Deflamat 2%

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Deflamat 2%

Property Description
Active ingredient Diclofenac (as salt, e.g., Diclofenac Sodium)
Form Topical Preparation (e.g., Gel or Solution)
Pharmacological class Nonsteroidal Anti-inflammatory Drug (NSAID)
Common use Localized relief of pain and swelling
Origin Synthetic Phenylacetic Acid Derivative

Defining the Drug's Identity and Class

Deflamat 2% is a specific pharmaceutical preparation whose identity centers on the active ingredient, Diclofenac. This compound belongs to the Nonsteroidal Anti-inflammatory Drug (NSAID) pharmacological class. Diclofenac itself is a synthetic substance, chemically known as a phenylacetic acid derivative. This medicine is recognized for its function as both an analgesic and anti-inflammatory agent. The utility of Diclofenac in managing inflammatory symptoms is a factor in its broad medical acceptance.

Composition and Formulation: The Meaning of "2% Topical Preparation"

The designation Deflamat 2% specifies that the medicine is a topical preparation, typically formulated as a gel or solution, and is intended for cutaneous administration—direct application to the skin. The "2%" explicitly denotes the concentration, signifying that Diclofenac constitutes two percent of the total product composition. This formulation offers differentiation: unlike oral NSAIDs, the topical approach aims to localize the therapeutic effect. Topical Diclofenac is absorbed through the skin to provide a targeted effect in the underlying tissues, an attribute recognized for managing localized discomfort. This provides an option when symptom relief is required only at a specific area.

High-Level Purpose: How Deflamat 2% Generally Helps

The overall purpose of Deflamat 2% is to provide localized relief from discomfort associated with pain and swelling. It achieves this by utilizing its core mechanism: the inhibition of prostaglandin synthesis. This action means the medicine helps to reduce the production of the body's chemical messengers that generate and sustain inflammatory signals. For instance, in a typical neutral use scenario, Deflamat 2% is applied to manage simple aches and discomfort in a specific joint or muscle. This targeted anti-inflammatory and analgesic effect is the primary function of the topical 2% formulation, establishing its general benefit for local symptom management.

Regulatory References

  1. NIH/NCBI Diclofenac Review

What side effects are possible with Deflamat 2%?

Possible Side Effects and Safety Information

The safety profile for Deflamat 2% (topical diclofenac) is defined primarily by local application site reactions, which are the most frequently documented adverse effects, and by potential systemic NSAID class risks as defined in official regulatory labeling.

Official Adverse Reaction Classification

Adverse reactions are classified by frequency, with the most common effects primarily related to the Skin and Subcutaneous Tissue Disorders. These are officially listed as:

Frequency Examples of Officially Documented Adverse Reactions
Common (1% to 10%) Application site dermatitis (including contact dermatitis), pruritus (itching), rash, erythema, and dry skin.
Uncommon (0.1% to 1%) Scaling, skin dehydration, and localized edema.
Rare (<0.1%) Bullous dermatitis and photosensitivity reaction.

Serious Adverse Reactions and Systemic Risks

Due to the medicine's classification as an NSAID, the regulatory documents include warnings for serious systemic risks, which may occur after systemic absorption. These label-documented serious reactions include serious cardiovascular thrombotic events (such as myocardial infarction or stroke) and serious gastrointestinal events (including bleeding, ulceration, and perforation).

Population-Specific and Time-Related Safety

Official labeling includes specific constraints for certain groups. The medicine is officially contraindicated in the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use is also contraindicated in patients with aspirin-sensitive asthma due to the risk of severe bronchospasm. The risk of serious cardiovascular thrombotic events may begin as early as the first weeks of treatment and may increase with duration of use.

Overdose and Emergency Response

Overdose and When to Seek Help

The overdose profile for Deflamat 2% relates to the potential for systemic toxicity from its active ingredient, Diclofenac, which may occur after accidental ingestion or excessive topical exposure.

Documented Manifestations and Severe Outcomes

Official regulatory documentation describes common systemic toxicity signs that may present as headache, dizziness, nausea, vomiting, epigastric pain, disorientation, and tinnitus.

Severe outcomes documented in prescribing information include serious organ damage: gastrointestinal hemorrhage, acute renal failure, and hepatic damage. Less frequent, but officially listed, severe complications include neurological events such as convulsions and coma. Elderly patients and those with pre-existing renal or hepatic impairment are officially noted as populations facing a greater risk of severe toxicity.

Mandated Emergency Action and Management

Management is based on the principle of symptomatic and supportive treatment, as regulatory sources state that no specific antidote is known for Diclofenac.

