Components:
Isopropyl Alcohol
Isopropyl Alcohol
Method of action:
Antifungal Broad Spectrum
Antifungal Broad Spectrum
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Name of the medicinal product

50% Isopropyl Alcohol

Qualitative and quantitative composition

Isopropyl Alcohol

Therapeutic indications

The information provided in Therapeutic indications of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
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Severe and chronic pain including that caused by trigeminal neuralgia may be relieved by injection of 50% Isopropyl Alcohol close to the nerve.

50% Isopropyl Alcohol is given intravenously in the treatment of acute poisoning from methanol.

Dosage (Posology) and method of administration

The information provided in Dosage (Posology) and method of administration of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
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Severe pain including trigeminal neuralgia

0.2ml, for a small nerve root to a maximum of 10ml for blockade of the coeliac ganglion. Injected into the individual nerve root or ganglion. The needle tip should ideally be located by radiographic or fluoroscopic means prior to dose delivery.

Methanol poisoning

A loading dose of 600 – 800mg/kg should be given. If used parenterally this should be in the form of 7.5ml/kg of a 10% infusion of Ethanol in 5% Glucose Solution for Infusion. The infusion should be given over 30minutes preferably via a central venous catheter.

The standard maintenance dose, for an average patient is 120-138mg of 100% ethanol/kg/hr (1.38ml of 10% ethanol/kg/hr) by the IV route.

Blood monitoring should occur every 1-2hours until a concentration of 1-1.5g/L is reached and thereafter at 2-4hourly intervals. After the loading dose maintenance concentrations should be reduced dependant on the normal drinking habits of the patient and any other concomitant treatments.

Patients treated with Ethanol require close monitoring preferably in a critical care area because of the risk of CNS and respiratory depression.

Amount

Absolute

(100%)

Ethanol

Volume 5%

Ethanol by IV Injection

Volume 10%

Ethanol by IV Injection

Loading Dose

Over 30 minutes

600 -800mg/kg

15ml/kg

7.5ml/kg

Standard maintenance dose

(non-drinker/child)

80-83

mg/kg/hr

1.66ml/kg/hr

0.83ml/kg/hr

Standard maintenance dose

(average adult)

120-138

mg/kg/hr

2.76/ml/kg/hr

1.38ml/kg/hr

Standard maintenance dose

(drinker)

184-196

mg/kg/hr

3.92ml/kg/hr

1.96ml/kg/hr

Maintenance dose during dialysis

(non-drinker/child)

200-213

mg/kg/hr

4.26ml/kg/hr

2.13ml/kg/hr

Maintenance dose during dialysis

(average adult)

240-268

mg/kg/hr

5.36ml/kg/hr

2.68ml/kg/hr

Maintenance dose during dialysis

(drinker)

308-326

mg/kg/hr

6.52ml/kg/hr

3.26ml/kg/hr

Ethanol can be added to peritoneal dialysate at a concentration of 1-2g/L of dialysate.

Contraindications

The information provided in Contraindications of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
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Known hypersensitivity to 50% Isopropyl Alcohol.

Special warnings and precautions for use

The information provided in Special warnings and precautions for use of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
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Women and the elderly may be more susceptible to the adverse effects of 50% Isopropyl Alcohol ingestion. Unpleasant reactions, similar to those occurring with disulfiram may occur when 50% Isopropyl Alcohol is taken concomitantly with chlorpropamide, metronidazole, and some cephalosporins. 50% Isopropyl Alcohol may cause hypoglycaemic reactions in patients receiving sulphonylurea (antidiabetic agents) or insulin, and may cause orthostatic hypotension in patients taking drugs with vasodilator action.

It may also aggravate peptic ulcer disease or hepatic impairment.

Effects on ability to drive and use machines

The information provided in Effects on ability to drive and use machines of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
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All processes requiring judgement and co-ordination are affected by 50% Isopropyl Alcohol and these include the driving of any form of transport and the operating of machinery.

Undesirable effects

The information provided in Undesirable effects of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
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Effects of 50% Isopropyl Alcohol at higher concentrations may include; nausea, vomiting, headache, dizziness and tremor. 50% Isopropyl Alcohol depresses medullary action causing lethargy, amnesia, hypothermia, hypoglycaemia (especially in children), stupor, coma, respiratory depression cardiomyopathy, hypotension or hypertension and cardiovascular collapse.

At low to moderate concentrations, 50% Isopropyl Alcohol acts as a stimulant depresses cortical function causing loss of judgement, emotional lability, muscle incoordination, visual impairment, slurred speech, ataxia, dysarthia and nystagmus.

