Recital

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Recital

Treatment option: Depression, Neurosis

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Recital

What Type of Medicine is Recital (Citalopram)?

Recital is a prescription antidepressant specifically classified as a Selective Serotonin Reuptake Inhibitor (SSRI). This medication is a synthetic small molecule drug entity intended for oral administration, typically formulated into film-coated tablets or an oral solution. This classification defines its action on the brain's serotonin system, providing a targeted approach to managing mood disorders.

The core substance of Recital is the active ingredient Citalopram. Recital's identity is defined by its mechanism, which functions to help maintain the chemical balance required for emotional well-being. Its pharmaceutical form, commonly the tablet, is designed for controlled systemic delivery via the oral route.


Composition, Origin, and Pharmaceutical Form

The active composition of Recital is Citalopram, generally present as the hydrobromide salt, constituting a single active ingredient product. Citalopram is of synthetic origin, meaning it is manufactured through controlled chemical synthesis.

Chemically, Citalopram is synthesized as a racemic compound, containing equal parts of two mirror-image molecular forms. This composition is a key structural characteristic that differentiates it from the analogue Escitalopram. The primary function of the oral form is to deliver the therapeutic action systemically after ingestion.


What is the General Purpose of an SSRI?

The general purpose of a medication classified as an SSRI is to support emotional well-being and help stabilize mood. Recital achieves this function through its mechanism principle: Selective Serotonin Reuptake Inhibition. This selective action is fundamental to its therapeutic utility, ensuring that the medication concentrates its effect on the pathways involved in regulating psychological response. By enhancing the availability of the neurotransmitter serotonin in the brain, Recital supports the chemical adjustments required to modulate mood.

Regulatory References

  1. Citalopram: MedlinePlus Drug Information

What side effects are possible with Recital?

Possible Side Effects and Safety Information

This summary outlines the official safety information for Recital as documented by government regulatory agencies. It explains the medicine's documented risks and required usage restrictions, but does not provide instructions for use or medical advice.


Documented Adverse Reactions

The most frequent safety concern associated with Recital is bleeding (hemorrhage), which is classified as a very common adverse reaction and can range from minor events to serious or life-threatening hemorrhage. Other common documented side effects include anemia, generalized pain, fever, swelling (peripheral edema), abdominal pain, indigestion (dyspepsia), and abnormal liver function test results.

Less common, yet documented, adverse reactions involve hypersensitivity/allergic reactions, low platelet counts (thrombocytopenia), and skin manifestations such as rash or itching.

Serious Safety Risks

Official regulatory documents detail the risk of major and fatal bleeding events. A specific warning is issued for the potential development of a spinal or epidural hematoma (a blood clot near the spine) following spinal procedures, which carries a risk of permanent paralysis. Rare, yet serious, adverse reactions include severe allergic reactions (anaphylactic shock) and severe skin reactions like Stevens-Johnson Syndrome (SJS).

Contraindications and Restrictions

Recital is contraindicated (must not be used) in patients who have active pathological bleeding or a known severe allergic reaction to the medicine. Official restrictions also advise against its use in patients with severe kidney impairment (creatinine clearance <15 mL/min) or those on dialysis, as well as patients with severe liver disease associated with blood clotting problems. Furthermore, premature discontinuation of Recital significantly increases the risk of developing blood clots (thrombotic events), specifically stroke in some populations. The medicine is not recommended for patients with prosthetic heart valves.

Overdose and Emergency Response

A Citalopram overdose is officially documented to involve both Central Nervous System (CNS) and serious cardiovascular manifestations. Documented CNS signs may include somnolence, agitation, tremor, dizziness, and seizures (convulsions). Severe presentations include loss of consciousness (coma) and vomiting. The most life-threatening outcomes are cardiovascular, including tachycardia, hypotension, and a dose-dependent risk of QTc interval prolongation. This electrical abnormality can lead to specific, severe cardiac arrhythmias such as Torsade de Pointes (TdP) and, ultimately, cardiac arrest. Serotonin Syndrome is also listed as a potential severe complication.

Because the regulatory label states that no specific antidote is known, management is restricted to symptomatic and supportive care. This officially described management involves mandatory monitoring of ECG and vital signs. Supportive measures like activated charcoal or stomach evacuation may be considered. Patients with hepatic impairment are noted to be at an increased risk for QTc prolongation.

