Bricasma

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Bricasma

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Bricasma

Property Description
Active Ingredient Terbutaline sulfate
Pharmacological Class Bronchodilator; Selective beta2-Agonist
Origin Synthetic compound
Common Function Reversing and preventing airway constriction
Forms Tablet, Solution for Injection, Inhalation Powder, Solution for Nebulization

Bricasma is a recognized brand designation for a prescription medication whose active substance is the synthetic compound Terbutaline sulfate. The drug is classified as a bronchodilator, and its core purpose is to provide immediate, symptomatic relief from the feeling of tightness and restriction caused by narrowed air passages in the lungs. It achieves this function as a selective beta-2 (beta2) adrenergic receptor agonist, which concentrates its physiological action primarily on the smooth muscle tissue of the bronchi. The formulation is clinically recognized for its rapid onset of action in easing breathing difficulty.

What Type of Medication is Bricasma?

Bricasma belongs to the pharmacological group of sympathomimetic amines, with a specific therapeutic role as a highly selective beta2-adrenergic receptor stimulant. The drug’s primary action is the direct relaxation of smooth muscle in the airways, a fundamental process known as bronchodilation. This specific mechanism differentiates it from other classes of airway medicines and is the basis for its utility in situations requiring the swift opening of constricted airways, such as managing episodic breathing difficulties. Terbutaline sulfate is recognized for its capability to reverse bronchospasm associated with reversible airway disease.

Composition and Available Forms of Terbutaline

The medication is a single-ingredient product, containing only Terbutaline supplied as the sulfate salt, and is designed for multiple administration routes, offering crucial versatility. It is commonly prepared in several different dosage forms, including the oral tablet, a sterile solution for injection (parenteral use), and various inhalation options. The inhalation forms, notably the powder-based Turbuhaler and the solution for nebulization, represent the most common and targeted administration methods, delivering the active agent directly to the pulmonary system.

Regulatory References

  1. Terbutaline - MedlinePlus Drug Information
  2. Terbutaline Sulfate Tablet Label - DailyMed

What side effects are possible with Bricasma?

Possible side effects and safety information

Terbutaline sulfate (Bricasma), as a selective beta-2 adrenergic agonist, has an officially documented safety profile, with adverse reactions categorized by frequency and the physiological systems affected, according to regulatory standards. These effects are often transient and may be observed more frequently at the start of treatment or during dose escalation, based on official safety notes.

Officially Documented Adverse Reactions

Frequency Classification System-Organ Class Examples of Side Effects
Very Common Nervous system disorders Tremor, Headache
Common Cardiac disorders Tachycardia (increased heart rate), Palpitations
Nervous system / Musculoskeletal Dizziness, Nervousness, Skeletal muscle cramps
Metabolism and nutrition disorders Hypokalaemia (low potassium levels)

Adverse reactions classified as Uncommon include angina (chest pain). Rare adverse events documented in regulatory labeling include urticaria (hives) and other forms of allergic reactions, such as angioedema. The frequency of effects like hyperglycaemia (elevated blood glucose) is classified as Not Known in some official sources.

Serious Adverse Reactions and Safety Considerations

The most serious documented safety concerns include the risk of paradoxical bronchospasm, an acute, severe worsening of breathing following administration, and severe allergic reactions. Regulatory caution is required for use in patients with pre-existing cardiovascular disorders (such as coronary insufficiency or hypertension) and conditions like diabetes mellitus or hyperthyroidism. The risk of hypokalaemia is an explicit safety concern, particularly when terbutaline is used concurrently with specific medications, such as diuretics or xanthines.

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory documents specify that an overdose of Terbutaline sulfate may present with acute signs of excessive sympathetic stimulation. These documented clinical manifestations primarily involve the cardiovascular and nervous systems, as detailed in the label.

