Components:
Method of action:
Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 19.03.2022
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Hydrazine sulfate merck
Hydrazine Sulfate
Locally widespread and disseminated forms of malignant neoplasms, including in patients with cytopenia caused by chemotherapy and radiation therapy and with jaundice, especially obturation, caused by liver metastases, including far-advanced stages, including the preterminal phase (to improve well-being).
Inside, за 1–2 ч до еды или через 1–2 ч после еды (или приема других препаратов) — по 1 табл. 3 раза в сутки, при неудовлетворительной переносимости — 2 табл. в сутки; курс — 100 табл. Повторный курс проводится с интервалом не менее 14 суток; число курсов не ограничивается, при этом интервалы между курсами увеличиваются на 1–2 нед.
Hypersensitivity.
Dyspeptic phenomena, including nausea, vomiting, belching (pass with a reduction in the dose or a 2-3-day break in treatment), rarely-insomnia, general agitation, transient symptoms of polyneuritis.
After oral administration at a dose of 60 mg Cmax in the blood of sick people is reached in 2 hours. When sampling 9 hours after the end of the 30-day course of treatment, from 0 to 89 ng/ml of Hydrazine sulfate is detected in the blood. Creates levels in the liver, kidneys and lungs that are 3-5 times higher than the concentration in the blood. In the body, it is oxidized, excreted in the urine, and partially in the acetylated form (according to experimental data obtained on rats and rabbits). Urinary excretion in healthy animals lasts up to 3 days and is approximately 50% of the administered amount (in tumor-bearing animals, excretion ends between the first and second days, and only 25% of the drug is excreted). It shows a tendency to accumulate in the body of tumor-bearing animals
- Other antitumor agents
Simultaneous administration with barbiturates leads to the development of toxic effects.
In experiments on laboratory animals, it has been shown that the preliminary intake of Hydrazine sulfate megska increases the effectiveness of many antitumor drugs (with the exception of cyclophosphane).
