Alidol

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Alidol

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Alidol

What is Alidol? Definition and Identity

Property Description
Active Ingredients Ibuprofen and Hyoscine Butylbromide
Form Oral Tablet (Fixed-Dose Combination)
Pharmacological Class Nonsteroidal Anti-inflammatory Drug (NSAID) and Antispasmodic Agent
Common Use Relief of spasmodic pain
Origin Synthetic chemical entities

Alidol is a pharmaceutical preparation defined by its structure as a fixed-dose combination product, delivering two distinct active compounds, Ibuprofen and Hyoscine Butylbromide, in a single oral tablet. This medicine is the result of synthesizing these two entities to provide a dual therapeutic effect, administered via the oral route.

The combination formulation is widely recognized for its clinical utility in treating pain where an underlying muscle contraction is present, distinguishing it from medications designed solely for general pain relief.

Composition and Dual Pharmacological Class

The active components in Alidol are the Nonsteroidal Anti-inflammatory Drug (NSAID) Ibuprofen and the antispasmodic agent Hyoscine Butylbromide. The fixed combination of an NSAID with a spasmolytic agent is a key feature that targets pain associated with smooth muscle spasms.

Ibuprofen is a widely known synthetic compound that achieves pain relief (analgesia) and reduced inflammation by inhibiting chemical messengers. Hyoscine Butylbromide, formally classified as an Anticholinergic Agent, acts to relax involuntary smooth muscle contractions. This unique composition is primarily positioned for patient groups experiencing pain characterized by acute, colicky discomfort.

The Integrated Purpose of Alidol

The overall purpose of Alidol is to provide effective relief for spasmodic pain by addressing both the muscle cramp and the resulting discomfort. The preparation is typically used in scenarios where pain is directly linked to internal muscular activity, such as in cases of severe menstrual cramping.

This integrated action ensures that while Ibuprofen addresses the pain and inflammation, Hyoscine Butylbromide directly targets and relaxes the contracting muscle, thereby reducing the source of the acute, sharp discomfort. The combination offers a comprehensive strategy for managing pain rooted in internal contractions.

Regulatory References

  1. Combination Therapy Studies (PubMed Central)

What side effects are possible with Alidol?

Possible Side Effects and Safety Information

Alidol, a medication related to the typical antipsychotic class, carries regulatory warnings regarding its safety profile, which primarily involves neurological and cardiovascular risks.

Serious and Clinically Significant Adverse Reactions

Official regulatory documents emphasize the risk of Increased Mortality in Elderly Patients with Dementia-Related Psychosis. This is a major safety concern associated with the entire class of antipsychotic drugs, and Alidol is not approved for this specific use. Additionally, the drug is associated with Neuroleptic Malignant Syndrome (NMS), a rare but potentially fatal condition characterized by muscle rigidity, high fever, altered mental status, and autonomic instability.

Cardiovascular Risks include reports of sudden death, QT-prolongation, and Torsades de Pointes (a form of ventricular tachycardia). The risk of these cardiac events is explicitly stated to be higher with intravenous administration and doses above recommended levels.

Uncontrolled movement disorders, known as Extrapyramidal Symptoms (EPS) and Tardive Dyskinesia (TD), are documented, with the risk of irreversible TD believed to increase with treatment duration and total cumulative dose. In rare cases, a severe encephalopathic syndrome followed by irreversible brain damage has been reported when Alidol was used in combination with lithium.

Population-Specific Safety Considerations

  • Elderly Patients with Dementia-Related Psychosis: Antipsychotic treatment in this population is associated with an increased risk of death (Black Box Warning).
  • Neonates: Exposure during the third trimester of pregnancy may result in extrapyramidal and/or withdrawal symptoms in the newborn after delivery.

Safety-Related Restrictions

Alidol is contraindicated in patients with known hypersensitivity to the drug, severe toxic central nervous system depression, or Parkinson's disease. Caution is advised for patients with existing cardiovascular disorders, and the drug may impair mental and/or physical abilities required for operating machinery or driving.

Overdose and Emergency Response

Overdose and When to Seek Help

Documented Overdose Manifestations

An overdose of Alidol may present with signs reflecting its dual components, including severe gastrointestinal distress such as nausea, vomiting, and stomach pain, progressing to signs of hemorrhage like bloody or black stools. Central Nervous System (CNS) effects are documented, manifesting as drowsiness, severe headache, and the potential for seizures. Additionally, anticholinergic toxicity may be observed, characterized by tachycardia, dry mouth, and urinary retention.