Documented Clinical Manifestations Physiological Systems Affected
Tachycardia (rapid heart rate), Palpitations, Cardiac Arrhythmias, Hypotension, Tremor, Tonic Muscle Cramps, Nervousness, Headache, Nausea. Cardiovascular, Central Nervous System, Metabolism/Electrolytes

Severe or life-threatening outcomes documented in labeling include myocardial ischemia, pulmonary edema, and severe metabolic disturbances such as significant hypokalemia and hyperglycemia. The regulatory guidance requires patients to seek immediate medical attention if the usual symptomatic relief decreases or if any signs of overdose appear. Urgent medical care is necessary following any significant accidental or intentional overexposure. The labeling also notes that large doses may aggravate pre-existing diabetes and ketoacidosis.

The management strategy officially described is symptomatic and supportive treatment. Procedural interventions such as gastric lavage and the administration of activated charcoal are described for significant oral overdose. The preferred antidote involves a cardioselective beta-receptor blocking agent; however, its use requires caution in individuals with a history of bronchospasm. Continuous monitoring of heart rate, blood pressure, acid-base balance, and electrolytes is a mandated requirement in this context.

Therapeutic Uses of Bricasma

What Bricasma Treats: Main Uses and Benefits

Bricasma, containing terbutaline, is commonly used across conditions characterized by periods of heightened symptoms that are relevant in conditions involving episodic or fluctuating manifestations, such as asthma, chronic bronchitis, and emphysema. The medication is applied in settings where symptoms create noticeable physiological strain caused by restricted air passages. This supportive application is relevant in conditions involving episodic or fluctuating manifestations, serving as an important part of symptomatic management.

The medication is applied in addressing symptom clusters that may become intense or disruptive, specifically wheezing, acute shortness of breath (dyspnea), and the feeling of chest tightness. The application is relevant for easing symptoms that interfere with daily comfort, offering symptomatic relief that supports patients during difficult episodes by easing distress.

Quick Fact: Relief for Bronchial Spasm The medication is commonly used to help with short-term symptomatic assistance during episodes of sudden bronchial spasm and associated symptoms related to physical discomfort, and is commonly used when short-term symptomatic assistance is needed.

“This therapeutic option supports the patient during difficult episodes by easing distress and may assist with maintaining functional stability when symptoms are more noticeable.”

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Eligibility Map: Who Can and Cannot Use Bricasma — Official Regulatory Information

Regulatory documents define the specific patient populations for whom Bricasma (terbutaline sulfate) is indicated, contraindicated, or restricted.

Eligibility Scope
Populations for whom use is allowed: Adults and adolescents 12 years of age and older for the prevention and reversal of bronchospasm.
Populations for whom use is not recommended: Children younger than 12 years of age (for oral and injectable forms).
Populations for whom use is contraindicated: Patients with a known hypersensitivity to terbutaline or other sympathomimetic amines. Pregnant women for tocolysis (stopping premature labor), as this use is not approved and is contraindicated for both oral and prolonged injectable administration.
Age, Condition, and Physiological Status Rules
Age-related eligibility rules: The minimum age for treatment of bronchospasm is 12 years.
Condition-specific eligibility rules (Use with Caution): Regulatory caution is mandated for patients with pre-existing cardiovascular disorders (including hypertension, arrhythmias, or ischemic heart disease), diabetes mellitus, hyperthyroidism, or convulsive disorders.
Pregnancy and lactation eligibility status: Use during pregnancy for bronchospasm should only occur if the potential benefit justifies the potential risk. The medicine is excreted into human milk.

Eligibility is primarily structured by a clear minimum age threshold and by absolute contraindications for hypersensitivity and for any use to stop premature labor. Caution is required for populations with specific comorbidities, which defines a conditional use eligibility status.

What should I know about interactions with other medicines?

Bricasma’s interaction profile is primarily defined by pharmacodynamic conflicts with other medication classes that affect the sympathetic nervous or cardiovascular systems, as documented in official regulatory labeling. Notably, the oral formulation is explicitly contraindicated for use in acute or maintenance tocolysis (treatment to delay delivery).

