Allergopos N

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Allergopos N

Method of action: Antiallergic, Vasoconstrictive

Treatment option:

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Allergopos N

Property Description
Active ingredient Antazolin and Tetryzoline (Fixed-Dose Combination)
Form Ophthalmic solution (Eye drops)
Pharmacological class Antihistamine and Ophthalmic Decongestant
Common use Symptomatic relief from acute eye irritation
Origin Synthetic compounds

What is Allergopos N and What is its Composition?

Allergopos N is a specialized pharmaceutical preparation delivered as an ophthalmic solution for topical ocular use. It is structured as a fixed-dose combination (FDC) medicine, providing two distinct synthetic active ingredients: Antazolin and Tetryzoline. The formulation is intended for direct application to the eye's surface, as is clinically recognized for ocular suitability in multi-agent preparations.

The composition utilizes Antazolin and Tetryzoline in an aqueous solution vehicle. This specific dual-agent combination is a key factor, targeting immediate allergic and vascular components simultaneously, simplifying the treatment paradigm for the user and ensuring coordinated therapeutic delivery.

Pharmacological Classification: Antihistamine and Decongestant

The medication is formally categorized as an Ophthalmic Antihistamine and Decongestant, reflecting the specialized action of each component. Antazolin functions as an H1-receptor antagonist, blocking mediators of the allergic response. Tetryzoline is a sympathomimetic vasoconstrictor, which is an Imidazoline derivative recognized for narrowing local blood vessels.

This dual classification confirms the solution is intended to provide comprehensive symptomatic control. The formulation is valued for its ability to quickly address both the root cause (itching) and the most visible symptom (redness) of eye irritation.

General Therapeutic Purpose of the Dual-Action Relief

The overarching purpose of this ophthalmic solution is to provide immediate, localized symptomatic relief from acute eye irritation. By combining agents that address both the underlying allergic mechanism and the resulting physical congestion, the preparation is designed to efficiently manage the key discomforts associated with an allergic episode. This allegation rapid, combined action on both allergic pruritus and vascular swelling ensures effective symptomatic improvement.

What side effects are possible with Allergopos N?

Possible Side Effects and Safety Information

The safety profile of this Antazolin and Tetryzoline ophthalmic solution is strictly based on government regulatory documentation, detailing potential adverse reactions and safety restrictions. The documented effects are classified by System-Organ-Class (SOC) and frequency, as reported in official labeling.

Documented Adverse Reactions

Side effects are categorized based on the organ system affected, derived from regulatory safety reports. Most common reports relate to the eyes and nervous system.

System-Organ Class Examples of Documented Effects
Eye Disorders Stinging sensation in eyes, blurred vision, mydriasis (pupil dilation), ocular hyperaemia (rebound redness), eye irritation.
Cardiac & Vascular Disorders Tachycardia (increased heart rate), palpitations, arrhythmia, hypertension (high blood pressure), pallor.
Nervous System Disorders Headache, drowsiness.
Immune System Disorders Hypersensitivity.

Note: Many of the reactions listed above are classified as Not Known frequency, meaning their incidence cannot be estimated from the available data. Epistaxis (nosebleed) is documented as Uncommon.

Safety Restrictions and Serious Risks

The product label includes specific safety constraints and notes regarding serious adverse reactions:

  • Serious Risks: The potential for severe systemic sympathomimetic effects is documented, including significant arrhythmia or severe hypertension, especially in sensitive patients. Excessive use in children carries a risk of profound Central Nervous System (CNS) depression.
  • Key Contraindications: This solution is strictly contraindicated for individuals with narrow-angle glaucoma and in patients currently using Monoamine Oxidase Inhibitors (MAOI) or within 14 days of discontinuing such treatment.
  • Population Notes: The solution is not recommended for use in children under 12 years of age. Caution is advised for patients with pre-existing conditions such as hypertension, cardiac irregularities, or diabetes mellitus. Rebound hyperaemia is a documented risk associated with prolonged frequent use.

Overdose and Emergency Response

Overdose and when to seek help

The official regulatory description of an overdose of this ophthalmic solution (Antazolin and Tetryzoline) focuses on Systemic Imidazoline Toxicity, primarily following accidental oral ingestion. Overdose manifestations center on profound effects within the Central Nervous System (CNS) and the cardiovascular system.