In any case of suspected overdose, immediate medical attention must be sought. Emergency services must be called immediately if the affected individual has collapsed, experienced a seizure, is having trouble breathing, or cannot be awakened.

Therapeutic Uses of Recital

Recital (Citalopram) may be part of symptomatic management for Major Depressive Disorder (MDD), addressing persistent low mood, feelings of hopelessness, and the loss of interest or pleasure in daily activities. This application provides support that helps ease the overall symptom burden, assisting with maintaining functional stability during difficult episodes. This medication is generally considered relevant for symptoms that interfere with daily functioning.

The medication is considered relevant in conditions characterized by periods of heightened symptoms, notably encompassing the core indications of MDD and Panic Disorder, and is considered relevant for addressing symptom clusters associated with Obsessive-Compulsive Disorder (OCD). This medication may also be part of symptomatic management in specific clinical contexts, such as addressing premenstrual mood fluctuations or assisting with behavioral disturbances in older adults. This usage is applied during phases where the patient experiences heightened discomfort and short-term symptomatic assistance is needed.

Quick Fact: Relevant for Persistent Low Mood

By helping to support emotional balance, Recital assists with maintaining functional stability during episodes of heightened physiological activity, which may help patients cope more steadily with symptom fluctuations.

Regulatory References

  1. National Library of Medicine MedlinePlus overview

Eligibility and Restrictions for Use

Who Can and Cannot Use Recital?

The population eligibility for Recital (Citalopram) is determined by official regulatory labeling, defining who is approved to use the medicine and who is strictly prohibited.

Populations Not Eligible (Contraindications)

Recital must not be used by patients who are currently taking or have stopped within the last 14 days a Monoamine Oxidase Inhibitor (MAOI). Use is also strictly prohibited in patients with a history of Congenital Long QT Syndrome or known QT interval prolongation and those taking other medicines known to prolong the QT interval.

Age-Based and Conditional Restrictions

Recital is approved only for adults (18 years and older). Safety and effectiveness have not been established for pediatric patients under the age of 18.

Conditional use applies to certain populations, often requiring a restricted maximum daily dosage. The maximum recommended dose is restricted for older adults (aged 60 and above), patients with hepatic impairment (liver disease), and individuals who are CYP2C19 poor metabolizers.

For patients with a history of seizures/epilepsy, use requires caution. While pregnancy and lactation are not absolute contraindications, use is conditional and requires careful monitoring.

What should I know about interactions with other medicines?

The official regulatory profile for Recital (Citalopram) identifies several medicinal products and substances that may result in clinically significant interactions. These interactions are categorized based on whether they pose a risk of additive pharmacodynamic effects or alter the drug's concentration in the body.

Contraindicated and Prohibited Combinations

Co-administration with Monoamine Oxidase Inhibitors (MAOIs) is formally contraindicated due to the high risk of severe serotonergic reactions. This prohibition requires a mandatory 14-day separation period after stopping an MAOI and before starting Citalopram, and at least a 7-day separation after stopping Citalopram before starting an MAOI. Citalopram is also contraindicated for use with Pimozide and other medicinal products known to prolong the QTc interval, due to the potential for additive cardiac rhythm effects.

Exposure Modification and Pharmacodynamic Risk

Citalopram's clearance is subject to pharmacokinetic interaction from inhibitors of CYP2C19 enzymes, such as Omeprazole and Cimetidine, which can increase drug exposure. Additionally, the risk of bleeding is officially increased when Citalopram is co-administered with drugs that interfere with hemostasis, including NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) and Warfarin. Furthermore, the herbal product St. John's Wort should not be used concomitantly due to the documented risk of additive serotonergic effects. Mandatory restrictions on the maximum daily dose apply to patients with hepatic impairment and the elderly due to reduced drug clearance.

Mechanism of Action

How Recital Works

The function of Recital is defined by its selective action on the brain's communication system, engaging a two-part cascade that produces specific physiological consequences.


