Adrekar

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Adrekar

Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Adrekar

Quick Facts

Property Description
Active ingredient Adenosine / Aervae Lanatae Herba (multi-component)
Form Injectable solution / Herbal decoction or extract
Pharmacological class Antiarrhythmic Agent (Class V) / Diuretic Phytomedicine
General purpose Rapid heart rhythm correction / Urinary tract support
Origin Endogenous nucleoside / Natural herb

What is Adrekar: Definition, Class, and Origin

Adrekar is a prescription pharmaceutical preparation primarily known as a trade name for the drug Adenosine, which is classified as an antiarrhythmic agent outside the core Vaughan-Williams system. Adenosine is an endogenous purine nucleoside naturally synthesized within the body. The pharmaceutical is presented as a sterile, single-ingredient, aqueous injectable solution designated for rapid intravenous use in controlled settings. Adenosine's unique characteristic is its ultra-short half-life, which is clinically recognized for facilitating the immediate, brief action required in acute rhythm management scenarios.

Compositional Nature: Nucleoside vs. Phytomedicine

The active ingredient of the branded Adrekar product is Adenosine. However, the compositional requirement of Aervae Lanatae Herba refers to the dried aerial parts of the herb Aerva lanata, utilized as a traditional, multi-component phytomedicine. This natural product is differentiated by its complex profile, which includes alkaloids and flavonoids. In contrast to the rapidly metabolized injectable nucleoside, the herbal preparation is typically prepared as a decoction for oral ingestion, demonstrating a difference in both composition and route of administration that distinguishes its use case entirely.

General Purpose and High-Level Utility

The general purpose of the Adenosine component is to effect a rapid electrical reset of the heart's rhythm. This action involves interrupting specific re-entry pathways that cause excessively fast heart rates. Conversely, the high-level utility of the Aervae Lanatae Herba composition is as a diuretic and anti-urolithiasis agent. This promotes increased urine output and is traditionally positioned for adults seeking natural support for fluid balance and the maintenance of urinary tract health.

Regulatory References

  1. Adenosine - StatPearls - NCBI Bookshelf
  2. Pharmacological Cardioversion - StatPearls - NCBI Bookshelf

What side effects are possible with Adrekar?

Possible Side Effects and Safety Information

The safety profile for Adrekar is structured around its two distinct components: the injectable Adenosine and the traditional herbal extract Aervae Lanatae Herba. All safety information is based strictly on government regulatory documents.

Adenosine (Injectable Solution) Safety Profile

Adverse reactions associated with the rapid administration of Adenosine are generally transient and short-duration, often resolving within a minute. The official labeling classifies these effects into frequency tiers:

  • Very Common (Affecting ge 1 in 10 individuals): Includes flushing, dyspnea (shortness of breath), chest discomfort/pressure, and headache. Disturbances in cardiac rhythm, such as sinus bradycardia and various degrees of AV block, are also very common.
  • Common: Adverse reactions listed in this tier include nausea, paresthesia (tingling or numbness), and general lightheadedness.

Serious Adverse Reactions and Restrictions

Regulatory documents list serious adverse reactions, including fatal or nonfatal cardiac arrest, ventricular fibrillation, and prolonged asystole. The medication is contraindicated in individuals with pre-existing second- or third-degree AV block or sinus node disease (unless a functioning pacemaker is present), and in those with known bronchospastic lung disease.

Aervae Lanatae Herba (Herbal Extract) Safety Profile

Unlike the injectable component, the herbal extract does not have a formal frequency-classified safety profile in standard pharmaceutical labels. Safety notes derived from government-associated traditional use research primarily center on the potential risks of long-term exposure. Concerns cited in literature suggest that structural changes in the urinary tract leading to potential renal failure may be associated with extended administration, traditionally limiting its use to shorter durations.