Severe Outcomes and Emergency Action

Overdose is associated with life-threatening outcomes, including severe hypotension, coma, acute liver and kidney failure, and potentially fatal gastrointestinal perforation. Given these risks, immediate medical attention is required for any suspected overdose. Regulator-mandated action includes contacting emergency services immediately for symptoms indicative of a severe event, such as slurred speech, sudden weakness, or vomiting blood.

Management and Monitoring

Management of an overdose is primarily symptomatic and supportive. While no specific antidote is known for the NSAID component, specific countermeasures like parasympathomimetics are documented for anticholinergic toxicity. Treatment procedures include stomach decontamination with activated charcoal and continuous monitoring of the patient's breathing and vital signs. Official labeling notes that older adults have a higher risk for severe GI adverse events.

Therapeutic Uses of Alidol

What Alidol Treats: Main Uses and Benefits

Alidol is commonly used for the short-term management of moderately severe acute pain. The preparation is relevant for easing symptoms that create noticeable physiological strain, often used during phases when symptoms become more noticeable.

Managing Symptom Intensity and Discomfort

This medication is applied across domains where additional symptomatic support is needed. Alidol is used to help with symptoms related to physical discomfort that may become intense or disruptive, offering symptomatic relief when manifestations are substantial and interfere with daily functioning. This is relevant in offering supportive relief during episodes where pain intensity is high, which helps to ease the overall burden of distress.

Supporting Stability During Acute Episodes

Alidol is relevant in contexts involving inflammatory or irritative states, helping to address associated aches and stiffness. It is commonly used in situations involving recurrent or episodic manifestations where short-term symptomatic assistance is appropriate. This support during difficult episodes helps to ease the overall burden of distress and contributes to improved comfort during symptomatic periods.


Quick Facts: Therapeutic Focus

  • Relief Domain: Used for managing symptoms related to physical discomfort and inflammatory or irritative states.
  • Clinical Context: Applied in situations involving episodic or fluctuating manifestations.

Eligibility and Restrictions for Use

Who can and cannot use Alidol?

Alidol's eligibility profile is strictly defined by regulatory documents, combining the restrictions of its two active agents (an NSAID and an Anticholinergic). Use is determined by the absence of specific health conditions, allergies, and patient status.


Absolute Contraindications

Alidol must not be used by individuals with a known hypersensitivity to Ibuprofen, Hyoscine Butylbromide, aspirin, other NSAIDs, or related drugs. It is also prohibited for patients with untreated narrow angle glaucoma, myasthenia gravis, and mechanical obstructions of the gastrointestinal or urinary tract. Use is strictly contraindicated for the treatment of peri-operative pain in the setting of Coronary Artery Bypass Graft (CABG) surgery.


Restrictions and Limitations

Age and Development: Safety and effectiveness have not been established in children (pediatric population). Older adults require cautious use due to increased risk of side effects, including gastrointestinal bleeding.

Physiological Status: The medicine is contraindicated during the third trimester of pregnancy and is not recommended during lactation.

Organ Function: It is contraindicated in advanced renal disease and requires caution in patients with liver cirrhosis or a history of recent myocardial infarction.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory information for Alidol, a fixed-dose combination of Ibuprofen and Hyoscine Butylbromide, defines interaction constraints across several domains.

Formally Restricted Combinations

Co-administration with other Nonsteroidal Anti-inflammatory Drugs (NSAIDs) or high-dose Aspirin is restricted, as government regulatory documents note an officially documented increased risk of serious gastrointestinal adverse events. Use with Anticoagulants, such as Warfarin, increases the risk of serious bleeding. For the parenteral administration of the antispasmodic component, co-use with anticoagulant drugs is restricted due to the risk of intramuscular haematoma.

Exposure and Effect Modifications

Ibuprofen is officially documented to increase the serum concentrations of certain substances, including Lithium and Methotrexate. Concomitant use with Diuretics (e.g., Furosemide) and Antihypertensive Agents (e.g., ACE inhibitors) is documented to reduce their intended effect. The anticholinergic effect of Hyoscine Butylbromide is officially described as being intensified when combined with other anticholinergic substances, such as Tricyclic Antidepressants and some Antihistamines.