Overdose

The information provided in Overdose of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Overdose in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
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Symptoms: Acute toxicity is primarily one of CNS depression.

Treatment:

In acute poisoning the stomach may be emptied by aspiration and lavage if indicated. If respiration is depressed, assisted respiration may be necessary. It is important to provide good supportive treatment and to keep the patient warm. Fluid balance should be maintained by the use of suitable electrolyte solution, and glucose may be needed for the treatment of hypoglycaemia.

Pharmacodynamic properties

The information provided in Pharmacodynamic properties of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
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Primary and continuous depressant of the central nervous system. It has a depressant action on the vasomotor-centre.

Subcutaneous tissues:

50% Isopropyl Alcohol injected hypodermically causes considerable pain followed by anaesthesia. If the injection is made close to the nerves, neuritis and nerve degeneration may occur. Injections in or near nerves are deliberately used to cause anaesthesia of protracted or even permanent character in the treatment of severe pain, for example, in tic doulourex.

Peripheral Nerves:

50% Isopropyl Alcohol blocks conduction in peripheral nerve by decreasing the maximal values of both the sodium and potassium conductances. The resting potential usually becomes slightly less negative.

Pharmacokinetic properties

The information provided in Pharmacokinetic properties of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
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50% Isopropyl Alcohol is rapidly distributed throughout the body. It readily crosses the placenta.

50% Isopropyl Alcohol is mainly metabolised in the liver and is converted by 50% Isopropyl Alcohol dehydrogenase to acetaldehyde and is then further oxidised to acetate. A hepatic microsomal oxidising system is also involved. About 90% to 98% of 50% Isopropyl Alcohol is oxidised and the remainder is excreted unchanged by the kidneys and the lungs and also in breast milk, saliva, sweat and other secretions.

Preclinical safety data

The information provided in Preclinical safety data of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
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There are no additional data of relevance to the prescriber.

Incompatibilities

The information provided in Incompatibilities of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
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None stated

Special precautions for disposal and other handling

The information provided in Special precautions for disposal and other handling of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
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None stated.

Administrative data
Name of the medicinal product
50% Isopropyl Alcohol
Qualitative and quantitative composition
Isopropyl Alcohol
Therapeutic indications
The information provided in Therapeutic indications of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
more... close

Severe and chronic pain including that caused by trigeminal neuralgia may be relieved by injection of 50% Isopropyl Alcohol close to the nerve.

50% Isopropyl Alcohol is given intravenously in the treatment of acute poisoning from methanol.

Dosage (Posology) and method of administration
The information provided in Dosage (Posology) and method of administration of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
more... close

Severe pain including trigeminal neuralgia

0.2ml, for a small nerve root to a maximum of 10ml for blockade of the coeliac ganglion. Injected into the individual nerve root or ganglion. The needle tip should ideally be located by radiographic or fluoroscopic means prior to dose delivery.

Methanol poisoning

A loading dose of 600 – 800mg/kg should be given. If used parenterally this should be in the form of 7.5ml/kg of a 10% infusion of Ethanol in 5% Glucose Solution for Infusion. The infusion should be given over 30minutes preferably via a central venous catheter.

The standard maintenance dose, for an average patient is 120-138mg of 100% ethanol/kg/hr (1.38ml of 10% ethanol/kg/hr) by the IV route.

Blood monitoring should occur every 1-2hours until a concentration of 1-1.5g/L is reached and thereafter at 2-4hourly intervals. After the loading dose maintenance concentrations should be reduced dependant on the normal drinking habits of the patient and any other concomitant treatments.

Patients treated with Ethanol require close monitoring preferably in a critical care area because of the risk of CNS and respiratory depression.

Amount

Absolute

(100%)

Ethanol

Volume 5%

Ethanol by IV Injection

Volume 10%

Ethanol by IV Injection

Loading Dose

Over 30 minutes

600 -800mg/kg

15ml/kg

7.5ml/kg

Standard maintenance dose

(non-drinker/child)

80-83

mg/kg/hr

1.66ml/kg/hr

0.83ml/kg/hr

Standard maintenance dose

(average adult)

120-138

mg/kg/hr

2.76/ml/kg/hr

1.38ml/kg/hr

Standard maintenance dose

(drinker)

184-196

mg/kg/hr

3.92ml/kg/hr

1.96ml/kg/hr

Maintenance dose during dialysis

(non-drinker/child)

200-213

mg/kg/hr

4.26ml/kg/hr

2.13ml/kg/hr

Maintenance dose during dialysis

(average adult)

240-268

mg/kg/hr

5.36ml/kg/hr

2.68ml/kg/hr

Maintenance dose during dialysis

(drinker)

308-326

mg/kg/hr

6.52ml/kg/hr

3.26ml/kg/hr

Ethanol can be added to peritoneal dialysate at a concentration of 1-2g/L of dialysate.