Selective Blockade of the Serotonin Transporter

Recital's primary mechanism is the selective inhibition of the Human Serotonin Transporter (hSERT), a presynaptic membrane protein that mediates the reuptake of the neurotransmitter Serotonin (5-HT) from the synaptic cleft. By blocking this transport function, the drug immediately ensures a higher concentration of free 5-HT is available to stimulate postsynaptic receptors. This precise molecular action initiates the entire physiological cascade by altering the chemical environment within central neural pathways.


Delayed Neuroadaptation and Circuit Modulation

The full physiological effect is not immediate but depends on a delayed adaptive process in the central nervous system. The chronic increase in 5-HT triggers a necessary downregulation of inhibitory presynaptic autoreceptors. This adaptation, which takes several weeks to develop, ultimately enhances serotonergic neurotransmission by removing a natural brake on 5-HT release, influencing the activity profile of the brain's affective and emotional circuits.

Dosage and Administration Information

How to Use Recital (Escitalopram)

Recital (escitalopram) is taken orally once daily, according to official instructions, and may be administered with or without food. The medicine is generally available as a tablet that should be swallowed whole.

Official Administration Guidelines

Administration Scope Detail
Route of Administration Oral
Timing & Food Once daily, with or without food
Adult Dosing Typically 10 mg once daily; maximum dose is 20 mg daily.
Adolescent Dosing 10 mg once daily; maximum 20 mg daily, but only after 3 weeks on the initial dose.
Elderly Dosing (>65 years) Maximum recommended dose is 10 mg daily.
Missed Dose Rule Take the next dose at the regularly scheduled time. Do not double the dose.

Procedural Instructions

  1. Take the prescribed dose once daily. The timing (morning or evening) can be chosen based on preference.
  2. Swallow the tablet without crushing or chewing.
  3. If a dose adjustment is necessary, the official instructions require waiting at least one week (three weeks for adolescents) before increasing the dose from 10 mg to 20 mg.
  4. When stopping treatment, the dose must be gradually reduced over a period of at least one to two weeks, as directed by a healthcare professional.

Recent Clinical Evidence

Research evidence / Overview of Studies for Recital (Citalopram)

Evidence for Use in Major Depressive Disorder (MDD)

Research concerning Citalopram (Recital) in Major Depressive Disorder includes short-term, double-blind, randomized controlled trials (RCTs). These studies were used in research exploring how symptoms change over time by comparing outcomes between patients receiving Citalopram against those receiving an inactive substance (a placebo) or another active medicine. Researchers specifically focused on outcomes reflecting daily functioning or activity level by measuring the intensity of depressive symptoms using standardized clinical scales, as well as the proportion of patients whose symptoms reached a specific threshold (response rates). The adult population was the main focus of this research, which was conducted during periods of increased symptom activity.

Studies reported how symptoms evolved in the observed populations during the typical treatment period of six to eight weeks. These findings describe patterns observed in the studies related to measured changes in symptom scores. However, findings related to achieving remission—the near-complete clearance of symptoms—were observed to be mixed or inconsistent across the meta-analyses pooling data from multiple trials. Data for long-term outcomes beyond the one-year mark are not fully established by controlled trials.

Evidence for Use in Panic Disorder (PD)

For conditions characterized by fluctuating or episodic manifestations such as Panic Disorder, Citalopram was evaluated in placebo-controlled RCTs. Research examined outcomes describing episodic or acute changes, focusing specifically on the frequency and intensity of panic attacks over defined time intervals. Studies observing responses over defined time intervals generally reported different patterns in the measured frequency of panic attacks between the Citalopram and placebo groups over approximately eight weeks. Comparative evidence is lacking against the most current range of other therapeutic approaches.

Evidence in Special Populations

Specific controlled research has explored the evidence base for use in older adults, noting that studies accounted for specific differences in observed effects in these populations. Additionally, controlled trials have explored the use of Citalopram in children and adolescents for conditions such as MDD and Obsessive-Compulsive Disorder (OCD). It is important to note that results apply only to the populations studied. Data for certain groups, such as pregnant or breastfeeding populations, remain insufficient from controlled trials, and follow-up durations were limited in many of the special population studies.

What is Still Uncertain About Recital

Research highlights what is known and what is still uncertain. Findings were mixed or inconsistent in the measurement of remission (full recovery) in short-term depression trials. Furthermore, there is limited information for long-term outcomes beyond approximately one year across all indications. Evidence quality varies across studies, particularly for conditions like Panic Disorder, where comparative evidence is often lacking against newer treatment options.