Interacting Medication Class Regulatory Interaction Classification and Outcome
beta-Blockers Pharmacodynamic Antagonism: May block the pulmonary effect of the medicine and can produce severe bronchospasm in asthmatic patients; generally not recommended.
Sympathomimetic Agents Additive Risk: Concomitant use is not recommended due to the potential for a deleterious combined effect on the cardiovascular system.
MAOIs & TCAs Vascular Potentiation: Must be administered with extreme caution due to the risk of potentiation of the vascular system action, a restriction that extends to within two weeks of discontinuation of those agents.
Non-Potassium Sparing Diuretics Electrolyte/ECG Worsening: Can acutely worsen the beta-agonist-induced hypokalemia and/or changes observed on the electrocardiogram.

Furthermore, the official labeling includes caution regarding non-medicinal substances. Regulatory advice indicates that interactions may occur with the use of alcohol and tobacco. Patients are formally advised to disclose the use of any herbal products or nutritional supplements to their healthcare professional.

Mechanism of Action

The pharmacological action of Terbutaline sulfate is centered on two highly specific mechanistic domains: the direct modulation of cell-surface receptors and the downstream cascade that leads to smooth muscle relaxation.

Selective Activation of beta2-Adrenergic Receptors

Terbutaline sulfate functions as a highly selective agonist at the beta2-adrenergic receptors (beta2-ARs) found predominantly on the smooth muscle of the airways. This interaction mimics the body's natural sympathetic signaling, rapidly initiating an intracellular cascade that results in the functional relaxation of smooth muscle in the bronchial tree.

Molecular Cascade Leading to Smooth Muscle Relaxation

Binding to the beta2-AR triggers the enzyme Adenyl Cyclase, leading to a rapid and substantial increase in the second messenger molecule cAMP. High cAMP levels inhibit Myosin Light-Chain Kinase (MLCK), which prevents the final steps of muscle contraction by reducing the availability of free calcium ( Ca^2+) ions. This sequence quickly results in the physiological effect of bronchodilation, which is the relaxation and widening of the air passages.

Dosage and Administration Information

Official Administration Guidelines for Bricasma

Bricasma (terbutaline sulfate) is administered via multiple routes, including oral tablets, inhalation (powder or nebulization solution), and parenteral injection, with the specific form determining the usage instructions. Dosage must always be individualized based on the patient's need.


Dosing and Frequency

Route of Administration Dosing Rule (Adults) Frequency/Timing
Oral Tablet 2.5 mg to 5 mg (max 15 mg/24 hr) 2 to 3 times per day
Inhalation (Turbuhaler) 0.25 mg to 0.5 mg (max 2 mg/24 hr) As required, or up to every 6 hours
Nebulization Solution 5 mg (approx 2 mL) for body weight >25 kg 2 up to 4 times per 24-hour period

Age-Specific Use: Oral tablets are dosed separately for children aged 7–15 years (typically 2.5 mg two to three times daily). Inhaled doses are also defined for children 7–12 years, maintaining a maximum 24-hour limit.


Procedural and Preparation Steps

  • Inhalation Technique: For powder inhalers (e.g., Turbuhaler), patients must be instructed to breathe in forcefully and deeply through the mouthpiece to ensure delivery of the optimal dose. The inhalation technique should be checked regularly.
  • Oral Rinse: Patients should be advised to, when possible, rinse their mouth after each inhalation use to minimize unnecessary systemic exposure to the medicine.
  • Nebulization: The solution for nebulization is typically ready for use without dilution and must not be mixed with alkaline solutions (pH higher than 7.0). Opened single-dose units must be used within 24 hours.
  • Timing: Inhaled bronchodilators should be used as required for initial therapy rather than regularly. There are no specific official restrictions regarding administration in relation to meals.

