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Medically reviewed by Fedorchenko Olga Valeryevna, PharmD. Last updated on 26.06.2023

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Temporary relief of symptoms associated w/ cold & flu including fever, aches, pains, nasal & sinus congestion, sneezing & minor throat pain, headache.
Acetaminophen (4-Way Cold) is a pain reliever and a fever reducer. It is used to treat many conditions such as: headache, muscle aches, arthritis, backache, toothaches, colds, and fevers.
Chlorpheniramine (4-Way Cold) is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in the body. Chlorpheniramine (4-Way Cold) prevents sneezing; itchy, watery eyes and nose; and other symptoms of allergies and hay fever.
Phenylpropanolamine (4-Way Cold) is a decongestant. It constricts (shrinks) blood vessels (veins and arteries). This reduces the blood flow to certain areas and allows nasal passages to open up.
4-Way Cold is used to treat nasal congestion; itchy, watery eyes; itchy throat; sneezing; headache; fever; and other symptoms associated with allergies, hay fever, and the common cold.
Phenylpropanolamine (4-Way Cold), an ingredient in this product, has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain Phenylpropanolamine (4-Way Cold).
4-Way Cold may also be used for purposes other than those listed in this medication guide.
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What is the most important information I should know about 4-Way Cold?
Co-administration w/ other analgesics, antipyretics or cold relief medicines, MAOIs (during & w/in 2 wk of stopping). Severe HTN or coronary artery disease.
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What other drugs will affect 4-Way Cold?
Acetaminophen (4-Way Cold) is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize Acetaminophen (4-Way Cold) [for example, carbamazepine (Tegretol), isoniazid (INH, Nydrazid, Laniazid), rifampin (Rifamate, Rifadin, Rimactane)] reduce the levels of Acetaminophen (4-Way Cold) and may decrease the action of Acetaminophen (4-Way Cold). Doses of Acetaminophen (4-Way Cold) greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for Acetaminophen (4-Way Cold) to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.
Cholestyramine (Questran) reduces the effect of Acetaminophen (4-Way Cold) by decreasing its absorption into the body from the intestine. Therefore, Acetaminophen (4-Way Cold) should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine.
Acetaminophen (4-Way Cold) doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of Acetaminophen (4-Way Cold) should be avoided during warfarin therapy
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What are the possible side effects of 4-Way Cold?
Skin rashes or minor GI disturbances.