Aferin

Moderate to severe pain of any origin: tension headache, migraine, dental pain, post-op pain, dysmenorrhoea, cancer pain, low back pain, fever & also symptomatic relief from colds and cough.

Co-administration w/ other analgesics, antipyretics or cold relief medicines, MAOIs (during & w/in 2 wk of stopping). Severe HTN or coronary artery disease.

Aferin is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize Aferin [for example, carbamazepine (Tegretol), isoniazid (INH, Nydrazid, Laniazid), rifampin (Rifamate, Rifadin, Rimactane)] reduce the levels of Aferin and may decrease the action of Aferin. Doses of Aferin greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for Aferin to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.

Cholestyramine (Questran) reduces the effect of Aferin by decreasing its absorption into the body from the intestine. Therefore, Aferin should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine.

Aferin doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of Aferin should be avoided during warfarin therapy

Very rarely (and usually mild) skin rashes and palpitations. Sedation and dizziness may occur after the intake of the yellow (night) tablet. In this case it is not advisable for patients who drive or operate machinery at night. Therefore the yellow tablet is recommended at bedtime.