Acemax

Acemax

A hexacarbon compound bound to glucose. It is found in citrus fruits and many vegetables. Ascorbic acid is an important nutrient in the human diet and is essential for the maintenance of connective tissue and bones. Its biologically active form, vitamin C, acts as a reducing agent and coenzyme in several metabolic pathways. Acemax is an antioxidant.

An indication is a term used to refer to a list of conditions, symptoms, or diseases for which a medication is prescribed or used by a patient. For example, acetaminophen or paracetamol is used by the patient for fever, or the doctor prescribes it for headaches or body aches. Now fever, headache, and body aches are all signs of paracetamol. The patient should be aware of the indications of medications used for common conditions, because they can be taken without a prescription at the pharmacy.

Glaucoma

It has been used for glaucoma patients. The drug reduces the formation of fluid in the eye, which leads to a decrease in intraocular pressure.

Neurological

In epilepsy, its main use is in the absence of seizures and myoclonic seizures.. It can be used for both type 1 and type 2 episodic ataxia (although it is assumed that the mechanisms are different between them).

In catamnestic epilepsy, with an increase in the frequency of seizures during menstruation, Acemax may be an adjunct to an anticonvulsant medication regimen to help reduce the frequency of seizures during menstruation.

It is also used to reduce the formation of cerebrospinal fluid in idiopathic intracranial hypertension and has been shown to be effective in some forms of periodic paralysis.

Marfan syndrome

This has been demonstrated in drug trials to relieve symptoms associated with dural ectasia in people with Marfan syndrome.

Sleep apnea

Off-label use includes Acemax as a combination drug that simply helps patients with sleep apnea by lowering blood pH and stimulating breathing.

Acute mountain sickness

Acemax it is a carbonic anhydrase inhibitor. Carbonic anhydrase is a protein in your body. Acemax reduces the activity of this protein.

Acemax is used for the treatment of glaucoma, as well as for the treatment and prevention of acute altitude sickness (altitude sickness). It is also used as part of some treatment plans for congestive heart failure and convulsive disorders.

Acemax may also be used for purposes other than those listed in this medication guide.

Preparation and storage

Solution For Parenteral Administration

Each 500 mg vial containing sterile Acemax sodium should be reconstituted with at least 5 ml of sterile water for injection before use. The reduced solutions retain their physical and chemical properties for 3 days when cooled at a temperature of 2° to 8°C (36° to 46°F) or 12 hours at a room temperature of 20° to 25°C (68° to 77°F). IT DOES NOT CONTAIN PRESERVATIVES. Direct intravenous route of administration is preferred.

Intramuscular administration is not recommended.

Glaucoma

Acemax should be used as a supplement to conventional therapy. The dosage used in the treatment of chronic simple (open-angle) glaucoma ranges from 250 mg to 1 g of Acemax per day, usually in divided doses for amounts over 250 mg. It has usually been found that a dosage exceeding 1 g per day does not give an increased effect. In all cases, the dosage should be adjusted with careful individual attention to both symptoms and eye strain. Constant medical supervision is recommended.

In the treatment of secondary glaucoma and in the preoperative treatment of some cases of acute congestive (angle-closure) glaucoma, the preferred dose is 250 mg every four hours, although some patients responded to 250 mg twice a day for short-term therapy.

In some acute cases, it may be more satisfactory to administer an initial dose of 500 mg, followed by 125 or 250 mg every four hours, depending on the specific case.

Intravenous therapy can be used to quickly relieve eye strain in acute cases. An additional effect was noted when Acemax was used in combination with myotics or mydriatics, as required by the case.

