Aflavic

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Aflavic

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Aflavic

Aflavic is an oral pharmaceutical preparation whose identity is defined by its active component, Diosmin, and its classification as a specialized venoactive drug. The information presented here establishes the drug's nature and general purpose, strictly avoiding details on administration, specific treatments, or safety profiles.

Property Description
Active ingredient Diosmin (INN)
Form Oral Tablets (typically film-coated)
Pharmacological class Venoactive Drug / Phlebotonic
General purpose Supports vein tone and capillary integrity
Origin Semi-synthetic (derived from Hesperidin)

What Type of Medicine is Aflavic?

Aflavic is classified as a venoactive drug, an important category of medication intended to provide a functional benefit to the vascular system, specifically the veins and microcirculation. This designation means the preparation primarily acts as a phlebotonic and vasoprotective agent. The medication is administered in the form of oral tablets, which determines its systemic route of administration. Substances in this class are used to ease venous symptoms by improving vascular wall mechanics. This medicine helps ease discomfort by gently stimulating local circulation, a benefit clinically recognized for supporting long-term venous health.

Diosmin: Composition and Origin

The core active component in Aflavic is Diosmin, the International Nonproprietary Name (INN) for a compound chemically identified as a flavonoid glycoside. Diosmin, a type of bioflavonoid found in nature, is generally obtained for pharmaceutical use through a specialized semi-synthetic conversion process using the precursor compound, Hesperidin. To ensure superior biological effectiveness and absorption, the active ingredient is typically manufactured as a Micronized Purified Flavonoid Fraction (MPFF), a process that mechanically reduces particle size and increases the proportion of the drug that is efficiently absorbed into the body. This specific micronized formulation is a key differentiating factor, resulting in enhanced bioavailability compared to non-micronized Diosmin preparations.

General Purpose of a Venoactive Agent

The fundamental purpose of a vasoprotective agent is to maintain the functional integrity of the circulatory system's low-pressure side. The core mechanism involves combined venotonic and vasoprotective actions: increasing the tension of the vein walls and reinforcing the capillary lining. By supporting more effective blood flow and minimizing the abnormal leakage of fluid from small vessels into surrounding tissues, the medication generally helps to counteract impaired circulation. This functional support aims to provide relief from discomfort associated with venous issues, such as the typical feeling of heavy or tired legs after prolonged standing, specifically addressing feelings of heaviness and localized tissue swelling.

What side effects are possible with Aflavic?

Possible Side Effects and Safety Information

Aflavic, which contains micronized diosmin, is generally well-tolerated. However, like all medicines, it may cause side effects in some individuals. These effects are typically mild and do not necessitate stopping the treatment.

Reported adverse reactions primarily involve the gastrointestinal tract, nervous system, and skin. Based on official regulatory classifications, these side effects are categorized by frequency:

Frequency of Adverse Reactions

Classification Effects Reported
Common Diarrhea, indigestion (dyspepsia), nausea, and vomiting.
Rare Dizziness, headache, general discomfort (malaise), rash, itching (pruritus), and hives (urticaria).
Frequency Not Known Abdominal pain, isolated swelling (edema) of the face, eyelids, and lips, and, in rare instances, rapid and extensive swelling (Quincke’s edema).

Safety Considerations and Restrictions

Consultation with a healthcare professional is advised regarding use during pregnancy and breastfeeding. While animal studies have not shown harmful effects, and no reports of harm in humans have been documented, breastfeeding is generally inadvisable due to the lack of definitive data on the passage of the active substance into human milk.

Aflavic is contraindicated for use in individuals with a known allergy or hypersensitivity to the active substance or any of the other ingredients. In cases of a severe allergic reaction, such as swelling of the face or throat, immediate medical attention is required. There are limited data on the effects of an overdose, though an excess dose may worsen existing gastrointestinal or skin side effects. Officially documented interactions with other medicines are currently not known, but patients should always inform their healthcare provider of any other medications or supplements they are taking.

Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory guidance for Aflavic, which contains the active substance Diosmin, is based on limited documented experience regarding over-ingestion of the drug.

The most frequently reported adverse events associated with taking an amount greater than the recommended dosage are generally mild and non-life-threatening, primarily involving the gastrointestinal and integumentary systems. These reported clinical manifestations include gastrointestinal events such as diarrhea, nausea, and abdominal pain, as well as skin events such as pruritus (itching) and rash. No specific serious or life-threatening outcomes, such as cardiac or central nervous system effects, are documented in the official overdose profile.


Regulator-Mandated Emergency Actions

Action Required Management Focus
Seek medical attention immediately The regulatory authority mandates immediate consultation with a doctor or pharmacist if the recommended dosage has been exceeded.
Symptomatic Management Only The official treatment approach for overdose is limited to treatment of clinical symptoms and supportive care.

No specific pharmacological antidote is known or referenced in the official prescribing information. No specific requirements for hospital monitoring or observation are detailed in the official overdose sections. Official documents contain no population-specific overdose considerations for groups such as children or patients with impaired organ function.

Therapeutic Uses of Aflavic

Main Uses and Therapeutic Intent

Aflavic is a pharmacological agent primarily used for its vasoprotective and venotonic properties. It is indicated for the management of symptoms associated with chronic venous insufficiency and the treatment of acute or chronic hemorrhoidal disease.

The medication is designed to act on the vascular return system by increasing venous tone and protecting the microcirculation. By reducing venous distensibility and addressing stasis, it helps manage the underlying physiological issues that lead to vascular discomfort.

Chronic Venous Insufficiency (CVI)

In the context of chronic venous insufficiency, Aflavic is utilized to alleviate various functional symptoms related to poor blood flow in the lower limbs. These symptoms often include:

  • Heavy Legs: A sensation of weight or tension in the legs, often worsening at the end of the day or after prolonged standing.
  • Pain and Cramps: Discomfort or nocturnal cramps associated with venous congestion.
  • Edema: Swelling of the lower legs and ankles caused by fluid retention in the tissues due to inefficient venous return.
  • Trophic Changes: Early-stage skin changes or discomfort resulting from long-term venous pressure.

Hemorrhoidal Disease

Aflavic is also indicated for the symptomatic treatment of hemorrhoids. It addresses both the inflammatory and vascular components of the condition.

  • Acute Episodes: During acute hemorrhoidal attacks, it is used to reduce swelling, pain, and bleeding by stabilizing the capillary walls and improving local venous drainage.
  • Chronic Management: For individuals with recurring hemorrhoidal issues, it may be used to manage persistent symptoms and reduce the frequency of inflammatory flare-ups.

Mechanisms of Action and Benefits

The primary benefit of Aflavic lies in its ability to modify the behavior of the veins and capillaries:

  • Venous Tone: It enhances the contraction of the venous wall, which helps push blood back toward the heart more efficiently.
  • Microcirculation Protection: It increases capillary resistance and reduces capillary permeability. This prevents excessive fluid from leaking into surrounding tissues, which is a primary cause of swelling.
  • Inflammatory Response: The components of the medication help inhibit the inflammatory process within the venous valves and walls, which can prevent or slow the progression of chronic venous disease.

Eligibility and Restrictions for Use

Official Population Eligibility for Aflavic (Diosmin)

The regulatory eligibility for Aflavic is defined by authoritative governmental labeling, which specifies who can use the medicine and who is formally restricted or contraindicated from its use. The medicine is primarily intended for the adult population.

Population Group Official Eligibility Status
Hypersensitivity/Allergy CONTRAINDICATED (Absolute restriction)
Pregnant Women NOT RECOMMENDED (Limited human data)
Lactating Women NOT RECOMMENDED (Passage into milk is unknown)
Pediatric Patients NOT RECOMMENDED (Safety and efficacy not established)

Eligibility Classifications and Restrictions

Contraindications: Aflavic is strictly contraindicated in patients with a known history of hypersensitivity or allergy to the active substance, Diosmin, or to any of the product’s excipients.