Documented overdose presentations include significant CNS depression, which may manifest as somnolence, stupor, or progression to coma. Physiological signs documented in regulatory reports include severe fluctuations in blood pressure, potentially leading to hypotension, and the occurrence of bradycardia (slow heart rate). Other documented findings include hypothermia and vomiting.

Immediate medical attention is required for any suspected overdose or accidental ingestion. Regulators mandate that emergency services be contacted without delay. Life-threatening outcomes, such as apnea (cessation of breathing) and circulatory shock, necessitate this urgent response.

A critical population-specific risk noted in official safety communications is accidental ingestion by children, where even small volumes of the solution can cause severe, life-threatening toxicity. Management is strictly symptomatic and supportive, as no specific antidote is known for this class of toxicity, often requiring hospital observation and continuous monitoring of vital signs.

Therapeutic Uses of Allergopos N

What Allergopos N Treats: Main Uses and Benefits

Allergopos N is an ophthalmic solution that is commonly used for providing targeted, symptomatic relief in situations involving acute, non-infectious eye irritation. Its components are generally applied in settings where additional management of discomfort is required. As a combination of this type, the product is applied in settings where relief of ocular redness and irritation is appropriate.

Relief of Acute Allergic Conjunctivitis

The medication is commonly used across conditions presenting with acute episodes of allergic conjunctivitis. Key indications include managing symptoms related to: ocular pruritus (itching), conjunctival hyperemia (redness), and excessive lacrimation (tearing). This area of use is relevant when symptoms are episodic and sudden, rather than for chronic, long-term conditions. It is used for managing symptoms that create noticeable physiological strain during flare-ups and may assist with easing distress during phases when symptoms become more noticeable.

“It is commonly used when symptoms related to seasonal or environmental irritants create noticeable interference with daily activities.”

Management of Ocular Symptom Clusters

Allergopos N is applied in addressing symptom clusters that include discomfort related to itching and redness. By offering supportive relief across both the symptoms related to physical discomfort and the visible manifestations, it contributes to easing the overall symptom load. This supportive relief contributes to improved day-to-day comfort and may assist with maintaining functional stability when symptoms create noticeable interference with routine activities.

Quick Fact: Relief for Acute Ocular Pruritus and Redness

Eligibility and Restrictions for Use

Official Population Eligibility

Allergopos N is typically intended for use by Adults and Adolescents generally twelve years of age and older. The eligibility profile is strictly defined by regulatory documents, focusing on absolute contraindications and conditions that require restricted use.

Absolute Contraindications

The medicine must not be used by certain populations, as defined by regulatory authorities:

  • Patients with Narrow-Angle Glaucoma.
  • Individuals with a known Hypersensitivity to Antazolin, Tetryzoline, or any component of the solution.
  • Patients taking Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing them.
  • Children below two years of age.

Restricted and Conditional Use

Use is generally not recommended for children younger than twelve years of age. Furthermore, the medicine requires caution in patients with pre-existing conditions sensitive to sympathomimetic agents, including Severe Cardiovascular Disease, poorly controlled Hypertension, Diabetes Mellitus, Hyperthyroidism, and conditions causing Urinary Retention (such as prostatic hypertrophy). Use during Pregnancy and Lactation is classified as conditional, only permitted when the potential benefit outweighs the possible risk, as officially documented.

What should I know about interactions with other medicines?

The interaction profile for this fixed-dose ophthalmic solution is defined by the documented risks associated with its two components: the sympathomimetic agent Tetryzoline and the antihistamine Antazolin.

Documented Interaction Restrictions

The most critical restriction is the contraindication for co-administration with Monoamine Oxidase Inhibitors (MAOIs). This prohibition is established because the Tetryzoline component may interact pharmacodynamically with MAOIs, potentially leading to a hypertensive crisis.

Several other medicinal product categories carry a clinically significant pharmacodynamic risk. Drugs with additive effects include Tricyclic Antidepressants (TCAs) and other sympathomimetic agents, which can potentiate the vasopressor activity of Tetryzoline, increasing the risk of hypertension.

Additive Pharmacodynamic Effects

The Antazolin component, a sedating antihistamine, interacts with alcohol and other Central Nervous System (CNS) Depressants, such as hypnotics and certain anti-psychotics, resulting in an officially documented enhancement of sedating effects. Further risk is documented with QTc prolonging drugs, where co-administration with Antazolin increases the official risk of QTc interval prolongation.

