Acide Folique Arrow

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Acide Folique Arrow

Property Description
Active Ingredient Folic Acid (Pteroylglutamic acid)
Form Tablet
Pharmacological Class Anti-anemic Agent, Vitamin B9
Common Use Support for cellular health and blood formation
Origin Synthetic form of Folate

What Type of Medicine is Acide Folique Arrow?

Acide Folique Arrow is a single-ingredient pharmaceutical preparation classified as an anti-anemic agent and a member of the Vitamin group, specifically the water-soluble B complex. The product is manufactured by Arrow Generics and its core substance, Folic Acid, is recognized as an essential nutrient critical for human health. This medication serves as a hematopoietic agent, meaning it provides the fundamental material necessary to support the continuous, healthy production of blood components. Its classification recognizes its therapeutic role in supporting physiological integrity in various patient groups.


Composition and Origin: Folic Acid as Pteroylglutamic Acid

The core active ingredient in this preparation is Folic Acid, chemically identified as Pteroylglutamic acid and commonly known as Vitamin B9. Folic Acid is used for the prevention of deficiency states. Acide Folique Arrow is presented in the standard dosage form of a tablet, intended for the oral route of administration. Folic Acid itself is the synthetic form of the naturally occurring nutrient Folate, and it is manufactured to ensure stable potency and high bioavailability compared to variable dietary intake.


What is the General Purpose of Taking Acide Folique Arrow?

The general purpose of this medicine is to provide an essential nutrient that ensures optimal cellular function. The underlying action involves Folic Acid's essential role in DNA synthesis, which directly enables the vital process of erythropoiesis, or red blood cell formation. By maintaining adequate reserves of this substance, the preparation helps support overall blood system efficiency and prevents the general consequences associated with a deficiency, making it a foundational element in supporting general physiological integrity.

What side effects are possible with Acide Folique Arrow?

Possible side effects and safety information

The official safety profile for Acide Folique Arrow (Folic Acid) is primarily structured around the risk of masking a specific concurrent deficiency and the classification of adverse events by physiological system.


Adverse Reactions and Frequencies

Adverse reactions are infrequent, particularly at standard supplementation doses. Reactions are grouped by the system-organ class affected, based on regulatory documentation:

  • Immune System Disorders: Hypersensitivity reactions are classified as Rare, meaning they may affect 1 to 10 users in every 10,000. Serious reactions, including anaphylaxis and angioedema (severe swelling), are documented as possible, rare outcomes of this hypersensitivity.
  • Gastrointestinal Disorders: Effects such as anorexia, nausea, abdominal distension, and flatulence have been reported. These non-serious effects are often classified as having a Frequency Not Known, meaning their precise occurrence rate cannot be estimated from available data.
  • Psychiatric/Nervous System Disorders: Irritability and sleep disturbances have been reported, primarily following the administration of large doses.

Safety Constraints and Considerations

The most critical safety consideration relates to the presence of other medical conditions. Folic Acid must not be used alone in the treatment of megaloblastic anaemia caused by an untreated Vitamin B12 deficiency (pernicious anaemia). Folic Acid may improve the patient's blood picture while simultaneously allowing irreversible neurological damage associated with the Vitamin B12 deficiency to progress unchecked. Therefore, the medicine is contraindicated in this specific context. Caution is also noted for use in individuals with folate-dependent tumours.

Overdose and Emergency Response

Overdose and when to seek help

The official regulatory documents regarding Acide Folique Arrow (Folic Acid) overdose establish that the medicine has a low acute and chronic toxicity profile. Regulatory sources consistently state that no specific symptoms of acute overdosage are formally documented or known. This absence of a specific clinical presentation means that no serious or irreversible symptoms of intoxication are associated with oral Folic Acid overdose.

This regulatory classification is consistent across official bodies, noting that even the ingestion of extremely high oral doses is described as unlikely to cause harm to patients.

Due to this low toxicity profile, official documentation states that no specific antidote or specialized emergency treatment procedures are generally required for the management of an acute overdose. There are no specific hospital monitoring requirements or population-specific risks (such as in pediatrics or the elderly) explicitly listed in the regulatory labeling for this scenario.