Contraindications
The information provided in Contraindications of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
more... close

Known hypersensitivity to 50% Isopropyl Alcohol.

Special warnings and precautions for use
The information provided in Special warnings and precautions for use of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
more... close

Women and the elderly may be more susceptible to the adverse effects of 50% Isopropyl Alcohol ingestion. Unpleasant reactions, similar to those occurring with disulfiram may occur when 50% Isopropyl Alcohol is taken concomitantly with chlorpropamide, metronidazole, and some cephalosporins. 50% Isopropyl Alcohol may cause hypoglycaemic reactions in patients receiving sulphonylurea (antidiabetic agents) or insulin, and may cause orthostatic hypotension in patients taking drugs with vasodilator action.

It may also aggravate peptic ulcer disease or hepatic impairment.

Effects on ability to drive and use machines
The information provided in Effects on ability to drive and use machines of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
more... close

All processes requiring judgement and co-ordination are affected by 50% Isopropyl Alcohol and these include the driving of any form of transport and the operating of machinery.

Undesirable effects
The information provided in Undesirable effects of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
more... close

Effects of 50% Isopropyl Alcohol at higher concentrations may include; nausea, vomiting, headache, dizziness and tremor. 50% Isopropyl Alcohol depresses medullary action causing lethargy, amnesia, hypothermia, hypoglycaemia (especially in children), stupor, coma, respiratory depression cardiomyopathy, hypotension or hypertension and cardiovascular collapse.

At low to moderate concentrations, 50% Isopropyl Alcohol acts as a stimulant depresses cortical function causing loss of judgement, emotional lability, muscle incoordination, visual impairment, slurred speech, ataxia, dysarthia and nystagmus.

Overdose
The information provided in Overdose of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Overdose in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
more... close

Symptoms: Acute toxicity is primarily one of CNS depression.

Treatment:

In acute poisoning the stomach may be emptied by aspiration and lavage if indicated. If respiration is depressed, assisted respiration may be necessary. It is important to provide good supportive treatment and to keep the patient warm. Fluid balance should be maintained by the use of suitable electrolyte solution, and glucose may be needed for the treatment of hypoglycaemia.

Pharmacodynamic properties
The information provided in Pharmacodynamic properties of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
more... close

Primary and continuous depressant of the central nervous system. It has a depressant action on the vasomotor-centre.

Subcutaneous tissues:

50% Isopropyl Alcohol injected hypodermically causes considerable pain followed by anaesthesia. If the injection is made close to the nerves, neuritis and nerve degeneration may occur. Injections in or near nerves are deliberately used to cause anaesthesia of protracted or even permanent character in the treatment of severe pain, for example, in tic doulourex.

Peripheral Nerves:

50% Isopropyl Alcohol blocks conduction in peripheral nerve by decreasing the maximal values of both the sodium and potassium conductances. The resting potential usually becomes slightly less negative.

Pharmacokinetic properties
The information provided in Pharmacokinetic properties of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
more... close

50% Isopropyl Alcohol is rapidly distributed throughout the body. It readily crosses the placenta.

50% Isopropyl Alcohol is mainly metabolised in the liver and is converted by 50% Isopropyl Alcohol dehydrogenase to acetaldehyde and is then further oxidised to acetate. A hepatic microsomal oxidising system is also involved. About 90% to 98% of 50% Isopropyl Alcohol is oxidised and the remainder is excreted unchanged by the kidneys and the lungs and also in breast milk, saliva, sweat and other secretions.

Preclinical safety data
The information provided in Preclinical safety data of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
more... close

There are no additional data of relevance to the prescriber.

Incompatibilities
The information provided in Incompatibilities of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
more... close

None stated

Special precautions for disposal and other handling
The information provided in Special precautions for disposal and other handling of 50% Isopropyl Alcohol is based on data of another medicine with exactly the same composition as the 50% Isopropyl Alcohol of the medicine (Isopropyl Alcohol). Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug 50% Isopropyl Alcohol directly from the package or from the pharmacist at the pharmacy.
more... close

None stated.

Administrative data
Available in countries
See all
close