Recent Clinical Evidence

Bricasma: Recent Clinical Evidence

Evidence for Use in Acute and Chronic Airway Conditions

The core research for Bricasma has been studied for conditions characterized by fluctuating or episodic manifestations, such as asthma and Chronic Obstructive Pulmonary Disease (COPD). Studies were evaluated where patients had outcomes related to physical discomfort stemming from bronchospasm. Researchers primarily utilized short-term Randomized Controlled Trials (RCTs) and crossover studies that explored the drug's activity. These trials monitored objective measurements of pulmonary function, such as FEV1, to evaluate changes measured in lung function. Findings describe patterns observed in the studies where patterns related to acute measurement shifts were observed in the study participants. Research also includes studies that examine the pharmacokinetic and pharmacodynamic (PK/PD) profiles across various administration methods.

Research Base for Acute Exacerbations and Symptom Relief

Research has explored scenarios relevant in trials assessing short-term or episodic symptom patterns, such as when conditions involve periods of heightened symptoms or acute breathing distress. Many of these acute studies were evaluated in designs that included a placebo comparator or compared different formulations of the drug itself. Findings indicate patterns of change that were measurable, both objectively (lung function) and subjectively (patient reports). The primary approach in many trials was studied for evaluating changes measured in lung function, and these results apply only to the populations studied.

Long-Term Studies and Limitations

The research on Bricasma primarily was studied for its use in exploring short-term symptom changes. The duration of follow-up in many of the core trials was limited to periods of weeks or a few months. Therefore, long-term effects are not fully established. Evidence is limited in terms of data tracking outcomes related to systemic or functional imbalance over many years. Furthermore, comparative evidence is lacking for many subgroups. A key gap is that many studies focus on surrogate outcomes (like FEV1 measurements) rather than long-term clinical outcomes reflecting daily functioning or data related to the avoidance of significant adverse events.

Evidence in Special Populations and Areas of Uncertainty

Studies were evaluated in specific groups, including Adults and Adolescents with asthma and COPD. Research was observed in some studies to include pediatric patients, particularly in scenarios involving severe, acute asthma flares. However, the evidence in this particular group is limited and primarily relates to urgent-care settings. The certainty of the evidence regarding sustained effects for the long-term course of the disease is still under investigation.

Key Studies & References Label: TERBUTALINE SULFATE tablet - US Prescribing Information

Frequently Asked Questions (FAQ)

Common questions about Bricasma (FAQ)

Q: Is Bricasma considered a 'reliever' or a 'preventer' type of medication?

A: Bricasma (terbutaline sulfate) is indicated for the prevention and reversal of bronchospasm. Official guidance on its use 'as required' for immediate effects suggests a role as a symptomatic relief medication, rather than a primary long-term preventer.


Q: How does the inhaled form of Bricasma compare to the tablet form in terms of onset of action?

A: The onset of effect is generally faster when Bricasma is used as an inhaled medication compared to the oral tablet form. For the tablets, regulatory data indicates that measurable improvement in breathing usually occurs within 30 minutes, with the most significant effect seen one to two hours after administration.


Q: Is it safe to use Bricasma if I am taking over-the-counter cold and flu medicines?

A: Regulatory documents advise caution regarding combined use with other sympathomimetic agents, as this can increase the potential for undesirable effects on the heart and circulatory system. Regulatory guidance recommends consulting with a healthcare professional regarding any concerns with non-prescription medicines.


Q: Is Bricasma used for long-term maintenance treatment or only for acute symptoms?

A: Official guidance indicates that beta-adrenergic agonist bronchodilators, when used alone, may not be sufficient to control symptoms for many patients with asthma. This suggests Bricasma's role is primarily for symptomatic or acute relief, and that anti-inflammatory agents like corticosteroids may need to be added for complete long-term management.


Q: What is the purpose of the 'Turbuhaler' device for Bricasma?

A: The Turbuhaler device is a type of dry powder inhaler designed to deliver the terbutaline sulfate directly to the lungs. This inhalation method is designed to deliver the medication directly to the pulmonary system to manage breathing difficulties.


Q: Why are people with hyperthyroidism advised to use Bricasma with caution?

A: People with hyperthyroidism (overactive thyroid) are often more sensitive to the effects of adrenergic medications like Bricasma. Because Bricasma can stimulate receptors in the heart, this increased sensitivity can lead to a higher risk of adverse cardiovascular events such as a fast or irregular heartbeat.


