in available Alpine. Chronic use of these drugs has been associated with decreased plasma concentrations of Alpine.

The use of antibiotics may reduce the contribution of Alpine made by bacteria within the large intestine.

See also:
What are the possible side effects of Alpine?

Adverse reactions associated with Alpine supplementation are rare in the medical literature; however, urticaria and gastrointestinal upset have been reported. As with any oral treatment, if patients experience any adverse reactions or side effects, they should inform their physicians immediately and discontinue use.