Administration Conditions and Food

Specific timing separation is required when co-administering Ibuprofen with low-dose Aspirin to mitigate interference with its antiplatelet effect. Alcohol consumption, particularly heavy use, is an officially documented risk factor for gastrointestinal bleeding. Administration immediately after a meal may result in a reduction in the rate of absorption of the Ibuprofen component.

Mechanism of Action

Alidol functions as an antagonist at dopamine D2 receptors in the central nervous system, particularly within the mesolimbic and mesocortical pathways. This interaction blocks the postsynaptic binding of the neurotransmitter dopamine, thereby modulating excessive dopaminergic activity. The central antagonism of D2 receptors mediates the primary pharmacological effect. In addition to its primary target, Alidol exhibits blocking action on several other G-protein coupled receptors, including noradrenergic, cholinergic, and histaminergic receptors. Its presence in the brain is significantly higher than in serum due to its highly lipophilic properties. Furthermore, blockade of dopamine receptors in the tuberoinfundibular pathway leads to the disinhibition of prolactin release.

Dosage and Administration Information

How Alidol is Used: Official Administration Guidelines

Alidol, a fixed-dose oral tablet combining Ibuprofen and Hyoscine Butylbromide, is administered according to specific principles. These principles govern the route, dosing schedule, duration, and conditions of intake, ensuring consistent use in clinical practice.


Administration Scope

Category Official Instruction
Route of administration Oral (by mouth).
Dosing schedule Standard dose: One tablet. Maximum dose: Three tablets per 24 hours.
Timing in relation to meals May be taken with or without food.
Preparation requirements The oral tablet must be swallowed whole with water. It must not be crushed, chewed, or divided.
Age-group administration Use in older adults requires the administration of the lowest effective dose for the shortest possible duration.
Special conditions Treatment is strictly limited to short-term use, typically for a duration not exceeding 3 days.

Procedural Structure and Constraints

The standard dosing regimen involves taking one tablet up to three times per day (TID), but a minimum interval of at least 6 to 8 hours must separate each dose. If a dose is missed, individuals should wait until the next scheduled time and not take a double dose to compensate. This approach enforces a controlled intake pattern, and the maximum daily limit must not be exceeded under any circumstance. The use protocol is defined as duration-limited, requiring discontinuation if symptoms persist or worsen beyond the specified short-term period.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Alidol


Evidence for Use in Primary Dysmenorrhea (Severe Menstrual Cramping)

Alidol (Ibuprofen and Hyoscine Butylbromide) was studied for its use in exploring outcomes related to physical discomfort linked to primary dysmenorrhea, which involves conditions characterized by fluctuating or episodic manifestations. Researchers have used short-term randomized controlled trials (RCTs) against placebo, as well as observational studies, to explore the effects in adult women. These studies typically focus on episodes where symptoms become more noticeable, tracking patient experiences over defined time intervals.

Outcomes related to physical discomfort and functional imbalance were measured during the study period. Researchers examined symptom intensity using standardized scales and recorded the patient-reported time to onset of symptom change. Findings describe patterns observed in the studies related to these short-term measurements of physical discomfort. The research focused predominantly on adult women with a clinical diagnosis of primary dysmenorrhea.


Evidence for Use in Colic-type Abdominal Pain

Research examined the combination's use in conditions associated with acute or disruptive episodes of cramping, or "colic-type," abdominal pain. The evidence was observed in double-blind, placebo-controlled studies and subsequent reviews. These studies were conducted during periods of increased symptom activity and studies explored short-term symptom changes in adult populations.

The research explored outcomes related to physical discomfort by examining absolute change in pain scores at very specific time points, such as 30 or 60 minutes after administration. Findings describe patterns observed in the studies regarding symptom evolution and the use of rescue medication. Research also describes how symptoms evolved in the observed populations during the defined time intervals.


Areas of Uncertainty and Remaining Research Gaps

Key research limitation frames include the fact that sample sizes were modest in some specialized studies, and evidence quality varies across studies, particularly when comparing results from different formulations (e.g., Ibuprofen combination versus Paracetamol combination). Because the follow-up durations were limited, questions remain about the long-term patterns of use and the need for more research exploring how symptoms change over time. Data for certain groups remain insufficient, particularly for older adults, children, or those with complex chronic health conditions.

Key Studies & References Combination Therapy Studies

Frequently Asked Questions (FAQ)

Common questions about Alidol (FAQ)

Q: Is Alidol an over-the-counter medicine or is it prescription only?