Epilepsy

It is not clear whether the positive effects observed in epilepsy are due to direct inhibition of carbonic anhydrase in the central nervous system, or whether they are due to a small degree of acidosis caused by a divided dosage. The best results to date have been seen in petit mal in children. Good results, however, have been seen in patients, both in children and adults, with other types of seizures, such as grand mal, mixed seizure patterns, myoclonic jerk patterns, etc.. D. The recommended total daily dose is from 8 to 30 mg per kg in divided doses. Although some patients respond to a low dose, the optimal range appears to be between 375 and 1000 mg per day. However, some researchers believe that daily doses exceeding 1 g do not give better results than a dose of 1 g. When prescribing Acemax in combination with other anticonvulsants, it is recommended that the initial dose is 250 mg once a day in addition to existing medications. This can be increased to the levels indicated above

The transition from other drugs to Acemax should be gradual and consistent with the usual practice of epilepsy therapy.

Congestive heart failure

For diuresis in congestive heart failure, the initial dose is usually 250 to 375 mg once a day in the morning (5 mg / kg). If the patient cannot continue to lose edematous fluid after the initial response, do not increase the dose, but allow the kidneys to recover by skipping the medication for the day.

Acemax gives the best diuretic results if taken alternately or for two days alternating with a day of rest.

Failures in therapy can be caused by overdose or too frequent dosages. The use of Acemax does not eliminate the need for other therapies, such as digitalis, bed rest, and salt restriction.

Drug-Induced Edema

The recommended dosage is 250 to 375 mg of Acemax once a day for one to two days, alternating with a day of rest.

Note: The dosage recommendations for glaucoma and epilepsy differ significantly from those for congestive heart failure, since the first two conditions do not depend on the inhibition of carbonic anhydrase in the kidneys, which requires intermittent dosage to recover from the inhibitory effect of the therapeutic agent.

Parenteral medications should be visually checked for solid particles and discoloration before administration, when the solution and container allow.

See also:
What is the most important information I need to know about Acemax?

Hypersensitivity to Acemax or any excipients in the composition. Since Acemax is a sulfonamide derivative, cross-sensitivity between Acemax, sulfonamides, and other sulfonamide derivatives is possible.

Acemax therapy is contraindicated in situations where the level of sodium and / or potassium in the blood serum is low, in cases of severe diseases or dysfunctions of the kidneys and liver, with adrenal insufficiency and hyperchloremic acidosis. It is contraindicated in patients with cirrhosis of the liver due to the risk of developing hepatic encephalopathy.

Long-term use of Acemax is contraindicated in patients with chronic noncongestive angle-closure glaucoma, as it can lead to organic angle closure, while the deterioration of glaucoma is masked by a decrease in intraocular pressure.

Use Acemax solution as directed by your doctor. Check the label on the medicine for accurate dosage instructions.

• Acemax solution is usually administered as an injection in a doctor's office, hospital, or clinic. If you use the Acemax solution at home, your doctor will teach you how to use it. Make sure you understand how to use the Acemax solution. Follow the procedures you are taught when you use the dose. If you have any questions, contact your doctor.
• Do not use Acemax solution if it contains particles, is cloudy or discolored, or if the bottle is cracked or damaged.
• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your healthcare provider how to dispose of these materials after use. Follow all local disposal regulations.
• If you missed a dose of Acemax solution, use it as soon as possible. If it's almost time for the next dose, skip the missed dose and return to your normal dosing schedule. Do not use 2 doses at once.

Ask your healthcare provider any questions about how to use the Acemax solution.

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Acemax is used to prevent and reduce the symptoms of altitude sickness. This medication can reduce the headache, fatigue, nausea, dizziness, and shortness of breath that can occur when you quickly climb to high altitudes (usually above 10,000 feet/3,048 meters). This is especially useful in situations where you can't do a slow climb. The best ways to prevent altitude sickness are to climb slowly, stopping for 24 hours during the climb to allow the body to adjust to the new altitude, and relax for the first 1-2 days.

This drug is also used together with other medications to treat a certain type of eye problem (open-angle glaucoma). Acemax is a "water tablet" (diuretic). This reduces the amount of fluid that can accumulate in the eye. It is also used to reduce the accumulation of body fluids (edema) caused by congestive heart failure or certain medications. Acemax may work less well over time, so it is usually only used for a short period.

It has also been used with other medications to treat certain types of seizures (petit mal and non-localized seizures).

