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Components:
Estradiol, Norethisteron
Method of action:
Endocrine Therapy, Estrogen-Progestational, Sex Hormones And Modulators Of The Genital System
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Medically reviewed by Oliinyk Elizabeth Ivanovna, Pharmacy. Last updated on 2019.11.17

Name of the medicinal product

Activella

Qualitative and quantitative composition

Estradiol; Norethisteron

Therapeutic indications

The information provided in Therapeutic indications of Activella is based on data of another medicine with exactly the same composition as the Activella of the medicine (Estradiol, Norethisteron). Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug Activella directly from the package or from the pharmacist at the pharmacy.
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Hormone Replacement Therapy (HRT) for oestrogen deficiency symptoms in postmenopausal women with at least 6 months since last menses.

).

The experience treating women older than 65 years is limited.

Dosage (Posology) and method of administration

The information provided in Dosage (Posology) and method of administration of Activella is based on data of another medicine with exactly the same composition as the Activella of the medicine (Estradiol, Norethisteron). Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug Activella directly from the package or from the pharmacist at the pharmacy.
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Activella is a continuous sequential HRT product for oral use.) should be used.

A switch to a higher dose combination product could be indicated if the response after 3 months is insufficient for symptom relief.

If the patient has forgotten to take a tablet, the tablet should be taken as soon as possible within the next 12 hours. If more than 12 hours have passed, the tablet should be discarded. Forgetting a dose may increase the likelihood of breakthrough bleeding and spotting.

Contraindications

The information provided in Contraindications of Activella is based on data of another medicine with exactly the same composition as the Activella of the medicine (Estradiol, Norethisteron). Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug Activella directly from the package or from the pharmacist at the pharmacy.
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- Known, past or suspected breast cancer

- Known, past or suspected oestrogen-dependent malignant tumours (e.g. endometrial cancer)

- Undiagnosed genital bleeding

- Untreated endometrial hyperplasia

- Previous or current venous thromboembolism (deep venous thrombosis, pulmonary embolism)

- Known thrombophilic disorders (e.g. protein C, protein S or antithrombin deficiency

- Active or previous arterial thromboembolic disease (e.g. angina, myocardial infarction)

- Acute liver disease or a history of liver disease as long as liver function tests have failed to return to normal

- Known hypersensitivity to the active substances or to any of the excipients

- Porphyria.

Special warnings and precautions for use

The information provided in Special warnings and precautions for use of Activella is based on data of another medicine with exactly the same composition as the Activella of the medicine (Estradiol, Norethisteron). Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug Activella directly from the package or from the pharmacist at the pharmacy.
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For the treatment of postmenopausal symptoms, HRT should only be initiated for symptoms that adversely affect quality of life. In all cases, a careful appraisal of the risks and benefits should be undertaken at least annually and HRT should only be continued as long as the benefit outweighs the risk.

Evidence regarding the risks associated with HRT in the treatment of premature menopause is limited. Due to the low level of absolute risk in younger women, however, the balance of benefits and risks for these women may be more favourable than in older women.

Medical examination/follow-up

Before initiating or reinstituting HRT, a complete personal and family medical history should be taken. Physical (including pelvic and breast) examination should be guided by this and by the contraindications and warnings for use. During treatment, periodic check-ups are recommended of a frequency and nature adapted to the individual woman. Women should be advised what changes in their breasts should be reported to their doctor or nurse (see 'Breast cancer' below). Investigations, including appropriate imaging tools, e.g. mammography, should be carried out in accordance with currently accepted screening practices and modified to the clinical needs of the individual.

Conditions which need supervision

If any of the following conditions are present, have occurred previously and/or have been aggravated during pregnancy or previous hormone treatment, the patient should be closely supervised. It should be taken into account that these conditions may recur or be aggravated during treatment with Activella in particular:

- Leiomyoma (uterine fibroids) or endometriosis

- Risk factors for thromboembolic disorders (see below)

- Risk factors for oestrogen dependent tumours, e.g. 1st degree heredity for breast cancer

- Hypertension

- Liver disorders (e.g. liver adenoma)

- Diabetes mellitus with or without vascular involvement

- Cholelithiasis

- Migraine or (severe) headache

- Systemic lupus erythematosus

- A history of endometrial hyperplasia (see below)

- Epilepsy

- Asthma

- Otosclerosis.