Age Restrictions: Use is confined to adults and older adults. The medicine is not recommended for use in children and adolescents because safety and efficacy data in the pediatric population have not been established by regulators.

Conditional Use: When used for the treatment of acute hemorrhoidal symptoms, the treatment must be of short duration. Regulatory labeling requires that if symptoms do not resolve quickly, a medical review, including a proctological examination, must be performed, as the medicine is not a substitute for specific treatment of other anal disorders.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documentation notes potential interactions for Aflavic (Diosmin) that fall into two main categories: effects on drug concentration (pharmacokinetic) and effects on blood clotting (pharmacodynamic).

Documented Interaction Patterns

Type of Interaction Description and Examples
Pharmacokinetic Alteration Diosmin may inhibit specific metabolic enzymes (CYP2C9, CYP2E1, CYP3A4) and the P-glycoprotein transporter. This can increase the systemic exposure and plasma concentration of co-administered drugs like Carbamazepine, Fexofenadine, and Diclofenac that are metabolized by these pathways.
Pharmacodynamic Effect Combining Aflavic with medications that slow blood clotting (e.g., Warfarin or Acenocoumarol) may lead to an increased risk of bruising and bleeding due to an additive effect.

Official Regulatory Constraints

While no absolute contraindicated drug combinations are formally listed in all regulatory documents, certain restrictions and warnings apply:

  • Scheduled Surgery: Use of the product must be stopped at least two weeks before any scheduled surgical procedure due to the potential for increased bleeding risk.
  • Anticoagulant Therapy: Patients taking anticoagulants require close monitoring for signs of bleeding.
  • Non-Medicinal Interactions: Consumption of alcohol is advised against, and specific herbal products known to affect blood thinning are also noted as potential interactants.

Mechanism of Action

Mechanism of Action: Cathepsin K (CTSK) Inhibition

Aflavic non-covalently binds to and inhibits the enzyme Cathepsin K ( CTSK), a cysteine protease active in osteoclast-mediated bone matrix resorption. The compound exhibits high selectivity for CTSK over related cysteine proteases, such as Cathepsin S and Cathepsin L, thereby localizing its effect to the bone resorption pathway. Inhibition of CTSK results in the reduction of collagen cleavage and subsequent dissolution of the hydroxyapatite mineral component of bone matrix by osteoclasts. The mechanistic cascade includes the reduction of N-telopeptide ( NTx) and C-telopeptide ( CTx) release, which are biomarkers of bone resorption.

Dosage and Administration Information

Aflavic is an oral venoactive preparation administered according to specific guidelines that detail the route, dose, and duration of use. The administration route is oral, with the medicine provided in tablet form. The tablets should be taken with meals to support proper intake conditions.

Usage is segmented into two distinct approaches based on the indication. For the symptomatic management of chronic venous insufficiency (CVI), the standard maintenance dose is typically 1000 mg per day. This regimen is designated for long-term treatment, often spanning several months, to provide ongoing support. The daily dose is often taken once daily or, alternatively, split into two divided intakes.

For the short-term management of acute hemorrhoidal symptoms, a specific high-dose loading regimen is used. This regimen involves an intake of 3000 mg daily for the initial four days, which is then reduced to 2000 mg daily for the subsequent three days. This total administration schedule is a fixed seven-day course, and these doses are administered in two divided doses each day. If a dose is missed, the standard procedure is to continue with the next scheduled dose at the regular time, without doubling the amount.

Recent Clinical Evidence

Aflavic: Overview of Research Evidence

This section outlines the structure of the clinical research that has explored the use of Aflavic (Diosmin) for its main indications, focusing on what outcomes were studied and where research limitations exist.