Overdose and Emergency Response

Overdose with the Adenosine component of Adrekar is formally documented in regulatory sources as a transient but severe accentuation of its physiological effects, leading to acute cardiovascular compromise. Immediate medical attention is required for any suspected overdosage.

Documented Clinical Manifestations

Overexposure is reported to cause severe hypotension, severe bradycardia, and sustained high-grade Atrioventricular (AV) block. Life-threatening outcomes explicitly documented in official labeling include asystole, cardiac arrest, and respiratory arrest, which have been reported as potentially fatal events. Seizure activity and non-fatal myocardial infarction are also listed as manifestations.

Regulator-Mandated Emergency Actions

Official labeling requires the immediate discontinuation of administration upon the development of severe symptoms such as persistent hypotension, high-grade AV block, or severe respiratory difficulties. Continuous ECG monitoring is mandated throughout the procedure to detect these critical events. Due to the ultra-short half-life, effects are usually short-lived; however, resuscitative measures must be immediately available. For managing persistent severe effects, symptomatic and supportive care is required, and the use of competitive antagonists like Theophylline is officially documented.

Population-Specific Considerations

Geriatric patients may exhibit increased sensitivity and potentially experience more adverse effects due to diminished function. Patients with recent heart transplantation (less than one year) are documented as having increased cardiac sensitivity.

Therapeutic Uses of Adrekar

What Adrekar Treats: Main Uses and Benefits


The therapeutic application of this preparation is divided into two distinct domains, addressing either acute, disruptive cardiac events or supportive, long-term health needs, depending on the active component. This medication is commonly used across specialized therapeutic areas to manage significant symptomatic burden.

Rapid Correction of Acute Cardiac Rhythms

This use is centered on a rapid action for the management of sudden, excessively fast heart rhythms, known as Supraventricular Tachycardia (SVT). It is applied during acute symptomatic episodes marked by severe palpitations, transient chest discomfort, or significant dizziness. The key benefit provided is that it may help manage the rapid rhythm and achieve conversion, which assists with maintaining functional stability and supports patients during difficult episodes of heightened physiological activity. The conditions where this is applied include Supraventricular Tachycardia (SVT) and its relevant subtypes.

Supportive Management of Urinary Tract Discomfort

The phytomedicine component is relevant for easing symptoms associated with conditions involving inflammatory or irritative states within the urinary tract, such as urolithiasis (kidney stone formation). It helps address symptom clusters that may become intense, such as painful or burning urination (dysuria), and is commonly used to help promote fluid elimination. This supportive function contributes to improved day-to-day comfort and supports the body's processes for managing small mineral deposits.

Adjunct in Cardiovascular Diagnostic Testing

A third clinical context involves its application as a diagnostic adjunct during specialized heart imaging procedures, such as pharmacologic stress testing. This approach is relevant when a patient is unable to undergo adequate exercise stress. The practical benefit is that it is applied in the diagnostic process to help evaluate blood flow to the heart muscle, assisting with informed clinical decision-making.


Quick Fact: Relief for Acute and Supportive Needs

Domain Conditions Managed Key Symptom Benefit
Cardiac Acute Supraventricular Tachycardia (SVT) Assists with stabilizing severe palpitations and dizziness.
Urinary Urolithiasis, Irritative States Helps ease painful/burning urination and supports fluid elimination.
Diagnostic Cardiovascular Assessment Supports necessary heart function evaluation when exercise is limited.

Regulatory References

  1. NIH StatPearls overview

Eligibility and Restrictions for Use

Adrekar refers to two distinct preparations, each with unique regulatory eligibility criteria.