When addressing an overdose, the only procedural instruction is the administration of general supportive care if clinically indicated. For specific, formal advice regarding overdose management and next steps, regulatory authorities mandate contacting a National Poisons Information Centre. This action reflects the low-risk nature and the expert guidance required as documented for this substance.

Therapeutic Uses of Acide Folique Arrow

Main Uses of Acide Folique Arrow

Acide Folique Arrow is a vitamin supplement containing folic acid, also known as vitamin B9. This essential nutrient plays a fundamental role in the production of genetic material and the formation of red blood cells. It is primarily used to manage conditions related to folic acid deficiency and to support specific physiological needs.

Management of Folic Acid Deficiency

The medication is used to treat documented folate deficiencies, which can result from various factors such as:

  • Inadequate Dietary Intake: Insufficient consumption of green leafy vegetables, legumes, and fortified grains.
  • Malabsorption Issues: Conditions that affect the body's ability to absorb nutrients in the digestive tract.
  • Increased Demand: Situations where the body requires higher levels of vitamin B9 than usual.

Prevention of Neural Tube Defects

A critical application of Acide Folique Arrow is in the prenatal context. It is frequently prescribed for women who are planning a pregnancy or who have recently become pregnant. Adequate intake of folic acid is essential for the proper development of the fetal nervous system. Specifically, it helps reduce the risk of neural tube defects, such as spina bifida, which occur in the early stages of fetal development.

Benefits for Hematological Health

By supporting the synthesis of red blood cells, folic acid helps maintain healthy blood levels and prevents certain types of anemia. In cases of macrocytic anemia, where red blood cells are abnormally large and inefficient at carrying oxygen, Acide Folique Arrow assists in restoring normal cell production and improving overall energy levels related to blood health.

Support for Cellular Function

Beyond blood health and pregnancy support, folic acid is a co-factor in several metabolic processes. It contributes to:

  • DNA Synthesis and Repair: Ensuring the integrity of genetic information during cell division.
  • Amino Acid Metabolism: Assisting in the processing of proteins within the body.
  • General Growth and Development: Supporting the rapid cell turnover required for tissue maintenance and growth.

Eligibility and Restrictions for Use

Who can and cannot use Acide Folique Arrow?

Acide Folique Arrow (Folic Acid) eligibility is defined by official regulatory documentation, focusing on patient health status and age. The medicine is contraindicated and must not be used if a patient has a known hypersensitivity to Folic Acid or any excipient in the tablet. Crucially, it is contraindicated in patients with untreated cobalamin (Vitamin B12) deficiency, as using Folic Acid alone can mask the deficiency’s symptoms while allowing irreversible neurological damage to progress.

Use is also restricted in patients with malignant disease, unless the megaloblastic anaemia is specifically caused by a folic acid deficiency.


Population Eligibility

Status/Group Official Rule
Pregnancy/Lactation Permitted for use during pregnancy and while breastfeeding.
Age Eligible for use in adults and children. The elderly on long-term therapy require B12 screening. Infants require a more suitable dosage form than the standard tablet.
Organ Function Permitted for use; patients on renal dialysis are eligible for prophylaxis.

Key Restriction: Folic Acid must not be given alone to treat undiagnosed megaloblastic anaemia; it must be co-administered with adequate Vitamin B12.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Acide Folique Arrow (Folic acid) has documented interactions with several classes of medicinal products, primarily impacting their efficacy or safety profile, as described in regulatory documentation.

Documented Interaction Categories

Folic acid can interact with two main categories of medicines based on its role in metabolism:

  • Anticonvulsants/Antiepileptics: Folic acid may increase the rate of metabolism of certain anticonvulsants, such as phenytoin, phenobarbital, and primidone, potentially leading to a decrease in their blood levels. This may necessitate monitoring and possible dose adjustment of the anticonvulsant as indicated by official guidance. The interaction may also be used in reverse, where anticonvulsants may reduce Folic acid levels, requiring supplementation.
  • Folate Antagonists (Antimetabolites): Folic acid can counteract the therapeutic effect of medicines that block its activity, such as methotrexate and pyrimethamine. For instance, in contexts where the full cytotoxic effect of methotrexate is required, high-dose Folic acid must be avoided. However, Folic acid is also specifically used as a rescue therapy to reduce the toxicity of high-dose methotrexate.

