Alcoliv

Alcoliv

Metadoxine

complex therapy of liver diseases, especially alcoholic etiology,

acute alcohol intoxication,

chronic alcoholism,

alcohol withdrawal syndrome.

Acute alcohol intoxication: 300-600 mg (5-10 ml) in/m or 300-900 mg (5-15 ml) v/v, depending on the degree of intoxication.

With intravenous administration, the required dose of the drug is diluted in 500 ml of isotonic sodium chloride solution or 5% dextrose (glucose) solution and administered drip for 1.5 hours.

Complex therapy of liver diseases and chronic alcoholism: inside: according to 1 table. 2 times a day (1000 mg) for 15-30 minutes before meals, the dose can be increased to 3 tablets (1500 mg) per day. The course of therapy should be at least 90 days.

Alcohol withdrawal syndrome: 900 mg (15 ml) as an intravenous infusion (see above) once a day for 3-7 days, depending on the patient's condition.

hypersensitivity to any component of the drug,

pregnancy,

lactation period.

With caution

Be used with caution in Parkinson's disease, levodopa if used simultaneously, because metadoxine reduces the effectiveness of the medication.

The ampoules of the solution for injection contain sodium metabisulfite. This substance can cause allergic reactions or an increase in asthma attacks in predisposed people, especially those suffering from bronchial asthma.

Allergic reactions. In patients suffering from bronchial asthma, it is possible to develop bronchospasm when using a solution for injection.

The hepatoprotective effect of methadoxin is due to the membrane-stabilizing effect and is based on the ability to restore the ratio of saturated and unsaturated free fatty acids. As a result, the resistance of hepatocytes to the action of lipid peroxidation, which occurs when exposed to various toxic agents, increases. The detoxification effect of methadoxin is due to the activation of liver enzymes involved in the metabolism of ethanol — alcohol dehydrogenase and acetaldehyde dehydrogenase, which accelerates the process of removing ethanol and acetaldehyde from the body, and therefore reduces their toxic effects.

Metadoxin prevents the accumulation of triglycerides in hepatocytes, and also prevents the formation of fibronectin and collagen, which significantly slows down the formation of cirrhosis of the liver.

The drug reduces the mental and somatic manifestations of the hangover syndrome, reduces the time of relief of the withdrawal syndrome.

Methadoxin activates the cholinergic and GABAergic neurotransmitter systems, improves the functions of thinking and short memory, and prevents the occurrence of motor arousal, which is caused by ethanol.

Metadoxine has a non-specific antidepressant and anxiolytic effects, reduces the craving for alcohol.

It is rapidly absorbed from the gastrointestinal tract, has a high bioavailability (60-80%). Binding to plasma proteins — 50%. It is metabolized in the liver to the active metabolites-pyridine and pyrrolidone carboxylate. T_1/2 when taken orally or parenterally, it is 40-60 minutes. 45-50% of the drug is excreted in the urine for 24 hours, 35-50% of the drug is excreted in the feces for 96 hours.

• Means for the treatment of alcoholism [Means for the correction of disorders in alcoholism, substance abuse and drug addiction]

When used together, it reduces the effectiveness of levodopa.