A Duo Ting

A Duo Ting

Erdosteine

The drug is indicated for the treatment of adults, adolescents and children weighing more than 15 kg in the following cases:

acute inflammatory diseases of the respiratory tract: laryngopharyngitis, acute bronchitis

rhinitis, sinusitis

exacerbations of chronic diseases of the respiratory tract: chronic bronchitis, COPD, hypersecretory asthma, Bronchiectasis, chronic bronchitis of smokers (including seasonal exacerbations)

complex therapy (with antibiotics): exacerbation of bronchitis of bacterial etiology

prevention of pneumonia and partial atelectasis after surgery.

Inside.

Adult. Капсулы — по 1 капс. (300 мг) 2–3 раза в день.

Granules for the preparation of a suspension for oral administration — 8.5 ml (300 mg) 2 times a day. Dosage by body weight: 10 mg / kg body weight 2 times a day.

Granules for the preparation of a solution for oral administration — 1 sachet (225 mg) 2-3 times a day.

Child. Рекомендуемая форма — гранулы для приготовления суспензии для приема внутрь. Режим дозирования определяется на основании массы тела и возраста следующим образом:

15-20 kg (from 3 to 6 years) - 2.5 ml 2 times a day

21-30 kg (from 7 to 12 years) - 5 ml 2 times a day

over 30 kg ( over 12 years) - 5 ml 3 times a day.

Method of preparation

Granules for the preparation of the suspension: заливают водой содержимое флакона (сухой гранулят) до специальной метки. Тщательно встряхивают, пока не образуется однородная суспензия. Проверяют уровень содержимого во флаконе и (если необходимо) добавляют воды и снова встряхивают флакон. Готовая суспензия может использоваться максимум в течение 10 дней, если будет храниться в холодильнике при температуре 2-8 °C.

Before each use, shake.

Granules for the preparation of an oral solution: содержимое саше растворяют в стакане воды или чая и принимают внутрь.

hypersensitivity to the ingredients of the drug containing free radicals SH

impaired liver function

renal impairment (creatinine cl <25 ml / min)

homocystinuria (the drug is a source of homocysteine, so it is possible to disrupt the metabolism of amino acids in patients who follow a diet with a reduced content of free methionine)

phenylketonuria (for granules for the preparation of suspension and solution, as they include aspartame)

pregnancy (I trimester)

age of children(up to 2 years).

With caution:

irrational use with antitussive therapy (possible accumulation of liquid secretions in the bronchi and increased risk of superinfection or bronchospasm)

renal impairment (possible accumulation of metabolites)

severe hepatic impairment (possible increase in T1/2).

On the part of the gastrointestinal organs: редко — изжога, тошнота, диарея. Очень редко в начале лечения — возможна утрата или изменение вкусовой чувствительности.

Allergic reactions: редко — покраснение кожи, крапивница.

No cases of overdose have been reported.

Treatment: в случае передозировки или при случайном употреблении детьми рекомендуется применение симптоматической терапии.

Effectiveness is due to the action of active metabolites. Thiol groups of metabolites cause the breakdown of disulfide bridges that bind the fibers of glycoproteins, which leads to a decrease in the elasticity and viscosity of sputum. As a result, erdostein improves and accelerates the release of the respiratory tract from secretion, improves the secretory function of the epithelium, and increases the efficiency of mucociliary transport in the upper and lower respiratory tract.

Erdostein topically, by means of amine groups, acts antagonistically on oxygen free radicals and prevents the suppression of alpha-1-antitrypsin in tobacco smokers, thereby reducing the damaging effect of tobacco smoke in chronic smokers.

Erdostein increases the concentration of IgA in the mucosa of the respiratory tract in patients with chronic obstructive respiratory diseases, and also reduces the suppressing effect of tobacco smoke on the function of granulocytes. When used together, erdostein increases the concentration of amoxicillin in the bronchial secretion, which makes it possible to achieve a faster response to treatment compared to monotherapy with amoxicillin.

The effect of therapy with the drug develops on 3-4 days of treatment. Erdostein, as such, does not contain free radicals SH. Therefore, the drug has no damaging effects on the gastrointestinal tract, and the side effects of the digestive system do not differ from the effects of placebo.

Rapidly absorbed in the gastrointestinal tract and metabolized in the liver to 3 active metabolites, the most important of which-n-thiodiglycolyl-homocysteine (metabolite 1 or M1). T1 / 2-more than 5 H.Repeated application does not affect the pharmacokinetic parameters. Cmax-3.46 UG / ml

In case of liver dysfunction, there is an increase in the indices Cmax and AUC. Perhaps an increase in T1 / 2 with a pronounced violation of liver function. With renal failure, the accumulation of metabolites is possible.

• Secretolytics and stimulants of motor function of the respiratory tract

When used together, erdostein increases the concentration of ampicillin in the bronchial secretion.