Injectable Adenosine (Antiarrhythmic Use)

Category Eligibility Statements (Official Labeling)
Populations for whom use is contraindicated Patients with second- or third-degree AV block or Sinus node disease (unless a functioning artificial pacemaker is present). Patients with known or suspected bronchospastic lung disease (e.g., asthma) or known hypersensitivity to adenosine.
Age-related eligibility rules Use for Paroxysmal Supraventricular Tachycardia (PSVT) is documented across all pediatric age groups. Safety and efficacy for the diagnostic use (stress testing) are not established in the pediatric population. Geriatric patients should be treated with caution due to potential diminished cardiac function.
Condition-specific eligibility rules No dose adjustment is officially required for patients with hepatic or renal impairment, as the drug's metabolism is independent of these organs.
Pregnancy and lactation eligibility status Classified as Pregnancy Category C. Use is generally not recommended unless the potential benefits clearly outweigh the risks. It is not known if the drug is excreted in human milk.

Herbal Preparation (Aervae Lanatae Herba)

Category Eligibility Statements (Official Monograph)
Populations for whom use is contraindicated Children under 12 years of age and women who are pregnant or breastfeeding are commonly restricted. Restrictions also apply to individuals with conditions such as hypercalcemia or specific renal bone disorders.

Connection to the overall eligibility profile: Official regulatory documents define eligibility via formal contraindications related to cardiac rhythm disorders and respiratory disease for the injectable form. Eligibility is further structured by age-related rules and specific patient condition restrictions, confirming that the two distinct forms of the medicine carry entirely separate population restrictions.

What should I know about interactions with other medicines?

The interaction profile for Adrekar’s Adenosine component is governed by documented effects on the drug's receptor binding and clearance. Methylxanthines, including caffeine and theophylline, are officially recognized as antagonists that can inhibit Adenosine's vasoactive and cardiac effects, potentially requiring larger doses for the intended pharmacological response. To manage this antagonism during diagnostic procedures, regulatory guidance stipulates that methylxanthine-containing products must be withheld for 12 to 24 hours prior to administration.

Conversely, Dipyridamole and other nucleoside transport inhibitors potentiate Adenosine by officially documented inhibition of its cellular uptake and subsequent metabolism, resulting in increased systemic exposure. Augmenting substances such as Dipyridamole should be formally withheld for a period of at least five half-lives prior to use, whenever clinically feasible.

Official documentation notes the potential for additive or synergistic depressant effects on the sinoatrial and atrioventricular nodes when Adenosine is used with Cardiac Glycosides (like Digoxin), Beta-Adrenergic Blocking Agents, or Calcium Channel Blocking Agents. Caution is directed for these combinations. Additionally, Carbamazepine has been associated with producing higher degrees of heart block. The herbal product Hawthorn is also officially documented to increase the pharmacological effects of Adenosine through synergism.

Mechanism of Action

How Adrekar Works: Mechanism of Action

The preparation associated with the name "Adrekar" involves two components with entirely separate and non-interacting mechanisms, acting on distinct physiological systems.


Cardiac Electrical Reset through AV Node Modulation

This mechanism is driven by the nucleoside component, Adenosine, which acts as an agonist at the Adenosine A1 receptors highly concentrated in the heart's atrioventricular (AV) node. This molecular interaction initiates an inhibitory cascade: it activates the Gi protein, which simultaneously opens K^+ channels (causing hyperpolarization) and inhibits Ca^2+ channels. The resulting dramatic shift in ion flow temporarily blocks electrical impulse conduction through the AV node, interrupting the sustained flow of the electrical impulse.


Renal Support via Fluid and Crystal Homeostasis

This second mechanism is governed by the multi-component phytomedicine, Aervae Lanatae Herba. Its active phytochemicals modulate the function of the renal tubules, leading to an increase in the excretion of water and electrolytes, which promotes diuresis. Furthermore, the mechanism includes the inhibition of enzymes involved in the synthesis of crystalline precursors and the modulation of urinary pH, which contributes to reducing the supersaturation of minerals in the urine.