Immediate medical attention is required for any suspected overdose or if severe clinical manifestations are observed. This action is critical for initiating necessary support and continuous intensive monitoring of vital signs and organ function in a medical setting.

Therapeutic Uses of Deflamat 2%

What Deflamat 2% Treats: Main Uses and Benefits

Deflamat 2% is primarily used for the supportive management of symptoms related to localized pain and inflammation in musculoskeletal areas. The active ingredient is generally used for the relief of symptoms associated with osteoarthritis of joints amenable to topical treatment, such as the knees and hands.

The preparation is considered relevant for easing symptoms associated with conditions that include acute soft tissue injuries (such as muscle strains, sprains, and contusions) and recurrent manifestations like localized joint pain and tendonitis. By easing these distressing manifestations, the product may contribute to improved day-to-day comfort and assists with maintaining functional stability during symptomatic phases.

“The product is applied in contexts where additional symptomatic support for mild to moderate discomfort is needed.”


Quick Fact: Relief for Localized Musculoskeletal Pain The primary therapeutic role of Deflamat 2% is to target pain and inflammation that is strictly confined to a specific area. It is used in areas where short-term symptom management is appropriate.

Regulatory References

  1. [DailyMed Label Information on Diclofenac Sodium Topical Gel

Eligibility and Restrictions for Use

Official Eligibility Profile for Deflamat 2%

This section defines who is eligible and who is prohibited from using Diclofenac 2% topical preparation, based strictly on government regulatory documentation.

Populations Absolutely Contraindicated

The medicine is strictly contraindicated and must not be used in the following populations:

  • Individuals with a history of allergic-type reactions (such as asthma, hives, or acute rhinitis) after taking aspirin or other NSAIDs.
  • Females starting at 30 weeks gestation (third trimester of pregnancy).
  • Children and adolescents under 14 years of age, due to insufficient data on efficacy and safety.
  • Patients in the setting of Coronary Artery Bypass Graft (CABG) surgery (perioperative period).

Restricted and Conditional Use

Population Category Regulatory Rule
Age Use is documented for Adults and Adolescents aged 14 and over. Older adults require particularly careful monitoring due to increased risk.
Organ Function Use should be avoided in patients with advanced renal disease or severe heart failure. Caution is advised for those with impaired hepatic or renal function.
Pregnancy/Lactation First/Second Trimester: Use is not recommended unless clearly necessary. Lactation: Should only be used under professional advice and must not be applied to the breasts or large skin areas.

What should I know about interactions with other medicines?

Interactions with other medicines and products

This section outlines the officially documented interaction profile for Deflamat 2% (diclofenac diethylamine) topical gel, strictly based on regulatory authority information. The key constraint governing the interaction profile is the very low systemic absorption of the active substance when the gel is applied topically.

Interaction Scope and Constraints

Feature Official Regulatory Statement
Interacting medicinal product categories Systemic Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Aspirin.
Mechanistic basis of interactions Interactions are very unlikely due to the very low systemic absorption of diclofenac with topical use.
Interaction-related restrictions None explicitly stated for co-administration of other medicinal products due to low systemic exposure.
Interaction relevance classification Very unlikely / not clinically significant (based on intended use).

Official Interaction Statements

Regulatory documents consistently state that interactions with other medicines are very unlikely when Deflamat 2% is used as intended. This conclusion is reached because the amount of diclofenac entering the systemic circulation from topical application is negligible.

However, a cautionary note exists for cases where the gel is applied over large areas of skin and/or over a prolonged period. In these specific circumstances, the potential for systemic exposure increases, and undesirable effects typically associated with systemic diclofenac, including those relevant to interactions (e.g., renal or hepatic effects), cannot be entirely excluded. The official profile does not establish specific timing rules or restrictions against co-administration of systemic medicines, relying on the low systemic exposure as the primary interaction mitigation factor.

Mechanism of Action

The active pharmaceutical ingredient in Deflamat 2% is diclofenac, a non-steroidal anti-inflammatory drug (NSAID).

Its primary biological target is the cyclooxygenase (COX) enzyme system, specifically acting as a non-selective inhibitor of both COX-1 and COX-2 isoforms, with a degree of selectivity toward COX-2 inhibition reported in in vitro studies. The drug competitively and reversibly occupies the active site of these enzymes, preventing the binding of the natural substrate, arachidonic acid.