Other Specific Interactions

  • 5-Fluorouracil and Capecitabine: Co-administration may increase the risk of gastrointestinal side effects, as reported in some official documentation.
  • Valproic Acid: This medicine may contribute to reduced folate levels in the body, which is often addressed by concurrent Folic acid administration.

It is officially noted that Folic acid supplementation can mask the hematological symptoms of Vitamin B12 deficiency (pernicious anemia) while neurological complications may continue to progress. This requires appropriate diagnostic steps before initiating high-dose therapy.

Mechanism of Action

The mechanism of Folic Acid is based on its role as a fundamental metabolic cofactor that is required for high-demand cellular processes, primarily cell division and DNA synthesis. It works by addressing a core biochemical requirement, not by directly blocking or stimulating signaling pathways.

The drug's action begins when the synthetic Folic Acid is biologically reduced to its active form, primarily 5-Methyltetrahydrofolate (5-MTHF), via the enzyme Dihydrofolate Reductase (DHFR). This active metabolite is an essential one-carbon unit donor in the nucleic acid synthesis pathway. By providing the necessary methyl groups, it allows enzymes like Thymidylate Synthase to correctly synthesize the DNA-specific base Thymidylate, along with other purine bases. The resulting physiological effect is the provision of precursors necessary for DNA synthesis in cells.

The mechanism's most critical systemic consequence occurs in the rapidly dividing cells of the hematopoietic system. When DNA precursor availability is ensured, the stem cells in the bone marrow can undergo normoblastic maturation, allowing for synchronous nuclear and cytoplasmic development. This action resolves the molecular substrate deficit leading to impaired cellular maturation, permitting the generation of mature, functional red and white blood cells.

This mechanism is functionally constrained by Vitamin B12, as B12 is mandatory for recycling active folate via Methionine Synthase; deficiency causes the 'methyl-trap' phenomenon, rendering Folic Acid functionally inert.

Dosage and Administration Information

How to Use Acide Folique Arrow: Administration Guidelines

Acide Folique Arrow is administered strictly via the oral route as a tablet and is intended to be swallowed whole with water. The medicine can be taken with or without food, as its absorption is generally not dependent on mealtimes.


Standard Dosing and Frequency

Most adult therapeutic regimens are prescribed for once daily use. The standard dose for treating megaloblastic anaemia is typically 5 mg daily, which is maintained for a specific course, such as four months or until the necessary response is achieved. For high-risk prevention of Neural Tube Defects (NTDs), a 5 mg daily dose is required to start prior to conception and continue throughout the first trimester of pregnancy. In cases requiring chronic prophylactic use, such as for chronic haemolytic states, the 5 mg dose may be administered intermittently, ranging from daily to weekly.


Administration Requirements and Constraints

If a dose is missed, instructions advise taking the forgotten dose as soon as it is remembered. However, a double dose must never be taken to compensate for the one that was missed. Furthermore, the administration of high-dose Folic Acid requires that any co-existing Vitamin B12 deficiency be ruled out or adequately managed as a procedural prerequisite. Dosing for children over one year and older adults generally follows the adult regimen, although specific pediatric doses (e.g., 500 micrograms per kg daily) are established for infants under one year.

Recent Clinical Evidence

Acide Folique Arrow is a medical product containing folic acid (also known as Vitamin B9), an essential nutrient involved in DNA synthesis and repair. The clinical evidence surrounding folic acid focuses on its role in preventing specific deficiencies and mitigating related health risks.


Clinical Research Overview

Research has consistently evaluated folic acid supplementation across several major populations. The strongest evidence base supports its use in periconceptional care.

Periconceptional Use

The primary body of research has investigated the effects of folic acid supplementation in individuals planning or capable of pregnancy.

  • Neural Tube Defects (NTDs): Numerous studies, including randomized controlled trials and large-scale observational studies, have assessed the relationship between maternal folic acid intake and the risk of NTDs (such as spina bifida and anencephaly) in infants. Evidence suggests that supplementation taken before and during early pregnancy is associated with a significantly reduced risk of NTDs.
  • Dosage Context: The recommended daily intake for this preventative use is widely standardized by public health bodies, typically at 0.4 mg to 0.8 mg.