Dosage and Administration Information

Adenosine (Intravenous Administration)

The Adenosine component is administered under strict supervision and is primarily delivered via a rapid intravenous (IV) bolus or a continuous IV infusion. The standard protocol for certain acute cardiac rhythms is a step-wise bolus: an initial dose of 6 mg is delivered rapidly, followed immediately by a saline flush. If the initial dose is unsuccessful within one to two minutes, a higher dose of 12 mg may be administered, also followed by an immediate flush. Correct use mandates that the bolus be administered via an IV site located as proximally as possible to ensure immediate drug delivery.

For diagnostic procedures, the drug is administered as a continuous peripheral intravenous infusion over a fixed duration of six minutes. Standard protocols specify several high-level dosing adjustments. For example, a reduced initial dose of 3 mg is required for patients who have undergone a heart transplant or who are taking specific medications that potentiate the drug’s effects. Pediatric administration is also specified on a weight-based scale (milligrams per kilogram).


Aervae Lanatae Herba (Oral Administration)

The official usage pattern for the Aervae Lanatae Herba component involves oral ingestion following specific preparation. This supportive use is traditionally based on preparing a decoction or infusion using the dried material and hot water. Following preparation, the infusion is typically administered multiple times daily, such as three times per day, over a short course for maintenance. Prepared infusions should not be stored for longer than two days.

Recent Clinical Evidence

Research evidence / Overview of Studies for Adrekar


Evidence from Studies for Acute Cardiac Rhythm Correction

The injectable component (Adenosine) was evaluated in numerous short-term Randomized Controlled Trials (RCTs) and systematic reviews for its use in conditions associated with acute or disruptive episodes, specifically Supraventricular Tachycardia (SVT). Studies monitored outcomes describing episodic or acute changes, such as the rate of measured rhythm conversion and the time required for those changes. Findings describe patterns observed in the studies where the agent was observed to achieve conversion to sinus rhythm. Comparative studies explored how the measurements of the agent compared to other therapies, and the data show patterns related to measured short-term rhythm changes.

What remains uncertain about this application is the durability of response. Because this is an acute, ultra-short-acting intervention, follow-up durations were limited to minutes or hours. Evidence is limited regarding the durability of response. Data for certain groups, particularly pediatric patients or the older adult population, remain insufficient.


Evidence from Studies for Diagnostic Use

This component was also studied for a distinct, non-therapeutic application as an adjunct during specialized cardiovascular diagnostic procedures. Observational cohort studies evaluated its use in patients unable to perform physical exercise. Research examined outcomes monitoring physiological strain, specifically focusing on the agent’s ability to induce physiological change for evaluating blood flow to the heart muscle. Diagnostic studies describe that the agent was observed to induce the change needed during imaging. Research describes the utility of this agent in diagnostic protocols when patients cannot complete physical exercise testing.


Evidence from Studies for Urinary Tract Support

For the herbal component (Aervae Lanatae Herba), the research landscape is significantly different, as evidence is limited and largely derived from preclinical laboratory work and animal studies. Research examined changes in urine volume and the impact on mineral crystal formation in the laboratory. Findings describe patterns observed in the studies where in-vitro work suggests the extract may interfere with the crystallization of kidney stone components. Animal studies explored the effect on urine volume, reporting patterns of increased output and reduced levels of stone-forming markers in rats.

What remains uncertain is significant due to the nature of the research. There is limited information for long-term outcomes and a notable absence of robust human-based Randomized Controlled Trials. The evidence is limited for the supportive uses of the herbal component based on the most rigorous scientific standards.

Frequently Asked Questions (FAQ)

Common questions about Adrekar (FAQ)


Q: Can Adrekar be used by people over the age of 65?

Official documentation indicates that the injectable component should be used with caution in patients who are over the age of 65. This is due to the potential for diminished cardiac function in older adults. Management of use for this population is handled by a qualified healthcare professional.


Q: What information is available about Adrekar use for people with kidney issues?