Reasons for immediate withdrawal of therapy

Therapy should be discontinued in case a contraindication is discovered and in the following situations:

- Jaundice or deterioration in liver function

- Significant increase in blood pressure

- New onset of migraine-type headache

- Pregnancy.

Endometrial hyperplasia and carcinoma

In women with an intact uterus, the risk of endometrial hyperplasia and carcinoma is increased when oestrogens are administered alone for prolonged periods. The reported increase in endometrial cancer risk among oestrogen-only users varies from 2- to 12-fold greater compared with non-users, depending on the duration of treatment and oestrogen dose. After stopping treatment the risk may remain elevated for at least 10 years.

The addition of a progestagen cyclically for at least 12 days per month/28 day cycle or continuous combined oestrogen-progestagen therapy in non-hysterectomised women prevents the excess risk associated with oestrogen-only HRT.

Breakthrough bleeding and spotting may occur during the first months of treatment. If breakthrough bleeding or spotting continues after the first months of treatment, appears after some time during therapy, or continues after treatment has been discontinued, the reason should be investigated, which may include endometrial biopsy to exclude endometrial malignancy.

Breast cancer

The overall evidence suggests an increased risk of breast cancer in women taking combined oestrogen-progestagen and possibly also oestrogen-only HRT that is dependent on the duration of taking HRT.

The randomised placebo-controlled trial, the Women's Health Initiative study (WHI), and epidemiological studies are consistent in finding an increased risk of breast cancer in women taking combined oestrogen-progestagen HRT that becomes apparent after about 3 years.

The excess risk becomes apparent within a few years of use, but returns to baseline within a few (at most 5) years after stopping treatment.

HRT, especially oestrogen-progestagen combined treatment, increases the density of mammographic images which may adversely affect the radiological detection of breast cancer.

Ovarian cancer

Ovarian cancer is much rarer than breast cancer. Epidemiological evidence from a large meta-analysis suggests a slightly increased risk in women taking oestrogen-only or combined oestrogen-progestagen HRT, which becomes apparent within 5 years of use and diminishes over time after stopping.

Some other studies, including the WHI trial, suggest that use of combined HRTs may be associated with a similar or slightly smaller risk.

Venous thromboembolism

HRT is associated with a 1.3- to 3-fold risk of developing venous thromboembolism (VTE), i.e. deep vein thrombosis or pulmonary embolism. The occurrence of such an event is more likely in the first year of HRT than later.

Patients with known thrombophilic states have an increased risk of VTE and HRT may add to this risk. HRT is therefore contraindicated in these patients.

Generally recognised risk factors for VTE include use of oestrogens, older age, major surgery, prolonged immobilisation, obesity (BMI > 30 kg/m2), pregnancy/postpartum period, systemic lupus erythematosus (SLE) and cancer. There is no consensus about the possible role of varicose veins in VTE.

As in all postoperative patients, prophylactic measures need to be considered to prevent VTE following surgery. If prolonged immobilisation is to follow elective surgery, temporarily stopping HRT 4 to 6 weeks earlier is recommended. Treatment should not be restarted until the woman is completely mobilised.

In women with no personal history of VTE but with a first degree relative with a history of venous thromboembolism at a young age, screening may be offered after careful counselling regarding its limitations (only a proportion of thrombophilic defects are identified by screening).

If a thrombophilic defect is identified which segregates with venous thromboembolism in family members or if the defect is 'severe' (e.g. antithrombin, protein S, or protein C deficiencies or a combination of defects), HRT is contraindicated.

Women already on chronic anticoagulant treatment require careful consideration of the benefit-risk of use of HRT.

If VTE develops after initiating therapy, the drug should be discontinued. Patients should be told to contact their doctors immediately when they are aware of a potential thromboembolic symptom (e.g. painful swelling of a leg, sudden pain in the chest, dyspnoea).

Coronary artery disease (CAD)

There is no evidence from randomised controlled trials of protection against myocardial infarction in women with or without existing CAD who received combined oestrogen-progestagen or oestrogen-only HRT.

