Ацизол

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Ацизол

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Ацизол

Property Description
Active ingredient Zinc Bisvinylimidazole Diacetate
Form Solution for injection
Pharmacological class Antidote
General purpose Counteracting acute toxic exposure and hypoxia
Origin Synthetic

What Type of Medicine is Ацизол (Acyzol)?

Ацизол is a synthetic medicinal preparation primarily classified as an antidote, and more generally, as a zinc preparation. Its specialized classification as a targeted antidote differentiates it from broad-spectrum detoxifying agents by focusing its action on a specific toxic mechanism, which is critical in emergency toxicology. Ацизол is particularly recognized as an established emergency treatment in the context of certain toxic gas exposures.

Composition: Zinc Bisvinylimidazole Diacetate and Pharmaceutical Form

The medicine is a single product centered on the active ingredient, Zinc Bisvinylimidazole Diacetate, a unique organozinc complex compound. This proprietary structure leverages the essential trace element Zinc to achieve its therapeutic function. The zinc-based nature of the drug significantly improves the elimination of carboxyhemoglobin, the complex formed after carbon monoxide exposure. Ацизол is supplied as a sterile aqueous solution for injection, a form that ensures rapid and complete delivery via the required parenteral intravenous infusion or intramuscular injection, highlighting its intended use in urgent clinical settings.

What is the General Purpose of Antidotal Zinc Preparations?

The general purpose of Ацизол is to serve as a pharmacological countermeasure by limiting cellular damage and systemic oxygen deprivation (hypoxia) following acute toxic exposure. The unique structure of Zinc Bisvinylimidazole Diacetate contributes to both antidotal action and protective effects, including cardioprotective and hepatoprotective benefits against toxic injury. The drug’s mechanism involves accelerating the elimination of the toxin’s complexes while simultaneously exerting a protective, antihypoxic effect on vital organs like the brain and heart, a critical function when dealing with the effects of carbon monoxide poisoning.

What side effects are possible with Ацизол?

Possible Side Effects and Safety Information

The safety profile for Ацизол (Zinc Bisvinylimidazole Diacetate) is defined by its regulatory documentation in its countries of approval, focusing on a limited range of adverse reactions. The information below is structured based strictly on reported data from official government-associated sources, such as publications citing the drug's approved labeling.


Documented Adverse Reactions and Frequency

Adverse reactions associated with Ацизол are reported as occurring infrequently or in rare cases, based on clinical experience reflected in regulatory texts. No adverse reactions are categorized as "Common" in the public summaries.

System-Organ Class Rare Adverse Reactions
Nervous System Disorders Headache
Gastrointestinal Disorders Nausea
Sensory System Disorders Metallic taste in the mouth

Safety Constraints and Time-Related Patterns

The official documentation specifies that the adverse effects observed with this medicine are typically transient. Furthermore, the regulatory safety profile indicates that the listed effects generally resolve upon discontinuation of the drug, establishing an expectation for their short-term nature.

No explicit, universally documented safety statements regarding specific constraints or risk modifications for special populations (such as older adults or those with renal impairment) are present in the public-facing regulatory summaries. The medicine’s safety context is tied to its specialized use as an antidote administered via parenteral delivery in acute toxicological settings.

Overdose and Emergency Response

Overdose and when to seek help

This information describes the official overdose profile for Ацизол (Zinc Bisvinylimidazole Diacetate), based strictly on documentation provided by national regulatory authorities. The profile outlines specific manifestations and mandated actions when the approved dose is exceeded.


Documented Overdose Manifestations

Official regulatory sources define the overdose presentation of Ацизол by a limited and specific set of clinical manifestations. These symptoms are documented as transient and non-severe.

Classification Manifestation as Documented in Regulatory Text
Sensory Metallic taste in the mouth
Neurological Headache
Gastrointestinal Nausea

Official Emergency Response and Management

Regulatory documentation indicates that the documented overdose symptoms do not constitute a medical emergency that requires specialized intervention. The official instructions define the required action and resolution process:

  • Required Action: Symptoms are stated to pass spontaneously upon the discontinuation of the drug.
  • Required Treatment: The documented manifestations do not require special treatment.
  • Antidote Status: No specific antidote is documented for the overdose in the official prescribing information.