Deficiency Correction

Folic acid is used to treat folate-deficiency anemia. Studies confirm that supplementation effectively restores normal serum folate levels and resolves the associated megaloblastic anemia.

  • Evidence Basis: This use is well-established and generally supported by clinical consensus and older, foundational research demonstrating the necessity of the vitamin for proper red blood cell formation.

Cardiovascular Health

Research exploring the role of folic acid in cardiovascular risk reduction has centered on its ability to lower homocysteine levels.

  • Homocysteine Hypothesis: Trials have investigated whether lowering elevated homocysteine levels through folic acid supplementation translates into a reduction in major cardiovascular events (e.g., heart attack, stroke).
  • Study Outcomes: While folic acid effectively lowers homocysteine, major meta-analyses and large trials have not established that this reduction leads to a clinically meaningful decrease in cardiovascular disease incidence or mortality in the general population.

Key Safety Context

In studies, folic acid supplementation is generally considered well-tolerated at standard doses. However, researchers emphasize that high doses may potentially mask the hematological symptoms of vitamin B12 deficiency, a condition that requires separate monitoring and treatment.

Key Studies & References

  1. Guidelines for the management of megaloblastic anaemia in adults
  2. Folic Acid for the Prevention of Neural Tube Defects: U.S. Preventive Services Task Force Recommendation Statement

Frequently Asked Questions (FAQ)

Common questions about Acide Folique Arrow (FAQ)


Q: What is the difference between the ingredient in Acide Folique Arrow and the natural nutrient folate?

Official product information describes Folic Acid as the synthetic form of the vitamin, chemically known as Pteroylglutamic acid. The term folate is a broader, generic term that covers the family of naturally occurring compounds found in food. Folic Acid is absorbed rapidly and effectively in the body, providing a stable source of the nutrient.


Q: What does 'neural tube defect' mean in the context of Acide Folique Arrow's purpose?

Neural Tube Defects (NTDs) are a group of serious birth defects that occur when the embryonic structure that develops into the baby's brain and spinal cord does not close properly. Examples of NTDs include spina bifida and anencephaly. Official guidance on Acide Folique Arrow focuses on its role in reducing the risk of these defects.


Q: Does Acide Folique Arrow interact with common over-the-counter vitamins or herbal supplements?

Official documents address potential interactions with certain over-the-counter products. For example, antacids containing aluminium or magnesium are typically recommended not to be taken within two hours of Folic Acid. Additionally, Folic Acid may potentially reduce how well the body can use zinc supplements.


Q: What is the official information regarding the use of Acide Folique Arrow while breastfeeding?

According to the official product information and regulatory guidance, Acide Folique Arrow is permitted for use during the breastfeeding period (lactation).


Q: Is it true that taking Acide Folique Arrow can help reduce general fatigue?

While the symptoms of folate deficiency and anemia can include feeling excessively tired or fatigued, the purpose of the medicine is to correct the diagnosed deficiency. The medicine is not indicated for treating general fatigue in individuals without a confirmed deficiency.


Q: Are there any scientific studies examining the use of folic acid supplements for supporting mental health?

Research has investigated the relationship between folate levels and mood or psychological function. Regulatory documents note that adverse events reported with large doses include irritability and sleep disturbances, and deficiency states have been linked to psychological problems.


Q: What is the relationship between Acide Folique Arrow and the amino acid homocysteine?

Acide Folique Arrow plays an essential role in the body's metabolism of homocysteine. Studies have specifically examined its ability to reduce elevated levels of this amino acid in the blood. However, official research reviews generally conclude that lowering homocysteine with Folic Acid has not been established to reduce the risk of major cardiovascular events.


Q: Does Acide Folique Arrow have any established uses outside of pregnancy and anemia treatment?

Yes, the official indications for the medicine include the prophylaxis (prevention) of folate deficiency in certain patient groups. This includes individuals with chronic haemolytic states, such as sickle cell anaemia or thalassaemia major, and patients undergoing renal dialysis.


Q: Why is the 5 mg strength of Acide Folique Arrow commonly prescribed?

The standard therapeutic dose is the dose established in regulatory documents for the treatment of diagnosed folate deficiency anemia. It is also the specific higher dose used for the high-risk prevention of Neural Tube Defects, which is higher than general over-the-counter supplementation.