The relative risk of CAD during use of combined oestrogen-progestagen HRT is slightly increased. As the baseline absolute risk of CAD is strongly dependent on age, the number of extra cases of CAD due to oestrogen-progestagen use is very low in healthy women close to menopause, but will rise with more advanced age.

Ischaemic stroke

Combined oestrogen-progestagen and oestrogen-only therapy are associated with an up to 1.5-fold increase in risk of ischaemic stroke. The relative risk does not change with age or time since menopause. However, as the baseline risk of stroke is strongly age-dependent, the overall risk of stroke in women who use HRT will increase with age.

Hypothyroidism

Patients who require thyroid hormone replacement therapy should have their thyroid function monitored regularly while on HRT to ensure that thyroid hormone levels remain in an acceptable range.

Angioedema

Oestrogens may induce or exacerbate symptoms of angioedema, in particular in women with hereditary angioedema.

Other conditions

Oestrogens may cause fluid retention, and therefore patients with cardiac or renal dysfunction should be carefully observed.

Women with pre-existing hypertriglyceridaemia should be followed closely during oestrogen replacement or hormone replacement therapy, since rare cases of large increases of plasma triglycerides leading to pancreatitis have been reported with oestrogen therapy in this condition.

Oestrogens increase thyroid binding globulin (TBG), leading to increased circulating total thyroid hormone, as measured by protein-bound iodine (PBI), T4 levels (by column or by radioimmunoassay) or T3 levels (by radioimmunoassay). T3 resin uptake is decreased, reflecting the elevated TBG. Free T4 and free T3 concentrations are unaltered. Other binding proteins may be elevated in serum, i.e. corticoid binding globulin (CBG), sex-hormone-binding globulin (SHBG) leading to increased circulating corticosteroids and sex steroids, respectively. Free or biological active hormone concentrations are unchanged. Other plasma proteins may be increased (angiotensinogen/renin substrate, alpha-I-antitrypsin and ceruloplasmin).

HRT use does not improve cognitive function. There is some evidence of increased risk of probable dementia in women who start using continuous combined or oestrogen-only HRT after the age of 65.

Activella tablets contain lactose monohydrate. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency, or glucose-galactose malabsorption should not take this medicine.

Effects on ability to drive and use machines

The information provided in Effects on ability to drive and use machines of Activella is based on data of another medicine with exactly the same composition as the Activella of the medicine (Estradiol, Norethisteron). Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug Activella directly from the package or from the pharmacist at the pharmacy.
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Activella has no known effect on the ability to drive or use machines.

Undesirable effects

The information provided in Undesirable effects of Activella is based on data of another medicine with exactly the same composition as the Activella of the medicine (Estradiol, Norethisteron). Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug Activella directly from the package or from the pharmacist at the pharmacy.
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Clinical experience

The most frequently reported adverse events during treatment in clinical trials conducted with an HRT product similar to Activella were breast tenderness and headache (reported in > 10% of patients).

The adverse events listed below may occur during oestrogen-progestagen treatment.

The frequencies are derived from clinical trials conducted with an HRT product similar to Activella and from a Post-marketing Surveillance study on Activella.

System organ class

Very common

> 1/10

Common

> 1/100; < 1/10

Uncommon

> 1/1,000; < 1/100

Rare

> 1/10,000; < 1/1,000

Infections and infestations

Vaginal candidiasis

Immune system disorders

Allergic reaction

Psychiatric disorders

Nervousness

Nervous system disorders

Headache

Dizziness

Migraine

Vertigo

Insomnia

Libido disorder NOS (not otherwise specified)

Depression

Vascular disorders

Increased blood pressure.

Aggravated hypertension

Peripheral embolism and thrombosis

Gastrointestinal disorders

Dyspepsia

Vomiting

Diarrhoea

Abdominal pain

Bloating

Flatulence

Nausea

Hepatobiliary disorders

Gall bladder disease

Gallstones

Skin and subcutaneous tissue disorders

Rash

Alopecia

Acne

Pruritus

Musculoskeletal and connective tissue disorders

Muscle cramps

Reproductive system and breast disorders

Breast tenderness

Vaginal haemorrhage

Uterine fibroid

Uterine fibroids aggravated.