Urgent medical help is not mandated for the self-limiting symptoms described. The overdose profile is classified by regulatory documents as mild, with symptoms resolving after the cessation of Ацизол administration.

Therapeutic Uses of Ацизол

What Ацизол Treats: Main Uses and Benefits

Ацизол (Zinc Bisvinylimidazole Diacetate) is a specialized medication classified as an antidote, generally used in urgent clinical settings to address the severe effects of specific acute toxic exposures. Its primary use is centered on addressing the consequences of toxic insult and acute hypoxia.

The medication is commonly used across conditions presenting with acute episodes of poisoning, which involve symptoms related to systemic oxygen starvation (hypoxia). Its core therapeutic applications are relevant for:

  • acute carbon monoxide (CO) poisoning,
  • addressing the resulting symptoms associated with toxicohypoxic encephalopathy, and
  • providing supportive cardioprotective and neuroprotective benefits against vital organ injury.

The benefit provided is focused on assisting the body's natural processes to clear the toxic complex, which may support the stabilization of the patient during a critical phase and contributes to easing the overall symptom load.

“The medication provides support that helps ease the overall symptom burden during periods of heightened discomfort.”

Quick Fact: Relief for Hypoxia

Quick Fact: Relief for Hypoxia

This medication is relevant for addressing symptoms of systemic oxygen starvation that follow toxic exposure, helping to alleviate the immediate distress and functional strain placed on vital organs.

Eligibility and Restrictions for Use

Who Can and Cannot Use Ацизол? (Official Regulatory Information)

Eligibility for Ацизол (Zinc Bisvinylimidazole Diacetate) is strictly defined by regulatory guidelines, focusing on age, physiological status, and underlying conditions. The medicine is primarily intended for use in adult patients 18 years of age and older.

Official Regulatory Exclusions (Contraindications)

Classification Population Group Constraint Basis
Absolute Contraindication Females during the period of lactation (breastfeeding). Reproductive Status
Absolute Contraindication Patients with known hypersensitivity to the drug or its components. Biological Risk
Not Recommended Children and adolescents under 18 years of age. Insufficient Data

Use with Caution (Conditional Eligibility)

Use of the medicine is permitted but requires explicit regulatory caution in the following patient groups, as noted in the official prescribing information:

  • Pregnant patients (use requires specific consideration).
  • Patients with a known pre-existing copper deficiency.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The officially documented interaction profile for Ацизол (Zinc Bisvinylimidazole Diacetate) is defined by specific procedural constraints and substance compatibility statements recorded in the authoritative regulatory labeling. This section describes the required restrictions and officially noted interaction patterns, adhering strictly to government documentation without providing clinical advice or therapeutic claims.


Drug-Drug Interaction Constraints

The official regulatory profile identifies a timing-based interaction rule that governs co-administration with the medicinal product Aminazine, known internationally as Chlorpromazine. The documentation mandates that the injection of Ацизол must be administered at least two hours apart from Aminazine. This procedural restriction is a required condition for use when these two medicines are co-administered. No other specific medicines or broad drug categories are explicitly listed as having interactions in the official documentation.


Interactions with Other Substances and Undocumented Categories

Regarding other common substances, the regulatory text explicitly states that the use of Zinc Bisvinylimidazole Diacetate is compatible with the presence of alcohol in the patient’s system. There are no documented statements regarding interactions with food, herbal products, or dietary supplements.

The regulatory profile does not list any formal contraindicated combinations. Likewise, the official labeling does not contain information detailing mechanistic interactions, such as those related to pharmacokinetic processes (CYP enzyme inhibition or induction, transporter effects) or pharmacodynamic synergy with other medicines.

Mechanism of Action

Modulation of Hemoglobin Oxygen Affinity

Acizol (zinc bisvinylimidazole diacetate) functions primarily through direct interaction with the hemoglobin molecule, the principal protein responsible for oxygen transport in blood. The drug influences the cooperative interaction within hemoglobin, resulting in two key effects on gas-carrying capacity. It facilitates the dissociation of carboxyhemoglobin (the complex formed with carbon monoxide) while simultaneously increasing the affinity of hemoglobin for oxygen. This modifies early molecular steps that influence gas-transport kinetics of the blood and establishes a regulated state within oxygen-carrying pathways.


