Medically reviewed by Fedorchenko Olga Valeryevna, PharmD. Last updated on 2020-03-24
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In combination therapy:
infected burns (grades I-II),
purulent inflammatory processes of soft tissues.
Infections of the skin, respiratory tract, ENT organs, urinary tract, wound infections (prevention and treatment).
Outwardly, applied directly to the affected surface. Bandages are carried out in 1-2 days.
Maximum doses for adults: single dose - 5 G, daily dose-15 G, for children over 3 years: single dose-300 mg, daily dose-300 mg.
With deep wounds, 5, 10 or 15 G of powder are introduced into the wound cavity.
If there is no improvement after treatment or new symptoms appear, you should consult your doctor.
Inside-0.5 G 5-6 times a day, the highest single dose - 2 G, daily - 7 G, children under 1 year-0.05-0.1 G per reception, 2-5 years-0.2 - 0.3 G, 6-12 years-0.3-0.5 g.with deep wounds injected into the wound cavity in the form of carefully ground sterilized powder (5-15 G), at the same time prescribes antibacterial
hypersensitivity to sulfanilamides,
diseases of the hematopoietic system,
Depression of bone hematopoiesis,
chronic heart failure,
renal / hepatic impairment,
congenital deficiency of glucose-6-phosphate dehydrogenase,
With caution: children under 3 years.
Hypersensitivity, diseases of the hematopoietic system, renal failure, thyrotoxicosis.
With hypersensitivity to sulfanilamide means, allergic reactions are possible, the development of which requires immediate withdrawal of the drug. In addition, headache, dizziness, nausea, vomiting, dyspepsia, cyanosis, leukopenia, agranulocytosis, crystalluria are possible.
If any of the side effects mentioned in the description are aggravated or the patient notices other side effects not mentioned in the description, you should inform your doctor.
Headache, dizziness, nausea, vomiting, cyanosis, leukopenia, agranulocytosis, allergic reactions.
Symptom: nausea, vomiting, intestinal colic, dizziness, headache, drowsiness, depression, fainting, confusion, visual impairment, fever, hematuria, crystalluria, with prolonged overdose: thrombocytopenia, leukopenia, megaloblastic anemia, jaundice.
Treatment: abundant drink, with accidental ingestion, gastric lavage.
Sulfanilamide is an antimicrobial bacteriostatic agent. The mechanism of action is associated with competitive antagonism with PABA and inhibition of dihydropteroate synthetase, which leads to a violation of the synthesis of dihydrofolic and then tetrahydrofolic acid, as a result of which the synthesis of nucleic acids of microorganisms is disrupted. Active against Gram positive and Gram negative microorganisms: Escherichia coli, Shigella spp., Vibrio cholerae, Clostridium spp., Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp., Actinomyces spp. Toxoplasma gondii.
Myelotoxic ls increase the manifestations of hematotoxicity of the drug.