Evidence for Use in Chronic Venous Insufficiency (CVI)

Studies exploring the use of Aflavic in patients with Chronic Venous Insufficiency (CVI) have focused mainly on Randomized Controlled Trials (RCTs) and systematic reviews. These studies were used in research exploring how symptoms change over time in adult patients diagnosed with CVI, a condition marked by functional limitations. The specific outcomes monitored included patient-reported outcomes describing perceived discomfort, such as the intensity of leg pain and the feeling of heaviness, as well as objective physical measures like localized tissue swelling (edema), which was measured by changes in calf circumference.

Findings describe patterns observed in the studies related to the measured scores for physical discomfort. Research also describes changes measured during the study period for objective outcomes, such as calf circumference. The certainty remains low regarding the long-term effects; research provides context but not individual predictions about sustained effects.

Evidence for Use in Acute Hemorrhoidal Symptoms

Research explored the use of Aflavic in conditions associated with acute or disruptive episodes, specifically during an acute hemorrhoidal crisis. The research examined short-term symptom changes, primarily through short-term RCTs. Outcomes monitored included scores for pain, anal bleeding, and swelling over defined, short time intervals, reflecting the nature of an acute episode.

Follow-up durations were limited to the short-term phase of observation for this condition. Limited information is available for long-term monitoring of symptoms or the management of subsequent episodes.

Research Gaps and Certainty

Clinical evidence for Aflavic is generally categorized as Moderate. This assessment indicates that while studies have explored how symptoms change, there is limited information in some areas, which affects the level of certainty. Research limitations include: follow-up durations limited to short-term outcomes, small sample sizes in some studies, and insufficient data for specific subgroups, such as patients with advanced CVI stages.

Key Studies & References

  1. Venoactive Drugs, Summary of the Clinical Trials and Guidelines (Addresses heterogeneity and certainty levels)

Frequently Asked Questions (FAQ)

Common questions about Aflavic (FAQ)

Q: What is Aflavic used for?

A: Aflavic is indicated by regulatory bodies for the treatment of mild to moderate chronic pain. Its use is based on its specific mechanism, which is believed to interfere with certain pain signals in the body.


Q: How quickly does Aflavic start working?

A: The time it takes for an individual to notice the effects of Aflavic can vary. Clinical study data suggests that some patients may begin to experience relief within the first few days of treatment, but it may take several weeks to observe the full potential effect.


Q: Can Aflavic be taken with other pain relievers?

A: It is important to discuss all medications, including other pain relievers (prescription or over-the-counter), with a healthcare professional before combining them with Aflavic. Taking Aflavic with certain other pain medications may increase the risk of side effects or change how the drugs work.


Q: Is Aflavic addictive?

A: Aflavic is not classified as a controlled substance and does not carry the same risk of physical dependence or addiction as certain other classes of pain medication, such as opioids. However, relying on any pain medication should be managed under a doctor's guidance.


Q: What should I do if I miss a dose of Aflavic?

A: If a dose is missed, it is generally advised to take it as soon as you remember, unless it is nearly time for your next scheduled dose. Skipping the missed dose and continuing with the regular schedule is often recommended in that case. Specific guidance for missed doses should be obtained from the prescribing information or a healthcare professional.

How should Aflavic be stored and disposed of?

Aflavic (Diosmin) tablets must be stored and disposed of according to official regulatory labeling to ensure product quality and safety.

Storage Requirements

The product must be stored at a temperature not exceeding 30 C (86 F). The tablets should be kept in their original blister pack and carton to protect the medicine from light and moisture. As a mandatory safety measure, Aflavic must always be stored out of the sight and reach of children.

Disposal Instructions

Official instructions require that any unused or expired Aflavic tablets must be disposed of according to local requirements for pharmaceutical waste. The medicine must not be thrown away via wastewater (such as flushing down a toilet or pouring down a drain) to prevent environmental contamination. The tablets are not classified as hazardous waste, but proper disposal procedures must still be followed.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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