Q: How long does it typically take for Acide Folique Arrow to begin acting within the body?

According to official pharmacokinetic data, Folic Acid is rapidly absorbed into the bloodstream from the digestive tract after being swallowed. It is then quickly converted in the plasma and liver into its metabolically active form, L-5-MTHF, which is ready for the body to use.


Q: Is it possible to take Acide Folique Arrow for a very long period, such as over several years?

For deficiency states caused by certain chronic conditions or long-term medical problems, regulatory guidance notes that the medication may be required for a prolonged period. This may mean taking the medicine for a long time, potentially for life, to prevent the deficiency from recurring.


Q: Can a skin reaction or rash be a known potential side effect of Acide Folique Arrow?

Yes, a skin reaction or rash can be a manifestation of a hypersensitivity reaction, which is documented as a Rare adverse effect (affecting 1 to 10 users in every 10,000). Documented symptoms of this reaction include hives (urticaria), itching, or redness ( erythema).


Q: Is there a risk of taking too much folic acid if a person also eats foods fortified with the vitamin?

Folic acid is generally well-tolerated, and official documents note that taking doses higher than needed is unlikely to cause harm. Any excess folate that is not utilized by the body is generally excreted unchanged via the urine.


Q: Are there known environmental factors, like heat or light, that can affect the quality of the medicine?

Official regulatory labeling requires that the tablets be kept under specific environmental conditions to maintain their quality. The medicine must be protected from light and stored at a temperature not exceeding 25 C.


Q: What common non-prescription pain relievers might interact with Acide Folique Arrow?

Paracetamol (acetaminophen) is not noted as having a significant interaction with Folic Acid. However, official guidance suggests that the use of other common non-prescription pain relievers, such as ibuprofen or aspirin, should be reviewed, particularly for patients also taking certain other prescription medicines.


Q: Is Acide Folique Arrow prescribed for people with kidney disease who are on dialysis?

Yes, the medicine is indicated for the prophylaxis (prevention of deficiency) in patients with kidney disease who are undergoing renal dialysis. This is because renal dialysis can sometimes lead to reduced folate levels.


Q: What is the purpose of the lactose ingredient listed in Acide Folique Arrow tablets?

Lactose Monohydrate is listed in the official documents as an excipient, meaning it is a non-active ingredient. Its general purpose in a tablet formulation is to act as a filler or binder to give the tablet its necessary size, shape, and structure.


Q: Does alcohol consumption affect the folate levels in the body while taking Acide Folique Arrow?

Yes, the official drug information notes that excessive consumption of alcohol may negatively affect the way the body handles the medicine. This may be due to alcohol reducing the absorption of Folic Acid from the gut and increasing its elimination from the body.


Q: What is the distinction between folic acid and L-5-methyltetrahydrofolate (L-5-MTHF)?

Folic Acid is the stable synthetic compound found in the tablet. L-5-methyltetrahydrofolate ( L-5-MTHF) is the biologically active form of folate. After ingestion, the body converts Folic Acid into L-5-MTHF, which is the predominant form that then circulates in the plasma and is used in essential body processes.


Q: Can Acide Folique Arrow affect a patient's sleep quality?

Yes, sleep disturbances are listed as a reported adverse reaction in official safety documents. These effects on sleep quality have been reported primarily following the administration of large doses of the medicine.


Q: Does taking Acide Folique Arrow change the color of urine or have other non-serious effects?

Official data notes that folate in excess of the body's requirements is naturally eliminated through the urine, being excreted unchanged. This process is common with water-soluble B vitamins and is the body's way of clearing any unneeded amount.

How should Acide Folique Arrow be stored and disposed of?

Storage and Protection Requirements

Official regulatory labeling dictates that Acide Folique Arrow must be stored under specific conditions to maintain product stability. The tablets must be kept at a temperature not exceeding 25 C and must be protected from light.

It is a mandatory requirement to store the medicine in its original container and keep it out of the sight and reach of children to ensure safety. The product must not be used after the expiration date printed on the packaging.

Disposal Instructions

To prevent environmental contamination, unused or expired Acide Folique Arrow must not be thrown into wastewater or household waste. Disposal must instead be carried out according to local regulations for pharmaceutical waste, which typically involves returning the product to a pharmacy or using a specific drug take-back program.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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