Components:

Nandrolone, Nandrolone Decanoate

Medically reviewed by Oliinyk Elizabeth Ivanovna, PharmD. Last updated on 22.03.2022

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Actdec Cadesol Ndt

Name of the medicinal product

Actdec

Therapeutic indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Actdec is indicated for the management of the anemia of renal insufficiency and has been shown to increase hemoglobin and red cell mass. Surgically induced anephric patients have been reported to be less responsive.

Managing anemia caused by kidney problems. It may also be used to treat other conditions as determined by your doctor.

Actdec is an anabolic steroid. It works by increasing the growth of certain tissues in the body and has been shown to improve the oxygen-carrying ability of blood by increasing hemoglobin and the size of red blood cells.

Dosage (Posology) and method of administration

Applies to the following strengths: phenpropionate 25 mg/mL; phenpropionate 50 mg/mL; decanoate 50 mg/mL; decanoate 100 mg/mL; decanoate 200 mg/mL

Usual Adult Dose for:

Breast Cancer
Anemia Associated with Chronic Renal Failure

Usual Pediatric Dose for:

Anemia Associated with Chronic Renal Failure

Usual Adult Dose for Breast Cancer

Control of metastatic breast cancer in women:

50 to 100 mg by deep intramuscular injection once a week.

Usual Adult Dose for Anemia Associated with Chronic Renal Failure

female: 50 to 100 mg by deep intramuscular injection once a week.

male: 100 to 200 mg by deep intramuscular injection once a week.

Usual Pediatric Dose for Anemia Associated with Chronic Renal Failure

2 to 13 years:

25 to 50 mg by deep intramuscular injecyion every 3 to 4 weeks.

> 13 years:

female: 50 to 100 mg by deep intramuscular injection once a week.

male: 100 to 200 mg by deep intramuscular injection once a week.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

More about Actdec

Actdec Side Effects
During Pregnancy
Drug Interactions
Drug class: androgens and anabolic steroids

Professional resources

Actdec (FDA)

Related treatment guides

Anemia Associated with Chronic Renal Failure
Breast Cancer

Contraindications

Androgens are contraindicated in men with carcinoma of the breast or known or suspected carcinoma of the prostate.

AndroGel® is not indicated for use in women, has not been evaluated in women, and must not be used in women.

Pregnant women should avoid skin contact with AndroGel® application sites in men. Actdec may cause fetal harm. In the event that unwashed or unclothed skin to which AndroGel® has been applied does come in direct contact with the skin of a pregnant woman, the general area of contact on the woman should be washed with soap and water as soon as possible. In vitro studies show that residual testosterone is removed from the skin surface by washing with soap and water.

AndroGel® should not be used in patients with known hypersensitivity to any of its ingredients, including testosterone USP that is chemically synthesized from soy.

Special warnings and precautions for use

Use Actdec as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Actdec is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Actdec at home, carefully follow the injection procedures taught to you by your health care provider.
If Actdec contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
If you miss a dose of Actdec, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Actdec.

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

How to use Ade topical

Interaction with other medicinal products and other forms of interaction

Decrease Actdec levels w/ enzyme-inducing agents. Increase Actdec levels w/ enzyme-inhibiting drugs. May improve glucose tolerance & decrease the need for insulin or other antidiabetic medicines in diabetics. High doses may enhance the anticoagulant action of coumarin type agents. May enhance oedema formations when co-administered w/ ACTH or corticosteroids. May decrease levels of thyroxine-binding globulin resulting in decreased total T4 serum levels & increase resin uptake of T3 & T4. Combination w/ recombinant human erythropoietin especially in females may enable a reduction of the erythropoietin dose to reduce anaemia.

Undesirable effects

Hepatic:

Hepatocellular neoplasms and peliosis hepatis have been reported in association with long-term androgenic anabolic steroid therapy.

Genitourinary System:

In men.

Prepubertal: Phallic enlargement and increased frequency of erections.
Postpubertal: Inhibition of testicular function, testicular atrophy and oligospermia, impotence, chronic priapism, epididymitis and bladder irritability.

In women: Clitoral enlargement, menstrual irregularities. In both sexes: Increased or decreased libido.

CNS:

Habituation, excitation, insomnia, depression.

Gastrointestinal:

Nausea, vomiting, diarrhea.

Hematologic:

Bleeding in patients on concomitant anticoagulant therapy.

Breast:

Gynecomastia.

Larynx:

Deepening of the voice in women.

Hair:

Hirsutism and male pattern of baldness in women.

Skin:

Acne (especially in women and prepubertal boys.)

Skeletal:

Premature closure of epiphyses in children.

Fluid and Electrolytes:

Edema, retention of serum electrolytes (sodium, chloride, potassium, phosphate, calcium).

Metabolic/Endocrine:

Decreased glucose tolerance, increased serum levels of low-density lipoprotein and decreased levels of high-density lipoprotein, increased creatine and creatinine excretion, increased serum levels of creatinine phosphokinase (CPK). Some virilizing changes in women are irreversible even after prompt discontinuance of therapy and are not prevented by concomitant use of estrogens.

Qualitative and quantitative composition

A potent androgenic steroid and major product secreted by the leydig cells of the testis. Its production is stimulated by luteinizing hormone from the pituitary gland. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to dihydrotestosterone or estradiol.