This interaction blocks the molecular pathway responsible for the synthesis of prostanoids, including prostaglandins (e.g., PGE₂) and thromboxanes. The intracellular consequence is a reduction in the total cellular concentration of these lipid mediators. Downstream, the systemic physiological consequence is the modulation of cellular processes mediated by prostanoids, such as vasodilation and increased vascular permeability, through the resulting decrease in their availability to local receptors and tissues.

Dosage and Administration Information

How to Use Deflamat 2%

This section outlines the general administration principles and dosing protocols for Diclofenac topical gel.

Administration and Dosage Protocol

The method of administration is topical (cutaneous) use. The product is formulated as a gel and is intended for direct application to the skin over the affected area. The exact dose applied is determined by the specific joint being treated and must be measured using the dosing card supplied with the product.

Joint Location Standard Dose per Application Maximum Daily Dose (Total)
Lower Extremity (e.g., knee) 4 grams 32 grams across all joints
Upper Extremity (e.g., hand) 2 grams (Limit is 8g for one upper joint)

The gel is typically applied to the affected area four times a day. In some instances, such as for acute trauma, the application frequency is twice a day, preferably morning and evening. The overall duration of use must adhere to the principle of using the lowest effective dosage for the shortest possible time.

Administration Constraints

To maintain proper use, the gel should be applied only to intact, clean skin. After application, the user must wash hands immediately, unless the hands are the area being treated. The treated site should not be covered with airtight occlusive dressings or subjected to external heat. Additionally, contact with the eyes and mucous membranes must be avoided, and a wait of at least one hour before showering or bathing the treated area is advised.

Note on Population Use: No dose adjustments are generally required for older adults or those with mild renal or hepatic impairment. The use of this topical preparation is not recommended for the pediatric population under 14 years of age.

Recent Clinical Evidence

Research evidence / Overview of Studies for Deflamat 2%

Evidence for Use in Chronic Pain (Localized Osteoarthritis)

Research exploring how symptoms change over time for localized osteoarthritis has primarily relied on short-term, controlled trials. These studies often compared the active preparation to a non-active gel, known as a vehicle. The trials included adults with confirmed, symptomatic osteoarthritis, focusing on joints such as the knee and hand that were included in the research protocols. Researchers monitored outcomes related to physical discomfort and changes in measures of daily functioning or activity level.

Findings describe patterns observed in these studies, with research observing measured changes in patient-reported pain scores when compared to the non-active vehicle. Systematic reviews and meta-analyses, which combine data from multiple RCTs, describe the observed patterns. Long-term effects are not fully established by controlled trials conducted over extended periods (e.g., beyond three months). This means that there is limited information for long-term outcomes regarding the continued evolution of patient-reported symptoms.


Evidence for Use in Acute Pain (Soft Tissue Injuries)

Studies focusing on episodes where symptoms become more noticeable—such as those linked to acute soft tissue injuries—have consisted mainly of short-term controlled trials. These trials included adults with recent-onset injuries like sprains or muscle strains. Research examined outcomes related to episodic or acute changes in pain and evaluated factors such as the time needed to reach a defined pain assessment threshold and the impact on tenderness to pressure over the injured area.

The evidence derived from these settings describes patterns observed in patients reporting symptom evolution over the short duration of the study. Studies report how symptoms evolved in the observed populations during the first 7 to 14 days following an injury. Data are still emerging for certain groups, and there is an absence of evidence regarding long-term implications, such as whether use was associated with the prevention of future recurrence.


Limitations and Research Gaps

The overall evidence summarizes the available research—and what is still uncertain. Evidence is limited regarding the clinical structure for all joints affected by osteoarthritis, as research has mainly been confined to the knee and hand. Additionally, comparative evidence is uncertain for certain scenarios, meaning the research has not directly compared the preparation against all other available topical treatments. The results apply only to the specific populations studied, meaning research does not determine whether an individual will respond similarly.

Frequently Asked Questions (FAQ)

Common questions about Deflamat 2% (FAQ)

Q: What specific types of pain or inflammation is Deflamat 2% typically used to treat?

Regulatory documents indicate that the primary uses for this medicine are for the localized management of pain and inflammation. Specifically, official product information covers conditions like osteoarthritis and acute soft tissue injuries, such as simple sprains and strains. This targeted effect is recognized for managing localized discomfort in a specific area.


Q: What are the signs of a serious or rare side effect when using Deflamat 2%?

While serious side effects are rare, official warnings cover potential systemic risks related to the NSAID class of medicines. Signs of these risks may include chest pain, shortness of breath, or slurred speech, related to cardiovascular events. Gastrointestinal issues may appear as bloody, black, tar-like stools or vomiting blood.