OTHER USES: This section contains uses of this drug that are not listed in the approved professional label of the drug, but that may be prescribed by your healthcare professional. Use this medication for the conditions listed in this section only if it has been prescribed by your healthcare provider.

Acemax can also be used to treat periodic paralysis.

How to use Acemax

If you are taking tablets, take this medicine orally, usually 1 to 4 times a day or as directed by your doctor. If you are taking long-acting capsules, take this medicine orally, usually 1 or 2 times a day, or as directed by your doctor. Swallow the long-acting capsules whole. Do not open, break, or chew the capsules. This can destroy the long-term effect of the drug and increase the side effects.

Acemax can be taken with or without food. Drink plenty of fluids unless otherwise prescribed by your doctor. Your dosage depends on your state of health and your response to the therapy.

To prevent altitude sickness, start taking Acemax 1-2 days before the start of the ascent. Continue to take it during the ascent and for at least 48 hours after reaching the final height. You may need to continue taking this medication while staying at a high altitude to control your symptoms. If you develop severe altitude sickness, it is important that you descend as quickly as possible. Acemax will not protect you from the serious consequences of severe altitude sickness.

If you are taking this medication for another medical condition (for example, glaucoma, seizures), use it regularly as prescribed to get the maximum benefit from it. To help you remember, take it at the same time every day. By taking the last dose early in the evening, you will get rid of the need to get up in the middle of the night to urinate. Consult your doctor or pharmacist if you have questions about your dosing schedule.

Do not increase, decrease, or discontinue this medication without first consulting your doctor. Some conditions may worsen when this drug is suddenly discontinued. You may need to gradually reduce the dose.

When used for a long period of time, this drug may not work as well and may require a different dosage. Your doctor will monitor your condition. Tell your doctor if your condition does not improve or worsens (for example, more frequent seizures).

This drug can reduce the level of potassium in the blood. Your doctor may recommend that you eat foods rich in potassium (such as bananas or orange juice) while you are taking this medicine. Your doctor may also prescribe you a potassium supplement to take during your treatment. Consult your doctor for more information.

See also:
What other drugs will affect Acemax?

DIAMOX changes the metabolism of phenytoin with an increase in the level of phenytoin in the blood serum. This may increase or exacerbate the occurrence of osteomalacia in some patients receiving chronic phenytoin therapy. Patients receiving chronic concomitant therapy are advised to exercise caution.

By reducing the gastrointestinal absorption of primidone, DIAMOX can reduce the concentration of primidone and its metabolites in the blood serum, with a possible subsequent decrease in the anticonvulsant effect. Caution should be exercised when starting, stopping, or changing the dose of DIAMOX in patients receiving primidone.

Due to possible additive effects with other carbonic anhydrase inhibitors, concomitant use is not recommended.

Apo-Acemax may enhance the action of other folic acid antagonists.

Apo-Acemax may increase or decrease blood glucose levels. This should be taken into account in patients receiving antidiabetic drugs.

Apo-Acemax reduces the excretion of amphetamine in the urine and may increase the magnitude and duration of their action.

Apo-Acemax reduces the excretion of quinidine in the urine and may enhance its effect.

Apo-Acemax can prevent the diuretic antiseptic effect of methenamine.

Apo-Acemax increases the excretion of lithium, and lithium can be reduced.

The simultaneous use of Apo-Acemax and sodium bicarbonate increases the risk of kidney stones.

APO-Acemax may increase cyclosporine levels.

See also:
What are the possible side effects of Acemax?

Common side effects of using this drug include numbness and tingling in the fingers and toes, as well as taste changes (paragesia), especially for carbonated drinks. Some may also experience blurred vision, but this usually disappears shortly after stopping taking the medication. Acemax also increases the risk of developing kidney stones from calcium oxalate and calcium phosphate. Everyone will experience more frequent urination as a result of using Acemax. You need to drink more fluids than usual to prevent dehydration and headaches.. Acemax prolongs the effects of amphetamines and related drugs. Acemax also causes metabolic acidosis