General disorders and administration site conditions

Oedema

Investigations

Weight increased

Post-marketing experience

In addition to the above mentioned adverse drug reactions, those presented below have been spontaneously reported, and are by an overall judgement considered possibly related to Activella treatment. Frequences of these adverse events cannot be estimated from the available data:

- Neoplasms benign and malignant (including cysts and polyps): Endometrial cancer

- Immune system disorders: Generalised hypersensitivity reactions (e.g. anaphylactic reaction/shock)

- Psychiatric disorders: Anxiety

- Nervous system disorders: Stroke

- Eye disorders: Visual disturbances

- Cardiac disorders: Myocardial infarction

- Vascular disorders: Hypertension aggravated

- Hepatobiliary disorders: Cholelithiasis aggravated, cholelithiasis recurrence

- Skin and subcutaneous tissue disorders: Seborrhoea, angioneurotic oedema, hirsutism

- Reproductive system and breast disorders: Endometrial hyperplasia, vulvovaginal pruritus

- Investigations: Weight decreased.

Other adverse reactions have been reported in association with oestrogen/progestagen treatment:

- Skin and subcutaneous disorders: Chloasma, erythema multiforme, erythema nodosum, haemorrhagic eruption, vascular purpura

- Probable dementia over the age of 65

- Dry eyes

- Tear film composition changes.

Breast cancer risk

An up to 2-fold increased risk of having breast cancer diagnosed is reported in women taking combined oestrogen-progestagen therapy for more than 5 years.

Any increased risk in users of oestrogen-only therapy is substantially lower than that seen in users of oestrogen-progestagen combinations.

The level of risk is dependent on the duration of use.

Results of the largest randomised placebo-controlled trial (WHI-study) and largest epidemiological study (MWS) are presented below:

Million Women Study - Estimated additional risk of breast cancer after 5 years' use

Age range (years)

Incidence per 1,000 never-users of HRTover 5 years

Risk ratio**

Additional cases per 1,000 HRT users over 5 years' use (95% CI)

Oestrogen-only HRT

50-65

9-12

1.2

1-2 (0-3)

Combined oestrogen-progestagen

50-65

9-12

1.7

6 (5-7)

* Taken from baseline incidence rates in developed countries.

** Overall risk ratio. The risk ratio is not constant but will increase with increasing duration on use.

Note: Since the background incidence of breast cancer differs by EU country, the number of additional cases of breast cancer will also change proportionately.

US WHI Studies - Additional risk of breast cancer after 5 years' use

Age range (years)

Incidence per 1,000 women in placebo arm over 5 years

Risk ratio and 95% CI

Additional cases per 1,000 HRT users over 5 years' use (95% CI)

CEE oestrogen-only

50-79

21

0.8 (0.7-1.0)

-4 (-6-0)*

CEE+MPA oestrogen-progestagen**

50-79

17

1.2 (1.0-1.5)

4 (0-9)

* WHI study in women with no uterus, which did not show an increase in risk of breast cancer.

** When the analysis was restricted to women who had not used HRT prior to the study there was no increased risk apparent during the first 5 years of treatment. After 5 years the risk was higher than in non-users.

Endometrial cancer risk

The endometrial cancer risk is about 5 in every 1,000 women with a uterus not using HRT.

In women with a uterus, use of oestrogen-only HRT is not recommended because it increases the risk of endometrial cancer.

Depending on the duration of oestrogen-only use and oestrogen dose, the increase in risk of endometrial cancer in epidemiological studies varied from between 5 and 55 extra cases diagnosed in every 1,000 women between the ages of 50 and 65.

Adding a progestagen to oestrogen-only therapy for at least 12 days per cycle can prevent this increased risk. In the Million Women Study the use of 5 years of combined (sequential or continuous) HRT did not increase the risk of endometrial cancer (RR of 1.0 (0.8-1.2)).

Ovarian cancer risk

Use of oestrogen-only or combined oestrogen-progestagen HRT has been associated with a slightly increased risk of having ovarian cancer diagnosed.