Q: Can I use Deflamat 2% under a heating pad or a cold pack?

Official guidance restricts applying external heat or airtight dressings to the treated area, as this may increase absorption. Regulatory product information does not, however, contain explicit restrictions regarding the use of cold packs with the gel.


Q: Are there any specific activities to avoid while using Deflamat 2%, such as sun exposure?

Official documents list a photosensitivity reaction (increased sensitivity to light) as a rare adverse effect. This means there is a potential for increased sensitivity to sunlight on the skin where the product was applied. Due to this documented risk, patient labels often describe the need to limit or avoid sun exposure and use protective clothing over the treated area.


Q: Can Deflamat 2% be used on large areas of the body?

Regulatory warnings caution that applying the gel over large areas of the skin may increase the potential for systemic absorption. Increased systemic absorption could lead to the possibility of side effects typically associated with oral NSAID use. Official patient labeling does not specify the exact size that defines a 'large area' of skin.


Q: Is the 2% concentration different from other strengths of the active ingredient?

Yes, the concentration is used to define the product’s specific regulatory approvals. The 2% formulation is officially indicated for the management of pain associated with conditions such as osteoarthritis. Other topical strengths of the active ingredient, such as 1% or 3%, may be approved by regulatory bodies for different medical conditions or joints.


Q: Can Deflamat 2% interact with common over-the-counter pain relievers like Tylenol (acetaminophen)?

Official interaction profiles generally conclude that an interaction is very unlikely because the topical gel has very low systemic absorption. Some regulatory health bodies have documented that concurrent use with acetaminophen (paracetamol) has not been associated with interactions due to low systemic absorption.


Q: Does Deflamat 2% interact with blood-thinning medicines (anticoagulants)?

Regulatory documents include cautions regarding co-administration with blood-thinning medicines (anticoagulants). While systemic absorption is low, the potential for an increased risk of bleeding with prolonged use or use over large skin areas cannot be entirely ruled out.


Q: Is it safe to use Deflamat 2% while taking prescribed medication for high blood pressure?

Regulatory documents contain precautionary statements regarding use in individuals with pre-existing high blood pressure or those taking specific medications. Although absorption is minimal, systemic use of NSAIDs has been linked to potential fluid retention or worsening of blood pressure in rare cases.


Q: Can individuals with a history of stomach ulcers use Deflamat 2%?

Official documents contain precautionary statements for patients with a history of stomach ulcers or gastrointestinal bleeding. This caution exists because the medicine belongs to the NSAID class, which carries a minimal, potential risk of serious gastrointestinal events.


Q: What should be done if I accidentally get Deflamat 2% in my eyes?

Regulatory safety instructions state that contact with the eyes and mucous membranes must be avoided. If accidental eye contact does occur, the action documented in patient safety information, if accidental contact occurs, is to immediately rinse the eye with plenty of cool water.


Q: Is it possible to develop an allergy to Deflamat 2% after using it for a while?

Officially documented adverse effects include various common skin reactions at the application site. These include contact dermatitis, rash, and itching, which are inflammatory reactions that may develop after starting use.


Q: What percentage of the medication is absorbed into the bloodstream from the 2% gel?

Studies and regulatory reviews have reported that the amount of medication absorbed into the bloodstream after topical application is minimal. Systemic levels typically fall within a range of 0.2% to 8% of the levels achieved when the same medicine is taken orally.


Q: Can the active ingredient in Deflamat 2% be found in other types of medicines?

Yes, the active ingredient, diclofenac, is recognized in official sources as being available in many different pharmaceutical forms. These include oral tablets, patches, and solutions, which are used for various different purposes besides the topical gel.

How should Deflamat 2% be stored and disposed of?

How to Store and Dispose of Deflamat 2% (Diclofenac Diethylamine Gel)

Deflamat 2% must be stored and disposed of strictly according to regulatory labeling to maintain its stability and prevent environmental harm.

Storage Requirements

Condition Requirement
Temperature Store at controlled room temperature, between 20°C and 25°C (68°F and 77°F).
Protection Keep in the original tube and protect from light.
Prohibition Do not freeze the product.
Safety Keep out of the sight and reach of children.

Disposal Instructions

Any unused or expired Deflamat 2% must be disposed of in accordance with local requirements for pharmaceutical waste. Diclofenac poses a risk to the aquatic environment, meaning the product must not be discarded into wastewater or sewage systems. Excess gel, if wiped off, should be placed in household waste.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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