Frequently Asked Questions (FAQ)

Common questions about Recital (FAQ)


Q: How quickly can I expect to feel a difference after starting Recital?

A: Studies and official information indicate that the full therapeutic effects of Recital generally develop over several weeks of continued use. Steady-state concentrations of the medicine are typically achieved in the body within about one to two weeks, which is a pharmacokinetic description.


Q: Can Recital be taken long-term?

A: The FDA labeling indicates that Recital is approved for the acute and maintenance treatment of major depressive disorder (MDD). Official guidance indicates that the long-term usefulness of the drug is typically re-evaluated by a healthcare provider.


Q: What are the signs that Recital might not be working?

A: Regulatory documents advise that patients should be monitored for any indication of clinical worsening, meaning that symptoms may be getting worse. Official advice highlights that close observation is important, especially during the first few months of therapy or whenever the dosage is changed.


Q: Does Recital need to be tapered off, or can I stop suddenly?

A: Official guidance recommends a gradual reduction in dose rather than stopping the medicine abruptly. This process is recommended to help manage the potential for experiencing certain physical symptoms, known as discontinuation syndrome.


Q: What kind of monitoring is typically involved when taking Recital?

A: Regulatory warnings require that all patients, particularly those aged 24 and younger, be closely monitored when starting treatment or changing the dose. Regulatory documents indicate this monitoring is advised to watch for signs of clinical worsening or the emergence of unusual changes in behavior.


Q: What are the known potential drug-disease interactions with Recital?

A: Caution is advised when using this medicine in patients with diseases or conditions that could cause altered metabolism or hemodynamic responses (changes to blood flow). This refers to conditions that may alter how the body processes or responds to the medicine.


Q: What is the biggest difference between Recital and [similar common drug name]?

A: Recital contains the active ingredient Citalopram, which is chemically a racemic compound, meaning it has two mirror-image molecular forms. The related medicine, escitalopram, is chemically distinct as it is the single-isomer form (S-enantiomer).


Q: Can women who are pregnant or breastfeeding use Recital?

A: Official guidance states that use during pregnancy is conditional. The potential benefits and risks must be considered in this situation, as there are potential short-term withdrawal symptoms in the baby after birth. For breastfeeding, the medicine passes into breast milk in small amounts, and official guidance suggests monitoring the baby for irritability or changes in feeding.


Q: Is it common to feel tired when taking Recital?

A: Fatigue (tiredness) and somnolence (sleepiness or unusual drowsiness) are listed as documented, common adverse reactions in official product information.


Q: Does Recital cause weight changes?

A: Official regulatory documents indicate that changes in body mass are possible. Both weight increased (common) and weight decreased (uncommon) are reported as potential side effects.


Q: Is there a generic version of Recital available?

A: The active ingredient in Recital is Citalopram, which is now available in generic formulations. This means the medicine is manufactured and sold under the non-proprietary name Citalopram.


Q: Why is Recital sometimes associated with heart-related issues?

A: Regulatory warnings highlight a potential risk of QT interval prolongation, which refers to a change in the electrical activity of the heart. Regulatory warnings highlight this risk, and the condition is a contraindication (prohibition of use) for some patients.


Q: Does Recital have a risk of dependence or addiction?

A: This medicine is not considered habit-forming or physically addictive. However, abruptly stopping the treatment can lead to withdrawal-like symptoms (discontinuation syndrome), and gradual reduction of the dose is the recommended approach to managing these symptoms.


Q: What are the initial expectations when starting Recital?

A: Studies and official information indicate that the full effect of the medicine may take several weeks to develop. Patients are monitored especially closely during the initial few months of drug therapy for changes in mood or behavior.


Q: Does Recital cause problems with vision?

A: Visual disturbance and Mydriasis (pupil dilation) are documented side effects. There is also a regulatory warning for a potential risk of angle-closure glaucoma in individuals with certain eye anatomy.


Q: Are there any black box warnings associated with Recital?

A: The FDA drug labeling contains a Boxed Warning regarding the increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults (age 24 and younger) taking antidepressants. Close monitoring is essential, particularly when treatment is started or the dose is changed.


Q: Does Recital interact with blood pressure medications?