A meta-analysis from 52 epidemiological studies reported an increased risk of ovarian cancer in women currently using HRT compared to women who have never used HRT (RR 1.43, 95% CI 1.31-1.56). For women aged 50 to 54 years taking 5 years of HRT, this results in about 1 extra case per 2,000 users. In women aged 50 to 54 who are not taking HRT, about 2 women in 2,000 will be diagnosed with ovarian cancer over a 5-year period.

Risk of venous thromboembolism

HRT is associated with a 1.3- to 3-fold increased relative risk of developing venous thromboembolism (VTE), i.e. deep vein thrombosis or pulmonary embolism. The occurrence of such an event is more likely in the first year of using HRT. Results of the WHI studies are presented below:

WHI Studies - Additional risk of VTE over 5 years' use

Age range (years)

Incidence per 1,000 women in placebo arm over 5 years

Risk ratio and 95% CI

Additional cases per 1,000 HRT users over 5 years' use (95% CI)

Oral oestrogen-only*

50-59

7

1.2 (0.6-2.4)

1 (-3-10)

Oral combined oestrogen-progestagen

50-59

4

2.3 (1.2-4.3)

5 (1-13)

* Study in women with no uterus.

Risk of coronary artery disease

The risk of coronary artery disease is slightly increased in users of combined oestrogen-progestagen HRT over the age of 60.

Risk of ischaemic stroke

The use of oestrogen-only and oestrogen-progestagen therapy is associated with an up to 1.5-fold increased relative risk of ischaemic stroke. The risk of haemorrhagic stroke is not increased during use of HRT.

This relative risk is not dependent on age or on duration of use, but the baseline risk is strongly age-dependent. The overall risk of stroke in women who use HRT will increase with age.

WHI Studies Combined - Additional risk of ischaemic stroke* over 5 years' use

Age range (years)

Incidence per 1,000 women in placebo arm over 5 years

Risk ratio and 95% CI

Additional cases per 1,000 HRT users over 5 years' use (95% CI)

50-59

8

1.3 (1.1-1.6)

3 (1-5)

* No differentiation was made between ischaemic and haemorrhagic stroke.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme

Website: www.mhra.gov.uk/yellowcard.

Overdose

The information provided in Overdose of Activella is based on data of another medicine with exactly the same composition as the Activella of the medicine (Estradiol, Norethisteron). Be careful and be sure to specify the information on the section Overdose in the instructions to the drug Activella directly from the package or from the pharmacist at the pharmacy.
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Symptoms of over dosage with oral oestrogens are breast tenderness, nausea, vomiting and/or metrorrhagia. Overdosage of progestagens may lead to a depressive mood, fatigue, acne and hirsutism. Treatment should be symptomatic.

Pharmacodynamic properties

The information provided in Pharmacodynamic properties of Activella is based on data of another medicine with exactly the same composition as the Activella of the medicine (Estradiol, Norethisteron). Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug Activella directly from the package or from the pharmacist at the pharmacy.
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Pharmacotherapeutic group: Progestagens and oestrogens, sequential preparations, ATC code: G03FB05.

Estradiol: The active ingredient, synthetic 17β-estradiol, is chemically and biologically identical to endogenous human estradiol. It substitutes for the loss of oestrogen production in postmenopausal women and alleviates menopausal symptoms.

Oestrogens prevent bone loss following menopause or ovariectomy.

Norethisterone acetate: Synthetic progestagen. As oestrogens promote the growth of the endometrium, unopposed oestrogens increase the risk of endometrial hyperplasia and cancer. The addition of a progestagen reduces the oestrogen-induced risk of endometrial hyperplasia in non-hysterectomised women.

Relief of postmenopausal symptoms is achieved during the first few weeks of treatment.

In a post-marketing study regular withdrawal bleeding with a mean duration of 3-4 days occurred in 91% of women who took Activella over 6 months. Withdrawal bleeding usually started a few days after the last tablet of the progestagen phase.

Oestrogen deficiency at menopause is associated with an increased bone turnover and decline in bone mass. The effect of oestrogens on the bone mineral density is dose-dependent. Protection appears to be effective for as long as treatment is continued. After discontinuation of HRT, bone mass is lost at a rate similar to that in untreated women.