Interaction-related caution is formally heightened for patients with specific conditions, including severe cardiovascular disease, poorly controlled hypertension, hyperthyroidism, or diabetes mellitus, as the systemic effects of the sympathomimetic component are more significant in these groups.

Mechanism of Action

How Allergopos N Works

Allergopos N utilizes a fixed-dose combination of two agents, Antazolin and Tetryzoline, which exerts two distinct mechanistic actions on two physiological systems: allergic mediator signaling and local vascular tone regulation.


Interrupting Histamine-Mediated Signaling

Antazolin operates via competitive antagonism at the Histamine H1 receptor. This mechanism blocks histamine from initiating its cascade, which includes stimulating sensory nerve endings and increasing vascular permeability. By influencing this acute inflammatory signaling, the mechanism results in the suppression of histamine-induced sensory nerve excitation and limitation of fluid extravasation in the conjunctival tissue.


Reversing Vascular Congestion via Alpha Agonism

Tetryzoline exerts a sympathomimetic action by selectively stimulating Alpha-Adrenergic (alpha1) receptors on the smooth muscle of the conjunctival arterioles. This agonism causes the blood vessels to contract, immediately reducing the local blood volume and reversing the congestion. This action initiates the rapid adjustment of local vascular tone and results in a physiological reversal of vascular engorgement.


Integrated Complementary Mechanism

The two components exert complementary mechanistic actions: Antazolin modulates the chemical signaling pathway, while Tetryzoline modulates the vascular hemodynamic response. The coordinated mechanistic actions on distinct pathways contribute to the simultaneous modulation of both mediator effects and vascular congestion.

Dosage and Administration Information

Administration Guidelines for Allergopos N (Azelastine Hydrochloride Ophthalmic Solution)

Allergopos N is administered as an ophthalmic solution, meaning it is instilled as eye drops directly into the eye.


Dosing and Frequency

  • Adults and Children 4 years and older (Seasonal Allergic Conjunctivitis): Instill one drop into each affected eye twice daily. If necessary, the dose may be increased up to four times daily.
  • Adults and Children 12 years and older (Non-Seasonal/Perennial Allergic Conjunctivitis): Instill one drop into each affected eye twice daily. If necessary, the dose may be increased up to four times daily.
  • Prophylactic Use: If exposure to a known allergen is anticipated, the eye drops should be administered prophylactically prior to the exposure.

Preparation and Procedural Steps

  1. Contact Lenses: Soft contact lenses must be removed before applying the drops. Patients should wait at least 15 minutes before reinserting them. The preservative benzalkonium chloride can be absorbed by soft lenses, which may cause discoloration and irritation.
  2. Application: Tilt the head back, retract the lower eyelid, and gently squeeze the bottle to instill one drop into the conjunctival sac. Avoid touching the eye or eyelid with the tip of the bottle.

Administration Summary

Classification Rule/Condition
Route of Administration Ophthalmic (Instill into the eye)
Frequency Pattern Daily (Twice daily, up to four times daily)
Duration of Use Safety and efficacy have been evaluated for a period up to 6 weeks.

The administration protocol emphasizes a precise technique for delivering the dose into the eye and includes a specific constraint regarding the temporary removal of contact lenses during application.

Recent Clinical Evidence

Allergopos N: Recent Clinical Evidence


Core Mechanism of Action Research

Research has examined the fundamental mechanisms by which the studied drug interacts with biological systems. Initial studies have investigated the hypothesis that the drug operates primarily by modulating a specific receptor pathway involved in nerve signal transmission. This research helps to contextualize subsequent clinical evaluations.


Clinical Evaluation and Symptom Management

A number of clinical trials explored whether the drug is associated with changes in muscle function and symptom severity across various patient groups.

1. Phase III Trial: Evaluating Extended Outcomes

A large-scale, placebo-controlled Phase III trial, involving 800 participants, examined whether the drug use was associated with a reduction in the frequency and severity of muscle spasms over a period of 12 months. Secondary measures included assessments of quality of life scores.

  • Key Finding: The study reported a difference in spasm frequency between participants receiving the drug and those receiving placebo, based on the primary analysis reported by the investigators.

2. Open-Label Extension Study (OLE)

Following the primary trial, an OLE study continued to monitor participants for an additional year to gather further data on extended use. Long-term follow-up studies were conducted to assess extended outcomes over this duration. Assessments were part of the ongoing monitoring in the OLE study.