Q: Is Bricasma a short-acting beta-agonist (SABA)?

A: Bricasma's active ingredient, terbutaline, is officially classified as a selective beta2-adrenergic receptor agonist. Its intended use is to provide immediate, symptomatic relief from bronchospasm, which fits the functional description of a short-acting medication.


Q: What is the meaning of the term 'bronchospasm' in the context of Bricasma's use?

A: In simple terms, bronchospasm is the sudden, involuntary tightening of the muscles surrounding the air passages in the lungs. Bricasma is used to help reverse and prevent this constriction, which opens the airways and eases breathing.


Q: Do studies exist comparing Bricasma to Salbutamol (Albuterol) for acute asthma relief?

A: The core clinical evidence for Bricasma often involves comparisons against a placebo or different formulations of terbutaline itself. Official information often notes that comprehensive comparative evidence with other specific beta2-agonists, such as Salbutamol (Albuterol), may be lacking for all patient subgroups.


Q: What is the typical duration of effect for Bricasma Turbuhaler?

A: Official product information states that the bronchodilator effect of terbutaline sulfate, the active ingredient in Bricasma, is often cited in product information as lasting up to six hours.


Q: What does it mean if Bricasma seems less effective than it was before?

A: Regulatory warnings state that if Bricasma becomes less effective in relieving symptoms, or if your need for the product increases, this suggests asthma may be destabilizing, which is a condition requiring prompt consultation with a healthcare professional for re-evaluation.


Q: Does using Bricasma affect the ability to drive or operate machinery?

A: Bricasma is associated with potential side effects such as tremor, nervousness, and dizziness. Regulatory labeling advises caution regarding activities like driving or operating machinery until a person knows how the medication affects them.


Q: What is the reported safety profile of Bricasma for older patients?

A: Official information indicates that studies have not identified age-related problems that would limit the usefulness of Bricasma specifically in the elderly. However, Official safety information notes that caution may be necessary due to the higher likelihood of age-related health conditions.


Q: Does Bricasma contain any propellants, lubricants, or preservatives?

A: The Bricasma Turbuhaler is a dry powder inhaler that contains the active ingredient, terbutaline sulfate, but does not contain any propellants. Regulatory documents list all components (excipients), which typically include only the active substance and sometimes a carrier, like lactose.


Q: How is Bricasma eliminated from the body?

A: Terbutaline is processed in the body primarily through natural chemical changes known as sulfation and glucuronidation (metabolism). The drug and its byproducts are mainly excreted through the urine.


Q: Is Bricasma typically used alone or with other medications for asthma?

A: Official guidance notes that using beta-agonist bronchodilators alone is often insufficient to fully manage asthma. Because of this, anti-inflammatory agents, such as inhaled corticosteroids, are often recommended to be added early in the treatment regimen for better disease control.


Q: What are the potential signs of an overdose with Bricasma?

A: Signs of using too much Bricasma are typically an exaggeration of the common side effects. These can include a very fast or irregular heartbeat (arrhythmias), chest discomfort, extreme nervousness, and muscle tremors. In severe cases, seizures, nausea, and vomiting may occur.

How should Bricasma be stored and disposed of?

How to Store and Dispose of Bricasma

To ensure Bricasma (terbutaline) maintains its stability and effectiveness, strict storage and handling guidelines must be followed as defined in regulatory documents.

Storage and Handling

  • Temperature: Do not store the inhaler above 30 C (86°F).
  • Protection: The product must be kept in a cool, dry place. Always ensure the cover is firmly in place/tightened to protect the dry powder from moisture.
  • Moisture: The mouthpiece must never get wet; wipe it with a clean dry tissue if needed.
  • Safety: The inhaler must be stored out of the reach and sight of children.

Disposal

Do not dispose of the used, damaged, or expired inhaler in household trash or by flushing it down a toilet. It must be returned to your pharmacist or local pharmacy for proper disposal according to local environmental regulations.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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