Evidence from the WHI trial and meta-analysis of trials show that current use of HRT, oestrogen alone or in combination with a progestagen - given to predominantly healthy women - reduces the risk of hip, vertebral, and other osteoporotic fractures. HRT may also prevent fractures in women with low bone density and/or established osteoporosis, but the evidence for that is limited.

Randomised, double-blind, placebo-controlled studies showed that 1 mg estradiol prevents the postmenopausal loss of bone minerals and increases the bone mineral density. The responses in the spine, femoral neck and trochanter were 2.8%, 1.6% and 2.5%, respectively, over 2 years with 1 mg 17ß-estradiol unopposed.

Pharmacokinetic properties

The information provided in Pharmacokinetic properties of Activella is based on data of another medicine with exactly the same composition as the Activella of the medicine (Estradiol, Norethisteron). Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug Activella directly from the package or from the pharmacist at the pharmacy.
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Following oral administration of 17β-estradiol in micronised form, rapid absorption from the gastrointestinal tract occurs. It undergoes extensive first-pass metabolism in the liver and other enteric organs, and a peak plasma concentration of approximately 27 pg/ml (range 13-40 pg/ml) occurs within 6 hours after intake of 1 mg. The area under the curve (AUC(0-tz))= 629 h x pg/ml. The half-life of 17β-estradiol is about 25 hours. It circulates bound to SHBG (37%) and to albumin (61%), while only approximately 1-2% is unbound. Metabolism of 17β-estradiol occurs mainly in the liver and the gut but also in target organs, and involves the formation of less active or inactive metabolites, including oestrone, catecholoestrogens and several oestrogen sulfates and glucuronides. Oestrogens are excreted with the bile, hydrolysed and reabsorbed (enterohepatic circulation), and mainly eliminated in urine in biologically inactive form.

After oral administration, norethisterone acetate is rapidly absorbed and transformed to norethisterone (NET). It undergoes first-pass metabolism in the liver and other enteric organs, and reaches a peak plasma concentration of approximately 9 ng/ml (range 6-11 ng/ml) within 1 hour after intake of 1 mg. The area under the curve (AUC(0-tz)) = 29 h x pg/ml. The terminal half-life of NET is about 10 hours. NET binds to SHBG (36%) and to albumin (61%). The most important metabolites are isomers of 5α-dihydro-NET and of tetrahydro-NET, which are excreted mainly in the urine as sulfate or glucuronide conjugates.

The pharmacokinetics of estradiol is not influenced by norethisterone acetate.

The pharmacokinetic properties in the elderly have not been studied.

Pharmacotherapeutic group

The information provided in Pharmacotherapeutic group of Activella is based on data of another medicine with exactly the same composition as the Activella of the medicine (Estradiol, Norethisteron). Be careful and be sure to specify the information on the section Pharmacotherapeutic group in the instructions to the drug Activella directly from the package or from the pharmacist at the pharmacy.
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Progestagens and oestrogens, sequential preparations, ATC code: G03FB05.

Preclinical safety data

The information provided in Preclinical safety data of Activella is based on data of another medicine with exactly the same composition as the Activella of the medicine (Estradiol, Norethisteron). Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug Activella directly from the package or from the pharmacist at the pharmacy.
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Animal studies with estradiol and norethisterone acetate have shown oestrogenic and progestagenic effects as expected. Both compounds induced adverse effects in preclinical reproductive toxicity studies, in particular embryotoxic effects and anomalies in urogenital tract development. Concerning other preclinic effects, the toxicity profiles of estradiol and norethisterone acetate are well-known and reveal no particular human risks beyond those discussed in other sections of the Summary of Product Characteristics and which generally apply to hormone substitution therapy.

Incompatibilities

The information provided in Incompatibilities of Activella is based on data of another medicine with exactly the same composition as the Activella of the medicine (Estradiol, Norethisteron). Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug Activella directly from the package or from the pharmacist at the pharmacy.
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Not applicable.

Special precautions for disposal and other handling

The information provided in Special precautions for disposal and other handling of Activella is based on data of another medicine with exactly the same composition as the Activella of the medicine (Estradiol, Norethisteron). Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug Activella directly from the package or from the pharmacist at the pharmacy.
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Any unused medicinal product or waste material should be disposed of in accordance with local requirements.

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