A: The regulatory status of Alidol, which is a combination of two active ingredients (Ibuprofen and Hyoscine Butylbromide), can vary by country and by the strength of the tablet. In many regions, medications combining an NSAID and an antispasmodic are available without a prescription, but this determination is based on the official product labeling specific to your location.

Q: How quickly should I feel the effects of taking Alidol?

A: Official information indicates that the antispasmodic component (Hyoscine Butylbromide) may start acting relatively quickly. Clinical studies have tracked the time until a patient reports a change in their symptoms, which for this combination is sometimes observed within 15 to 30 minutes after administration.

Q: What are the most common minor side effects of Alidol?

A: Regulatory documents list common side effects associated with the ingredients in Alidol. These minor effects may include dry mouth, dizziness, mild constipation, or headache. Side effects are generally mild and temporary, and the occurrence varies between individuals.

Q: How long does one dose of Alidol usually last?

A: The official dosing schedule requires a minimum interval of at least 6 to 8 hours between doses. This minimum interval generally reflects the expected duration of the therapeutic effect.

Q: Does Alidol cause drowsiness?

A: Both active ingredients in Alidol have been associated with central nervous system effects, such as dizziness or mild drowsiness, in some users. Because of this possibility, official warnings advise caution, as the medication may impair the mental and physical abilities needed for driving or operating machinery.

Q: Is there a generic version of Alidol available?

A: Alidol is a fixed-dose combination of two active ingredients, Ibuprofen and Hyoscine Butylbromide, both of which are commonly available as generic medications. Regulatory requirements state that any approved generic equivalent must contain the identical active ingredients in the same strength as the brand name product.

Q: Can Alidol be taken with antacids?

A: Antacids may alter the rate at which the Ibuprofen component of Alidol is absorbed into the body. Official guidance often suggests separating the administration of Ibuprofen and antacids to ensure that the medication is taken up properly. It is important to discuss with a healthcare professional how to manage taking antacids concurrently.

Q: Is Alidol safe for people who are generally healthy?

A: Official information defines who should not use the medication by listing contraindications, such as severe kidney disease or hypersensitivity to NSAIDs. In the absence of these contraindications, the medicine is authorized for short-term use only.

Q: Are there any long-term effects of using Alidol?

A: Regulatory guidelines state that treatment with Alidol is strictly limited to short-term use, typically no longer than 3 days. Extended use beyond this short duration is associated with an increased, officially documented risk of serious adverse events, particularly affecting the gastrointestinal tract and the cardiovascular system.

Q: What kind of research has been done on Alidol?

A: Official regulatory submissions include data from clinical studies, such as short-term randomized controlled trials against placebo. These studies have explored the effects of Alidol on spasmodic pain, specifically focusing on conditions like primary dysmenorrhea (severe menstrual cramping) and colic-type abdominal pain.

Q: What evidence supports the effectiveness of Alidol?

A: The effectiveness of Alidol is supported by evidence from clinical trials. These studies examined outcomes related to physical discomfort, tracking changes in symptom intensity and the patient-reported time to symptom change over specific, short time intervals.

Q: What are the signs of a serious, but rare, allergic reaction to Alidol?

A: Official safety warnings advise that severe allergic reactions to the NSAID component, while rare, are possible. Signs can include swelling of the face or throat, hives, a severe skin rash with blistering, or difficulty breathing. These events are considered medical emergencies.

Q: How long before surgery should I stop taking Alidol?

A: The Ibuprofen component can affect platelet function. For this reason, the drug is contraindicated (must not be used) for pain around the time of Coronary Artery Bypass Graft (CABG) surgery. The specific timing of discontinuation before other major surgery is a clinical decision that depends on the surgical procedure and patient factors.

Q: What is the difference in strength between the brand name Alidol and its generic?

A: Official regulatory standards require that an approved generic version of Alidol contain the identical active ingredients, Ibuprofen and Hyoscine Butylbromide, in the same strength as the brand-name product. This ensures that the generic version is bioequivalent to the branded product.

Q: Is Alidol the same type of drug as ibuprofen or acetaminophen?

A: Alidol is a fixed-dose combination product containing Ibuprofen, which is an NSAID, and Hyoscine Butylbromide, an antispasmodic. It is therefore not the same as single-ingredient Ibuprofen, nor is it related to acetaminophen (paracetamol), which belongs to a different class of pain relievers.

Q: What is the difference between Alidol and other common pain relievers?