️ Regulation of Cellular Tolerance to Reduced Oxygen

The compound affects biological systems that experience oxygen-related stress. Acizol exhibits antihypoxic and antioxidant properties, engaging mechanisms that modulate overall oxygen consumption at the cellular level. This contributes to the stabilization of physiological processes by increasing the functional tolerance of critical tissues, specifically cerebral and myocardial tissue, to reduced oxygen availability. The mechanism supports the regulation of processes driven by distinct signaling patterns, influencing the effects of excessive mediator activity on cellular integrity.

Dosage and Administration Information

The administration of Ацизол (Zinc Bisvinylimidazole Diacetate) is structured by specific protocols for acute toxic exposure. The medication is available in two forms that define the route of delivery: an aqueous solution for intramuscular (IM) injection at 60 mg/mL and an oral capsule at 120 mg.

The use protocol is time-critical and involves administration beginning as early as possible following the patient's removal from the toxic environment. For the injection route, the acute initial dose is 1 mL (60 mg) IM. This may be followed by a single repeat dose of 1 mL one hour later. The maximum daily dose for the IM route is restricted to 240 mg (4 mL).

When the oral capsule is administered, the standard dose is 120 mg, with a potential second dose 1.5 to 2 hours after the first. The total daily intake must not exceed 480 mg. Following the initial acute administration, the IM regimen transitions to a divided daily maintenance schedule, where the 60 mg dose is given two to four times per day. The full course of treatment, combining the acute and maintenance phases, typically lasts between 7 and 10 days. Dosage adjustments for specific age or impairment groups are not provided within the standard usage parameters.


Recent Clinical Evidence

Research Evidence / Overview of Studies for Ацизол

Evidence for Use in Acute Carbon Monoxide Poisoning

Research has examined Zinc Bisvinylimidazole Diacetate (Ацизол) in the context of treating patients with acute carbon monoxide (CO) poisoning. Studies conducted during periods of increased symptom activity include comparative clinical trials, which explore how patients respond against control or comparison groups. The primary focus of this research has been to monitor outcomes related to systemic or functional imbalance, such as measurements of carboxyhemoglobin clearance.

The studies monitored short-term changes in key biomarkers. Findings show patterns related to the changes in carboxyhemoglobin (COHb) concentration in the bloodstream, a key measurement during acute poisoning. Research also describes patterns in the time to recovery of consciousness, or resolution of acute physical discomfort, observed in the studied populations.


Research on Protective Effects for Vital Organs

In addition to the main focus on antidotal study, research has also explored protective effects relevant in conditions associated with acute or disruptive episodes, such as severe toxic exposure. Studies primarily include experimental data derived from laboratory settings and animal models simulating extreme oxygen deprivation (hypoxia) and toxic damage.

Findings indicate patterns related to indicators of tissue damage observed under these specific experimental conditions. Because these findings predominantly come from experimental or pre-clinical models, the certainty remains low regarding their direct and specific translation to complex human clinical situations.


What Research Gaps and Uncertainties Remain

The research landscape for Ацизол is limited by several factors. The volume of independent clinical trials and comprehensive systematic reviews accessible in major international literature databases varies across studies. Furthermore, sample sizes were modest in some of the referenced studies, and the data for certain groups remain insufficient, particularly concerning long-term outcomes and special populations.

Frequently Asked Questions (FAQ)

Common questions about Ацизол (FAQ)


Q: Is Ацизол the same type of drug as other common treatments for this condition?

Official regulatory information classifies Ацизол (Zinc Bisvinylimidazole Diacetate) as a synthetic antidote and a zinc preparation. This specialized classification is noted to differentiate it from broad-spectrum detoxifying agents by focusing its action on a specific toxic mechanism, which is critical in emergency toxicology settings.


Q: How long does it typically take to see the effects of Ацизол?