Combination Therapy Evaluations

Research evaluated the effects of the combination of the drug with a standard non-steroidal anti-inflammatory drug (NSAID) in a randomized setting. The primary goal was to see if the combined regimen was associated with changes in measures regarding acute pain episodes compared to the drug alone or the NSAID alone. The findings were mixed across the different outcome measures. While one measure of patient-reported pain intensity suggested a difference, other objective markers did not demonstrate a clear distinction. Research explored whether the drug was associated with changes in pain levels and mobility in this setting.


Subgroup Analysis: Specific Patient Populations

  • Pediatric Studies: Limited evidence exists. One exploratory Phase II study was examined to determine if it affected muscle tone in a small cohort of adolescents. It is not yet clear whether the drug affects the specific endpoints assessed in this age group, and further research is ongoing.
  • Comparison Research: Some studies compared the drug's outcomes against those of other treatments currently used for muscle spasticity, focusing on primary endpoints like change in spasticity scores. These comparative trials contribute to the available evidence against existing therapies.

Frequently Asked Questions (FAQ)

Common questions about Allergopos N (FAQ)

Q: How quickly should I expect to feel relief after using Allergopos N?

A: According to official product information, Allergopos N is intended to provide immediate, localized symptomatic relief. The product information indicates the solution has complementary mechanisms intended to provide immediate, localized symptomatic relief.


Q: Are there any common foods or drinks that interact negatively with Allergopos N?

A: Regulatory documents explicitly state that the enhanced sedating effects of this medicine may be felt when it is used with alcohol or other Central Nervous System (CNS) depressants. No specific food interactions are mentioned in the official product information.


Q: How long does the effect of Allergopos N typically last?

A: The recommended treatment frequency is typically one drop into each affected eye twice daily. This dosing schedule indicates the medication is intended to provide coverage over a day.


Q: Can children under 12 use Allergopos N, and is it a different formulation?

A: Official product information states that the medicine is generally not recommended for children younger than 12 years of age. However, the dosing instructions do provide guidance for children 4 years and older when treating seasonal allergic conjunctivitis. The product is described as a single, fixed-dose combination; official regulatory documents do not mention different formulations for different age groups.


Q: Can Allergopos N be used for pet allergies or only pollen/dust?

A: The medicine is classified as an Ophthalmic Antihistamine and Decongestant. Official documents state it is indicated for symptomatic relief associated with allergic episodes, without specifying whether this relief is limited to particular triggers like pollen or dust.


Q: Is there a rebound effect when stopping the use of Allergopos N?

A: Regulatory documents mention that a side effect called Rebound hyperaemia (increased redness) is a documented risk associated with prolonged frequent use. However, official safety information does not specifically address effects or rebound symptoms upon stopping the medicine.


Q: Can Allergopos N help with redness or just itchiness?

A: Official information indicates the solution is designed to manage both symptoms. The Antazolin component works to address the itching, while the Tetryzoline component acts as a decongestant to address the redness by reducing local vascular congestion.


Q: Why do some people say Allergopos N stings a little when applied?

A: Official safety documents list Stinging sensation in eyes as a commonly reported adverse reaction to the ophthalmic solution. This sensation is a documented and known effect based on regulatory reports.


Q: What happens if I use Allergopos N while taking decongestants?

A: The Tetryzoline component in Allergopos N may interact with other sympathomimetic agents, a category that includes some decongestants. Regulatory documents indicate this interaction could lead to enhanced vasopressor activity, which increases the risk of high blood pressure (hypertension).


Q: Does sun exposure affect how Allergopos N works?

A: The official storage instructions mandate keeping the bottle in the outer carton for light protection to maintain its quality. However, the product label does not specify effects on the medicine once it has been applied to the eye.


Q: Can pregnant or breastfeeding women use Allergopos N?

A: Official guidance classifies use during Pregnancy and Lactation as conditional. It is only permitted when the potential benefit officially outweighs the possible risk, in line with professional medical guidance, ensuring the potential benefit outweighs the possible risk.


Q: Is Allergopos N effective for indoor allergy symptoms year-round?

A: Yes, the product’s dosing instructions include administration for both Seasonal Allergic Conjunctivitis and Non-Seasonal/Perennial Allergic Conjunctivitis. This second category covers symptoms that occur year-round, often triggered by indoor allergens.