The official label for the injectable Adenosine component states that no dose adjustment is formally required for patients with kidney (renal) impairment, as the drug's metabolism is independent of these organs. Conversely, the herbal component may have restrictions or be contraindicated for individuals with certain renal bone disorders, according to traditional use guidelines.


Q: What information is available regarding Adrekar use during pregnancy?

The injectable Adenosine component is generally not recommended for use during pregnancy. The classification of the injectable component indicates that use is generally restricted unless a healthcare provider determines that the potential benefit outweighs the risk. The traditional use guidance for the herbal component commonly restricts its use for women who are pregnant. It is not known if the injectable component is excreted in human milk.


Q: Why is Adrekar not recommended for certain patients with heart issues?

The injectable component, Adenosine, is specifically contraindicated in patients with pre-existing heart rhythm issues such as second- or third-degree AV block or sinus node disease (unless a functioning pacemaker is present). This is because the drug's mechanism involves temporarily blocking electrical signals in the heart's AV node, which poses a risk when the block is already present.


Q: Does Adrekar have a black box warning from the FDA or similar bodies?

Official regulatory labels for the injectable component, Adenosine, list serious adverse reactions such as fatal cardiac arrest and ventricular fibrillation. While the provided information does not explicitly confirm the presence of a formal Boxed Warning, the regulatory label does list these serious adverse reactions.


Q: What is the primary mechanism of action of Adrekar?

Adrekar is composed of two parts with separate functions. The injectable Adenosine works by briefly blocking electrical conduction in the heart's AV node to help reset the rhythm. The herbal component, Aervae Lanatae Herba, is understood to work by increasing urine output, which promotes fluid balance.


Q: Is Adrekar similar to other medicines used for the same condition?

The injectable component, Adenosine, is classified as an antiarrhythmic agent (Class V), placing it in the general class of medicines used to correct certain heart rhythm problems. Studies have examined its short-term rhythm changes compared to other therapies. The herbal component is a diuretic phytomedicine, a distinct class used to increase urine flow.


Q: Can Adrekar affect sleep patterns?

Official safety documents do not specifically list changes to sleep patterns. However, common side effects of the injectable component can include mild neurological effects such as headache and lightheadedness. These effects, if they occur, are generally known to be short in duration.


Q: How long does Adrekar typically stay in a person's system?

The injectable Adenosine component is known for its ultra-short half-life, which is why it is used for immediate, brief action in acute settings. Its effects, including common side effects, typically resolve within minutes.


Q: Is Adrekar available in a generic version?

The active ingredient in the injectable component, Adenosine, is a widely used drug. The patents and exclusivities for the single-agent injectable solution have expired, and generic versions are available from various manufacturers.


Q: Do studies suggest Adrekar is a long-term treatment?

Studies for the injectable component are short-term and limited to minutes or hours, reflecting its role as an acute, ultra-short-acting intervention. For the herbal component, research is limited, and it is traditionally restricted to shorter durations due to cited concerns regarding potential long-term effects on the urinary tract.


Q: Can Adrekar be stopped suddenly, or does it need to be tapered?

The injectable Adenosine solution's effect ceases almost immediately after administration is stopped due to its ultra-short half-life, and no tapering is applicable. The injectable component is typically used for acute interventions in a controlled medical setting. Regulatory documentation does not contain explicit instructions for tapering the herbal component.


Q: Are there any known interactions between Adrekar and herbal remedies?

Official regulatory documentation lists interactions with common drug classes and specific agents. The herbal product Hawthorn is specifically documented to increase the pharmacological effects of the injectable Adenosine component through a synergistic effect.


Q: Do children ever use Adrekar?

The injectable Adenosine component is documented for use across all pediatric age groups for a specific heart condition (Paroxysmal Supraventricular Tachycardia, or PSVT). However, its use for diagnostic procedures has not been established in children. The herbal component is generally restricted and not recommended for children under 12 years of age.


Q: Can Adrekar change blood pressure readings?