A: Alidol provides dual action by combining an anti-inflammatory pain reliever (Ibuprofen) with an agent that relaxes internal muscle cramps (Hyoscine Butylbromide). This composition allows it to address both the spasm and the resulting pain, unlike single-ingredient pain medications.

Q: Is it normal to feel a little dizzy when first starting Alidol?

A: Official safety information lists dizziness as a possible side effect of the antispasmodic component (Hyoscine Butylbromide). This effect may be more noticeable when first starting treatment.

Q: Can older adults generally take Alidol?

A: Older adults may take Alidol, but caution is advised due to a documented increased risk of side effects, including serious gastrointestinal bleeding. Regulatory documents state that use in older adults necessitates the lowest effective dose be administered for the shortest possible duration.

Q: Are there any known issues with taking Alidol while driving?

A: Yes, official documents warn that Alidol may cause side effects such as dizziness, drowsiness, or visual disturbances. If these effects occur, they can impair the mental and physical abilities required for safely operating a vehicle or machinery, so caution is advised.

Q: What should I do if I miss a scheduled dose of Alidol?

A: Official instructions advise that if a dose is missed, you should not take a double dose to compensate. You should wait until the next scheduled time and continue with your regular regimen. The maximum daily limit must not be exceeded.

Q: Is Alidol considered a narcotic or opioid?

A: No. Official classification defines Alidol as a combination of a Nonsteroidal Anti-inflammatory Drug (NSAID) and an Anticholinergic Antispasmodic Agent. It is not classified as a controlled substance, narcotic, or opioid.

Q: Why do some people experience headaches when they take Alidol?

A: Headache is listed in regulatory documents as a possible adverse reaction. It is a known potential side effect associated with both the NSAID (Ibuprofen) and antispasmodic components of the medicine.

Q: What if I'm taking herbal supplements—do they interact with Alidol?

A: Some herbal supplements may interact with Alidol, particularly those that can affect the risk of bleeding or possess anticholinergic properties (effects similar to the antispasmodic). Consultation with a healthcare professional regarding potential interactions with specific supplements is advisable.

Q: Is Alidol habit-forming?

A: No. Alidol is not classified as a controlled substance and is not an opioid. Official information indicates it does not carry the same risk of physical dependence or habit formation that is associated with narcotic pain medications.

Q: Is it normal for Alidol to cause mild constipation?

A: Yes, constipation is listed in official safety information as a possible side effect. This is linked to the antispasmodic component, Hyoscine Butylbromide, which works by relaxing muscles, including those in the gut, which can slow intestinal movement.

Q: Does Alidol affect blood pressure readings?

A: Official warnings state that the NSAID component (Ibuprofen) may reduce the effectiveness of certain blood pressure medications. Additionally, the NSAID component has been associated with the potential for new-onset or worsening high blood pressure in some individuals.

Q: Can people who are lactose intolerant take Alidol?

A: Whether Alidol contains non-active ingredients like lactose depends on the specific formulation. You would need to check the Excipients (non-active ingredients) section of the official prescribing information for the particular tablet to determine if it is suitable for someone with lactose intolerance.

Q: What are the chances of experiencing a severe side effect from Alidol?

A: Regulatory documents classify adverse reactions based on their frequency (e.g., common, uncommon, rare). Severe side effects, such as serious gastrointestinal bleeding or severe allergic reactions, are generally classified as rare or very rare. The risk may increase with higher doses or use beyond the recommended short-term duration.

Q: Why is Alidol sometimes prescribed for short-term use only?

A: Alidol is officially recommended only for short-term use, typically not exceeding 3 days. This duration limit is imposed because official warnings state that long-term use of the NSAID component carries an increased and documented risk of serious adverse events, particularly concerning the cardiovascular and gastrointestinal systems.

How should Alidol be stored and disposed of?

How to Store and Dispose of Alidol

Storage Requirements

Alidol tablets must be stored at a temperature below 30°C in a dry place and be protected from light. The medicine must remain in its original container and must not be used after the printed expiry date. It is strictly required to store the medicine in a secure location that is out of the sight and reach of children to prevent accidental ingestion.

Disposal Instructions

Disposal of unused or expired Alidol must follow official regulatory guidance. Patients must ask their pharmacist how to throw away medicines no longer required. It is advised not to throw away the medicine via wastewater or household waste and to return it to a pharmacist or official take-back program to help protect the environment.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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