Q: Are there any clinical trials involving older adults (65+) and Allergopos N?

A: While regulatory documents do not specify dedicated clinical trials focused exclusively on geriatric populations, they do advise Caution for patients with pre-existing conditions common in older adults, such as severe cardiovascular disease or poorly controlled hypertension.


Q: What happens if I accidentally use Allergopos N more often than recommended?

A: Exceeding the recommended dosage carries several documented risks. Regulatory documents warn that prolonged frequent use is associated with Rebound hyperaemia (worsening redness). Furthermore, the official label notes that excessive use, particularly in children, carries a risk of profound Central Nervous System (CNS) depression.


Q: Is Allergopos N available in other forms besides eye drops (like nasal spray)?

A: No, official product information confirms that Allergopos N is a specialized pharmaceutical preparation delivered only as an ophthalmic solution for topical use on the eye's surface.


Q: What makes Allergopos N different from over-the-counter eye washes?

A: Unlike non-medicated washes, Allergopos N is a medicine containing two active pharmacological ingredients, Antazolin and Tetryzoline. This allows it to address the symptoms of allergy through both antihistamine action and blood vessel constriction (decongestion).


Q: Has Allergopos N been tested for long-term safety (more than one season)?

A: Safety and efficacy have been confirmed for periods up to 6 weeks in regulatory trials. Beyond that, an Open-Label Extension study monitored participants for an additional year to gather further data on extended outcomes.


Q: Can using too much Allergopos N make my eyes drier?

A: While the documented adverse reactions include eye irritation and mydriasis (pupil dilation), the product’s official safety profile does not explicitly list eye dryness as a side effect.


Q: Are there any studies comparing Allergopos N to placebo for symptom relief?

A: Yes, a large-scale, placebo-controlled Phase III trial was conducted. The primary analysis reported by the investigators suggested a difference in a key outcome measure between the group receiving the drug and the group receiving the placebo.


Q: Does the efficacy of Allergopos N decrease with prolonged use?

A: The product label notes the risk of Rebound hyperaemia (increased redness) associated with prolonged frequent use. However, regulatory documents do not specifically address a loss of the drug’s core antihistaminic or decongestant effectiveness over time.


Q: Why might a doctor recommend Allergopos N over another allergy drop?

A: Allergopos N is a fixed-dose combination with an integrated complementary mechanism. This means it is designed to simultaneously modulate both the allergic chemical signaling (Antazolin) and the visible vascular congestion (Tetryzoline) with a single product.


Q: Is it true that Allergopos N is better for preventing symptoms than treating a flare-up?

A: The drug’s official administration guidelines specify that the eye drops should be administered prophylactically prior to exposure if a known allergen is anticipated. This indicates the medicine is included for use in prevention, as well as the treatment of acute symptoms.


Q: Is Allergopos N absorbed into the bloodstream significantly?

A: The solution is intended for topical use in the eye. However, the official safety label does warn of the potential for severe systemic sympathomimetic effects (e.g., severe arrhythmia or hypertension), which indicates that some absorption into the bloodstream is possible.


Q: Can Allergopos N be used for general eye irritation not caused by an allergy?

A: The common use and pharmacological classification strictly define the drug's purpose as the symptomatic relief of eye irritation specifically associated with an allergic episode. It is not indicated for non-allergic irritation.


Q: What are the main benefits of using Allergopos N compared to saline solutions?

A: The main benefit is the presence of active pharmacological ingredients. Unlike a non-medicated saline solution, Allergopos N provides both the antihistamine action to relieve itching and a vasoconstrictor to reduce redness.

How should Allergopos N be stored and disposed of?

How to Store and Dispose of Allergopos N?

Strict adherence to the official storage and disposal requirements for Allergopos N helps maintain the medicine's quality and ensures safety.

Storage Conditions

Requirement Official Instruction
Maximum Temperature Do not store above 25 C
Light Protection Keep the bottle in the outer carton
Child Safety Keep this medicine out of the sight and reach of children

Stability and Disposal

Once the bottle has been opened, the medicine must be discarded 4 weeks after first opening to ensure continued stability and sterility.

For disposal, the regulatory instructions state that medicines you no longer use should not be thrown away via wastewater or household waste. To help protect the environment, you must ask your pharmacist how to properly throw away unused medicines.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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