The injectable Adenosine component acts as a vasodilator, which involves opening blood vessels. This effect can lead to changes in blood pressure, including reports of both hypotension (decreased blood pressure) and clinically significant hypertension (increased blood pressure), according to official documentation.


Q: Is Adrekar a controlled substance?

The active ingredient in the injectable component, Adenosine, is a naturally occurring nucleoside. It is not classified as a controlled substance by the U.S. Controlled Substances Act or other governmental agencies, indicating a low potential for dependency or abuse.


Q: Are headaches a common initial side effect when starting Adrekar?

Headache is classified as a Very Common side effect of the injectable Adenosine component, affecting a significant number of individuals. These adverse reactions are generally transient and short-duration, suggesting they are commonly experienced quickly after administration and resolve rapidly.


Q: What is Adrekar's main active ingredient?

The preparation known as Adrekar contains two distinct active ingredients. The first is Adenosine, a nucleoside used as an antiarrhythmic agent. The second is Aervae Lanatae Herba, a multi-component phytomedicine used for its traditional diuretic and urinary tract support properties.


Q: Is it possible to develop a dependency on Adrekar?

The injectable component, Adenosine, is not classified as a controlled substance by regulatory bodies, which suggests a low potential for abuse or dependency. The medicine is typically used for acute, brief intervention in controlled medical settings.


Q: Are there known allergic reactions associated with Adrekar?

The injectable Adenosine component is officially contraindicated (not used) in patients with a known hypersensitivity (allergic reaction) to adenosine. The regulatory text confirms that the injection is not used for individuals with a known allergy to the substance.


Q: What are the general exclusion criteria for using Adrekar?

Exclusion criteria are defined for each component. For the injectable form, official contraindications include pre-existing heart rhythm disorders or certain lung diseases. For the herbal form, restrictions commonly include children under 12, pregnant or breastfeeding women, and those with certain bone or calcium disorders.


Q: What is the typical timeframe for clinical trials on Adrekar?

Research on the injectable component for acute use is generally defined by short-term trials, with follow-up periods often limited to minutes or hours, reflecting the brief action of the drug. The research on the herbal component has limited long-term follow-up.


Q: How does Adrekar affect the liver?

The official product information for the injectable Adenosine component indicates that no dose adjustment is officially required for patients with liver (hepatic) impairment. This is because the drug's metabolism pathway operates independently of the liver and kidneys.


Q: Are there any long-term health concerns associated with Adrekar use?

For the injectable component, the acute nature of its use means long-term data are limited. For the herbal component, concerns cited in traditional use literature suggest that structural changes in the urinary tract that could lead to renal issues may be associated with extended administration, traditionally limiting its use to shorter durations.


Q: Can Adrekar affect concentration or memory?

The official safety profile for the injectable component lists several neurological effects as common, including headache, lightheadedness, and tingling or numbness (paresthesia). These effects, if experienced, are generally associated with the acute nature and short duration of the drug's action.


Q: What is the patent status or exclusivity period for Adrekar?

The core component, Adenosine, is a widely available generic drug. The patents and exclusivities for the single-agent injectable solution have expired, making generic versions available for the component intended for acute intravenous use.


How should Adrekar be stored and disposed of?

How to Store and Dispose of Adrekar (Adenosine Solution for Injection)

The official storage requirements for Adrekar injection mandate that the product be kept below 25 C or at Controlled Room Temperature (20 to 25 C). It is strictly required that the solution not be refrigerated or frozen, as this may lead to crystallization. The solution must be clear and colorless, and it should be visually inspected for any particulate matter before use.

Since the product is preservative-free and intended for single use, the solution must be used immediately after opening, and any unused portion must be discarded. To ensure safety, the medicine must be stored out of the reach and sight of children.

Disposal must be managed strictly according to regulatory guidelines. Unused product and waste material must not be disposed of via household waste or wastewater; instead, disposal should adhere to local requirements for pharmaceutical waste.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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