Clinical studies have examined outcomes related to the drug’s use, including monitoring patterns in the time to recovery of consciousness and the resolution of acute physical discomfort in patients. Specific timeframes for effects are not routinely published in publicly accessible regulatory summaries.


Q: Are there any food or drink restrictions while using Ацизол?

Official regulatory documentation does not list any restrictions related to food consumption. The regulatory text explicitly states that the use of Zinc Bisvinylimidazole Diacetate is compatible with the presence of alcohol. No official statements are documented regarding interactions with herbal products or dietary supplements.


Q: Does Ацизол interact with common pain relievers?

Regulatory documents mandate a specific timing restriction with one medicine, Aminazine (Chlorpromazine). No other specific medicines or broad drug categories, including common pain relievers, are explicitly detailed as having documented interactions in the official prescribing information.


Q: Are the side effects of Ацизол temporary or long-lasting?

Official product information specifies that the adverse effects observed with this medicine are typically transient (short-term in nature). Furthermore, these effects are expected to generally resolve upon discontinuation of the drug.


Q: What are the main risks associated with stopping Ацизол suddenly?

The regulatory safety profile indicates that the drug’s observed effects generally resolve upon discontinuation. The official documents do not contain statements detailing risks or a required tapering schedule (gradual reduction) associated with stopping the medicine.


Q: How often is Ацизол typically taken?

Following the initial acute phase, the regimen transitions to a maintenance schedule where the medicine is given two to four times per day. The full course of treatment, combining the acute and maintenance phases, typically lasts between 7 and 10 days, as specified in the official labeling.


Q: Is there a risk of allergic reactions to Ацизол?

The official regulatory information indicates that the medicine is absolutely contraindicated (must not be used) for patients with known hypersensitivity to the drug or any of its components. This contraindication signals that a risk of a serious allergic reaction exists.


Q: What happens if Ацизол is taken for a long period of time?

The full course of treatment, which includes the initial acute phase and the maintenance phase, is officially specified to typically last between 7 and 10 days. Official regulatory documents do not provide information on the effects or consequences of use beyond this specific duration.


Q: How is the effectiveness of Ацизол measured in clinical trials?

Clinical studies primarily monitor outcomes related to systemic or functional balance following toxic exposure. These measurements typically include indicators such as carboxyhemoglobin (COHb) concentration in the bloodstream and the time it takes for recovery of consciousness or resolution of acute discomfort in studied populations.


Q: Is a gradual discontinuation of Ацизол necessary?

The official prescribing information does not describe a required process for tapering or gradual discontinuation of the medicine. The safety profile, instead, notes that the observed effects generally resolve upon discontinuation.


Q: Are there age limitations for taking Ацизол?

The medicine is primarily intended for use in adult patients aged 18 years and older. Official regulatory documentation states that use in children and adolescents under 18 years of age is not recommended due to insufficient data.


Q: Are there different forms of Ацизол available (e.g., tablet, liquid)?

According to the official product information, Ацизол is available in two distinct forms: an aqueous solution intended for intramuscular (IM) injection and an oral capsule.


Q: Can I start taking Ацизол if I'm already on another long-term medication?

The regulatory profile specifically mandates that the injection of Ацизол must be administered at least two hours apart from the medicine Aminazine (Chlorpromazine). Official documentation does not list any other broad drug categories that are absolutely restricted for use in combination.

How should Ацизол be stored and disposed of?

How to Store and Dispose of Ацизол?

The storage and disposal of Ацизол (Zinc Bisvinylimidazole Diacetate) must strictly follow official regulatory requirements to ensure product stability and safety.

Storage Conditions

  • Temperature and Light: The solution must be stored at a temperature not exceeding 25 C and protected from light. It must be kept in its original primary packaging until the time of use.
  • Child Safety: Store the medicine in a place out of the reach and sight of children.

Disposal Instructions

  • Single-Use Rule: As a single-use solution for injection, any unused portion must be immediately discarded after the initial administration.
  • Pharmaceutical Waste: Disposal of expired or unused product and its packaging must adhere to local pharmaceutical waste regulations.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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