A: Regulatory documents indicate that this medicine has been shown to interact with Metoprolol, a beta-blocker often used for blood pressure. This interaction could potentially increase the risk of side effects from Metoprolol.


Q: Why do people confuse Recital with other drugs?

A: Confusion is possible because the active ingredient, Citalopram, is chemically related to the drug Escitalopram, and both belong to the same pharmacological class. Furthermore, the medicine is marketed under various brand names globally.


Q: Is Recital a controlled substance?

A: Recital (Citalopram) is classified as an SSRI (Selective Serotonin Reuptake Inhibitor) antidepressant. It is not listed as a scheduled controlled substance by the DEA in the US.


Q: Is it safe to take herbal supplements with Recital?

A: Regulatory information advises caution when combining Recital with herbal products. The concomitant use of the herbal product St. John's Wort, for example, is associated with an increased risk of a severe condition called Serotonin Syndrome.


Q: Can Recital affect fertility?

A: Official information indicates that for men, this medicine may possibly reduce sperm quality, although it is not definitively known whether this affects fertility. For women, there is no current evidence suggesting it reduces fertility.


Q: What if I experience unusual mood changes on Recital?

A: Patients, particularly those younger than 25, are advised to be monitored for clinical worsening and the emergence of suicidal thoughts and behaviors, as well as other unusual changes in behavior. Official documents highlight that this monitoring is particularly important when first starting treatment or changing the dose.


Q: What happens if I accidentally take two doses of Recital?

A: The official product labeling contains a dedicated section for Overdosage that lists reported symptoms from human experience. These symptoms may include dizziness, sweating, tremor, and nausea.


Q: How do I know if the side effects I'm feeling are normal for Recital?

A: Official documents classify documented side effects by their frequency (e.g., very common, common, uncommon) and list those reported in clinical trials. This allows for a factual description of what is commonly observed with the drug.


Q: Is it true that Recital can cause dry mouth?

A: Dry mouth is listed in regulatory documents as a documented, common adverse reaction associated with the use of this medicine.


Q: Are there any specific lifestyle changes recommended while taking Recital?

A: Regulatory documents advise caution when operating machinery or driving until you know how the medicine affects you, as it may interfere with cognitive and motor performance. The label also advises against drinking alcohol.


Q: Does Recital cause sexual side effects?

A: Sexual side effects are documented in regulatory information. These include ejaculation disorder (primarily delayed ejaculation) and impotence in males, as well as decreased libido and anorgasmia in both males and females.


Q: Do the effects of Recital wear off over time?

A: The drug is approved for maintenance treatment, and studies have demonstrated a benefit of continuing therapy to delay the recurrence of depression, suggesting that the benefits of the treatment can be sustained.


Q: Do I need a special prescription or monitoring program for Recital?

A: The drug is available only by prescription. Official warnings require that all treated patients, particularly young adults, be closely monitored for clinical worsening and the emergence of suicidal thoughts and behaviors.


Q: Is it safe to drive while taking Recital?

A: The label advises caution when operating machinery or driving until you know how Recital affects you. This warning is based on the possibility that the medicine could affect a person's ability to think clearly or react quickly.


Q: Do studies suggest Recital helps with sleep?

A: Official information suggests the medicine may impact sleep, as both Insomnia (trouble sleeping) and somnolence (sleepiness) are listed as common documented adverse reactions.

How should Recital be stored and disposed of?

How to Store and Dispose of Recital (Citalopram)

Official regulatory guidelines dictate specific methods for storing and disposing of Recital to maintain its effectiveness and ensure safety.

Storage Requirements

Condition Regulatory Requirement
Temperature Store at controlled room temperature, typically 20 C to 25 C (68 F to 77 F). Do not allow the medication to freeze or be exposed to excess heat.
Container & Protection Keep Recital in its original, tightly closed container. Store away from moisture, such as in a bathroom, and out of direct light.
Safety Keep the medication out of the sight and reach of children.

Disposal Instructions

To dispose of unused or expired Recital, utilize a drug take-back program or mail-back envelope when available. If not available, most medicines can be safely disposed of in household trash after being mixed with an undesirable substance (e.g., dirt) and placed in a sealed bag. Do not flush this medicine down the toilet unless explicitly instructed by the official product label.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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